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PubMed code 17574423

Compile data set for download or QSAR
Found 44 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Renin


(Homo sapiens (Human))		BDBM17996
PNG
(1,4-benzoxazin-3-one, 33 | N-{2-[(2S)-6-(2,4-diami...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2O[C@](C)(C(=O)N(CCNC(C)=O)c2c1)c1ccccc1 |r|
Show InChI InChI=1S/C25H28N6O3/c1-4-18-21(22(26)30-24(27)29-18)16-10-11-20-19(14-16)31(13-12-28-15(2)32)23(33)25(3,34-20)17-8-6-5-7-9-17/h5-11,14H,4,12-13H2,1-3H3,(H,28,32)(H4,26,27,29,30)/t25-/m0/s1
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n/an/a 0.800n/an/an/an/an/an/a



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Renin


(Homo sapiens (Human))		BDBM17989
PNG
(1,4-benzoxazin-3-one, 26 | N-{2-[6-(2,4-diamino-6-...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(C)(C(=O)N(CCNC(C)=O)c2c1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C25H26F2N6O3/c1-4-18-21(22(28)32-24(29)31-18)14-5-6-20-19(9-14)33(8-7-30-13(2)34)23(35)25(3,36-20)15-10-16(26)12-17(27)11-15/h5-6,9-12H,4,7-8H2,1-3H3,(H,30,34)(H4,28,29,31,32)
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n/an/a 1n/an/an/an/a7.422



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM18005
PNG
(1,4-benzoxazin-3-one, 42 | methyl N-{2-[6-(2,4-dia...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(C)(C(=O)N(CCNC(=O)OC)c2c1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C25H26F2N6O4/c1-4-17-20(21(28)32-23(29)31-17)13-5-6-19-18(9-13)33(8-7-30-24(35)36-3)22(34)25(2,37-19)14-10-15(26)12-16(27)11-14/h5-6,9-12H,4,7-8H2,1-3H3,(H,30,35)(H4,28,29,31,32)
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n/an/a 2n/an/an/an/an/an/a



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM18001
PNG
(1,4-benzoxazin-3-one, 38 | N-{2-[6-(2,4-diamino-6-...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(C)(C(=O)N(CCNC(=O)CO)c2c1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C25H26F2N6O4/c1-3-17-21(22(28)32-24(29)31-17)13-4-5-19-18(8-13)33(7-6-30-20(35)12-34)23(36)25(2,37-19)14-9-15(26)11-16(27)10-14/h4-5,8-11,34H,3,6-7,12H2,1-2H3,(H,30,35)(H4,28,29,31,32)
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n/an/a 3n/an/an/an/an/an/a



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Renin


(Homo sapiens (Human))		BDBM18002
PNG
(1,4-benzoxazin-3-one, 39 | 3-[6-(2,4-diamino-6-eth...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(C)(C(=O)N(CCC(=O)NC)c2c1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C25H26F2N6O3/c1-4-17-21(22(28)32-24(29)31-17)13-5-6-19-18(9-13)33(8-7-20(34)30-3)23(35)25(2,36-19)14-10-15(26)12-16(27)11-14/h5-6,9-12H,4,7-8H2,1-3H3,(H,30,34)(H4,28,29,31,32)
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n/an/a 6n/an/an/an/an/an/a



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM17994
PNG
(1,4-benzoxazin-3-one, 31 | N-{2-[2-(3-chlorophenyl...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(C)(C(=O)N(CCNC(C)=O)c2c1)c1cccc(Cl)c1
Show InChI InChI=1S/C25H27ClN6O3/c1-4-18-21(22(27)31-24(28)30-18)15-8-9-20-19(12-15)32(11-10-29-14(2)33)23(34)25(3,35-20)16-6-5-7-17(26)13-16/h5-9,12-13H,4,10-11H2,1-3H3,(H,29,33)(H4,27,28,30,31)
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n/an/a 7n/an/an/an/an/an/a



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Renin


(Homo sapiens (Human))		BDBM17988
PNG
(1,4-benzoxazin-3-one, 25 | 6-(2,4-diamino-6-ethylp...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(C)(C(=O)N(CCCOC)c2c1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C25H27F2N5O3/c1-4-18-21(22(28)31-24(29)30-18)14-6-7-20-19(10-14)32(8-5-9-34-3)23(33)25(2,35-20)15-11-16(26)13-17(27)12-15/h6-7,10-13H,4-5,8-9H2,1-3H3,(H4,28,29,30,31)
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n/an/a 7n/an/an/an/a7.422



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Renin


(Homo sapiens (Human))		BDBM17995
PNG
(1,4-benzoxazin-3-one, 32 | N-{2-[6-(2,4-diamino-6-...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(C)(C(=O)N(CCNC(C)=O)c2c1)c1cc(F)ccc1F
Show InChI InChI=1S/C25H26F2N6O3/c1-4-18-21(22(28)32-24(29)31-18)14-5-8-20-19(11-14)33(10-9-30-13(2)34)23(35)25(3,36-20)16-12-15(26)6-7-17(16)27/h5-8,11-12H,4,9-10H2,1-3H3,(H,30,34)(H4,28,29,31,32)
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n/an/a 7n/an/an/an/an/an/a



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM17984
PNG
(1,4-benzoxazin-3-one, 21 | N-{2-[6-(2,4-diamino-6-...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(C)(C(=O)N(CCNC(C)=O)c2c1)C(F)(F)F
Show InChI InChI=1S/C20H23F3N6O3/c1-4-12-15(16(24)28-18(25)27-12)11-5-6-14-13(9-11)29(8-7-26-10(2)30)17(31)19(3,32-14)20(21,22)23/h5-6,9H,4,7-8H2,1-3H3,(H,26,30)(H4,24,25,27,28)
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n/an/a 17n/an/an/an/a7.422



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Renin


(Homo sapiens (Human))		BDBM17983
PNG
(1,4-benzoxazin-3-one, 20 | N-{2-[6-(2,4-diamino-6-...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(C)(C)C(=O)N(CCNC(C)=O)c2c1
Show InChI InChI=1S/C20H26N6O3/c1-5-13-16(17(21)25-19(22)24-13)12-6-7-15-14(10-12)26(9-8-23-11(2)27)18(28)20(3,4)29-15/h6-7,10H,5,8-9H2,1-4H3,(H,23,27)(H4,21,22,24,25)
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n/an/a 20n/an/an/an/a7.422



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Renin


(Homo sapiens (Human))		BDBM17993
PNG
(1,4-benzoxazin-3-one, 30 | N-{2-[2-(4-chlorophenyl...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(C)(C(=O)N(CCNC(C)=O)c2c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H27ClN6O3/c1-4-18-21(22(27)31-24(28)30-18)15-5-10-20-19(13-15)32(12-11-29-14(2)33)23(34)25(3,35-20)16-6-8-17(26)9-7-16/h5-10,13H,4,11-12H2,1-3H3,(H,29,33)(H4,27,28,30,31)
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n/an/a>40n/an/an/an/an/an/a



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Renin


(Homo sapiens (Human))		BDBM18008
PNG
(1,4-benzoxazin-3-one, 45 | 6-(2,4-diamino-6-ethylp...)
Show SMILES CCOCCCN1C(=O)C(C)(Oc2ccc(cc12)-c1c(N)nc(N)nc1CC)c1cc(F)cc(F)c1
Show InChI InChI=1S/C26H29F2N5O3/c1-4-19-22(23(29)32-25(30)31-19)15-7-8-21-20(11-15)33(9-6-10-35-5-2)24(34)26(3,36-21)16-12-17(27)14-18(28)13-16/h7-8,11-14H,4-6,9-10H2,1-3H3,(H4,29,30,31,32)
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n/an/a 41n/an/an/an/an/an/a



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Renin


(Homo sapiens (Human))		BDBM18000
PNG
(1,4-benzoxazin-3-one, 37 | 6-(2,4-diamino-6-ethylp...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(C)(C(=O)N(CCCCO)c2c1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C25H27F2N5O3/c1-3-18-21(22(28)31-24(29)30-18)14-6-7-20-19(10-14)32(8-4-5-9-33)23(34)25(2,35-20)15-11-16(26)13-17(27)12-15/h6-7,10-13,33H,3-5,8-9H2,1-2H3,(H4,28,29,30,31)
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n/an/a 43n/an/an/an/an/an/a



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Renin


(Homo sapiens (Human))		BDBM18011
PNG
((2S)-6-(2,4-diamino-6-ethylpyrimidin-5-yl)-2-(3,5-...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2O[C@](C)(C(=O)N(CCCC(F)(F)F)c2c1)c1cc(F)cc(F)c1 |r|
Show InChI InChI=1S/C25H24F5N5O2/c1-3-17-20(21(31)34-23(32)33-17)13-5-6-19-18(9-13)35(8-4-7-25(28,29)30)22(36)24(2,37-19)14-10-15(26)12-16(27)11-14/h5-6,9-12H,3-4,7-8H2,1-2H3,(H4,31,32,33,34)/t24-/m0/s1
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n/an/a 48n/an/an/an/an/an/a



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Renin


(Homo sapiens (Human))		BDBM17985
PNG
(1,4-benzoxazin-3-one, 22 | 6-(2,4-diamino-6-ethylp...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(C)(CC)C(=O)N(CCCOC)c2c1
Show InChI InChI=1S/C21H29N5O3/c1-5-14-17(18(22)25-20(23)24-14)13-8-9-16-15(12-13)26(10-7-11-28-4)19(27)21(3,6-2)29-16/h8-9,12H,5-7,10-11H2,1-4H3,(H4,22,23,24,25)
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n/an/a 52n/an/an/an/a7.422



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Renin


(Homo sapiens (Human))		BDBM17992
PNG
(1,4-benzoxazin-3-one, 29 | N-{2-[6-(2,4-diamino-6-...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(C)(C(=O)N(CCNC(C)=O)c2c1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H27F3N6O3/c1-4-18-21(22(30)34-24(31)33-18)15-8-9-20-19(12-15)35(11-10-32-14(2)36)23(37)25(3,38-20)16-6-5-7-17(13-16)26(27,28)29/h5-9,12-13H,4,10-11H2,1-3H3,(H,32,36)(H4,30,31,33,34)
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n/an/a 60n/an/an/an/an/an/a



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM18006
PNG
(1,4-benzoxazin-3-one, 43 | 4-[6-(2,4-diamino-6-eth...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(C)(C(=O)N(CCCC#N)c2c1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C25H24F2N6O2/c1-3-18-21(22(29)32-24(30)31-18)14-6-7-20-19(10-14)33(9-5-4-8-28)23(34)25(2,35-20)15-11-16(26)13-17(27)12-15/h6-7,10-13H,3-5,9H2,1-2H3,(H4,29,30,31,32)
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n/an/a 62n/an/an/an/an/an/a



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Renin


(Homo sapiens (Human))		BDBM17991
PNG
(1,4-benzoxazin-3-one, 28 | 6-(2,4-diamino-6-ethylp...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(C)(C(=O)N(CCCOC)c2c1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C25H27F2N5O3/c1-4-18-21(22(28)31-24(29)30-18)14-6-9-20-19(12-14)32(10-5-11-34-3)23(33)25(2,35-20)15-7-8-16(26)17(27)13-15/h6-9,12-13H,4-5,10-11H2,1-3H3,(H4,28,29,30,31)
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n/an/a 66n/an/an/an/an/an/a



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Renin


(Homo sapiens (Human))		BDBM17981
PNG
(1,4-benzoxazin-3-one, 18 | 6-(2,4-diamino-6-ethylp...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(C(=O)N(CCCOC)c2c1)c1cccc(F)c1F
Show InChI InChI=1S/C24H25F2N5O3/c1-3-16-19(22(27)30-24(28)29-16)13-8-9-18-17(12-13)31(10-5-11-33-2)23(32)21(34-18)14-6-4-7-15(25)20(14)26/h4,6-9,12,21H,3,5,10-11H2,1-2H3,(H4,27,28,29,30)
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n/an/a 72n/an/an/an/a7.422



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Renin


(Homo sapiens (Human))		BDBM17982
PNG
(1,4-benzoxazin-3-one, 19 | 6-(2,4-diamino-6-ethylp...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(C)(C)C(=O)N(CCCOC)c2c1
Show InChI InChI=1S/C20H27N5O3/c1-5-13-16(17(21)24-19(22)23-13)12-7-8-15-14(11-12)25(9-6-10-27-4)18(26)20(2,3)28-15/h7-8,11H,5-6,9-10H2,1-4H3,(H4,21,22,23,24)
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n/an/a 90n/an/an/an/a7.422



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Renin


(Homo sapiens (Human))		BDBM17980
PNG
(1,4-benzoxazin-3-one, 17 | 6-(2,4-diamino-6-ethylp...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(C(=O)N(CCCOC)c2c1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C24H25F2N5O3/c1-3-17-20(22(27)30-24(28)29-17)13-5-6-19-18(11-13)31(7-4-8-33-2)23(32)21(34-19)14-9-15(25)12-16(26)10-14/h5-6,9-12,21H,3-4,7-8H2,1-2H3,(H4,27,28,29,30)
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n/an/a 95n/an/an/an/a7.422



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Renin


(Homo sapiens (Human))		BDBM17987
PNG
(1,4-benzoxazin-3-one, 24 | N-{2-[6-(2,4-diamino-6-...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC3(CC3)C(=O)N(CCNC(C)=O)c2c1
Show InChI InChI=1S/C20H24N6O3/c1-3-13-16(17(21)25-19(22)24-13)12-4-5-15-14(10-12)26(9-8-23-11(2)27)18(28)20(29-15)6-7-20/h4-5,10H,3,6-9H2,1-2H3,(H,23,27)(H4,21,22,24,25)
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n/an/a 100n/an/an/an/a7.422



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Renin


(Homo sapiens (Human))		BDBM17974
PNG
((2R)-6-(2,4-diamino-6-ethylpyrimidin-5-yl)-4-(3-me...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2O[C@H](C)C(=O)N(CCCOC)c2c1 |r|
Show InChI InChI=1S/C19H25N5O3/c1-4-13-16(17(20)23-19(21)22-13)12-6-7-15-14(10-12)24(8-5-9-26-3)18(25)11(2)27-15/h6-7,10-11H,4-5,8-9H2,1-3H3,(H4,20,21,22,23)/t11-/m1/s1
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n/an/a 125n/an/an/an/a7.422



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Renin


(Homo sapiens (Human))		BDBM18010
PNG
(1,4-benzoxazin-3-one, rac-47 | 6-(2,4-diamino-6-et...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(C)(C(=O)N(CCCC(F)(F)F)c2c1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C25H24F5N5O2/c1-3-17-20(21(31)34-23(32)33-17)13-5-6-19-18(9-13)35(8-4-7-25(28,29)30)22(36)24(2,37-19)14-10-15(26)12-16(27)11-14/h5-6,9-12H,3-4,7-8H2,1-2H3,(H4,31,32,33,34)
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n/an/a 141n/an/an/an/an/an/a



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM17990
PNG
(1,4-benzoxazin-3-one, 27 | 6-(2,4-diamino-6-ethylp...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(CC)(C(=O)N(CCCOC)c2c1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C26H29F2N5O3/c1-4-19-22(23(29)32-25(30)31-19)15-7-8-21-20(11-15)33(9-6-10-35-3)24(34)26(5-2,36-21)16-12-17(27)14-18(28)13-16/h7-8,11-14H,4-6,9-10H2,1-3H3,(H4,29,30,31,32)
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n/an/a 175n/an/an/an/a7.422



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM18007
PNG
(1,4-benzoxazin-3-one, 44 | 6-(2,4-diamino-6-ethylp...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(C)(C(=O)N(CCCOC(F)(F)F)c2c1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C25H24F5N5O3/c1-3-17-20(21(31)34-23(32)33-17)13-5-6-19-18(9-13)35(7-4-8-37-25(28,29)30)22(36)24(2,38-19)14-10-15(26)12-16(27)11-14/h5-6,9-12H,3-4,7-8H2,1-2H3,(H4,31,32,33,34)
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n/an/a 182n/an/an/an/an/an/a



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM18009
PNG
(1,4-benzoxazin-3-one, 46 | 6-(2,4-diamino-6-ethylp...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(C)(C(=O)N(CCOCC(F)(F)F)c2c1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C25H24F5N5O3/c1-3-17-20(21(31)34-23(32)33-17)13-4-5-19-18(8-13)35(6-7-37-12-25(28,29)30)22(36)24(2,38-19)14-9-15(26)11-16(27)10-14/h4-5,8-11H,3,6-7,12H2,1-2H3,(H4,31,32,33,34)
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n/an/a 188n/an/an/an/an/an/a



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM18003
PNG
(1,4-benzoxazin-3-one, 40 | 2-[6-(2,4-diamino-6-eth...)
Show SMILES CCNC(=O)CN1C(=O)C(C)(Oc2ccc(cc12)-c1c(N)nc(N)nc1CC)c1cc(F)cc(F)c1
Show InChI InChI=1S/C25H26F2N6O3/c1-4-17-21(22(28)32-24(29)31-17)13-6-7-19-18(8-13)33(12-20(34)30-5-2)23(35)25(3,36-19)14-9-15(26)11-16(27)10-14/h6-11H,4-5,12H2,1-3H3,(H,30,34)(H4,28,29,31,32)
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n/an/a 200n/an/an/an/an/an/a



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM17978
PNG
(1,4-benzoxazin-3-one, 15 | 6-(2,4-diamino-6-ethylp...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(C(=O)N(CCCOC)c2c1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C24H25F2N5O3/c1-3-17-20(22(27)30-24(28)29-17)13-6-8-19-18(12-13)31(9-4-10-33-2)23(32)21(34-19)14-5-7-15(25)16(26)11-14/h5-8,11-12,21H,3-4,9-10H2,1-2H3,(H4,27,28,29,30)
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n/an/a 206n/an/an/an/a7.422



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Renin


(Homo sapiens (Human))		BDBM17977
PNG
(1,4-benzoxazin-3-one, 14 | 6-(2,4-diamino-6-ethylp...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(C(=O)N(CCCOC)c2c1)c1ccccc1
Show InChI InChI=1S/C24H27N5O3/c1-3-17-20(22(25)28-24(26)27-17)16-10-11-19-18(14-16)29(12-7-13-31-2)23(30)21(32-19)15-8-5-4-6-9-15/h4-6,8-11,14,21H,3,7,12-13H2,1-2H3,(H4,25,26,27,28)
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n/an/a 220n/an/an/an/a7.422



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Renin


(Homo sapiens (Human))		BDBM17970
PNG
(1,4-benzoxazine, 7 | 6-ethyl-5-[4-(3-methoxypropyl...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(C)CN(CCCOC)c2c1
Show InChI InChI=1S/C19H27N5O2/c1-4-14-17(18(20)23-19(21)22-14)13-6-7-16-15(10-13)24(8-5-9-25-3)11-12(2)26-16/h6-7,10,12H,4-5,8-9,11H2,1-3H3,(H4,20,21,22,23)
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n/an/a 235n/an/an/an/a7.422



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Renin


(Homo sapiens (Human))		BDBM17986
PNG
(1,4-benzoxazin-3-one, 23 | 6-(2,4-diamino-6-ethylp...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(CC)(CC)C(=O)N(CCCOC)c2c1
Show InChI InChI=1S/C22H31N5O3/c1-5-15-18(19(23)26-21(24)25-15)14-9-10-17-16(13-14)27(11-8-12-29-4)20(28)22(6-2,7-3)30-17/h9-10,13H,5-8,11-12H2,1-4H3,(H4,23,24,25,26)
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n/an/a 245n/an/an/an/a7.422



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Renin


(Homo sapiens (Human))		BDBM17972
PNG
(1,4-benzoxazine, 9 | 6-ethyl-5-[(2S)-4-(3-methoxyp...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2O[C@@H](C)CN(CCCOC)c2c1 |r|
Show InChI InChI=1S/C19H27N5O2/c1-4-14-17(18(20)23-19(21)22-14)13-6-7-16-15(10-13)24(8-5-9-25-3)11-12(2)26-16/h6-7,10,12H,4-5,8-9,11H2,1-3H3,(H4,20,21,22,23)/t12-/m0/s1
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n/an/a 310n/an/an/an/a7.422



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Renin


(Homo sapiens (Human))		BDBM17979
PNG
(1,4-benzoxazin-3-one, 16 | 6-(2,4-diamino-6-ethylp...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(C(=O)N(CCCOC)c2c1)c1ccc(F)cc1
Show InChI InChI=1S/C24H26FN5O3/c1-3-17-20(22(26)29-24(27)28-17)15-7-10-19-18(13-15)30(11-4-12-32-2)23(31)21(33-19)14-5-8-16(25)9-6-14/h5-10,13,21H,3-4,11-12H2,1-2H3,(H4,26,27,28,29)
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n/an/a 325n/an/an/an/a7.422



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Renin


(Homo sapiens (Human))		BDBM17971
PNG
(1,4-benzoxazine, 8 | 6-ethyl-5-[(2R)-4-(3-methoxyp...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2O[C@H](C)CN(CCCOC)c2c1 |r|
Show InChI InChI=1S/C19H27N5O2/c1-4-14-17(18(20)23-19(21)22-14)13-6-7-16-15(10-13)24(8-5-9-25-3)11-12(2)26-16/h6-7,10,12H,4-5,8-9,11H2,1-3H3,(H4,20,21,22,23)/t12-/m1/s1
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n/an/a 325n/an/an/an/a7.422



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Renin


(Homo sapiens (Human))		BDBM17976
PNG
(1,4-benzoxazin-3-one, 13 | 6-(2,4-diamino-6-ethylp...)
Show SMILES CCCC1Oc2ccc(cc2N(CCCOC)C1=O)-c1c(N)nc(N)nc1CC
Show InChI InChI=1S/C21H29N5O3/c1-4-7-17-20(27)26(10-6-11-28-3)15-12-13(8-9-16(15)29-17)18-14(5-2)24-21(23)25-19(18)22/h8-9,12,17H,4-7,10-11H2,1-3H3,(H4,22,23,24,25)
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n/an/a 430n/an/an/an/a7.422



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Renin


(Homo sapiens (Human))		BDBM17973
PNG
(1,4-benzoxazin-3-one, 10 | 6-(2,4-diamino-6-ethylp...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(C)C(=O)N(CCCOC)c2c1
Show InChI InChI=1S/C19H25N5O3/c1-4-13-16(17(20)23-19(21)22-13)12-6-7-15-14(10-12)24(8-5-9-26-3)18(25)11(2)27-15/h6-7,10-11H,4-5,8-9H2,1-3H3,(H4,20,21,22,23)
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n/an/a 520n/an/an/an/a7.422



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Renin


(Homo sapiens (Human))		BDBM18004
PNG
(1,4-benzoxazin-3-one, 41 | N-{2-[6-(2,4-diamino-6-...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(C)(C(=O)N(CCNS(C)(=O)=O)c2c1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C24H26F2N6O4S/c1-4-17-20(21(27)31-23(28)30-17)13-5-6-19-18(9-13)32(8-7-29-37(3,34)35)22(33)24(2,36-19)14-10-15(25)12-16(26)11-14/h5-6,9-12,29H,4,7-8H2,1-3H3,(H4,27,28,30,31)
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n/an/a 630n/an/an/an/an/an/a



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair
Renin


(Homo sapiens (Human))		BDBM17997
PNG
(1,4-benzoxazin-3-one, 34 | N-{2-[(2R)-6-(2,4-diami...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2O[C@@](C)(C(=O)N(CCNC(C)=O)c2c1)c1ccccc1 |r|
Show InChI InChI=1S/C25H28N6O3/c1-4-18-21(22(26)30-24(27)29-18)16-10-11-20-19(14-16)31(13-12-28-15(2)32)23(33)25(3,34-20)17-8-6-5-7-9-17/h5-11,14H,4,12-13H2,1-3H3,(H,28,32)(H4,26,27,29,30)/t25-/m1/s1
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n/an/a 860n/an/an/an/an/an/a



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Renin


(Homo sapiens (Human))		BDBM17998
PNG
(1,4-benzoxazin-3-one, 35 | 6-(2,4-diamino-6-ethylp...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(C)(C(=O)N(CCCO)c2c1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C24H25F2N5O3/c1-3-17-20(21(27)30-23(28)29-17)13-5-6-19-18(9-13)31(7-4-8-32)22(33)24(2,34-19)14-10-15(25)12-16(26)11-14/h5-6,9-12,32H,3-4,7-8H2,1-2H3,(H4,27,28,29,30)
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n/an/a 890n/an/an/an/an/an/a



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Renin


(Homo sapiens (Human))		BDBM17975
PNG
((2S)-6-(2,4-diamino-6-ethylpyrimidin-5-yl)-4-(3-me...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2O[C@@H](C)C(=O)N(CCCOC)c2c1 |r|
Show InChI InChI=1S/C19H25N5O3/c1-4-13-16(17(20)23-19(21)22-13)12-6-7-15-14(10-12)24(8-5-9-26-3)18(25)11(2)27-15/h6-7,10-11H,4-5,8-9H2,1-3H3,(H4,20,21,22,23)/t11-/m0/s1
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n/an/a 1.04E+3n/an/an/an/a7.422



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Renin


(Homo sapiens (Human))		BDBM17999
PNG
(1,4-benzoxazin-3-one, 36 | 6-(2,4-diamino-6-ethylp...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OC(C)(C(=O)N(CCO)c2c1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C23H23F2N5O3/c1-3-16-19(20(26)29-22(27)28-16)12-4-5-18-17(8-12)30(6-7-31)21(32)23(2,33-18)13-9-14(24)11-15(25)10-13/h4-5,8-11,31H,3,6-7H2,1-2H3,(H4,26,27,28,29)
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n/an/a 1.08E+3n/an/an/an/an/an/a



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Renin


(Homo sapiens (Human))		BDBM17968
PNG
(1,4-benzoxazine, 5 | 6-ethyl-5-[4-(3-methoxypropyl...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OCCN(CCCOC)c2c1
Show InChI InChI=1S/C18H25N5O2/c1-3-13-16(17(19)22-18(20)21-13)12-5-6-15-14(11-12)23(8-10-25-15)7-4-9-24-2/h5-6,11H,3-4,7-10H2,1-2H3,(H4,19,20,21,22)
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n/an/a 2.70E+3n/an/an/an/a7.422



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Renin


(Homo sapiens (Human))		BDBM17969
PNG
(1,4-benzoxazin-3-one, 6 | 6-(2,4-diamino-6-ethylpy...)
Show SMILES CCc1nc(N)nc(N)c1-c1ccc2OCC(=O)N(CCCOC)c2c1
Show InChI InChI=1S/C18H23N5O3/c1-3-12-16(17(19)22-18(20)21-12)11-5-6-14-13(9-11)23(7-4-8-25-2)15(24)10-26-14/h5-6,9H,3-4,7-8,10H2,1-2H3,(H4,19,20,21,22)
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n/an/a 3.90E+3n/an/an/an/a7.422



Pfizer



Assay Description
The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...

Bioorg Med Chem 15: 5912-49 (2007)


Article DOI: 10.1016/j.bmc.2007.05.069
BindingDB Entry DOI: 10.7270/Q2FX77QX
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
* indicates data uncertainty>20%