Found 60 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234509
(4-(2-(5-chloro-1-methyl-1H-imidazol-4-yl)ethylamin...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCc2ncn(C)c2Cl)cc[nH]c1=O)N1CCOCC1 Show InChI InChI=1S/C23H26ClN7O2/c1-14-11-15(31-7-9-33-10-8-31)12-18-20(14)29-22(28-18)19-16(3-6-26-23(19)32)25-5-4-17-21(24)30(2)13-27-17/h3,6,11-13H,4-5,7-10H2,1-2H3,(H,28,29)(H2,25,26,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234523
(4-(2-(5-chloro-1,2-dimethyl-1H-imidazol-4-yl)ethyl...)Show SMILES Cc1nc(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c(Cl)n1C Show InChI InChI=1S/C24H28ClN7O2/c1-14-12-16(32-8-10-34-11-9-32)13-19-21(14)30-23(29-19)20-17(4-7-27-24(20)33)26-6-5-18-22(25)31(3)15(2)28-18/h4,7,12-13H,5-6,8-11H2,1-3H3,(H,29,30)(H2,26,27,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 66 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234524
(CHEMBL256908 | ethyl 1-(2-(3-(4-methyl-6-morpholin...)Show SMILES CCOC(=O)c1cnn(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1 Show InChI InChI=1S/C25H29N7O4/c1-3-36-25(34)17-14-28-32(15-17)7-6-26-19-4-5-27-24(33)21(19)23-29-20-13-18(12-16(2)22(20)30-23)31-8-10-35-11-9-31/h4-5,12-15H,3,6-11H2,1-2H3,(H,29,30)(H2,26,27,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234518
(4-(2-(5-bromo-1-methyl-1H-imidazol-4-yl)ethylamino...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCc2ncn(C)c2Br)cc[nH]c1=O)N1CCOCC1 Show InChI InChI=1S/C23H26BrN7O2/c1-14-11-15(31-7-9-33-10-8-31)12-18-20(14)29-22(28-18)19-16(3-6-26-23(19)32)25-5-4-17-21(24)30(2)13-27-17/h3,6,11-13H,4-5,7-10H2,1-2H3,(H,28,29)(H2,25,26,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234525
(4-(2-(5-chloro-1-(2-fluoroethyl)-1H-imidazol-4-yl)...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCc2ncn(CCF)c2Cl)cc[nH]c1=O)N1CCOCC1 Show InChI InChI=1S/C24H27ClFN7O2/c1-15-12-16(32-8-10-35-11-9-32)13-19-21(15)31-23(30-19)20-17(2-6-28-24(20)34)27-5-3-18-22(25)33(7-4-26)14-29-18/h2,6,12-14H,3-5,7-11H2,1H3,(H,30,31)(H2,27,28,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234506
(4-(2-(4-bromo-1H-pyrazol-1-yl)ethylamino)-3-(4-met...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCn2cc(Br)cn2)cc[nH]c1=O)N1CCOCC1 Show InChI InChI=1S/C22H24BrN7O2/c1-14-10-16(29-6-8-32-9-7-29)11-18-20(14)28-21(27-18)19-17(2-3-25-22(19)31)24-4-5-30-13-15(23)12-26-30/h2-3,10-13H,4-9H2,1H3,(H,27,28)(H2,24,25,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234505
(4-(2-(5-chloro-1-ethyl-1H-imidazol-4-yl)ethylamino...)Show SMILES CCn1cnc(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1Cl Show InChI InChI=1S/C24H28ClN7O2/c1-3-31-14-28-18(22(31)25)5-6-26-17-4-7-27-24(33)20(17)23-29-19-13-16(12-15(2)21(19)30-23)32-8-10-34-11-9-32/h4,7,12-14H,3,5-6,8-11H2,1-2H3,(H,29,30)(H2,26,27,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234522
(CHEMBL256909 | methyl 1-(2-(3-(4-methyl-6-morpholi...)Show SMILES COC(=O)c1cnn(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1 Show InChI InChI=1S/C24H27N7O4/c1-15-11-17(30-7-9-35-10-8-30)12-19-21(15)29-22(28-19)20-18(3-4-26-23(20)32)25-5-6-31-14-16(13-27-31)24(33)34-2/h3-4,11-14H,5-10H2,1-2H3,(H,28,29)(H2,25,26,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 91 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234510
(4-(2-(4-chloro-3-methyl-1H-pyrazol-1-yl)ethylamino...)Show SMILES Cc1nn(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)cc1Cl Show InChI InChI=1S/C23H26ClN7O2/c1-14-11-16(30-7-9-33-10-8-30)12-19-21(14)28-22(27-19)20-18(3-4-26-23(20)32)25-5-6-31-13-17(24)15(2)29-31/h3-4,11-13H,5-10H2,1-2H3,(H,27,28)(H2,25,26,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234512
(4-(2-(4-bromo-3-(hydroxymethyl)-1H-pyrazol-1-yl)et...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCn2cc(Br)c(CO)n2)cc[nH]c1=O)N1CCOCC1 Show InChI InChI=1S/C23H26BrN7O3/c1-14-10-15(30-6-8-34-9-7-30)11-18-21(14)28-22(27-18)20-17(2-3-26-23(20)33)25-4-5-31-12-16(24)19(13-32)29-31/h2-3,10-12,32H,4-9,13H2,1H3,(H,27,28)(H2,25,26,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM27879
(4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O)N1CCOCC1 |r| Show InChI InChI=1S/C25H26ClN5O3/c1-15-11-18(31-7-9-34-10-8-31)13-20-23(15)30-24(29-20)22-19(5-6-27-25(22)33)28-14-21(32)16-3-2-4-17(26)12-16/h2-6,11-13,21,32H,7-10,14H2,1H3,(H,29,30)(H2,27,28,33)/t21-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234527
(4-(2-(4-bromo-3-methyl-1H-pyrazol-1-yl)ethylamino)...)Show SMILES Cc1nn(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)cc1Br Show InChI InChI=1S/C23H26BrN7O2/c1-14-11-16(30-7-9-33-10-8-30)12-19-21(14)28-22(27-19)20-18(3-4-26-23(20)32)25-5-6-31-13-17(24)15(2)29-31/h3-4,11-13H,5-10H2,1-2H3,(H,27,28)(H2,25,26,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM27879
(4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O)N1CCOCC1 |r| Show InChI InChI=1S/C25H26ClN5O3/c1-15-11-18(31-7-9-34-10-8-31)13-20-23(15)30-24(29-20)22-19(5-6-27-25(22)33)28-14-21(32)16-3-2-4-17(26)12-16/h2-6,11-13,21,32H,7-10,14H2,1H3,(H,29,30)(H2,27,28,33)/t21-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R expressed in SAL cells |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234521
(4-(2-(4-methyl-1H-pyrazol-1-yl)ethylamino)-3-(4-me...)Show SMILES Cc1cnn(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1 Show InChI InChI=1S/C23H27N7O2/c1-15-13-26-30(14-15)6-5-24-18-3-4-25-23(31)20(18)22-27-19-12-17(11-16(2)21(19)28-22)29-7-9-32-10-8-29/h3-4,11-14H,5-10H2,1-2H3,(H,27,28)(H2,24,25,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234513
(4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(4-me...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCn2cc(Cl)cn2)cc[nH]c1=O)N1CCOCC1 Show InChI InChI=1S/C22H24ClN7O2/c1-14-10-16(29-6-8-32-9-7-29)11-18-20(14)28-21(27-18)19-17(2-3-25-22(19)31)24-4-5-30-13-15(23)12-26-30/h2-3,10-13H,4-9H2,1H3,(H,27,28)(H2,24,25,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234506
(4-(2-(4-bromo-1H-pyrazol-1-yl)ethylamino)-3-(4-met...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCn2cc(Br)cn2)cc[nH]c1=O)N1CCOCC1 Show InChI InChI=1S/C22H24BrN7O2/c1-14-10-16(29-6-8-32-9-7-29)11-18-20(14)28-21(27-18)19-17(2-3-25-22(19)31)24-4-5-30-13-15(23)12-26-30/h2-3,10-13H,4-9H2,1H3,(H,27,28)(H2,24,25,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 144 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R expressed in SAL cells |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234519
(4-(2-(2,5-dichloro-1-methyl-1H-imidazol-4-yl)ethyl...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCc2nc(Cl)n(C)c2Cl)cc[nH]c1=O)N1CCOCC1 Show InChI InChI=1S/C23H25Cl2N7O2/c1-13-11-14(32-7-9-34-10-8-32)12-17-19(13)30-21(28-17)18-15(3-6-27-22(18)33)26-5-4-16-20(24)31(2)23(25)29-16/h3,6,11-12H,4-5,7-10H2,1-2H3,(H,28,30)(H2,26,27,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234529
(4-(2-(5-bromo-1-ethyl-1H-imidazol-4-yl)ethylamino)...)Show SMILES CCn1cnc(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1Br Show InChI InChI=1S/C24H28BrN7O2/c1-3-31-14-28-18(22(31)25)5-6-26-17-4-7-27-24(33)20(17)23-29-19-13-16(12-15(2)21(19)30-23)32-8-10-34-11-9-32/h4,7,12-14H,3,5-6,8-11H2,1-2H3,(H,29,30)(H2,26,27,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 172 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234503
(4-(2-(1-methyl-1H-imidazol-4-yl)ethylamino)-3-(4-m...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCc2cn(C)cn2)cc[nH]c1=O)N1CCOCC1 Show InChI InChI=1S/C23H27N7O2/c1-15-11-17(30-7-9-32-10-8-30)12-19-21(15)28-22(27-19)20-18(4-6-25-23(20)31)24-5-3-16-13-29(2)14-26-16/h4,6,11-14H,3,5,7-10H2,1-2H3,(H,27,28)(H2,24,25,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234527
(4-(2-(4-bromo-3-methyl-1H-pyrazol-1-yl)ethylamino)...)Show SMILES Cc1nn(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)cc1Br Show InChI InChI=1S/C23H26BrN7O2/c1-14-11-16(30-7-9-33-10-8-30)12-19-21(14)28-22(27-19)20-18(3-4-26-23(20)32)25-5-6-31-13-17(24)15(2)29-31/h3-4,11-13H,5-10H2,1-2H3,(H,27,28)(H2,25,26,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 197 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R expressed in SAL cells |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234528
(4-(2-(1-ethyl-5-ethynyl-1H-imidazol-4-yl)ethylamin...)Show SMILES CCn1cnc(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1C#C Show InChI InChI=1S/C26H29N7O2/c1-4-22-19(29-16-32(22)5-2)6-8-27-20-7-9-28-26(34)23(20)25-30-21-15-18(14-17(3)24(21)31-25)33-10-12-35-13-11-33/h1,7,9,14-16H,5-6,8,10-13H2,2-3H3,(H,30,31)(H2,27,28,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 243 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234523
(4-(2-(5-chloro-1,2-dimethyl-1H-imidazol-4-yl)ethyl...)Show SMILES Cc1nc(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c(Cl)n1C Show InChI InChI=1S/C24H28ClN7O2/c1-14-12-16(32-8-10-34-11-9-32)13-19-21(14)30-23(29-19)20-17(4-7-27-24(20)33)26-6-5-18-22(25)31(3)15(2)28-18/h4,7,12-13H,5-6,8-11H2,1-3H3,(H,29,30)(H2,26,27,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 266 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R expressed in SAL cells |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234508
(4-(2-(5-methyl-1H-pyrazol-1-yl)ethylamino)-3-(4-me...)Show SMILES Cc1ccnn1CCNc1cc[nH]c(=O)c1-c1nc2c(C)cc(cc2[nH]1)N1CCOCC1 Show InChI InChI=1S/C23H27N7O2/c1-15-13-17(29-9-11-32-12-10-29)14-19-21(15)28-22(27-19)20-18(4-5-25-23(20)31)24-7-8-30-16(2)3-6-26-30/h3-6,13-14H,7-12H2,1-2H3,(H,27,28)(H2,24,25,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234529
(4-(2-(5-bromo-1-ethyl-1H-imidazol-4-yl)ethylamino)...)Show SMILES CCn1cnc(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1Br Show InChI InChI=1S/C24H28BrN7O2/c1-3-31-14-28-18(22(31)25)5-6-26-17-4-7-27-24(33)20(17)23-29-19-13-16(12-15(2)21(19)30-23)32-8-10-34-11-9-32/h4,7,12-14H,3,5-6,8-11H2,1-2H3,(H,29,30)(H2,26,27,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 284 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R expressed in SAL cells |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234502
(4-(2-(3-methyl-1H-pyrazol-1-yl)ethylamino)-3-(4-me...)Show SMILES Cc1ccn(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)n1 Show InChI InChI=1S/C23H27N7O2/c1-15-13-17(29-9-11-32-12-10-29)14-19-21(15)27-22(26-19)20-18(3-5-25-23(20)31)24-6-8-30-7-4-16(2)28-30/h3-5,7,13-14H,6,8-12H2,1-2H3,(H,26,27)(H2,24,25,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234501
(4-(2-(5-chloro-1-(2-methoxyethyl)-1H-imidazol-4-yl...)Show SMILES COCCn1cnc(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1Cl Show InChI InChI=1S/C25H30ClN7O3/c1-16-13-17(32-8-11-36-12-9-32)14-20-22(16)31-24(30-20)21-18(3-6-28-25(21)34)27-5-4-19-23(26)33(15-29-19)7-10-35-2/h3,6,13-15H,4-5,7-12H2,1-2H3,(H,30,31)(H2,27,28,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234510
(4-(2-(4-chloro-3-methyl-1H-pyrazol-1-yl)ethylamino...)Show SMILES Cc1nn(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)cc1Cl Show InChI InChI=1S/C23H26ClN7O2/c1-14-11-16(30-7-9-33-10-8-30)12-19-21(14)28-22(27-19)20-18(3-4-26-23(20)32)25-5-6-31-13-17(24)15(2)29-31/h3-4,11-13H,5-10H2,1-2H3,(H,27,28)(H2,25,26,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 292 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R expressed in SAL cells |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234519
(4-(2-(2,5-dichloro-1-methyl-1H-imidazol-4-yl)ethyl...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCc2nc(Cl)n(C)c2Cl)cc[nH]c1=O)N1CCOCC1 Show InChI InChI=1S/C23H25Cl2N7O2/c1-13-11-14(32-7-9-34-10-8-32)12-17-19(13)30-21(28-17)18-15(3-6-27-22(18)33)26-5-4-16-20(24)31(2)23(25)29-16/h3,6,11-12H,4-5,7-10H2,1-2H3,(H,28,30)(H2,26,27,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 306 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R expressed in SAL cells |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234526
(4-(2-(1H-pyrazol-1-yl)ethylamino)-3-(4-methyl-6-mo...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCn2cccn2)cc[nH]c1=O)N1CCOCC1 Show InChI InChI=1S/C22H25N7O2/c1-15-13-16(28-9-11-31-12-10-28)14-18-20(15)27-21(26-18)19-17(3-5-24-22(19)30)23-6-8-29-7-2-4-25-29/h2-5,7,13-14H,6,8-12H2,1H3,(H,26,27)(H2,23,24,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234509
(4-(2-(5-chloro-1-methyl-1H-imidazol-4-yl)ethylamin...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCc2ncn(C)c2Cl)cc[nH]c1=O)N1CCOCC1 Show InChI InChI=1S/C23H26ClN7O2/c1-14-11-15(31-7-9-33-10-8-31)12-18-20(14)29-22(28-18)19-16(3-6-26-23(19)32)25-5-4-17-21(24)30(2)13-27-17/h3,6,11-13H,4-5,7-10H2,1-2H3,(H,28,29)(H2,25,26,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 336 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R expressed in SAL cells |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234518
(4-(2-(5-bromo-1-methyl-1H-imidazol-4-yl)ethylamino...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCc2ncn(C)c2Br)cc[nH]c1=O)N1CCOCC1 Show InChI InChI=1S/C23H26BrN7O2/c1-14-11-15(31-7-9-33-10-8-31)12-18-20(14)29-22(28-18)19-16(3-6-26-23(19)32)25-5-4-17-21(24)30(2)13-27-17/h3,6,11-13H,4-5,7-10H2,1-2H3,(H,28,29)(H2,25,26,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 343 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R expressed in SAL cells |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234517
(4-(2-(5-chloro-1-isopropyl-1H-imidazol-4-yl)ethyla...)Show SMILES CC(C)n1cnc(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1Cl Show InChI InChI=1S/C25H30ClN7O2/c1-15(2)33-14-29-19(23(33)26)5-6-27-18-4-7-28-25(34)21(18)24-30-20-13-17(12-16(3)22(20)31-24)32-8-10-35-11-9-32/h4,7,12-15H,5-6,8-11H2,1-3H3,(H,30,31)(H2,27,28,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234520
(4-(2-(1-isopropyl-1H-imidazol-4-yl)ethylamino)-3-(...)Show SMILES CC(C)n1cnc(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1 Show InChI InChI=1S/C25H31N7O2/c1-16(2)32-14-18(28-15-32)4-6-26-20-5-7-27-25(33)22(20)24-29-21-13-19(12-17(3)23(21)30-24)31-8-10-34-11-9-31/h5,7,12-16H,4,6,8-11H2,1-3H3,(H,29,30)(H2,26,27,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234520
(4-(2-(1-isopropyl-1H-imidazol-4-yl)ethylamino)-3-(...)Show SMILES CC(C)n1cnc(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1 Show InChI InChI=1S/C25H31N7O2/c1-16(2)32-14-18(28-15-32)4-6-26-20-5-7-27-25(33)22(20)24-29-21-13-19(12-17(3)23(21)30-24)31-8-10-34-11-9-31/h5,7,12-16H,4,6,8-11H2,1-3H3,(H,29,30)(H2,26,27,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 365 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R expressed in SAL cells |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234513
(4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(4-me...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCn2cc(Cl)cn2)cc[nH]c1=O)N1CCOCC1 Show InChI InChI=1S/C22H24ClN7O2/c1-14-10-16(29-6-8-32-9-7-29)11-18-20(14)28-21(27-18)19-17(2-3-25-22(19)31)24-4-5-30-13-15(23)12-26-30/h2-3,10-13H,4-9H2,1H3,(H,27,28)(H2,24,25,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 376 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R expressed in SAL cells |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234521
(4-(2-(4-methyl-1H-pyrazol-1-yl)ethylamino)-3-(4-me...)Show SMILES Cc1cnn(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1 Show InChI InChI=1S/C23H27N7O2/c1-15-13-26-30(14-15)6-5-24-18-3-4-25-23(31)20(18)22-27-19-12-17(11-16(2)21(19)28-22)29-7-9-32-10-8-29/h3-4,11-14H,5-10H2,1-2H3,(H,27,28)(H2,24,25,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 397 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R expressed in SAL cells |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234502
(4-(2-(3-methyl-1H-pyrazol-1-yl)ethylamino)-3-(4-me...)Show SMILES Cc1ccn(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)n1 Show InChI InChI=1S/C23H27N7O2/c1-15-13-17(29-9-11-32-12-10-29)14-19-21(15)27-22(26-19)20-18(3-5-25-23(20)31)24-6-8-30-7-4-16(2)28-30/h3-5,7,13-14H,6,8-12H2,1-2H3,(H,26,27)(H2,24,25,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 422 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R expressed in SAL cells |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234525
(4-(2-(5-chloro-1-(2-fluoroethyl)-1H-imidazol-4-yl)...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCc2ncn(CCF)c2Cl)cc[nH]c1=O)N1CCOCC1 Show InChI InChI=1S/C24H27ClFN7O2/c1-15-12-16(32-8-10-35-11-9-32)13-19-21(15)31-23(30-19)20-17(2-6-28-24(20)34)27-5-3-18-22(25)33(7-4-26)14-29-18/h2,6,12-14H,3-5,7-11H2,1H3,(H,30,31)(H2,27,28,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 451 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R expressed in SAL cells |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234505
(4-(2-(5-chloro-1-ethyl-1H-imidazol-4-yl)ethylamino...)Show SMILES CCn1cnc(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1Cl Show InChI InChI=1S/C24H28ClN7O2/c1-3-31-14-28-18(22(31)25)5-6-26-17-4-7-27-24(33)20(17)23-29-19-13-16(12-15(2)21(19)30-23)32-8-10-34-11-9-32/h4,7,12-14H,3,5-6,8-11H2,1-2H3,(H,29,30)(H2,26,27,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 469 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R expressed in SAL cells |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234504
(4-(2-(4-bromo-5-(hydroxymethyl)-1H-pyrazol-1-yl)et...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCn2ncc(Br)c2CO)cc[nH]c1=O)N1CCOCC1 Show InChI InChI=1S/C23H26BrN7O3/c1-14-10-15(30-6-8-34-9-7-30)11-18-21(14)29-22(28-18)20-17(2-3-26-23(20)33)25-4-5-31-19(13-32)16(24)12-27-31/h2-3,10-12,32H,4-9,13H2,1H3,(H,28,29)(H2,25,26,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234511
(4-(2-(1-ethyl-1H-imidazol-4-yl)ethylamino)-3-(4-me...)Show SMILES CCn1cnc(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1 Show InChI InChI=1S/C24H29N7O2/c1-3-30-14-17(27-15-30)4-6-25-19-5-7-26-24(32)21(19)23-28-20-13-18(12-16(2)22(20)29-23)31-8-10-33-11-9-31/h5,7,12-15H,3-4,6,8-11H2,1-2H3,(H,28,29)(H2,25,26,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 480 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234515
(4-(2-(4-bromo-5-methyl-1H-pyrazol-1-yl)ethylamino)...)Show SMILES Cc1c(Br)cnn1CCNc1cc[nH]c(=O)c1-c1nc2c(C)cc(cc2[nH]1)N1CCOCC1 Show InChI InChI=1S/C23H26BrN7O2/c1-14-11-16(30-7-9-33-10-8-30)12-19-21(14)29-22(28-19)20-18(3-4-26-23(20)32)25-5-6-31-15(2)17(24)13-27-31/h3-4,11-13H,5-10H2,1-2H3,(H,28,29)(H2,25,26,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 510 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234503
(4-(2-(1-methyl-1H-imidazol-4-yl)ethylamino)-3-(4-m...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCc2cn(C)cn2)cc[nH]c1=O)N1CCOCC1 Show InChI InChI=1S/C23H27N7O2/c1-15-11-17(30-7-9-32-10-8-30)12-19-21(15)28-22(27-19)20-18(4-6-25-23(20)31)24-5-3-16-13-29(2)14-26-16/h4,6,11-14H,3,5,7-10H2,1-2H3,(H,27,28)(H2,24,25,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 521 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R expressed in SAL cells |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234524
(CHEMBL256908 | ethyl 1-(2-(3-(4-methyl-6-morpholin...)Show SMILES CCOC(=O)c1cnn(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1 Show InChI InChI=1S/C25H29N7O4/c1-3-36-25(34)17-14-28-32(15-17)7-6-26-19-4-5-27-24(33)21(19)23-29-20-13-18(12-16(2)22(20)30-23)31-8-10-35-11-9-31/h4-5,12-15H,3,6-11H2,1-2H3,(H,29,30)(H2,26,27,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 531 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R expressed in SAL cells |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234508
(4-(2-(5-methyl-1H-pyrazol-1-yl)ethylamino)-3-(4-me...)Show SMILES Cc1ccnn1CCNc1cc[nH]c(=O)c1-c1nc2c(C)cc(cc2[nH]1)N1CCOCC1 Show InChI InChI=1S/C23H27N7O2/c1-15-13-17(29-9-11-32-12-10-29)14-19-21(15)28-22(27-19)20-18(4-5-25-23(20)31)24-7-8-30-16(2)3-6-26-30/h3-6,13-14H,7-12H2,1-2H3,(H,27,28)(H2,24,25,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 542 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R expressed in SAL cells |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234507
(4-(2-(1-(2-methoxyethyl)-1H-imidazol-4-yl)ethylami...)Show SMILES COCCn1cnc(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1 Show InChI InChI=1S/C25H31N7O3/c1-17-13-19(32-8-11-35-12-9-32)14-21-23(17)30-24(29-21)22-20(4-6-27-25(22)33)26-5-3-18-15-31(16-28-18)7-10-34-2/h4,6,13-16H,3,5,7-12H2,1-2H3,(H,29,30)(H2,26,27,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234511
(4-(2-(1-ethyl-1H-imidazol-4-yl)ethylamino)-3-(4-me...)Show SMILES CCn1cnc(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1 Show InChI InChI=1S/C24H29N7O2/c1-3-30-14-17(27-15-30)4-6-25-19-5-7-26-24(32)21(19)23-28-20-13-18(12-16(2)22(20)29-23)31-8-10-33-11-9-31/h5,7,12-15H,3-4,6,8-11H2,1-2H3,(H,28,29)(H2,25,26,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 583 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R expressed in SAL cells |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234526
(4-(2-(1H-pyrazol-1-yl)ethylamino)-3-(4-methyl-6-mo...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCn2cccn2)cc[nH]c1=O)N1CCOCC1 Show InChI InChI=1S/C22H25N7O2/c1-15-13-16(28-9-11-31-12-10-28)14-18-20(15)27-21(26-18)19-17(3-5-24-22(19)30)23-6-8-29-7-2-4-25-29/h2-5,7,13-14H,6,8-12H2,1H3,(H,26,27)(H2,23,24,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 613 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R expressed in SAL cells |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234501
(4-(2-(5-chloro-1-(2-methoxyethyl)-1H-imidazol-4-yl...)Show SMILES COCCn1cnc(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1Cl Show InChI InChI=1S/C25H30ClN7O3/c1-16-13-17(32-8-11-36-12-9-32)14-20-22(16)31-24(30-20)21-18(3-6-28-25(21)34)27-5-4-19-23(26)33(15-29-19)7-10-35-2/h3,6,13-15H,4-5,7-12H2,1-2H3,(H,30,31)(H2,27,28,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 622 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R expressed in SAL cells |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234514
(4-(2-(4-chloro-5-methyl-1H-pyrazol-1-yl)ethylamino...)Show SMILES Cc1c(Cl)cnn1CCNc1cc[nH]c(=O)c1-c1nc2c(C)cc(cc2[nH]1)N1CCOCC1 Show InChI InChI=1S/C23H26ClN7O2/c1-14-11-16(30-7-9-33-10-8-30)12-19-21(14)29-22(28-19)20-18(3-4-26-23(20)32)25-5-6-31-15(2)17(24)13-27-31/h3-4,11-13H,5-10H2,1-2H3,(H,28,29)(H2,25,26,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234516
(1-(2-(3-(4-methyl-6-morpholino-1H-benzo[d]imidazol...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCn2cc(cn2)C#N)cc[nH]c1=O)N1CCOCC1 Show InChI InChI=1S/C23H24N8O2/c1-15-10-17(30-6-8-33-9-7-30)11-19-21(15)29-22(28-19)20-18(2-3-26-23(20)32)25-4-5-31-14-16(12-24)13-27-31/h2-3,10-11,13-14H,4-9H2,1H3,(H,28,29)(H2,25,26,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 680 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234512
(4-(2-(4-bromo-3-(hydroxymethyl)-1H-pyrazol-1-yl)et...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCn2cc(Br)c(CO)n2)cc[nH]c1=O)N1CCOCC1 Show InChI InChI=1S/C23H26BrN7O3/c1-14-10-15(30-6-8-34-9-7-30)11-18-21(14)28-22(27-18)20-17(2-3-26-23(20)33)25-4-5-31-12-16(24)19(13-32)29-31/h2-3,10-12,32H,4-9,13H2,1H3,(H,27,28)(H2,25,26,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 697 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R expressed in SAL cells |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234515
(4-(2-(4-bromo-5-methyl-1H-pyrazol-1-yl)ethylamino)...)Show SMILES Cc1c(Br)cnn1CCNc1cc[nH]c(=O)c1-c1nc2c(C)cc(cc2[nH]1)N1CCOCC1 Show InChI InChI=1S/C23H26BrN7O2/c1-14-11-16(30-7-9-33-10-8-30)12-19-21(14)29-22(28-19)20-18(3-4-26-23(20)32)25-5-6-31-15(2)17(24)13-27-31/h3-4,11-13H,5-10H2,1-2H3,(H,28,29)(H2,25,26,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R expressed in SAL cells |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234522
(CHEMBL256909 | methyl 1-(2-(3-(4-methyl-6-morpholi...)Show SMILES COC(=O)c1cnn(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1 Show InChI InChI=1S/C24H27N7O4/c1-15-11-17(30-7-9-35-10-8-30)12-19-21(15)29-22(28-19)20-18(3-4-26-23(20)32)25-5-6-31-14-16(13-27-31)24(33)34-2/h3-4,11-14H,5-10H2,1-2H3,(H,28,29)(H2,25,26,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 711 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R expressed in SAL cells |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234514
(4-(2-(4-chloro-5-methyl-1H-pyrazol-1-yl)ethylamino...)Show SMILES Cc1c(Cl)cnn1CCNc1cc[nH]c(=O)c1-c1nc2c(C)cc(cc2[nH]1)N1CCOCC1 Show InChI InChI=1S/C23H26ClN7O2/c1-14-11-16(30-7-9-33-10-8-30)12-19-21(14)29-22(28-19)20-18(3-4-26-23(20)32)25-5-6-31-15(2)17(24)13-27-31/h3-4,11-13H,5-10H2,1-2H3,(H,28,29)(H2,25,26,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 777 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R expressed in SAL cells |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234504
(4-(2-(4-bromo-5-(hydroxymethyl)-1H-pyrazol-1-yl)et...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCn2ncc(Br)c2CO)cc[nH]c1=O)N1CCOCC1 Show InChI InChI=1S/C23H26BrN7O3/c1-14-10-15(30-6-8-34-9-7-30)11-18-21(14)29-22(28-18)20-17(2-3-26-23(20)33)25-4-5-31-19(13-32)16(24)12-27-31/h2-3,10-12,32H,4-9,13H2,1H3,(H,28,29)(H2,25,26,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 796 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R expressed in SAL cells |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234516
(1-(2-(3-(4-methyl-6-morpholino-1H-benzo[d]imidazol...)Show SMILES Cc1cc(cc2[nH]c(nc12)-c1c(NCCn2cc(cn2)C#N)cc[nH]c1=O)N1CCOCC1 Show InChI InChI=1S/C23H24N8O2/c1-15-10-17(30-6-8-33-9-7-30)11-19-21(15)29-22(28-19)20-18(2-3-26-23(20)32)25-4-5-31-14-16(12-24)13-27-31/h2-3,10-11,13-14H,4-9H2,1H3,(H,28,29)(H2,25,26,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 821 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R expressed in SAL cells |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234517
(4-(2-(5-chloro-1-isopropyl-1H-imidazol-4-yl)ethyla...)Show SMILES CC(C)n1cnc(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1Cl Show InChI InChI=1S/C25H30ClN7O2/c1-15(2)33-14-29-19(23(33)26)5-6-27-18-4-7-28-25(34)21(18)24-30-20-13-17(12-16(3)22(20)31-24)32-8-10-35-11-9-32/h4,7,12-15H,5-6,8-11H2,1-3H3,(H,30,31)(H2,27,28,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.14E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R expressed in SAL cells |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234507
(4-(2-(1-(2-methoxyethyl)-1H-imidazol-4-yl)ethylami...)Show SMILES COCCn1cnc(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1 Show InChI InChI=1S/C25H31N7O3/c1-17-13-19(32-8-11-35-12-9-32)14-21-23(17)30-24(29-21)22-20(4-6-27-25(22)33)26-5-3-18-15-31(16-28-18)7-10-34-2/h4,6,13-16H,3,5,7-12H2,1-2H3,(H,29,30)(H2,26,27,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R expressed in SAL cells |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50234528
(4-(2-(1-ethyl-5-ethynyl-1H-imidazol-4-yl)ethylamin...)Show SMILES CCn1cnc(CCNc2cc[nH]c(=O)c2-c2nc3c(C)cc(cc3[nH]2)N2CCOCC2)c1C#C Show InChI InChI=1S/C26H29N7O2/c1-4-22-19(29-16-32(22)5-2)6-8-27-20-7-9-28-26(34)23(20)25-30-21-15-18(14-17(3)24(21)31-25)33-10-12-35-13-11-33/h1,7,9,14-16H,5-6,8,10-13H2,2-3H3,(H,30,31)(H2,27,28,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R expressed in SAL cells |
Bioorg Med Chem Lett 18: 1702-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.049
BindingDB Entry DOI: 10.7270/Q2NV9J1M |
More data for this
Ligand-Target Pair | |
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