Found 44 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235550
(1-(4-(5-((4-aminocyclohexylidene)methyl)pyrrolo[1,...)Show SMILES NC1CCC(CC1)=Cc1ccn2ncnc(Oc3ccc(NC(=O)NC(=O)Cc4ccc(F)cc4)cc3F)c12 Show InChI InChI=1S/C28H26F2N6O3/c29-20-5-1-18(2-6-20)14-25(37)35-28(38)34-22-9-10-24(23(30)15-22)39-27-26-19(11-12-36(26)33-16-32-27)13-17-3-7-21(31)8-4-17/h1-2,5-6,9-13,15-16,21H,3-4,7-8,14,31H2,(H2,34,35,37,38)/b17-13- | PDB
MMDB
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UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235572
(CHEMBL400332 | N-(4-(6-(3-(dimethylamino)propoxy)-...)Show SMILES CN(C)CCCOc1cn2ncnc(Oc3ccc(NC(=O)c4c(F)cccc4F)cc3F)c2c1C Show InChI InChI=1S/C25H24F3N5O3/c1-15-21(35-11-5-10-32(2)3)13-33-23(15)25(29-14-30-33)36-20-9-8-16(12-19(20)28)31-24(34)22-17(26)6-4-7-18(22)27/h4,6-9,12-14H,5,10-11H2,1-3H3,(H,31,34) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235548
(CHEMBL254280 | N1-(4-(6-(3-(dimethylamino)propoxy)...)Show SMILES CN(C)CCCOc1cn2ncnc(Oc3ccc(NC(=O)CC(=O)Nc4ccc(F)cc4)cc3F)c2c1C Show InChI InChI=1S/C27H28F2N6O4/c1-17-23(38-12-4-11-34(2)3)15-35-26(17)27(30-16-31-35)39-22-10-9-20(13-21(22)29)33-25(37)14-24(36)32-19-7-5-18(28)6-8-19/h5-10,13,15-16H,4,11-12,14H2,1-3H3,(H,32,36)(H,33,37) | PDB
MMDB
KEGG
UniProtKB/SwissProt
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
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Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235540
(2,6-difluoro-N-(3-fluoro-4-(5-methyl-6-(2-(4-methy...)Show SMILES CN1CCN(CCOc2cn3ncnc(Oc4ccc(NC(=O)c5c(F)cccc5F)cc4F)c3c2C)CC1 Show InChI InChI=1S/C27H27F3N6O3/c1-17-23(38-13-12-35-10-8-34(2)9-11-35)15-36-25(17)27(31-16-32-36)39-22-7-6-18(14-21(22)30)33-26(37)24-19(28)4-3-5-20(24)29/h3-7,14-16H,8-13H2,1-2H3,(H,33,37) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235547
(1-(4-(5-(((3R,4R)-4-amino-3-hydroxypiperidin-1-yl)...)Show SMILES N[C@@H]1CCN(Cc2ccn3ncnc(Oc4ccc(NC(=O)NC(=O)Cc5ccc(F)cc5)cc4F)c23)C[C@H]1O Show InChI InChI=1S/C27H27F2N7O4/c28-18-3-1-16(2-4-18)11-24(38)34-27(39)33-19-5-6-23(20(29)12-19)40-26-25-17(7-10-36(25)32-15-31-26)13-35-9-8-21(30)22(37)14-35/h1-7,10,12,15,21-22,37H,8-9,11,13-14,30H2,(H2,33,34,38,39)/t21-,22-/m1/s1 | PDB
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235565
(2,5-difluoro-N-(3-fluoro-4-(5-methyl-6-(2-(4-methy...)Show SMILES CN1CCN(CCOc2cn3ncnc(Oc4ccc(NC(=O)c5cc(F)ccc5F)cc4F)c3c2C)CC1 Show InChI InChI=1S/C27H27F3N6O3/c1-17-24(38-12-11-35-9-7-34(2)8-10-35)15-36-25(17)27(31-16-32-36)39-23-6-4-19(14-22(23)30)33-26(37)20-13-18(28)3-5-21(20)29/h3-6,13-16H,7-12H2,1-2H3,(H,33,37) | PDB
MMDB
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235556
(1-(4-(6-(3-(dimethylamino)propoxy)-5-methylpyrrolo...)Show SMILES CN(C)CCCOc1cn2ncnc(Oc3ccc(NC(=O)NC(=O)Cc4ccc(F)cc4)cc3F)c2c1C Show InChI InChI=1S/C27H28F2N6O4/c1-17-23(38-12-4-11-34(2)3)15-35-25(17)26(30-16-31-35)39-22-10-9-20(14-21(22)29)32-27(37)33-24(36)13-18-5-7-19(28)8-6-18/h5-10,14-16H,4,11-13H2,1-3H3,(H2,32,33,36,37) | PDB
MMDB
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235573
(CHEMBL399698 | N1-(3-fluoro-4-(5-methyl-6-(2-(4-me...)Show SMILES CN1CCN(CCOc2cn3ncnc(Oc4ccc(NC(=O)CC(=O)Nc5ccc(F)cc5)cc4F)c3c2C)CC1 Show InChI InChI=1S/C29H31F2N7O4/c1-19-25(41-14-13-37-11-9-36(2)10-12-37)17-38-28(19)29(32-18-33-38)42-24-8-7-22(15-23(24)31)35-27(40)16-26(39)34-21-5-3-20(30)4-6-21/h3-8,15,17-18H,9-14,16H2,1-2H3,(H,34,39)(H,35,40) | PDB
MMDB
KEGG
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235544
(1-(4-(5-((4-aminopiperidin-1-yl)methyl)pyrrolo[1,2...)Show SMILES NC1CCN(Cc2ccn3ncnc(Oc4ccc(NC(=O)NC(=O)Cc5ccc(F)cc5)cc4F)c23)CC1 Show InChI InChI=1S/C27H27F2N7O3/c28-19-3-1-17(2-4-19)13-24(37)34-27(38)33-21-5-6-23(22(29)14-21)39-26-25-18(7-12-36(25)32-16-31-26)15-35-10-8-20(30)9-11-35/h1-7,12,14,16,20H,8-11,13,15,30H2,(H2,33,34,37,38) | PDB
MMDB
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| CHEMBL
PC cid
PC sid
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| PDB
Article
PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235567
(1-(3-fluoro-4-(5-methyl-6-(2-(4-methylpiperazin-1-...)Show SMILES CN1CCN(CCOc2cn3ncnc(Oc4ccc(NC(=O)NC(=O)Cc5ccc(F)cc5)cc4F)c3c2C)CC1 Show InChI InChI=1S/C29H31F2N7O4/c1-19-25(41-14-13-37-11-9-36(2)10-12-37)17-38-27(19)28(32-18-33-38)42-24-8-7-22(16-23(24)31)34-29(40)35-26(39)15-20-3-5-21(30)6-4-20/h3-8,16-18H,9-15H2,1-2H3,(H2,34,35,39,40) | PDB
MMDB
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GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235558
(5-chloro-2-fluoro-N-(3-fluoro-4-(5-methyl-6-(2-(4-...)Show SMILES CN1CCN(CCOc2cn3ncnc(Oc4ccc(NC(=O)c5cc(Cl)ccc5F)cc4F)c3c2C)CC1 Show InChI InChI=1S/C27H27ClF2N6O3/c1-17-24(38-12-11-35-9-7-34(2)8-10-35)15-36-25(17)27(31-16-32-36)39-23-6-4-19(14-22(23)30)33-26(37)20-13-18(28)3-5-21(20)29/h3-6,13-16H,7-12H2,1-2H3,(H,33,37) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235575
(CHEMBL253222 | N-(4-(6-(3-(dimethylamino)propoxy)-...)Show SMILES CN(C)CCCOc1cn2ncnc(Oc3ccc(NC(=O)c4cccnc4)cc3F)c2c1C Show InChI InChI=1S/C24H25FN6O3/c1-16-21(33-11-5-10-30(2)3)14-31-22(16)24(27-15-28-31)34-20-8-7-18(12-19(20)25)29-23(32)17-6-4-9-26-13-17/h4,6-9,12-15H,5,10-11H2,1-3H3,(H,29,32) | PDB
MMDB
KEGG
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235543
(2-fluoro-N-(3-fluoro-4-(5-methyl-6-(2-(4-methylpip...)Show SMILES CN1CCN(CCOc2cn3ncnc(Oc4ccc(NC(=O)c5ccccc5F)cc4F)c3c2C)CC1 Show InChI InChI=1S/C27H28F2N6O3/c1-18-24(37-14-13-34-11-9-33(2)10-12-34)16-35-25(18)27(30-17-31-35)38-23-8-7-19(15-22(23)29)32-26(36)20-5-3-4-6-21(20)28/h3-8,15-17H,9-14H2,1-2H3,(H,32,36) | PDB
MMDB
KEGG
UniProtKB/SwissProt
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235571
(2-fluoro-N-(3-fluoro-4-(5-methyl-6-(2-(4-methylpip...)Show SMILES CN1CCN(CCOc2cn3ncnc(Oc4ccc(NC(=O)c5cc(C)ccc5F)cc4F)c3c2C)CC1 Show InChI InChI=1S/C28H30F2N6O3/c1-18-4-6-22(29)21(14-18)27(37)33-20-5-7-24(23(30)15-20)39-28-26-19(2)25(16-36(26)32-17-31-28)38-13-12-35-10-8-34(3)9-11-35/h4-7,14-17H,8-13H2,1-3H3,(H,33,37) | PDB
MMDB
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GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235546
(3-acetyl-N-(3-fluoro-4-(5-methyl-6-(2-(4-methylpip...)Show SMILES CN1CCN(CCOc2cn3ncnc(Oc4ccc(NC(=O)c5cccc(c5)C(C)=O)cc4F)c3c2C)CC1 Show InChI InChI=1S/C29H31FN6O4/c1-19-26(39-14-13-35-11-9-34(3)10-12-35)17-36-27(19)29(31-18-32-36)40-25-8-7-23(16-24(25)30)33-28(38)22-6-4-5-21(15-22)20(2)37/h4-8,15-18H,9-14H2,1-3H3,(H,33,38) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235561
(CHEMBL401344 | N1-(3-fluoro-4-(5-methyl-6-(2-morph...)Show SMILES Cc1c(OCCN2CCOCC2)cn2ncnc(Oc3ccc(NC(=O)CC(=O)Nc4ccc(F)cc4)cc3F)c12 Show InChI InChI=1S/C28H28F2N6O5/c1-18-24(40-13-10-35-8-11-39-12-9-35)16-36-27(18)28(31-17-32-36)41-23-7-6-21(14-22(23)30)34-26(38)15-25(37)33-20-4-2-19(29)3-5-20/h2-7,14,16-17H,8-13,15H2,1H3,(H,33,37)(H,34,38) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235563
(CHEMBL254907 | N1-(4-(6-(2-(dimethylamino)ethoxy)-...)Show SMILES CN(C)CCOc1cn2ncnc(Oc3ccc(NC(=O)CC(=O)Nc4ccc(F)cc4)cc3F)c2c1C Show InChI InChI=1S/C26H26F2N6O4/c1-16-22(37-11-10-33(2)3)14-34-25(16)26(29-15-30-34)38-21-9-8-19(12-20(21)28)32-24(36)13-23(35)31-18-6-4-17(27)5-7-18/h4-9,12,14-15H,10-11,13H2,1-3H3,(H,31,35)(H,32,36) | PDB
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| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235545
(1-(3-fluoro-4-(5-((piperidin-4-ylamino)methyl)pyrr...)Show SMILES Fc1ccc(CC(=O)NC(=O)Nc2ccc(Oc3ncnn4ccc(CNC5CCNCC5)c34)c(F)c2)cc1 Show InChI InChI=1S/C27H27F2N7O3/c28-19-3-1-17(2-4-19)13-24(37)35-27(38)34-21-5-6-23(22(29)14-21)39-26-25-18(9-12-36(25)33-16-32-26)15-31-20-7-10-30-11-8-20/h1-6,9,12,14,16,20,30-31H,7-8,10-11,13,15H2,(H2,34,35,37,38) | PDB
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| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235554
(1-(4-(6-(2-(dimethylamino)ethoxy)-5-methylpyrrolo[...)Show SMILES CN(C)CCOc1cn2ncnc(Oc3ccc(NC(=O)NC(=O)Cc4ccc(F)cc4)cc3F)c2c1C Show InChI InChI=1S/C26H26F2N6O4/c1-16-22(37-11-10-33(2)3)14-34-24(16)25(29-15-30-34)38-21-9-8-19(13-20(21)28)31-26(36)32-23(35)12-17-4-6-18(27)7-5-17/h4-9,13-15H,10-12H2,1-3H3,(H2,31,32,35,36) | PDB
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| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235555
(CHEMBL251980 | N-(3-fluoro-4-(5-methyl-6-(2-(4-met...)Show SMILES CN1CCN(CCOc2cn3ncnc(Oc4ccc(NC(=O)c5cccnc5)cc4F)c3c2C)CC1 Show InChI InChI=1S/C26H28FN7O3/c1-18-23(36-13-12-33-10-8-32(2)9-11-33)16-34-24(18)26(29-17-30-34)37-22-6-5-20(14-21(22)27)31-25(35)19-4-3-7-28-15-19/h3-7,14-17H,8-13H2,1-2H3,(H,31,35) | PDB
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PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235553
(1-(4-(5-((3-(aminomethyl)azetidin-1-yl)methyl)pyrr...)Show SMILES NCC1CN(Cc2ccn3ncnc(Oc4ccc(NC(=O)NC(=O)Cc5ccc(F)cc5)cc4F)c23)C1 Show InChI InChI=1S/C26H25F2N7O3/c27-19-3-1-16(2-4-19)9-23(36)33-26(37)32-20-5-6-22(21(28)10-20)38-25-24-18(7-8-35(24)31-15-30-25)14-34-12-17(11-29)13-34/h1-8,10,15,17H,9,11-14,29H2,(H2,32,33,36,37) | PDB
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| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235559
(CHEMBL399674 | N-(3-fluoro-4-(5-methyl-6-(2-(4-met...)Show SMILES CN1CCN(CCOc2cn3ncnc(Oc4ccc(NC(=O)c5cccs5)cc4F)c3c2C)CC1 Show InChI InChI=1S/C25H27FN6O3S/c1-17-21(34-12-11-31-9-7-30(2)8-10-31)15-32-23(17)25(27-16-28-32)35-20-6-5-18(14-19(20)26)29-24(33)22-4-3-13-36-22/h3-6,13-16H,7-12H2,1-2H3,(H,29,33) | PDB
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PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235549
((S)-1-(4-(5-((3-aminopyrrolidin-1-yl)methyl)pyrrol...)Show SMILES N[C@H]1CCN(Cc2ccn3ncnc(Oc4ccc(NC(=O)NC(=O)Cc5ccc(F)cc5)cc4F)c23)C1 Show InChI InChI=1S/C26H25F2N7O3/c27-18-3-1-16(2-4-18)11-23(36)33-26(37)32-20-5-6-22(21(28)12-20)38-25-24-17(7-10-35(24)31-15-30-25)13-34-9-8-19(29)14-34/h1-7,10,12,15,19H,8-9,11,13-14,29H2,(H2,32,33,36,37)/t19-/m0/s1 | PDB
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| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM50235544
(1-(4-(5-((4-aminopiperidin-1-yl)methyl)pyrrolo[1,2...)Show SMILES NC1CCN(Cc2ccn3ncnc(Oc4ccc(NC(=O)NC(=O)Cc5ccc(F)cc5)cc4F)c23)CC1 Show InChI InChI=1S/C27H27F2N7O3/c28-19-3-1-17(2-4-19)13-24(37)34-27(38)33-21-5-6-23(22(29)14-21)39-26-25-18(7-12-36(25)32-16-31-26)15-35-10-8-20(30)9-11-35/h1-7,12,14,16,20H,8-11,13,15,30H2,(H2,33,34,37,38) | PDB
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| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of TrkA |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235564
(1-(3-fluoro-4-(5-phenylpyrrolo[1,2-f][1,2,4]triazi...)Show SMILES Fc1ccc(CC(=O)NC(=O)Nc2ccc(Oc3ncnn4ccc(-c5ccccc5)c34)c(F)c2)cc1 Show InChI InChI=1S/C27H19F2N5O3/c28-19-8-6-17(7-9-19)14-24(35)33-27(36)32-20-10-11-23(22(29)15-20)37-26-25-21(18-4-2-1-3-5-18)12-13-34(25)31-16-30-26/h1-13,15-16H,14H2,(H2,32,33,35,36) | PDB
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| Article
PubMed
| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235570
(1-(3-fluoro-4-(5-(piperazin-1-ylmethyl)pyrrolo[1,2...)Show SMILES Fc1ccc(CC(=O)NC(=O)Nc2ccc(Oc3ncnn4ccc(CN5CCNCC5)c34)c(F)c2)cc1 Show InChI InChI=1S/C26H25F2N7O3/c27-19-3-1-17(2-4-19)13-23(36)33-26(37)32-20-5-6-22(21(28)14-20)38-25-24-18(7-10-35(24)31-16-30-25)15-34-11-8-29-9-12-34/h1-7,10,14,16,29H,8-9,11-13,15H2,(H2,32,33,36,37) | PDB
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PubMed
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235562
(1-(4-(5-((4-acetamidopiperidin-1-yl)methyl)pyrrolo...)Show SMILES CC(=O)NC1CCN(Cc2ccn3ncnc(Oc4ccc(NC(=O)NC(=O)Cc5ccc(F)cc5)cc4F)c23)CC1 Show InChI InChI=1S/C29H29F2N7O4/c1-18(39)34-22-9-11-37(12-10-22)16-20-8-13-38-27(20)28(32-17-33-38)42-25-7-6-23(15-24(25)31)35-29(41)36-26(40)14-19-2-4-21(30)5-3-19/h2-8,13,15,17,22H,9-12,14,16H2,1H3,(H,34,39)(H2,35,36,40,41) | PDB
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PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235551
((R)-1-(4-(5-((3-aminopyrrolidin-1-yl)methyl)pyrrol...)Show SMILES N[C@@H]1CCN(Cc2ccn3ncnc(Oc4ccc(NC(=O)NC(=O)Cc5ccc(F)cc5)cc4F)c23)C1 Show InChI InChI=1S/C26H25F2N7O3/c27-18-3-1-16(2-4-18)11-23(36)33-26(37)32-20-5-6-22(21(28)12-20)38-25-24-17(7-10-35(24)31-15-30-25)13-34-9-8-19(29)14-34/h1-7,10,12,15,19H,8-9,11,13-14,29H2,(H2,32,33,36,37)/t19-/m1/s1 | PDB
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| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235552
(2-fluoro-N-(3-fluoro-4-(5-methyl-6-(2-morpholinoet...)Show SMILES Cc1c(OCCN2CCOCC2)cn2ncnc(Oc3ccc(NC(=O)c4cc(C)ccc4F)cc3F)c12 Show InChI InChI=1S/C27H27F2N5O4/c1-17-3-5-21(28)20(13-17)26(35)32-19-4-6-23(22(29)14-19)38-27-25-18(2)24(15-34(25)31-16-30-27)37-12-9-33-7-10-36-11-8-33/h3-6,13-16H,7-12H2,1-2H3,(H,32,35) | PDB
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| n/a | n/a | 510 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235568
(2-fluoro-N-(3-fluoro-4-(5-methylpyrrolo[1,2-f][1,2...)Show SMILES Cc1ccn2ncnc(Oc3ccc(NC(=O)c4ccccc4F)cc3F)c12 Show InChI InChI=1S/C20H14F2N4O2/c1-12-8-9-26-18(12)20(23-11-24-26)28-17-7-6-13(10-16(17)22)25-19(27)14-4-2-3-5-15(14)21/h2-11H,1H3,(H,25,27) | PDB
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PubMed
| n/a | n/a | 760 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235542
(CHEMBL253223 | N1-(3-fluoro-4-(5-methylpyrrolo[1,2...)Show SMILES Cc1ccn2ncnc(Oc3ccc(NC(=O)CC(=O)Nc4ccc(F)cc4)cc3F)c12 Show InChI InChI=1S/C22H17F2N5O3/c1-13-8-9-29-21(13)22(25-12-26-29)32-18-7-6-16(10-17(18)24)28-20(31)11-19(30)27-15-4-2-14(23)3-5-15/h2-10,12H,11H2,1H3,(H,27,30)(H,28,31) | PDB
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PubMed
| n/a | n/a | 780 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235541
(1-(3-fluoro-4-(5-((4-methylpiperazin-1-yl)methyl)p...)Show SMILES CN1CCN(Cc2ccn3ncnc(Oc4ccc(NC(=O)NC(=O)Cc5ccc(F)cc5)cc4F)c23)CC1 Show InChI InChI=1S/C27H27F2N7O3/c1-34-10-12-35(13-11-34)16-19-8-9-36-25(19)26(30-17-31-36)39-23-7-6-21(15-22(23)29)32-27(38)33-24(37)14-18-2-4-20(28)5-3-18/h2-9,15,17H,10-14,16H2,1H3,(H2,32,33,37,38) | PDB
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PubMed
| n/a | n/a | 860 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235560
(1-(3-fluoro-4-(5-((4-hydroxypiperidin-1-yl)methyl)...)Show SMILES OC1CCN(Cc2ccn3ncnc(Oc4ccc(NC(=O)NC(=O)Cc5ccc(F)cc5)cc4F)c23)CC1 Show InChI InChI=1S/C27H26F2N6O4/c28-19-3-1-17(2-4-19)13-24(37)33-27(38)32-20-5-6-23(22(29)14-20)39-26-25-18(7-12-35(25)31-16-30-26)15-34-10-8-21(36)9-11-34/h1-7,12,14,16,21,36H,8-11,13,15H2,(H2,32,33,37,38) | PDB
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PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235569
(1-(3-fluoro-4-(5-(morpholinomethyl)pyrrolo[1,2-f][...)Show SMILES Fc1ccc(CC(=O)NC(=O)Nc2ccc(Oc3ncnn4ccc(CN5CCOCC5)c34)c(F)c2)cc1 Show InChI InChI=1S/C26H24F2N6O4/c27-19-3-1-17(2-4-19)13-23(35)32-26(36)31-20-5-6-22(21(28)14-20)38-25-24-18(7-8-34(24)30-16-29-25)15-33-9-11-37-12-10-33/h1-8,14,16H,9-13,15H2,(H2,31,32,35,36) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 990 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235566
(1-(4-(5-((4-(aminomethyl)piperidin-1-yl)methyl)pyr...)Show SMILES NCC1CCN(Cc2ccn3ncnc(Oc4ccc(NC(=O)NC(=O)Cc5ccc(F)cc5)cc4F)c23)CC1 Show InChI InChI=1S/C28H29F2N7O3/c29-21-3-1-18(2-4-21)13-25(38)35-28(39)34-22-5-6-24(23(30)14-22)40-27-26-20(9-12-37(26)33-17-32-27)16-36-10-7-19(15-31)8-11-36/h1-6,9,12,14,17,19H,7-8,10-11,13,15-16,31H2,(H2,34,35,38,39) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235557
(1-(4-(5-((3-aminopropylamino)methyl)pyrrolo[1,2-f]...)Show SMILES NCCCNCc1ccn2ncnc(Oc3ccc(NC(=O)NC(=O)Cc4ccc(F)cc4)cc3F)c12 Show InChI InChI=1S/C25H25F2N7O3/c26-18-4-2-16(3-5-18)12-22(35)33-25(36)32-19-6-7-21(20(27)13-19)37-24-23-17(14-29-10-1-9-28)8-11-34(23)31-15-30-24/h2-8,11,13,15,29H,1,9-10,12,14,28H2,(H2,32,33,35,36) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50235574
(1-(4-(5-chloropyrrolo[1,2-f][1,2,4]triazin-4-yloxy...)Show SMILES Fc1ccc(CC(=O)NC(=O)Nc2ccc(Oc3ncnn4ccc(Cl)c34)c(F)c2)cc1 Show InChI InChI=1S/C21H14ClF2N5O3/c22-15-7-8-29-19(15)20(25-11-26-29)32-17-6-5-14(10-16(17)24)27-21(31)28-18(30)9-12-1-3-13(23)4-2-12/h1-8,10-11H,9H2,(H2,27,28,30,31) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant c-Met expressed in insect cell-baculovirus expression system |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50235544
(1-(4-(5-((4-aminopiperidin-1-yl)methyl)pyrrolo[1,2...)Show SMILES NC1CCN(Cc2ccn3ncnc(Oc4ccc(NC(=O)NC(=O)Cc5ccc(F)cc5)cc4F)c23)CC1 Show InChI InChI=1S/C27H27F2N7O3/c28-19-3-1-17(2-4-19)13-24(37)34-27(38)33-21-5-6-23(22(29)14-21)39-26-25-18(7-12-36(25)32-16-31-26)15-35-10-8-20(30)9-11-35/h1-7,12,14,16,20H,8-11,13,15,30H2,(H2,33,34,37,38) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50235544
(1-(4-(5-((4-aminopiperidin-1-yl)methyl)pyrrolo[1,2...)Show SMILES NC1CCN(Cc2ccn3ncnc(Oc4ccc(NC(=O)NC(=O)Cc5ccc(F)cc5)cc4F)c23)CC1 Show InChI InChI=1S/C27H27F2N7O3/c28-19-3-1-17(2-4-19)13-24(37)34-27(38)33-21-5-6-23(22(29)14-21)39-26-25-18(7-12-36(25)32-16-31-26)15-35-10-8-20(30)9-11-35/h1-7,12,14,16,20H,8-11,13,15,30H2,(H2,33,34,37,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of IGF1R |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50235544
(1-(4-(5-((4-aminopiperidin-1-yl)methyl)pyrrolo[1,2...)Show SMILES NC1CCN(Cc2ccn3ncnc(Oc4ccc(NC(=O)NC(=O)Cc5ccc(F)cc5)cc4F)c23)CC1 Show InChI InChI=1S/C27H27F2N7O3/c28-19-3-1-17(2-4-19)13-24(37)34-27(38)33-21-5-6-23(22(29)14-21)39-26-25-18(7-12-36(25)32-16-31-26)15-35-10-8-20(30)9-11-35/h1-7,12,14,16,20H,8-11,13,15,30H2,(H2,33,34,37,38) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of CDK2 |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Receptor tyrosine-protein kinase erbB-2
(Homo sapiens (Human)) | BDBM50235544
(1-(4-(5-((4-aminopiperidin-1-yl)methyl)pyrrolo[1,2...)Show SMILES NC1CCN(Cc2ccn3ncnc(Oc4ccc(NC(=O)NC(=O)Cc5ccc(F)cc5)cc4F)c23)CC1 Show InChI InChI=1S/C27H27F2N7O3/c28-19-3-1-17(2-4-19)13-24(37)34-27(38)33-21-5-6-23(22(29)14-21)39-26-25-18(7-12-36(25)32-16-31-26)15-35-10-8-20(30)9-11-35/h1-7,12,14,16,20H,8-11,13,15,30H2,(H2,33,34,37,38) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of HER2 |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50235544
(1-(4-(5-((4-aminopiperidin-1-yl)methyl)pyrrolo[1,2...)Show SMILES NC1CCN(Cc2ccn3ncnc(Oc4ccc(NC(=O)NC(=O)Cc5ccc(F)cc5)cc4F)c23)CC1 Show InChI InChI=1S/C27H27F2N7O3/c28-19-3-1-17(2-4-19)13-24(37)34-27(38)33-21-5-6-23(22(29)14-21)39-26-25-18(7-12-36(25)32-16-31-26)15-35-10-8-20(30)9-11-35/h1-7,12,14,16,20H,8-11,13,15,30H2,(H2,33,34,37,38) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of MK2 |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50235544
(1-(4-(5-((4-aminopiperidin-1-yl)methyl)pyrrolo[1,2...)Show SMILES NC1CCN(Cc2ccn3ncnc(Oc4ccc(NC(=O)NC(=O)Cc5ccc(F)cc5)cc4F)c23)CC1 Show InChI InChI=1S/C27H27F2N7O3/c28-19-3-1-17(2-4-19)13-24(37)34-27(38)33-21-5-6-23(22(29)14-21)39-26-25-18(7-12-36(25)32-16-31-26)15-35-10-8-20(30)9-11-35/h1-7,12,14,16,20H,8-11,13,15,30H2,(H2,33,34,37,38) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of lck |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
Insulin receptor
(Homo sapiens (Human)) | BDBM50235544
(1-(4-(5-((4-aminopiperidin-1-yl)methyl)pyrrolo[1,2...)Show SMILES NC1CCN(Cc2ccn3ncnc(Oc4ccc(NC(=O)NC(=O)Cc5ccc(F)cc5)cc4F)c23)CC1 Show InChI InChI=1S/C27H27F2N7O3/c28-19-3-1-17(2-4-19)13-24(37)34-27(38)33-21-5-6-23(22(29)14-21)39-26-25-18(7-12-36(25)32-16-31-26)15-35-10-8-20(30)9-11-35/h1-7,12,14,16,20H,8-11,13,15,30H2,(H2,33,34,37,38) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of InsR |
Bioorg Med Chem Lett 18: 1945-51 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.121
BindingDB Entry DOI: 10.7270/Q2125SFV |
More data for this
Ligand-Target Pair | |
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