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PubMed code 17507218

Compile data set for download or QSAR
Found 28 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20384
PNG
(3-[1-(4-bromophenyl)ethyl]-1-isoquinolin-5-ylurea ...)
Show SMILES CC(NC(=O)Nc1cccc2cnccc12)c1ccc(Br)cc1
Show InChI InChI=1S/C18H16BrN3O/c1-12(13-5-7-15(19)8-6-13)21-18(23)22-17-4-2-3-14-11-20-10-9-16(14)17/h2-12H,1H3,(H2,21,22,23)
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n/an/an/an/a 26n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem Lett 17: 3894-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.105
BindingDB Entry DOI: 10.7270/Q2NV9GH2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20402
PNG
(1-isoquinolin-5-yl-3-{2-[4-(trifluoromethyl)phenyl...)
Show SMILES CC(C)(NC(=O)Nc1cccc2cnccc12)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C20H18F3N3O/c1-19(2,14-6-8-15(9-7-14)20(21,22)23)26-18(27)25-17-5-3-4-13-12-24-11-10-16(13)17/h3-12H,1-2H3,(H2,25,26,27)
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n/an/an/an/a 94n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem Lett 17: 3894-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.105
BindingDB Entry DOI: 10.7270/Q2NV9GH2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20394
PNG
(3-{1-[3-fluoro-4-(trifluoromethyl)phenyl]propyl}-1...)
Show SMILES CCC(NC(=O)Nc1cccc2cnccc12)c1ccc(c(F)c1)C(F)(F)F
Show InChI InChI=1S/C20H17F4N3O/c1-2-17(12-6-7-15(16(21)10-12)20(22,23)24)26-19(28)27-18-5-3-4-13-11-25-9-8-14(13)18/h3-11,17H,2H2,1H3,(H2,26,27,28)
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n/an/an/an/a 109n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem Lett 17: 3894-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.105
BindingDB Entry DOI: 10.7270/Q2NV9GH2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20386
PNG
(3-{1-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl}-1-...)
Show SMILES CC(NC(=O)Nc1cccc2cnccc12)c1ccc(c(F)c1)C(F)(F)F
Show InChI InChI=1S/C19H15F4N3O/c1-11(12-5-6-15(16(20)9-12)19(21,22)23)25-18(27)26-17-4-2-3-13-10-24-8-7-14(13)17/h2-11H,1H3,(H2,25,26,27)
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n/an/an/an/a 19n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem Lett 17: 3894-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.105
BindingDB Entry DOI: 10.7270/Q2NV9GH2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20392
PNG
(3-[1-(4-tert-butyl-2-ethylphenyl)ethyl]-1-isoquino...)
Show SMILES CCc1cc(ccc1C(C)NC(=O)Nc1cccc2cnccc12)C(C)(C)C
Show InChI InChI=1S/C24H29N3O/c1-6-17-14-19(24(3,4)5)10-11-20(17)16(2)26-23(28)27-22-9-7-8-18-15-25-13-12-21(18)22/h7-16H,6H2,1-5H3,(H2,26,27,28)
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n/an/an/an/a 20n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem Lett 17: 3894-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.105
BindingDB Entry DOI: 10.7270/Q2NV9GH2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20397
PNG
(3-(2-cyano-1-phenylethyl)-1-isoquinolin-5-ylurea |...)
Show SMILES O=C(NC(CC#N)c1ccccc1)Nc1cccc2cnccc12
Show InChI InChI=1S/C19H16N4O/c20-11-9-17(14-5-2-1-3-6-14)22-19(24)23-18-8-4-7-15-13-21-12-10-16(15)18/h1-8,10,12-13,17H,9H2,(H2,22,23,24)
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n/an/an/an/a 1.59E+4n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem Lett 17: 3894-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.105
BindingDB Entry DOI: 10.7270/Q2NV9GH2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20387
PNG
(3-isoquinolin-5-yl-1-{phenyl[4-(trifluoromethyl)ph...)
Show SMILES FC(F)(F)c1ccc(cc1)C(NC(=O)Nc1cccc2cnccc12)c1ccccc1
Show InChI InChI=1S/C24H18F3N3O/c25-24(26,27)19-11-9-17(10-12-19)22(16-5-2-1-3-6-16)30-23(31)29-21-8-4-7-18-15-28-14-13-20(18)21/h1-15,22H,(H2,29,30,31)
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n/an/an/an/a 147n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem Lett 17: 3894-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.105
BindingDB Entry DOI: 10.7270/Q2NV9GH2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20393
PNG
(3-[1-(2,4-di-tert-butylphenyl)ethyl]-1-isoquinolin...)
Show SMILES CC(NC(=O)Nc1cccc2cnccc12)c1ccc(cc1C(C)(C)C)C(C)(C)C
Show InChI InChI=1S/C26H33N3O/c1-17(20-12-11-19(25(2,3)4)15-22(20)26(5,6)7)28-24(30)29-23-10-8-9-18-16-27-14-13-21(18)23/h8-17H,1-7H3,(H2,28,29,30)
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n/an/an/an/a 17n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem Lett 17: 3894-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.105
BindingDB Entry DOI: 10.7270/Q2NV9GH2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20404
PNG
(3-1H-indazol-4-yl-1-[(1S)-1-[4-(trifluoromethyl)ph...)
Show SMILES C[C@H](NC(=O)Nc1cccc2[nH]ncc12)c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C17H15F3N4O/c1-10(11-5-7-12(8-6-11)17(18,19)20)22-16(25)23-14-3-2-4-15-13(14)9-21-24-15/h2-10H,1H3,(H,21,24)(H2,22,23,25)/t10-/m0/s1
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n/an/an/an/a 248n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem Lett 17: 3894-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.105
BindingDB Entry DOI: 10.7270/Q2NV9GH2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20405
PNG
(3-1H-indazol-4-yl-1-[(1R)-1-[4-(trifluoromethyl)ph...)
Show SMILES C[C@@H](NC(=O)Nc1cccc2[nH]ncc12)c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C17H15F3N4O/c1-10(11-5-7-12(8-6-11)17(18,19)20)22-16(25)23-14-3-2-4-15-13(14)9-21-24-15/h2-10H,1H3,(H,21,24)(H2,22,23,25)/t10-/m1/s1
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n/an/an/an/a 41n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem Lett 17: 3894-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.105
BindingDB Entry DOI: 10.7270/Q2NV9GH2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20406
PNG
(3-1H-indazol-4-yl-1-[(1S)-1-(4-methylphenyl)ethyl]...)
Show SMILES C[C@H](NC(=O)Nc1cccc2[nH]ncc12)c1ccc(C)cc1 |r|
Show InChI InChI=1S/C17H18N4O/c1-11-6-8-13(9-7-11)12(2)19-17(22)20-15-4-3-5-16-14(15)10-18-21-16/h3-10,12H,1-2H3,(H,18,21)(H2,19,20,22)/t12-/m0/s1
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n/an/an/an/a 749n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem Lett 17: 3894-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.105
BindingDB Entry DOI: 10.7270/Q2NV9GH2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20389
PNG
(3-isoquinolin-5-yl-1-{phenyl[4-(piperidin-1-yl)phe...)
Show SMILES O=C(NC(c1ccccc1)c1ccc(cc1)N1CCCCC1)Nc1cccc2cnccc12
Show InChI InChI=1S/C28H28N4O/c33-28(30-26-11-7-10-23-20-29-17-16-25(23)26)31-27(21-8-3-1-4-9-21)22-12-14-24(15-13-22)32-18-5-2-6-19-32/h1,3-4,7-17,20,27H,2,5-6,18-19H2,(H2,30,31,33)
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n/an/an/an/a 171n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem Lett 17: 3894-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.105
BindingDB Entry DOI: 10.7270/Q2NV9GH2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20396
PNG
(3-[2-(dimethylamino)-1-phenylethyl]-1-isoquinolin-...)
Show SMILES CN(C)CC(NC(=O)Nc1cccc2cnccc12)c1ccccc1
Show InChI InChI=1S/C20H22N4O/c1-24(2)14-19(15-7-4-3-5-8-15)23-20(25)22-18-10-6-9-16-13-21-12-11-17(16)18/h3-13,19H,14H2,1-2H3,(H2,22,23,25)
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n/an/an/an/a 3.10E+4n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem Lett 17: 3894-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.105
BindingDB Entry DOI: 10.7270/Q2NV9GH2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20399
PNG
(3-{cyclopentyl[4-(trifluoromethyl)phenyl]methyl}-1...)
Show SMILES FC(F)(F)c1ccc(cc1)C(NC(=O)Nc1cccc2cnccc12)C1CCCC1
Show InChI InChI=1S/C23H22F3N3O/c24-23(25,26)18-10-8-16(9-11-18)21(15-4-1-2-5-15)29-22(30)28-20-7-3-6-17-14-27-13-12-19(17)20/h3,6-15,21H,1-2,4-5H2,(H2,28,29,30)
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n/an/an/an/a 476n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem Lett 17: 3894-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.105
BindingDB Entry DOI: 10.7270/Q2NV9GH2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20403
PNG
(3-1H-indazol-4-yl-1-{1-[4-(trifluoromethyl)phenyl]...)
Show SMILES CC(NC(=O)Nc1cccc2[nH]ncc12)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C17H15F3N4O/c1-10(11-5-7-12(8-6-11)17(18,19)20)22-16(25)23-14-3-2-4-15-13(14)9-21-24-15/h2-10H,1H3,(H,21,24)(H2,22,23,25)
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n/an/an/an/a 47n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem Lett 17: 3894-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.105
BindingDB Entry DOI: 10.7270/Q2NV9GH2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20385
PNG
(3-[1-(4-tert-butylphenyl)ethyl]-1-isoquinolin-5-yl...)
Show SMILES CC(NC(=O)Nc1cccc2cnccc12)c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C22H25N3O/c1-15(16-8-10-18(11-9-16)22(2,3)4)24-21(26)25-20-7-5-6-17-14-23-13-12-19(17)20/h5-15H,1-4H3,(H2,24,25,26)
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n/an/an/an/a 24n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem Lett 17: 3894-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.105
BindingDB Entry DOI: 10.7270/Q2NV9GH2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20400
PNG
(1-{cyclohexyl[4-(trifluoromethyl)phenyl]methyl}-3-...)
Show SMILES FC(F)(F)c1ccc(cc1)C(NC(=O)Nc1cccc2cnccc12)C1CCCCC1
Show InChI InChI=1S/C24H24F3N3O/c25-24(26,27)19-11-9-17(10-12-19)22(16-5-2-1-3-6-16)30-23(31)29-21-8-4-7-18-15-28-14-13-20(18)21/h4,7-16,22H,1-3,5-6H2,(H2,29,30,31)
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n/an/an/an/a 287n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem Lett 17: 3894-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.105
BindingDB Entry DOI: 10.7270/Q2NV9GH2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20407
PNG
(3-1H-indazol-4-yl-1-[(1R)-1-(4-methylphenyl)ethyl]...)
Show SMILES C[C@@H](NC(=O)Nc1cccc2[nH]ncc12)c1ccc(C)cc1 |r|
Show InChI InChI=1S/C17H18N4O/c1-11-6-8-13(9-7-11)12(2)19-17(22)20-15-4-3-5-16-14(15)10-18-21-16/h3-10,12H,1-2H3,(H,18,21)(H2,19,20,22)/t12-/m1/s1
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n/an/an/an/a 73n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem Lett 17: 3894-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.105
BindingDB Entry DOI: 10.7270/Q2NV9GH2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20408
PNG
(3-1H-indazol-4-yl-1-[(1S)-1-(naphthalen-2-yl)ethyl...)
Show SMILES C[C@H](NC(=O)Nc1cccc2[nH]ncc12)c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C20H18N4O/c1-13(15-10-9-14-5-2-3-6-16(14)11-15)22-20(25)23-18-7-4-8-19-17(18)12-21-24-19/h2-13H,1H3,(H,21,24)(H2,22,23,25)/t13-/m0/s1
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n/an/an/an/a 3.75E+3n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem Lett 17: 3894-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.105
BindingDB Entry DOI: 10.7270/Q2NV9GH2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20388
PNG
(1-[(4-tert-butylphenyl)(phenyl)methyl]-3-isoquinol...)
Show SMILES CC(C)(C)c1ccc(cc1)C(NC(=O)Nc1cccc2cnccc12)c1ccccc1
Show InChI InChI=1S/C27H27N3O/c1-27(2,3)22-14-12-20(13-15-22)25(19-8-5-4-6-9-19)30-26(31)29-24-11-7-10-21-18-28-17-16-23(21)24/h4-18,25H,1-3H3,(H2,29,30,31)
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n/an/an/an/a 125n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem Lett 17: 3894-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.105
BindingDB Entry DOI: 10.7270/Q2NV9GH2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20391
PNG
(3-[1-(4-tert-butyl-2-methylphenyl)ethyl]-1-isoquin...)
Show SMILES CC(NC(=O)Nc1cccc2cnccc12)c1ccc(cc1C)C(C)(C)C
Show InChI InChI=1S/C23H27N3O/c1-15-13-18(23(3,4)5)9-10-19(15)16(2)25-22(27)26-21-8-6-7-17-14-24-12-11-20(17)21/h6-14,16H,1-5H3,(H2,25,26,27)
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n/an/an/an/a 46n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem Lett 17: 3894-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.105
BindingDB Entry DOI: 10.7270/Q2NV9GH2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20395
PNG
(1-isoquinolin-5-yl-3-(1-phenylpropyl)urea | isoqui...)
Show SMILES CCC(NC(=O)Nc1cccc2cnccc12)c1ccccc1
Show InChI InChI=1S/C19H19N3O/c1-2-17(14-7-4-3-5-8-14)21-19(23)22-18-10-6-9-15-13-20-12-11-16(15)18/h3-13,17H,2H2,1H3,(H2,21,22,23)
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n/an/an/an/a 2.58E+3n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem Lett 17: 3894-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.105
BindingDB Entry DOI: 10.7270/Q2NV9GH2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20409
PNG
(3-1H-indazol-4-yl-1-[(1R)-1-(naphthalen-2-yl)ethyl...)
Show SMILES C[C@@H](NC(=O)Nc1cccc2[nH]ncc12)c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C20H18N4O/c1-13(15-10-9-14-5-2-3-6-16(14)11-15)22-20(25)23-18-7-4-8-19-17(18)12-21-24-19/h2-13H,1H3,(H,21,24)(H2,22,23,25)/t13-/m1/s1
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n/an/an/an/a 123n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem Lett 17: 3894-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.105
BindingDB Entry DOI: 10.7270/Q2NV9GH2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20334
PNG
(1-Isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-ur...)
Show SMILES FC(F)(F)c1ccc(CNC(=O)Nc2cccc3cnccc23)cc1
Show InChI InChI=1S/C18H14F3N3O/c19-18(20,21)14-6-4-12(5-7-14)10-23-17(25)24-16-3-1-2-13-11-22-9-8-15(13)16/h1-9,11H,10H2,(H2,23,24,25)
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n/an/an/an/a 4n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem Lett 17: 3894-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.105
BindingDB Entry DOI: 10.7270/Q2NV9GH2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20383
PNG
(1-isoquinolin-5-yl-3-{1-[4-(trifluoromethyl)phenyl...)
Show SMILES CC(NC(=O)Nc1cccc2cnccc12)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H16F3N3O/c1-12(13-5-7-15(8-6-13)19(20,21)22)24-18(26)25-17-4-2-3-14-11-23-10-9-16(14)17/h2-12H,1H3,(H2,24,25,26)
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n/an/an/an/a 22n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem Lett 17: 3894-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.105
BindingDB Entry DOI: 10.7270/Q2NV9GH2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20398
PNG
(3-{cyclopropyl[4-(trifluoromethyl)phenyl]methyl}-1...)
Show SMILES FC(F)(F)c1ccc(cc1)C(NC(=O)Nc1cccc2cnccc12)C1CC1
Show InChI InChI=1S/C21H18F3N3O/c22-21(23,24)16-8-6-14(7-9-16)19(13-4-5-13)27-20(28)26-18-3-1-2-15-12-25-11-10-17(15)18/h1-3,6-13,19H,4-5H2,(H2,26,27,28)
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n/an/an/an/a 149n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem Lett 17: 3894-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.105
BindingDB Entry DOI: 10.7270/Q2NV9GH2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20401
PNG
(3-[2-(4-chlorophenyl)propan-2-yl]-1-isoquinolin-5-...)
Show SMILES CC(C)(NC(=O)Nc1cccc2cnccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H18ClN3O/c1-19(2,14-6-8-15(20)9-7-14)23-18(24)22-17-5-3-4-13-12-21-11-10-16(13)17/h3-12H,1-2H3,(H2,22,23,24)
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n/an/an/an/a 143n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem Lett 17: 3894-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.105
BindingDB Entry DOI: 10.7270/Q2NV9GH2
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20390
PNG
(1-(diphenylmethyl)-3-isoquinolin-5-ylurea | isoqui...)
Show SMILES O=C(NC(c1ccccc1)c1ccccc1)Nc1cccc2cnccc12
Show InChI InChI=1S/C23H19N3O/c27-23(25-21-13-7-12-19-16-24-15-14-20(19)21)26-22(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-16,22H,(H2,25,26,27)
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n/an/an/an/a 600n/an/a7.422



Abbott Laboratories



Assay Description
The functional antagonist activity of compounds at the TRPV1 receptor was determined with a Ca2+ influx assay by measuring the effect on capsaicin (0...

Bioorg Med Chem Lett 17: 3894-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.105
BindingDB Entry DOI: 10.7270/Q2NV9GH2
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%