Found 54 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50241325
(CHEMBL251348 | N-(4-(2-(1-isobutyl-1,2,3,6-tetrahy...)Show SMILES CC(C)CN1CCC(=CC1)c1nc(Oc2cccc3sc(NC(C)=O)nc23)cc(n1)-c1ccc(cc1)C(F)(F)F |c:7| Show InChI InChI=1S/C29H28F3N5O2S/c1-17(2)16-37-13-11-20(12-14-37)27-34-22(19-7-9-21(10-8-19)29(30,31)32)15-25(35-27)39-23-5-4-6-24-26(23)36-28(40-24)33-18(3)38/h4-11,15,17H,12-14,16H2,1-3H3,(H,33,36,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM20557
(AMG 517 | CHEMBL229430 | JMC503515 Compound 23 | N...)Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C20H13F3N4O2S/c1-11(28)26-19-27-18-15(3-2-4-16(18)30-19)29-17-9-14(24-10-25-17)12-5-7-13(8-6-12)20(21,22)23/h2-10H,1H3,(H,26,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225031
(CHEMBL251565 | tert-butyl 4-(4-(2-acetamidobenzo[d...)Show SMILES CC(=O)Nc1nc2c(Oc3cc(nc(n3)C3=CCN(CC3)C(=O)OC(C)(C)C)-c3ccc(cc3)C(F)(F)F)cccc2s1 |t:16| Show InChI InChI=1S/C30H28F3N5O4S/c1-17(39)34-27-37-25-22(6-5-7-23(25)43-27)41-24-16-21(18-8-10-20(11-9-18)30(31,32)33)35-26(36-24)19-12-14-38(15-13-19)28(40)42-29(2,3)4/h5-12,16H,13-15H2,1-4H3,(H,34,37,39) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM20557
(AMG 517 | CHEMBL229430 | JMC503515 Compound 23 | N...)Show SMILES CC(=O)Nc1nc2c(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C20H13F3N4O2S/c1-11(28)26-19-27-18-15(3-2-4-16(18)30-19)29-17-9-14(24-10-25-17)12-5-7-13(8-6-12)20(21,22)23/h2-10H,1H3,(H,26,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225032
(CHEMBL249731 | N-(4-(2-(pyridin-4-yl)-6-(4-(triflu...)Show SMILES CC(=O)Nc1nc2c(Oc3cc(nc(n3)-c3ccncc3)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C25H16F3N5O2S/c1-14(34)30-24-33-22-19(3-2-4-20(22)36-24)35-21-13-18(15-5-7-17(8-6-15)25(26,27)28)31-23(32-21)16-9-11-29-12-10-16/h2-13H,1H3,(H,30,33,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50241322
(CHEMBL398411 | N-(4-(2-morpholino-6-(4-(trifluorom...)Show SMILES CC(=O)Nc1nc2c(Oc3cc(nc(n3)N3CCOCC3)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C24H20F3N5O3S/c1-14(33)28-23-31-21-18(3-2-4-19(21)36-23)35-20-13-17(15-5-7-16(8-6-15)24(25,26)27)29-22(30-20)32-9-11-34-12-10-32/h2-8,13H,9-12H2,1H3,(H,28,31,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225033
(CHEMBL249983 | N-(4-(2-methyl-6-(4-(trifluoromethy...)Show SMILES CC(=O)Nc1nc2c(Oc3cc(nc(C)n3)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C21H15F3N4O2S/c1-11-25-15(13-6-8-14(9-7-13)21(22,23)24)10-18(26-11)30-16-4-3-5-17-19(16)28-20(31-17)27-12(2)29/h3-10H,1-2H3,(H,27,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225027
(CHEMBL400571 | N-(4-(2-(1-(pyridin-2-yl)ethylamino...)Show SMILES CC(Nc1nc(Oc2cccc3sc(NC(C)=O)nc23)cc(n1)-c1ccc(cc1)C(F)(F)F)c1ccccn1 |w:1.0| Show InChI InChI=1S/C27H21F3N6O2S/c1-15(19-6-3-4-13-31-19)32-25-34-20(17-9-11-18(12-10-17)27(28,29)30)14-23(35-25)38-21-7-5-8-22-24(21)36-26(39-22)33-16(2)37/h3-15H,1-2H3,(H,32,34,35)(H,33,36,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225038
(CHEMBL250185 | N-(4-(2-(piperidin-1-yl)-6-(4-(trif...)Show SMILES CC(=O)Nc1nc2c(Oc3cc(nc(n3)N3CCCCC3)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C25H22F3N5O2S/c1-15(34)29-24-32-22-19(6-5-7-20(22)36-24)35-21-14-18(16-8-10-17(11-9-16)25(26,27)28)30-23(31-21)33-12-3-2-4-13-33/h5-11,14H,2-4,12-13H2,1H3,(H,29,32,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225027
(CHEMBL400571 | N-(4-(2-(1-(pyridin-2-yl)ethylamino...)Show SMILES CC(Nc1nc(Oc2cccc3sc(NC(C)=O)nc23)cc(n1)-c1ccc(cc1)C(F)(F)F)c1ccccn1 |w:1.0| Show InChI InChI=1S/C27H21F3N6O2S/c1-15(19-6-3-4-13-31-19)32-25-34-20(17-9-11-18(12-10-17)27(28,29)30)14-23(35-25)38-21-7-5-8-22-24(21)36-26(39-22)33-16(2)37/h3-15H,1-2H3,(H,32,34,35)(H,33,36,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225031
(CHEMBL251565 | tert-butyl 4-(4-(2-acetamidobenzo[d...)Show SMILES CC(=O)Nc1nc2c(Oc3cc(nc(n3)C3=CCN(CC3)C(=O)OC(C)(C)C)-c3ccc(cc3)C(F)(F)F)cccc2s1 |t:16| Show InChI InChI=1S/C30H28F3N5O4S/c1-17(39)34-27-37-25-22(6-5-7-23(25)43-27)41-24-16-21(18-8-10-20(11-9-18)30(31,32)33)35-26(36-24)19-12-14-38(15-13-19)28(40)42-29(2,3)4/h5-12,16H,13-15H2,1-4H3,(H,34,37,39) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225037
(CHEMBL251352 | N-(4-(2-(pyridin-2-ylmethylamino)-6...)Show SMILES CC(=O)Nc1nc2c(Oc3cc(nc(NCc4ccccn4)n3)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C26H19F3N6O2S/c1-15(36)32-25-35-23-20(6-4-7-21(23)38-25)37-22-13-19(16-8-10-17(11-9-16)26(27,28)29)33-24(34-22)31-14-18-5-2-3-12-30-18/h2-13H,14H2,1H3,(H,31,33,34)(H,32,35,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50241325
(CHEMBL251348 | N-(4-(2-(1-isobutyl-1,2,3,6-tetrahy...)Show SMILES CC(C)CN1CCC(=CC1)c1nc(Oc2cccc3sc(NC(C)=O)nc23)cc(n1)-c1ccc(cc1)C(F)(F)F |c:7| Show InChI InChI=1S/C29H28F3N5O2S/c1-17(2)16-37-13-11-20(12-14-37)27-34-22(19-7-9-21(10-8-19)29(30,31)32)15-25(35-27)39-23-5-4-6-24-26(23)36-28(40-24)33-18(3)38/h4-11,15,17H,12-14,16H2,1-3H3,(H,33,36,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50241327
(CHEMBL248741 | tert-butyl 4-(4-(2-acetamidobenzo[d...)Show SMILES CC(=O)Nc1nc2c(Oc3cc(nc(n3)N3CCN(CC3)C(=O)OC(C)(C)C)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C29H29F3N6O4S/c1-17(39)33-26-36-24-21(6-5-7-22(24)43-26)41-23-16-20(18-8-10-19(11-9-18)29(30,31)32)34-25(35-23)37-12-14-38(15-13-37)27(40)42-28(2,3)4/h5-11,16H,12-15H2,1-4H3,(H,33,36,39) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225025
(CHEMBL446455 | N-(4-(2-(pyridin-4-ylmethylamino)-6...)Show SMILES CC(=O)Nc1nc2c(Oc3cc(nc(NCc4ccncc4)n3)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C26H19F3N6O2S/c1-15(36)32-25-35-23-20(3-2-4-21(23)38-25)37-22-13-19(17-5-7-18(8-6-17)26(27,28)29)33-24(34-22)31-14-16-9-11-30-12-10-16/h2-13H,14H2,1H3,(H,31,33,34)(H,32,35,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50241328
(CHEMBL251556 | N-(4-(2-(4-isobutylpiperazin-1-yl)-...)Show SMILES CC(C)CN1CCN(CC1)c1nc(Oc2cccc3sc(NC(C)=O)nc23)cc(n1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C28H29F3N6O2S/c1-17(2)16-36-11-13-37(14-12-36)26-33-21(19-7-9-20(10-8-19)28(29,30)31)15-24(34-26)39-22-5-4-6-23-25(22)35-27(40-23)32-18(3)38/h4-10,15,17H,11-14,16H2,1-3H3,(H,32,35,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225029
(CHEMBL251559 | N-(4-(2-(pyridin-3-ylmethylamino)-6...)Show SMILES CC(=O)Nc1nc2c(Oc3cc(nc(NCc4cccnc4)n3)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C26H19F3N6O2S/c1-15(36)32-25-35-23-20(5-2-6-21(23)38-25)37-22-12-19(17-7-9-18(10-8-17)26(27,28)29)33-24(34-22)31-14-16-4-3-11-30-13-16/h2-13H,14H2,1H3,(H,31,33,34)(H,32,35,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225028
(CHEMBL249984 | N-(4-(2-(dimethylamino)-6-(4-(trifl...)Show SMILES CN(C)c1nc(Oc2cccc3sc(NC(C)=O)nc23)cc(n1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C22H18F3N5O2S/c1-12(31)26-21-29-19-16(5-4-6-17(19)33-21)32-18-11-15(27-20(28-18)30(2)3)13-7-9-14(10-8-13)22(23,24)25/h4-11H,1-3H3,(H,26,29,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225024
(CHEMBL398410 | N-(4-(2-amino-6-(4-(trifluoromethyl...)Show SMILES CC(=O)Nc1nc2c(Oc3cc(nc(N)n3)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C20H14F3N5O2S/c1-10(29)25-19-28-17-14(3-2-4-15(17)31-19)30-16-9-13(26-18(24)27-16)11-5-7-12(8-6-11)20(21,22)23/h2-9H,1H3,(H2,24,26,27)(H,25,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225038
(CHEMBL250185 | N-(4-(2-(piperidin-1-yl)-6-(4-(trif...)Show SMILES CC(=O)Nc1nc2c(Oc3cc(nc(n3)N3CCCCC3)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C25H22F3N5O2S/c1-15(34)29-24-32-22-19(6-5-7-20(22)36-24)35-21-14-18(16-8-10-17(11-9-16)25(26,27)28)30-23(31-21)33-12-3-2-4-13-33/h5-11,14H,2-4,12-13H2,1H3,(H,29,32,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225037
(CHEMBL251352 | N-(4-(2-(pyridin-2-ylmethylamino)-6...)Show SMILES CC(=O)Nc1nc2c(Oc3cc(nc(NCc4ccccn4)n3)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C26H19F3N6O2S/c1-15(36)32-25-35-23-20(6-4-7-21(23)38-25)37-22-13-19(16-8-10-17(11-9-16)26(27,28)29)33-24(34-22)31-14-18-5-2-3-12-30-18/h2-13H,14H2,1H3,(H,31,33,34)(H,32,35,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225023
(CHEMBL398968 | N-(4-(2-((1-isobutylpiperidin-2-yl)...)Show SMILES CC(C)CN1CCCCC1CNc1nc(Oc2cccc3sc(NC(C)=O)nc23)cc(n1)-c1ccc(cc1)C(F)(F)F |w:9.10| Show InChI InChI=1S/C30H33F3N6O2S/c1-18(2)17-39-14-5-4-7-22(39)16-34-28-36-23(20-10-12-21(13-11-20)30(31,32)33)15-26(37-28)41-24-8-6-9-25-27(24)38-29(42-25)35-19(3)40/h6,8-13,15,18,22H,4-5,7,14,16-17H2,1-3H3,(H,34,36,37)(H,35,38,40) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225025
(CHEMBL446455 | N-(4-(2-(pyridin-4-ylmethylamino)-6...)Show SMILES CC(=O)Nc1nc2c(Oc3cc(nc(NCc4ccncc4)n3)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C26H19F3N6O2S/c1-15(36)32-25-35-23-20(3-2-4-21(23)38-25)37-22-13-19(17-5-7-18(8-6-17)26(27,28)29)33-24(34-22)31-14-16-9-11-30-12-10-16/h2-13H,14H2,1H3,(H,31,33,34)(H,32,35,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225032
(CHEMBL249731 | N-(4-(2-(pyridin-4-yl)-6-(4-(triflu...)Show SMILES CC(=O)Nc1nc2c(Oc3cc(nc(n3)-c3ccncc3)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C25H16F3N5O2S/c1-14(34)30-24-33-22-19(3-2-4-20(22)36-24)35-21-13-18(15-5-7-17(8-6-15)25(26,27)28)31-23(32-21)16-9-11-29-12-10-16/h2-13H,1H3,(H,30,33,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225029
(CHEMBL251559 | N-(4-(2-(pyridin-3-ylmethylamino)-6...)Show SMILES CC(=O)Nc1nc2c(Oc3cc(nc(NCc4cccnc4)n3)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C26H19F3N6O2S/c1-15(36)32-25-35-23-20(5-2-6-21(23)38-25)37-22-12-19(17-7-9-18(10-8-17)26(27,28)29)33-24(34-22)31-14-16-4-3-11-30-13-16/h2-13H,14H2,1H3,(H,31,33,34)(H,32,35,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225035
(CHEMBL251560 | N-(4-(2-(1-(pyridin-3-yl)ethylamino...)Show SMILES CC(Nc1nc(Oc2cccc3sc(NC(C)=O)nc23)cc(n1)-c1ccc(cc1)C(F)(F)F)c1cccnc1 |w:1.0| Show InChI InChI=1S/C27H21F3N6O2S/c1-15(18-5-4-12-31-14-18)32-25-34-20(17-8-10-19(11-9-17)27(28,29)30)13-23(35-25)38-21-6-3-7-22-24(21)36-26(39-22)33-16(2)37/h3-15H,1-2H3,(H,32,34,35)(H,33,36,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225033
(CHEMBL249983 | N-(4-(2-methyl-6-(4-(trifluoromethy...)Show SMILES CC(=O)Nc1nc2c(Oc3cc(nc(C)n3)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C21H15F3N4O2S/c1-11-25-15(13-6-8-14(9-7-13)21(22,23)24)10-18(26-11)30-16-4-3-5-17-19(16)28-20(31-17)27-12(2)29/h3-10H,1-2H3,(H,27,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225035
(CHEMBL251560 | N-(4-(2-(1-(pyridin-3-yl)ethylamino...)Show SMILES CC(Nc1nc(Oc2cccc3sc(NC(C)=O)nc23)cc(n1)-c1ccc(cc1)C(F)(F)F)c1cccnc1 |w:1.0| Show InChI InChI=1S/C27H21F3N6O2S/c1-15(18-5-4-12-31-14-18)32-25-34-20(17-8-10-19(11-9-17)27(28,29)30)13-23(35-25)38-21-6-3-7-22-24(21)36-26(39-22)33-16(2)37/h3-15H,1-2H3,(H,32,34,35)(H,33,36,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225023
(CHEMBL398968 | N-(4-(2-((1-isobutylpiperidin-2-yl)...)Show SMILES CC(C)CN1CCCCC1CNc1nc(Oc2cccc3sc(NC(C)=O)nc23)cc(n1)-c1ccc(cc1)C(F)(F)F |w:9.10| Show InChI InChI=1S/C30H33F3N6O2S/c1-18(2)17-39-14-5-4-7-22(39)16-34-28-36-23(20-10-12-21(13-11-20)30(31,32)33)15-26(37-28)41-24-8-6-9-25-27(24)38-29(42-25)35-19(3)40/h6,8-13,15,18,22H,4-5,7,14,16-17H2,1-3H3,(H,34,36,37)(H,35,38,40) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225028
(CHEMBL249984 | N-(4-(2-(dimethylamino)-6-(4-(trifl...)Show SMILES CN(C)c1nc(Oc2cccc3sc(NC(C)=O)nc23)cc(n1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C22H18F3N5O2S/c1-12(31)26-21-29-19-16(5-4-6-17(19)33-21)32-18-11-15(27-20(28-18)30(2)3)13-7-9-14(10-8-13)22(23,24)25/h4-11H,1-3H3,(H,26,29,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50241328
(CHEMBL251556 | N-(4-(2-(4-isobutylpiperazin-1-yl)-...)Show SMILES CC(C)CN1CCN(CC1)c1nc(Oc2cccc3sc(NC(C)=O)nc23)cc(n1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C28H29F3N6O2S/c1-17(2)16-36-11-13-37(14-12-36)26-33-21(19-7-9-20(10-8-19)28(29,30)31)15-24(34-26)39-22-5-4-6-23-25(22)35-27(40-23)32-18(3)38/h4-10,15,17H,11-14,16H2,1-3H3,(H,32,35,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225024
(CHEMBL398410 | N-(4-(2-amino-6-(4-(trifluoromethyl...)Show SMILES CC(=O)Nc1nc2c(Oc3cc(nc(N)n3)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C20H14F3N5O2S/c1-10(29)25-19-28-17-14(3-2-4-15(17)31-19)30-16-9-13(26-18(24)27-16)11-5-7-12(8-6-11)20(21,22)23/h2-9H,1H3,(H2,24,26,27)(H,25,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50241329
(CHEMBL401192 | N-(4-(2-((1-isobutylpiperidin-3-yl)...)Show SMILES CC(C)CN1CCCC(CNc2nc(Oc3cccc4sc(NC(C)=O)nc34)cc(n2)-c2ccc(cc2)C(F)(F)F)C1 |w:8.8| Show InChI InChI=1S/C30H33F3N6O2S/c1-18(2)16-39-13-5-6-20(17-39)15-34-28-36-23(21-9-11-22(12-10-21)30(31,32)33)14-26(37-28)41-24-7-4-8-25-27(24)38-29(42-25)35-19(3)40/h4,7-12,14,18,20H,5-6,13,15-17H2,1-3H3,(H,34,36,37)(H,35,38,40) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50241329
(CHEMBL401192 | N-(4-(2-((1-isobutylpiperidin-3-yl)...)Show SMILES CC(C)CN1CCCC(CNc2nc(Oc3cccc4sc(NC(C)=O)nc34)cc(n2)-c2ccc(cc2)C(F)(F)F)C1 |w:8.8| Show InChI InChI=1S/C30H33F3N6O2S/c1-18(2)16-39-13-5-6-20(17-39)15-34-28-36-23(21-9-11-22(12-10-21)30(31,32)33)14-26(37-28)41-24-7-4-8-25-27(24)38-29(42-25)35-19(3)40/h4,7-12,14,18,20H,5-6,13,15-17H2,1-3H3,(H,34,36,37)(H,35,38,40) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225036
(1-(4-(2-acetamidobenzo[d]thiazol-4-yloxy)-6-(4-(tr...)Show SMILES CC(=O)Nc1nc2c(Oc3cc(nc(n3)N3CCC(CC3)C(O)=O)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C26H22F3N5O4S/c1-14(35)30-25-33-22-19(3-2-4-20(22)39-25)38-21-13-18(15-5-7-17(8-6-15)26(27,28)29)31-24(32-21)34-11-9-16(10-12-34)23(36)37/h2-8,13,16H,9-12H2,1H3,(H,36,37)(H,30,33,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50241322
(CHEMBL398411 | N-(4-(2-morpholino-6-(4-(trifluorom...)Show SMILES CC(=O)Nc1nc2c(Oc3cc(nc(n3)N3CCOCC3)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C24H20F3N5O3S/c1-14(33)28-23-31-21-18(3-2-4-19(21)36-23)35-20-13-17(15-5-7-16(8-6-15)24(25,26)27)29-22(30-20)32-9-11-34-12-10-32/h2-8,13H,9-12H2,1H3,(H,28,31,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225034
(CHEMBL398293 | N-(4-(5-methyl-6-(4-(trifluoromethy...)Show SMILES CC(=O)Nc1nc2c(Oc3ncnc(-c4ccc(cc4)C(F)(F)F)c3C)cccc2s1 Show InChI InChI=1S/C21H15F3N4O2S/c1-11-17(13-6-8-14(9-7-13)21(22,23)24)25-10-26-19(11)30-15-4-3-5-16-18(15)28-20(31-16)27-12(2)29/h3-10H,1-2H3,(H,27,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50241323
(CHEMBL251604 | N-(4-(2-(3-hydroxypiperidin-1-yl)-6...)Show SMILES CC(=O)Nc1nc2c(Oc3cc(nc(n3)N3CCCC(O)C3)-c3ccc(cc3)C(F)(F)F)cccc2s1 |w:19.20| Show InChI InChI=1S/C25H22F3N5O3S/c1-14(34)29-24-32-22-19(5-2-6-20(22)37-24)36-21-12-18(15-7-9-16(10-8-15)25(26,27)28)30-23(31-21)33-11-3-4-17(35)13-33/h2,5-10,12,17,35H,3-4,11,13H2,1H3,(H,29,32,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225030
(CHEMBL249528 | N-(4-(2-(4-hydroxypiperidin-1-yl)-6...)Show SMILES CC(=O)Nc1nc2c(Oc3cc(nc(n3)N3CCC(O)CC3)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C25H22F3N5O3S/c1-14(34)29-24-32-22-19(3-2-4-20(22)37-24)36-21-13-18(15-5-7-16(8-6-15)25(26,27)28)30-23(31-21)33-11-9-17(35)10-12-33/h2-8,13,17,35H,9-12H2,1H3,(H,29,32,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50241323
(CHEMBL251604 | N-(4-(2-(3-hydroxypiperidin-1-yl)-6...)Show SMILES CC(=O)Nc1nc2c(Oc3cc(nc(n3)N3CCCC(O)C3)-c3ccc(cc3)C(F)(F)F)cccc2s1 |w:19.20| Show InChI InChI=1S/C25H22F3N5O3S/c1-14(34)29-24-32-22-19(5-2-6-20(22)37-24)36-21-12-18(15-7-9-16(10-8-15)25(26,27)28)30-23(31-21)33-11-3-4-17(35)13-33/h2,5-10,12,17,35H,3-4,11,13H2,1H3,(H,29,32,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50241327
(CHEMBL248741 | tert-butyl 4-(4-(2-acetamidobenzo[d...)Show SMILES CC(=O)Nc1nc2c(Oc3cc(nc(n3)N3CCN(CC3)C(=O)OC(C)(C)C)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C29H29F3N6O4S/c1-17(39)33-26-36-24-21(6-5-7-22(24)43-26)41-23-16-20(18-8-10-19(11-9-18)29(30,31)32)34-25(35-23)37-12-14-38(15-13-37)27(40)42-28(2,3)4/h5-11,16H,12-15H2,1-4H3,(H,33,36,39) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50241330
(CHEMBL398829 | N-(4-(2-((1-isobutylpiperidin-4-yl)...)Show SMILES CC(C)CN1CCC(CNc2nc(Oc3cccc4sc(NC(C)=O)nc34)cc(n2)-c2ccc(cc2)C(F)(F)F)CC1 Show InChI InChI=1S/C30H33F3N6O2S/c1-18(2)17-39-13-11-20(12-14-39)16-34-28-36-23(21-7-9-22(10-8-21)30(31,32)33)15-26(37-28)41-24-5-4-6-25-27(24)38-29(42-25)35-19(3)40/h4-10,15,18,20H,11-14,16-17H2,1-3H3,(H,34,36,37)(H,35,38,40) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50241330
(CHEMBL398829 | N-(4-(2-((1-isobutylpiperidin-4-yl)...)Show SMILES CC(C)CN1CCC(CNc2nc(Oc3cccc4sc(NC(C)=O)nc34)cc(n2)-c2ccc(cc2)C(F)(F)F)CC1 Show InChI InChI=1S/C30H33F3N6O2S/c1-18(2)17-39-13-11-20(12-14-39)16-34-28-36-23(21-7-9-22(10-8-21)30(31,32)33)15-26(37-28)41-24-5-4-6-25-27(24)38-29(42-25)35-19(3)40/h4-10,15,18,20H,11-14,16-17H2,1-3H3,(H,34,36,37)(H,35,38,40) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225030
(CHEMBL249528 | N-(4-(2-(4-hydroxypiperidin-1-yl)-6...)Show SMILES CC(=O)Nc1nc2c(Oc3cc(nc(n3)N3CCC(O)CC3)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C25H22F3N5O3S/c1-14(34)29-24-32-22-19(3-2-4-20(22)37-24)36-21-13-18(15-5-7-16(8-6-15)25(26,27)28)30-23(31-21)33-11-9-17(35)10-12-33/h2-8,13,17,35H,9-12H2,1H3,(H,29,32,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225026
(CHEMBL251189 | N-(4-(5-amino-6-(4-(trifluoromethyl...)Show SMILES CC(=O)Nc1nc2c(Oc3ncnc(-c4ccc(cc4)C(F)(F)F)c3N)cccc2s1 Show InChI InChI=1S/C20H14F3N5O2S/c1-10(29)27-19-28-17-13(3-2-4-14(17)31-19)30-18-15(24)16(25-9-26-18)11-5-7-12(8-6-11)20(21,22)23/h2-9H,24H2,1H3,(H,27,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50241326
(CHEMBL251349 | N-(4-(2-(1-isobutylpiperidin-4-yl)-...)Show SMILES CC(C)CN1CCC(CC1)c1nc(Oc2cccc3sc(NC(C)=O)nc23)cc(n1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C29H30F3N5O2S/c1-17(2)16-37-13-11-20(12-14-37)27-34-22(19-7-9-21(10-8-19)29(30,31)32)15-25(35-27)39-23-5-4-6-24-26(23)36-28(40-24)33-18(3)38/h4-10,15,17,20H,11-14,16H2,1-3H3,(H,33,36,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50241326
(CHEMBL251349 | N-(4-(2-(1-isobutylpiperidin-4-yl)-...)Show SMILES CC(C)CN1CCC(CC1)c1nc(Oc2cccc3sc(NC(C)=O)nc23)cc(n1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C29H30F3N5O2S/c1-17(2)16-37-13-11-20(12-14-37)27-34-22(19-7-9-21(10-8-19)29(30,31)32)15-25(35-27)39-23-5-4-6-24-26(23)36-28(40-24)33-18(3)38/h4-10,15,17,20H,11-14,16H2,1-3H3,(H,33,36,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225034
(CHEMBL398293 | N-(4-(5-methyl-6-(4-(trifluoromethy...)Show SMILES CC(=O)Nc1nc2c(Oc3ncnc(-c4ccc(cc4)C(F)(F)F)c3C)cccc2s1 Show InChI InChI=1S/C21H15F3N4O2S/c1-11-17(13-6-8-14(9-7-13)21(22,23)24)25-10-26-19(11)30-15-4-3-5-16-18(15)28-20(31-16)27-12(2)29/h3-10H,1-2H3,(H,27,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50241324
(CHEMBL249732 | N-(4-(2-(1,2,3,6-tetrahydropyridin-...)Show SMILES CC(=O)Nc1nc2c(Oc3cc(nc(n3)C3=CCNCC3)-c3ccc(cc3)C(F)(F)F)cccc2s1 |t:16| Show InChI InChI=1S/C25H20F3N5O2S/c1-14(34)30-24-33-22-19(3-2-4-20(22)36-24)35-21-13-18(15-5-7-17(8-6-15)25(26,27)28)31-23(32-21)16-9-11-29-12-10-16/h2-9,13,29H,10-12H2,1H3,(H,30,33,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225026
(CHEMBL251189 | N-(4-(5-amino-6-(4-(trifluoromethyl...)Show SMILES CC(=O)Nc1nc2c(Oc3ncnc(-c4ccc(cc4)C(F)(F)F)c3N)cccc2s1 Show InChI InChI=1S/C20H14F3N5O2S/c1-10(29)27-19-28-17-13(3-2-4-14(17)31-19)30-18-15(24)16(25-9-26-18)11-5-7-12(8-6-11)20(21,22)23/h2-9H,24H2,1H3,(H,27,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50225036
(1-(4-(2-acetamidobenzo[d]thiazol-4-yloxy)-6-(4-(tr...)Show SMILES CC(=O)Nc1nc2c(Oc3cc(nc(n3)N3CCC(CC3)C(O)=O)-c3ccc(cc3)C(F)(F)F)cccc2s1 Show InChI InChI=1S/C26H22F3N5O4S/c1-14(35)30-25-33-22-19(3-2-4-20(22)39-25)38-21-13-18(15-5-7-17(8-6-15)26(27,28)29)31-24(32-21)34-11-9-16(10-12-34)23(36)37/h2-8,13,16H,9-12H2,1H3,(H,36,37)(H,30,33,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50241321
(CHEMBL249778 | N-(4-(5-(dimethylamino)-6-(4-(trifl...)Show SMILES CN(C)c1c(Oc2cccc3sc(NC(C)=O)nc23)ncnc1-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C22H18F3N5O2S/c1-12(31)28-21-29-18-15(5-4-6-16(18)33-21)32-20-19(30(2)3)17(26-11-27-20)13-7-9-14(10-8-13)22(23,24)25/h4-11H,1-3H3,(H,28,29,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 660 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of acid induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50241324
(CHEMBL249732 | N-(4-(2-(1,2,3,6-tetrahydropyridin-...)Show SMILES CC(=O)Nc1nc2c(Oc3cc(nc(n3)C3=CCNCC3)-c3ccc(cc3)C(F)(F)F)cccc2s1 |t:16| Show InChI InChI=1S/C25H20F3N5O2S/c1-14(34)30-24-33-22-19(3-2-4-20(22)36-24)35-21-13-18(15-5-7-17(8-6-15)25(26,27)28)31-23(32-21)16-9-11-29-12-10-16/h2-9,13,29H,10-12H2,1H3,(H,30,33,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 910 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Rattus norvegicus (rat)) | BDBM50241321
(CHEMBL249778 | N-(4-(5-(dimethylamino)-6-(4-(trifl...)Show SMILES CN(C)c1c(Oc2cccc3sc(NC(C)=O)nc23)ncnc1-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C22H18F3N5O2S/c1-12(31)28-21-29-18-15(5-4-6-16(18)33-21)32-20-19(30(2)3)17(26-11-27-20)13-7-9-14(10-8-13)22(23,24)25/h4-11H,1-3H3,(H,28,29,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed inhibition of capsaicin induced calcium influx |
Bioorg Med Chem Lett 17: 6539-45 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.080
BindingDB Entry DOI: 10.7270/Q2FX7961 |
More data for this
Ligand-Target Pair | |
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