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PubMed code 18353639

Compile data set for download or QSAR
Found 27 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H3 receptor


(Homo sapiens (Human))
BDBM50237869
PNG
((+/-)-2-(1,3-bis(2-(2-methylpyrrolidin-1-yl)ethyl)...)
Show SMILES [#6]-[#6]-1-[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7]1-[#6]-[#6]-[#7](-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-2-[#6])\[#6]-1=[#6](/C#N)C#N |w:1.0,18.20|
Show InChI InChI=1S/C20H32N6/c1-17-5-3-7-23(17)9-11-25-13-14-26(20(25)19(15-21)16-22)12-10-24-8-4-6-18(24)2/h17-18H,3-14H2,1-2H3
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0.330n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cells


Bioorg Med Chem Lett 18: 2288-91 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.006
BindingDB Entry DOI: 10.7270/Q2KW5FSF
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))
BDBM50237870
PNG
(2-(1,3-bis(2-((S)-2-methylpyrrolidin-1-yl)ethyl)im...)
Show SMILES [#6]-[#6@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7]1-[#6]-[#6]-[#7](-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6@@H]-2-[#6])\[#6]-1=[#6](/C#N)C#N
Show InChI InChI=1S/C20H32N6/c1-17-5-3-7-23(17)9-11-25-13-14-26(20(25)19(15-21)16-22)12-10-24-8-4-6-18(24)2/h17-18H,3-14H2,1-2H3/t17-,18-/m0/s1
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0.340n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cells


Bioorg Med Chem Lett 18: 2288-91 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.006
BindingDB Entry DOI: 10.7270/Q2KW5FSF
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))
BDBM50237874
PNG
((+/-)-2-(1-(2-(2-methylpyrrolidin-1-yl)ethyl)-3-(2...)
Show SMILES [#6]-[#6]-1-[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7]1-[#6]-[#6]-[#7](-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)\[#6]-1=[#6](/C#N)C#N |w:1.0|
Show InChI InChI=1S/C20H32N6/c1-18-6-5-9-24(18)12-13-26-15-14-25(20(26)19(16-21)17-22)11-10-23-7-3-2-4-8-23/h18H,2-15H2,1H3
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0.380n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cells


Bioorg Med Chem Lett 18: 2288-91 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.006
BindingDB Entry DOI: 10.7270/Q2KW5FSF
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))
BDBM50237872
PNG
(2-(3-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)-1-(2-(...)
Show SMILES [#6]-[#6@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7]1-[#6]-[#6]-[#7](-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6@H]-2-[#6])\[#6]-1=[#6](\C#N)C#N
Show InChI InChI=1S/C20H32N6/c1-17-5-3-7-23(17)9-11-25-13-14-26(20(25)19(15-21)16-22)12-10-24-8-4-6-18(24)2/h17-18H,3-14H2,1-2H3/t17-,18+
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0.470n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cells


Bioorg Med Chem Lett 18: 2288-91 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.006
BindingDB Entry DOI: 10.7270/Q2KW5FSF
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50237870
PNG
(2-(1,3-bis(2-((S)-2-methylpyrrolidin-1-yl)ethyl)im...)
Show SMILES [#6]-[#6@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7]1-[#6]-[#6]-[#7](-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6@@H]-2-[#6])\[#6]-1=[#6](/C#N)C#N
Show InChI InChI=1S/C20H32N6/c1-17-5-3-7-23(17)9-11-25-13-14-26(20(25)19(15-21)16-22)12-10-24-8-4-6-18(24)2/h17-18H,3-14H2,1-2H3/t17-,18-/m0/s1
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0.480n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membrane


Bioorg Med Chem Lett 18: 2288-91 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.006
BindingDB Entry DOI: 10.7270/Q2KW5FSF
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))
BDBM50159110
PNG
(1-(3-(4-(piperidin-1-ylmethyl)phenoxy)propyl)piper...)
Show SMILES C(COc1ccc(CN2CCCCC2)cc1)CN1CCCCC1
Show InChI InChI=1S/C20H32N2O/c1-3-12-21(13-4-1)16-7-17-23-20-10-8-19(9-11-20)18-22-14-5-2-6-15-22/h8-11H,1-7,12-18H2
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0.570n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cells


Bioorg Med Chem Lett 18: 2288-91 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.006
BindingDB Entry DOI: 10.7270/Q2KW5FSF
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50237869
PNG
((+/-)-2-(1,3-bis(2-(2-methylpyrrolidin-1-yl)ethyl)...)
Show SMILES [#6]-[#6]-1-[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7]1-[#6]-[#6]-[#7](-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-2-[#6])\[#6]-1=[#6](/C#N)C#N |w:1.0,18.20|
Show InChI InChI=1S/C20H32N6/c1-17-5-3-7-23(17)9-11-25-13-14-26(20(25)19(15-21)16-22)12-10-24-8-4-6-18(24)2/h17-18H,3-14H2,1-2H3
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0.680n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membrane


Bioorg Med Chem Lett 18: 2288-91 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.006
BindingDB Entry DOI: 10.7270/Q2KW5FSF
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50237874
PNG
((+/-)-2-(1-(2-(2-methylpyrrolidin-1-yl)ethyl)-3-(2...)
Show SMILES [#6]-[#6]-1-[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7]1-[#6]-[#6]-[#7](-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)\[#6]-1=[#6](/C#N)C#N |w:1.0|
Show InChI InChI=1S/C20H32N6/c1-18-6-5-9-24(18)12-13-26-15-14-25(20(26)19(16-21)17-22)11-10-23-7-3-2-4-8-23/h18H,2-15H2,1H3
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0.690n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membrane


Bioorg Med Chem Lett 18: 2288-91 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.006
BindingDB Entry DOI: 10.7270/Q2KW5FSF
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50237872
PNG
(2-(3-(2-((R)-2-methylpyrrolidin-1-yl)ethyl)-1-(2-(...)
Show SMILES [#6]-[#6@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7]1-[#6]-[#6]-[#7](-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6@H]-2-[#6])\[#6]-1=[#6](\C#N)C#N
Show InChI InChI=1S/C20H32N6/c1-17-5-3-7-23(17)9-11-25-13-14-26(20(25)19(15-21)16-22)12-10-24-8-4-6-18(24)2/h17-18H,3-14H2,1-2H3/t17-,18+
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0.770n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membrane


Bioorg Med Chem Lett 18: 2288-91 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.006
BindingDB Entry DOI: 10.7270/Q2KW5FSF
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50237875
PNG
(2-(1,3-bis(2-((R)-2-methylpyrrolidin-1-yl)ethyl)im...)
Show SMILES [#6]-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7]1-[#6]-[#6]-[#7](-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6@H]-2-[#6])\[#6]-1=[#6](/C#N)C#N
Show InChI InChI=1S/C20H32N6/c1-17-5-3-7-23(17)9-11-25-13-14-26(20(25)19(15-21)16-22)12-10-24-8-4-6-18(24)2/h17-18H,3-14H2,1-2H3/t17-,18-/m1/s1
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1.10n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membrane


Bioorg Med Chem Lett 18: 2288-91 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.006
BindingDB Entry DOI: 10.7270/Q2KW5FSF
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50159110
PNG
(1-(3-(4-(piperidin-1-ylmethyl)phenoxy)propyl)piper...)
Show SMILES C(COc1ccc(CN2CCCCC2)cc1)CN1CCCCC1
Show InChI InChI=1S/C20H32N2O/c1-3-12-21(13-4-1)16-7-17-23-20-10-8-19(9-11-20)18-22-14-5-2-6-15-22/h8-11H,1-7,12-18H2
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1.26n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membrane


Bioorg Med Chem Lett 18: 2288-91 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.006
BindingDB Entry DOI: 10.7270/Q2KW5FSF
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))
BDBM50237875
PNG
(2-(1,3-bis(2-((R)-2-methylpyrrolidin-1-yl)ethyl)im...)
Show SMILES [#6]-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7]1-[#6]-[#6]-[#7](-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6@H]-2-[#6])\[#6]-1=[#6](/C#N)C#N
Show InChI InChI=1S/C20H32N6/c1-17-5-3-7-23(17)9-11-25-13-14-26(20(25)19(15-21)16-22)12-10-24-8-4-6-18(24)2/h17-18H,3-14H2,1-2H3/t17-,18-/m1/s1
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1.30n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cells


Bioorg Med Chem Lett 18: 2288-91 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.006
BindingDB Entry DOI: 10.7270/Q2KW5FSF
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))
BDBM50237878
PNG
(2-(1,3-bis(3-(piperidin-1-yl)propyl)imidazolidin-2...)
Show SMILES N#C\[#6](C#N)=[#6]-1\[#7](-[#6]-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1
Show InChI InChI=1S/C22H36N6/c23-19-21(20-24)22-27(15-7-13-25-9-3-1-4-10-25)17-18-28(22)16-8-14-26-11-5-2-6-12-26/h1-18H2
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2.40n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cells


Bioorg Med Chem Lett 18: 2288-91 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.006
BindingDB Entry DOI: 10.7270/Q2KW5FSF
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50237878
PNG
(2-(1,3-bis(3-(piperidin-1-yl)propyl)imidazolidin-2...)
Show SMILES N#C\[#6](C#N)=[#6]-1\[#7](-[#6]-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1
Show InChI InChI=1S/C22H36N6/c23-19-21(20-24)22-27(15-7-13-25-9-3-1-4-10-25)17-18-28(22)16-8-14-26-11-5-2-6-12-26/h1-18H2
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2.60n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membrane


Bioorg Med Chem Lett 18: 2288-91 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.006
BindingDB Entry DOI: 10.7270/Q2KW5FSF
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50237871
PNG
(2-(1-(2-(piperidin-1-yl)ethyl)-3-(3-(piperidin-1-y...)
Show SMILES N#C\[#6](C#N)=[#6]-1/[#7](-[#6]-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1
Show InChI InChI=1S/C21H34N6/c22-18-20(19-23)21-26(13-7-12-24-8-3-1-4-9-24)16-17-27(21)15-14-25-10-5-2-6-11-25/h1-17H2
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6.30n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membrane


Bioorg Med Chem Lett 18: 2288-91 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.006
BindingDB Entry DOI: 10.7270/Q2KW5FSF
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))
BDBM50237871
PNG
(2-(1-(2-(piperidin-1-yl)ethyl)-3-(3-(piperidin-1-y...)
Show SMILES N#C\[#6](C#N)=[#6]-1/[#7](-[#6]-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1
Show InChI InChI=1S/C21H34N6/c22-18-20(19-23)21-26(13-7-12-24-8-3-1-4-9-24)16-17-27(21)15-14-25-10-5-2-6-11-25/h1-17H2
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6.60n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cells


Bioorg Med Chem Lett 18: 2288-91 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.006
BindingDB Entry DOI: 10.7270/Q2KW5FSF
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50237873
PNG
(2-(1-(4-(piperidin-1-yl)butyl)-3-(2-(piperidin-1-y...)
Show SMILES N#C\[#6](C#N)=[#6]-1/[#7](-[#6]-[#6]-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1
Show InChI InChI=1S/C22H36N6/c23-19-21(20-24)22-27(14-8-7-13-25-9-3-1-4-10-25)17-18-28(22)16-15-26-11-5-2-6-12-26/h1-18H2
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8.60n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membrane


Bioorg Med Chem Lett 18: 2288-91 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.006
BindingDB Entry DOI: 10.7270/Q2KW5FSF
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))
BDBM50237873
PNG
(2-(1-(4-(piperidin-1-yl)butyl)-3-(2-(piperidin-1-y...)
Show SMILES N#C\[#6](C#N)=[#6]-1/[#7](-[#6]-[#6]-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1
Show InChI InChI=1S/C22H36N6/c23-19-21(20-24)22-27(14-8-7-13-25-9-3-1-4-10-25)17-18-28(22)16-15-26-11-5-2-6-12-26/h1-18H2
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16n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cells


Bioorg Med Chem Lett 18: 2288-91 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.006
BindingDB Entry DOI: 10.7270/Q2KW5FSF
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))
BDBM50237879
PNG
(2-(1,3-bis(2-(piperidin-1-yl)ethyl)imidazolidin-2-...)
Show SMILES N#C\[#6](C#N)=[#6]-1\[#7](-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1
Show InChI InChI=1S/C20H32N6/c21-17-19(18-22)20-25(13-11-23-7-3-1-4-8-23)15-16-26(20)14-12-24-9-5-2-6-10-24/h1-16H2
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24n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cells


Bioorg Med Chem Lett 18: 2288-91 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.006
BindingDB Entry DOI: 10.7270/Q2KW5FSF
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))
BDBM50237876
PNG
(2-(1-(naphthalen-1-ylmethyl)-3-(3-(piperidin-1-yl)...)
Show SMILES N#C\[#6](C#N)=[#6]-1\[#7](-[#6]-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)-[#6]-[#6]-[#7]-1-[#6]-c1cccc2ccccc12
Show InChI InChI=1S/C25H29N5/c26-18-23(19-27)25-29(15-7-14-28-12-4-1-5-13-28)16-17-30(25)20-22-10-6-9-21-8-2-3-11-24(21)22/h2-3,6,8-11H,1,4-5,7,12-17,20H2
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36n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cells


Bioorg Med Chem Lett 18: 2288-91 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.006
BindingDB Entry DOI: 10.7270/Q2KW5FSF
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50237879
PNG
(2-(1,3-bis(2-(piperidin-1-yl)ethyl)imidazolidin-2-...)
Show SMILES N#C\[#6](C#N)=[#6]-1\[#7](-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1
Show InChI InChI=1S/C20H32N6/c21-17-19(18-22)20-25(13-11-23-7-3-1-4-8-23)15-16-26(20)14-12-24-9-5-2-6-10-24/h1-16H2
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55n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membrane


Bioorg Med Chem Lett 18: 2288-91 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.006
BindingDB Entry DOI: 10.7270/Q2KW5FSF
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50237877
PNG
(2-(1-(2-((3-(dimethylamino)propyl)(ethyl)amino)eth...)
Show SMILES [#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#7](-[#6])-[#6])-[#6]-[#6]-[#7]1-[#6]-[#6]-[#7](-[#6]-c2cccc3ccccc23)\[#6]-1=[#6](/C#N)C#N
Show InChI InChI=1S/C26H34N6/c1-4-30(14-8-13-29(2)3)15-16-31-17-18-32(26(31)24(19-27)20-28)21-23-11-7-10-22-9-5-6-12-25(22)23/h5-7,9-12H,4,8,13-18,21H2,1-3H3
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75n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membrane


Bioorg Med Chem Lett 18: 2288-91 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.006
BindingDB Entry DOI: 10.7270/Q2KW5FSF
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))
BDBM50237877
PNG
(2-(1-(2-((3-(dimethylamino)propyl)(ethyl)amino)eth...)
Show SMILES [#6]-[#6]-[#7](-[#6]-[#6]-[#6]-[#7](-[#6])-[#6])-[#6]-[#6]-[#7]1-[#6]-[#6]-[#7](-[#6]-c2cccc3ccccc23)\[#6]-1=[#6](/C#N)C#N
Show InChI InChI=1S/C26H34N6/c1-4-30(14-8-13-29(2)3)15-16-31-17-18-32(26(31)24(19-27)20-28)21-23-11-7-10-22-9-5-6-12-25(22)23/h5-7,9-12H,4,8,13-18,21H2,1-3H3
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83n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in monkey COS7 cells


Bioorg Med Chem Lett 18: 2288-91 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.006
BindingDB Entry DOI: 10.7270/Q2KW5FSF
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50237876
PNG
(2-(1-(naphthalen-1-ylmethyl)-3-(3-(piperidin-1-yl)...)
Show SMILES N#C\[#6](C#N)=[#6]-1\[#7](-[#6]-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)-[#6]-[#6]-[#7]-1-[#6]-c1cccc2ccccc12
Show InChI InChI=1S/C25H29N5/c26-18-23(19-27)25-29(15-7-14-28-12-4-1-5-13-28)16-17-30(25)20-22-10-6-9-21-8-2-3-11-24(21)22/h2-3,6,8-11H,1,4-5,7,12-17,20H2
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690n/an/an/an/an/an/an/an/a



Kyowa Hakko Kogyo Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from histamine H3 receptor in rat striatal membrane


Bioorg Med Chem Lett 18: 2288-91 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.006
BindingDB Entry DOI: 10.7270/Q2KW5FSF
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50237870
PNG
(2-(1,3-bis(2-((S)-2-methylpyrrolidin-1-yl)ethyl)im...)
Show SMILES [#6]-[#6@H]-1-[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7]1-[#6]-[#6]-[#7](-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6@@H]-2-[#6])\[#6]-1=[#6](/C#N)C#N
Show InChI InChI=1S/C20H32N6/c1-17-5-3-7-23(17)9-11-25-13-14-26(20(25)19(15-21)16-22)12-10-24-8-4-6-18(24)2/h17-18H,3-14H2,1-2H3/t17-,18-/m0/s1
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n/an/a 1.90n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co. Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H3 receptor in rat forebrain assessed as inhibition of [3H]histamine release from synaptosomes


Bioorg Med Chem Lett 18: 2288-91 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.006
BindingDB Entry DOI: 10.7270/Q2KW5FSF
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50237869
PNG
((+/-)-2-(1,3-bis(2-(2-methylpyrrolidin-1-yl)ethyl)...)
Show SMILES [#6]-[#6]-1-[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#7]1-[#6]-[#6]-[#7](-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-2-[#6])\[#6]-1=[#6](/C#N)C#N |w:1.0,18.20|
Show InChI InChI=1S/C20H32N6/c1-17-5-3-7-23(17)9-11-25-13-14-26(20(25)19(15-21)16-22)12-10-24-8-4-6-18(24)2/h17-18H,3-14H2,1-2H3
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n/an/a 4.90n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co. Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H3 receptor in rat forebrain assessed as inhibition of [3H]histamine release from synaptosomes


Bioorg Med Chem Lett 18: 2288-91 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.006
BindingDB Entry DOI: 10.7270/Q2KW5FSF
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50237878
PNG
(2-(1,3-bis(3-(piperidin-1-yl)propyl)imidazolidin-2...)
Show SMILES N#C\[#6](C#N)=[#6]-1\[#7](-[#6]-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1
Show InChI InChI=1S/C22H36N6/c23-19-21(20-24)22-27(15-7-13-25-9-3-1-4-10-25)17-18-28(22)16-8-14-26-11-5-2-6-12-26/h1-18H2
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n/an/a 28n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co. Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H3 receptor in rat forebrain assessed as inhibition of [3H]histamine release from synaptosomes


Bioorg Med Chem Lett 18: 2288-91 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.006
BindingDB Entry DOI: 10.7270/Q2KW5FSF
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%