Found 36 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50264364
(CHEMBL491229 | trans-4-[5-(4-Fluoro-phenyl)-1H-ben...)Show SMILES Fc1ccc(cc1)-c1ccc2nc([nH]c2c1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:19.25,wD:16.18,(9.47,-34.56,;8.18,-35.41,;8.26,-36.94,;6.98,-37.78,;5.61,-37.08,;5.52,-35.55,;6.8,-34.71,;4.32,-37.92,;4.41,-39.46,;3.12,-40.29,;1.76,-39.59,;.32,-40.15,;-.65,-38.94,;.19,-37.66,;1.68,-38.06,;2.96,-37.23,;-2.18,-39.02,;-3.02,-37.72,;-4.57,-37.81,;-5.27,-39.18,;-4.43,-40.48,;-2.89,-40.4,;-5.97,-40.56,;-7.5,-40.32,;-8.59,-41.4,;-7.74,-38.79,;-9.03,-37.95,;-8.95,-36.41,;-7.57,-35.7,;-6.27,-36.55,;-6.36,-38.09,)| Show InChI InChI=1S/C26H21FN2O2/c27-19-8-5-16(6-9-19)18-7-10-22-23(15-18)29-24(28-22)17-11-13-26(14-12-17)21-4-2-1-3-20(21)25(30)31-26/h1-10,15,17H,11-14H2,(H,28,29)/t17-,26- | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant NPYY5 receptor expressed in mouse LMtk cells |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50264493
(CHEMBL489608 | trans-4-[5-(5-Trifluoromethyl-[1,2,...)Show SMILES FC(F)(F)c1nc(no1)-c1ccc2[nH]c(nc2c1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:21.27,wD:18.20,(7.51,-37.15,;6.75,-38.49,;5.36,-37.84,;8.14,-39.15,;6.2,-39.93,;4.72,-40.33,;4.64,-41.87,;6.08,-42.41,;7.04,-41.21,;3.36,-42.71,;3.44,-44.25,;2.15,-45.08,;.79,-44.38,;-.64,-44.94,;-1.61,-43.73,;-.77,-42.45,;.71,-42.85,;1.99,-42.02,;-3.15,-43.81,;-3.99,-42.51,;-5.53,-42.6,;-6.23,-43.97,;-5.39,-45.27,;-3.85,-45.19,;-6.94,-45.35,;-8.46,-45.1,;-9.55,-46.19,;-8.7,-43.58,;-9.99,-42.74,;-9.92,-41.2,;-8.53,-40.49,;-7.24,-41.34,;-7.32,-42.88,)| Show InChI InChI=1S/C23H17F3N4O3/c24-23(25,26)21-29-19(30-33-21)13-5-6-16-17(11-13)28-18(27-16)12-7-9-22(10-8-12)15-4-2-1-3-14(15)20(31)32-22/h1-6,11-12H,7-10H2,(H,27,28)/t12-,22- | KEGG
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant NPYY5 receptor expressed in mouse LMtk cells |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50264441
(CHEMBL491239 | trans-6-Chloro-2-(3'-oxo-3'H-spiro[...)Show SMILES COC(=O)c1cc2[nH]c(nc2cc1Cl)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:17.22,wD:14.15,(31.64,-2.03,;30.27,-1.33,;28.98,-2.17,;29.06,-3.7,;27.61,-1.47,;26.33,-2.3,;24.97,-1.6,;23.53,-2.16,;22.57,-.95,;23.41,.33,;24.89,-.07,;26.17,.76,;27.53,.07,;28.82,.91,;21.03,-1.03,;20.19,.27,;18.65,.18,;17.95,-1.19,;18.79,-2.49,;20.33,-2.41,;17.24,-2.57,;15.72,-2.33,;14.63,-3.41,;15.47,-.8,;14.18,.04,;14.26,1.58,;15.65,2.29,;16.94,1.44,;16.86,-.1,)| Show InChI InChI=1S/C22H19ClN2O4/c1-28-20(26)14-10-17-18(11-16(14)23)25-19(24-17)12-6-8-22(9-7-12)15-5-3-2-4-13(15)21(27)29-22/h2-5,10-12H,6-9H2,1H3,(H,24,25)/t12-,22- | KEGG
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant NPYY5 receptor expressed in mouse LMtk cells |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50264395
(CHEMBL490824 | trans-4-(5-Chloro-6-phenyl-1H-benzo...)Show SMILES Clc1cc2[nH]c(nc2cc1-c1ccccc1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:19.25,wD:16.18,(4.88,-25.91,;3.6,-26.75,;2.23,-26.06,;.95,-26.89,;-.53,-26.49,;-1.37,-27.78,;-.4,-28.98,;1.03,-28.43,;2.39,-29.12,;3.68,-28.29,;5.05,-28.98,;5.12,-30.52,;6.49,-31.22,;7.79,-30.38,;7.7,-28.84,;6.33,-28.15,;-2.91,-27.86,;-3.75,-26.55,;-5.29,-26.64,;-6,-28.01,;-5.15,-29.31,;-3.61,-29.23,;-6.7,-29.39,;-8.23,-29.15,;-9.31,-30.24,;-8.47,-27.62,;-9.76,-26.78,;-9.68,-25.24,;-8.29,-24.53,;-7,-25.38,;-7.08,-26.92,)| Show InChI InChI=1S/C26H21ClN2O2/c27-21-15-23-22(14-19(21)16-6-2-1-3-7-16)28-24(29-23)17-10-12-26(13-11-17)20-9-5-4-8-18(20)25(30)31-26/h1-9,14-15,17H,10-13H2,(H,28,29)/t17-,26- | KEGG
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant NPYY5 receptor expressed in mouse LMtk cells |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50264328
(CHEMBL489587 | trans-4-(5-Phenyl-1H-benzoimidazol-...)Show SMILES O=C1O[C@]2(CC[C@@H](CC2)c2nc3ccc(cc3[nH]2)-c2ccccc2)c2ccccc12 |r,wU:3.2,wD:6.9,(15.66,-28.28,;16.75,-27.19,;18.28,-27.44,;18.98,-26.06,;19.69,-24.69,;21.23,-24.6,;22.07,-25.9,;21.37,-27.28,;19.82,-27.36,;23.6,-25.82,;24.57,-27.02,;26.01,-26.47,;27.37,-27.17,;28.66,-26.34,;28.57,-24.8,;27.21,-24.11,;25.93,-24.94,;24.45,-24.54,;29.86,-23.96,;31.23,-24.66,;32.52,-23.82,;32.43,-22.28,;31.05,-21.59,;29.77,-22.43,;17.89,-24.97,;17.98,-23.43,;16.68,-22.58,;15.3,-23.28,;15.22,-24.82,;16.51,-25.67,)| Show InChI InChI=1S/C26H22N2O2/c29-25-20-8-4-5-9-21(20)26(30-25)14-12-18(13-15-26)24-27-22-11-10-19(16-23(22)28-24)17-6-2-1-3-7-17/h1-11,16,18H,12-15H2,(H,27,28)/t18-,26- | KEGG
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant NPYY5 receptor expressed in mouse LMtk cells |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50264365
(CHEMBL491230 | trans-4-(5-Benzoyl-1H-benzoimidazol...)Show SMILES O=C(c1ccccc1)c1ccc2nc([nH]c2c1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:20.26,wD:17.19,(29.22,-34.77,;29.3,-36.31,;30.67,-37,;30.75,-38.53,;32.12,-39.23,;33.41,-38.39,;33.32,-36.85,;31.95,-36.16,;28.01,-37.15,;28.09,-38.69,;26.81,-39.52,;25.44,-38.82,;24.01,-39.37,;23.04,-38.17,;23.88,-36.89,;25.37,-37.29,;26.65,-36.46,;21.51,-38.25,;20.66,-36.95,;19.12,-37.04,;18.42,-38.41,;19.26,-39.71,;20.8,-39.63,;17.72,-39.79,;16.19,-39.54,;15.1,-40.63,;15.95,-38.02,;14.66,-37.17,;14.74,-35.63,;16.12,-34.93,;17.42,-35.78,;17.33,-37.32,)| Show InChI InChI=1S/C27H22N2O3/c30-24(17-6-2-1-3-7-17)19-10-11-22-23(16-19)29-25(28-22)18-12-14-27(15-13-18)21-9-5-4-8-20(21)26(31)32-27/h1-11,16,18H,12-15H2,(H,28,29)/t18-,27- | KEGG
UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant NPYY5 receptor expressed in mouse LMtk cells |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50264366
(CHEMBL491427 | trans-4-(5-Pyridin-2-yl-1H-benzoimi...)Show SMILES O=C1O[C@]2(CC[C@@H](CC2)c2nc3cc(ccc3[nH]2)-c2ccccn2)c2ccccc12 |r,wU:3.2,wD:6.9,(-9.28,-3.73,;-8.19,-2.64,;-6.66,-2.88,;-5.96,-1.51,;-5.26,-.14,;-3.72,-.05,;-2.87,-1.35,;-3.58,-2.73,;-5.12,-2.8,;-1.34,-1.27,;-.5,.01,;.99,-.39,;2.27,.44,;3.63,-.25,;3.71,-1.78,;2.42,-2.62,;1.06,-1.92,;-.37,-2.47,;4.92,.59,;4.82,2.12,;6.11,2.96,;7.49,2.27,;7.57,.73,;6.28,-.11,;-7.05,-.42,;-6.96,1.12,;-8.26,1.97,;-9.64,1.27,;-9.72,-.27,;-8.43,-1.11,)| Show InChI InChI=1S/C25H21N3O2/c29-24-18-5-1-2-6-19(18)25(30-24)12-10-16(11-13-25)23-27-21-9-8-17(15-22(21)28-23)20-7-3-4-14-26-20/h1-9,14-16H,10-13H2,(H,27,28)/t16-,25- | KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant NPYY5 receptor expressed in mouse LMtk cells |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50264394
(CHEMBL455815 | trans-4-(5-Chloro-6-trifluoromethyl...)Show SMILES FC(F)(F)c1cc2nc([nH]c2cc1Cl)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:17.22,wD:14.15,(29.18,-16.29,;27.86,-15.53,;28.6,-14.18,;27.14,-16.89,;26.49,-14.83,;25.21,-15.66,;23.85,-14.97,;22.41,-15.52,;21.44,-14.32,;22.29,-13.04,;23.77,-13.44,;25.05,-12.6,;26.41,-13.29,;27.7,-12.45,;19.91,-14.4,;19.07,-13.1,;17.53,-13.18,;16.82,-14.55,;17.67,-15.85,;19.21,-15.77,;16.12,-15.93,;14.6,-15.69,;13.51,-16.78,;14.35,-14.16,;13.06,-13.32,;13.14,-11.78,;14.53,-11.08,;15.82,-11.92,;15.74,-13.47,)| Show InChI InChI=1S/C21H16ClF3N2O2/c22-15-10-17-16(9-14(15)21(23,24)25)26-18(27-17)11-5-7-20(8-6-11)13-4-2-1-3-12(13)19(28)29-20/h1-4,9-11H,5-8H2,(H,26,27)/t11-,20- | KEGG
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant NPYY5 receptor expressed in mouse LMtk cells |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50264367
(CHEMBL521959 | trans-4-(5-Pyridin-3-yl-1H-benzoimi...)Show SMILES O=C1O[C@]2(CC[C@@H](CC2)c2nc3cc(ccc3[nH]2)-c2cccnc2)c2ccccc12 |r,wU:3.2,wD:6.9,(15.61,-4.12,;16.7,-3.04,;18.22,-3.28,;18.93,-1.9,;19.63,-.53,;21.17,-.44,;22.01,-1.74,;21.31,-3.12,;19.77,-3.2,;23.55,-1.66,;24.39,-.38,;25.87,-.78,;27.15,.05,;28.51,-.64,;28.6,-2.18,;27.31,-3.01,;25.95,-2.31,;24.52,-2.87,;29.8,.2,;29.71,1.73,;30.99,2.57,;32.37,1.87,;32.45,.34,;31.17,-.5,;17.84,-.81,;17.92,.73,;16.63,1.58,;15.24,.87,;15.16,-.67,;16.45,-1.51,)| Show InChI InChI=1S/C25H21N3O2/c29-24-19-5-1-2-6-20(19)25(30-24)11-9-16(10-12-25)23-27-21-8-7-17(14-22(21)28-23)18-4-3-13-26-15-18/h1-8,13-16H,9-12H2,(H,27,28)/t16-,25- | KEGG
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| CHEMBL
PC cid
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UniChem
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| Article
PubMed
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant NPYY5 receptor expressed in mouse LMtk cells |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50264444
(CHEMBL490427 | trans-4-[5-(5-Methyl-[1,3,4]oxadiaz...)Show SMILES Cc1nnc(o1)-c1ccc2[nH]c(nc2c1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:18.24,wD:15.17,(6.6,-22.73,;6.06,-24.16,;6.9,-25.45,;5.93,-26.65,;4.5,-26.1,;4.57,-24.56,;3.21,-26.94,;3.29,-28.48,;2.01,-29.31,;.64,-28.62,;-.79,-29.17,;-1.76,-27.97,;-.92,-26.69,;.57,-27.08,;1.85,-26.25,;-3.29,-28.05,;-4.13,-26.75,;-5.67,-26.83,;-6.38,-28.2,;-5.54,-29.5,;-3.99,-29.42,;-7.08,-29.58,;-8.61,-29.34,;-9.69,-30.43,;-8.85,-27.81,;-10.14,-26.97,;-10.06,-25.43,;-8.67,-24.73,;-7.38,-25.57,;-7.47,-27.12,)| Show InChI InChI=1S/C23H20N4O3/c1-13-26-27-21(29-13)15-6-7-18-19(12-15)25-20(24-18)14-8-10-23(11-9-14)17-5-3-2-4-16(17)22(28)30-23/h2-7,12,14H,8-11H2,1H3,(H,24,25)/t14-,23- | KEGG
UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant NPYY5 receptor expressed in mouse LMtk cells |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50264442
(CHEMBL491436 | trans-4-Chloro-2-(3'-oxo-3'H-spiro[...)Show SMILES COC(=O)c1ccc2nc([nH]c2c1Cl)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:17.22,wD:14.15,(8.15,-15.53,;8.06,-14,;6.69,-13.3,;6.61,-11.77,;5.4,-14.14,;5.49,-15.68,;4.2,-16.51,;2.84,-15.81,;1.41,-16.37,;.44,-15.17,;1.28,-13.88,;2.76,-14.28,;4.04,-13.45,;3.96,-11.92,;-1.1,-15.25,;-1.94,-13.94,;-3.48,-14.03,;-4.18,-15.4,;-3.34,-16.7,;-1.8,-16.62,;-4.88,-16.78,;-6.41,-16.54,;-7.5,-17.62,;-6.65,-15.01,;-7.94,-14.17,;-7.86,-12.63,;-6.48,-11.92,;-5.18,-12.77,;-5.27,-14.31,)| Show InChI InChI=1S/C22H19ClN2O4/c1-28-20(26)14-6-7-16-18(17(14)23)25-19(24-16)12-8-10-22(11-9-12)15-5-3-2-4-13(15)21(27)29-22/h2-7,12H,8-11H2,1H3,(H,24,25)/t12-,22- | KEGG
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant NPYY5 receptor expressed in mouse LMtk cells |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50264492
(CHEMBL522589 | trans-4-[5-(5-Methyl-[1,2,4]oxadiaz...)Show SMILES Cc1nc(no1)-c1ccc2[nH]c(nc2c1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:18.24,wD:15.17,(20.48,-8.99,;19.93,-10.43,;18.44,-10.83,;18.37,-12.37,;19.8,-12.91,;20.77,-11.72,;17.08,-13.21,;17.16,-14.75,;15.88,-15.58,;14.52,-14.88,;13.08,-15.44,;12.11,-14.24,;12.96,-12.95,;14.44,-13.35,;15.72,-12.52,;10.58,-14.32,;9.74,-13.01,;8.2,-13.1,;7.49,-14.47,;8.33,-15.77,;9.88,-15.69,;6.79,-15.85,;5.26,-15.61,;4.18,-16.7,;5.02,-14.08,;3.73,-13.24,;3.81,-11.7,;5.2,-10.99,;6.49,-11.84,;6.41,-13.38,)| Show InChI InChI=1S/C23H20N4O3/c1-13-24-21(27-30-13)15-6-7-18-19(12-15)26-20(25-18)14-8-10-23(11-9-14)17-5-3-2-4-16(17)22(28)29-23/h2-7,12,14H,8-11H2,1H3,(H,25,26)/t14-,23- | KEGG
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| n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant NPYY5 receptor expressed in mouse LMtk cells |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50264444
(CHEMBL490427 | trans-4-[5-(5-Methyl-[1,3,4]oxadiaz...)Show SMILES Cc1nnc(o1)-c1ccc2[nH]c(nc2c1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:18.24,wD:15.17,(6.6,-22.73,;6.06,-24.16,;6.9,-25.45,;5.93,-26.65,;4.5,-26.1,;4.57,-24.56,;3.21,-26.94,;3.29,-28.48,;2.01,-29.31,;.64,-28.62,;-.79,-29.17,;-1.76,-27.97,;-.92,-26.69,;.57,-27.08,;1.85,-26.25,;-3.29,-28.05,;-4.13,-26.75,;-5.67,-26.83,;-6.38,-28.2,;-5.54,-29.5,;-3.99,-29.42,;-7.08,-29.58,;-8.61,-29.34,;-9.69,-30.43,;-8.85,-27.81,;-10.14,-26.97,;-10.06,-25.43,;-8.67,-24.73,;-7.38,-25.57,;-7.47,-27.12,)| Show InChI InChI=1S/C23H20N4O3/c1-13-26-27-21(29-13)15-6-7-18-19(12-15)25-20(24-18)14-8-10-23(11-9-14)17-5-3-2-4-16(17)22(28)30-23/h2-7,12,14H,8-11H2,1H3,(H,24,25)/t14-,23- | KEGG
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| n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant NPYY5 receptor expressed in mouse LMtk cells assessed as inhibition of NPY-induced calcium increase |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50264494
(CHEMBL521750 | trans-4-[5-(2-Methyl-2H-tetrazol-5-...)Show SMILES Cn1nnc(n1)-c1ccc2[nH]c(nc2c1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:18.24,wD:15.17,(29.77,-38.49,;29.22,-39.92,;30.06,-41.21,;29.1,-42.41,;27.66,-41.87,;27.74,-40.33,;26.37,-42.71,;26.46,-44.24,;25.17,-45.08,;23.81,-44.38,;22.38,-44.93,;21.41,-43.73,;22.25,-42.45,;23.73,-42.85,;25.01,-42.02,;19.87,-43.81,;19.03,-42.51,;17.49,-42.6,;16.79,-43.97,;17.63,-45.26,;19.17,-45.19,;16.08,-45.34,;14.56,-45.1,;13.47,-46.19,;14.32,-43.57,;13.03,-42.73,;13.1,-41.19,;14.49,-40.49,;15.78,-41.34,;15.7,-42.88,)| Show InChI InChI=1S/C22H20N6O2/c1-28-26-20(25-27-28)14-6-7-17-18(12-14)24-19(23-17)13-8-10-22(11-9-13)16-5-3-2-4-15(16)21(29)30-22/h2-7,12-13H,8-11H2,1H3,(H,23,24)/t13-,22- | KEGG
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| n/a | n/a | 5.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant NPYY5 receptor expressed in mouse LMtk cells |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50264492
(CHEMBL522589 | trans-4-[5-(5-Methyl-[1,2,4]oxadiaz...)Show SMILES Cc1nc(no1)-c1ccc2[nH]c(nc2c1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:18.24,wD:15.17,(20.48,-8.99,;19.93,-10.43,;18.44,-10.83,;18.37,-12.37,;19.8,-12.91,;20.77,-11.72,;17.08,-13.21,;17.16,-14.75,;15.88,-15.58,;14.52,-14.88,;13.08,-15.44,;12.11,-14.24,;12.96,-12.95,;14.44,-13.35,;15.72,-12.52,;10.58,-14.32,;9.74,-13.01,;8.2,-13.1,;7.49,-14.47,;8.33,-15.77,;9.88,-15.69,;6.79,-15.85,;5.26,-15.61,;4.18,-16.7,;5.02,-14.08,;3.73,-13.24,;3.81,-11.7,;5.2,-10.99,;6.49,-11.84,;6.41,-13.38,)| Show InChI InChI=1S/C23H20N4O3/c1-13-24-21(27-30-13)15-6-7-18-19(12-15)26-20(25-18)14-8-10-23(11-9-14)17-5-3-2-4-16(17)22(28)29-23/h2-7,12,14H,8-11H2,1H3,(H,25,26)/t14-,23- | KEGG
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| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant NPYY5 receptor expressed in mouse LMtk cells assessed as inhibition of NPY-induced calcium increase |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50264494
(CHEMBL521750 | trans-4-[5-(2-Methyl-2H-tetrazol-5-...)Show SMILES Cn1nnc(n1)-c1ccc2[nH]c(nc2c1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:18.24,wD:15.17,(29.77,-38.49,;29.22,-39.92,;30.06,-41.21,;29.1,-42.41,;27.66,-41.87,;27.74,-40.33,;26.37,-42.71,;26.46,-44.24,;25.17,-45.08,;23.81,-44.38,;22.38,-44.93,;21.41,-43.73,;22.25,-42.45,;23.73,-42.85,;25.01,-42.02,;19.87,-43.81,;19.03,-42.51,;17.49,-42.6,;16.79,-43.97,;17.63,-45.26,;19.17,-45.19,;16.08,-45.34,;14.56,-45.1,;13.47,-46.19,;14.32,-43.57,;13.03,-42.73,;13.1,-41.19,;14.49,-40.49,;15.78,-41.34,;15.7,-42.88,)| Show InChI InChI=1S/C22H20N6O2/c1-28-26-20(25-27-28)14-6-7-17-18(12-14)24-19(23-17)13-8-10-22(11-9-13)16-5-3-2-4-15(16)21(29)30-22/h2-7,12-13H,8-11H2,1H3,(H,23,24)/t13-,22- | KEGG
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| n/a | n/a | 7.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant NPYY5 receptor expressed in mouse LMtk cells assessed as inhibition of NPY-induced calcium increase |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50264397
(CHEMBL522768 | trans-2-(3'-Oxo-3'H-spiro[cyclohex-...)Show SMILES COC(=O)c1ccc2nc([nH]c2c1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:16.21,wD:13.14,(9.19,-.42,;7.9,-1.26,;6.53,-.57,;6.45,.97,;5.24,-1.41,;5.32,-2.94,;4.04,-3.78,;2.68,-3.08,;1.24,-3.63,;.28,-2.43,;1.12,-1.15,;2.6,-1.55,;3.88,-.72,;-1.26,-2.51,;-2.1,-1.21,;-3.64,-1.3,;-4.34,-2.67,;-3.5,-3.96,;-1.96,-3.89,;-5.05,-4.04,;-6.57,-3.8,;-7.66,-4.89,;-6.81,-2.28,;-8.1,-1.44,;-8.02,.1,;-6.64,.81,;-5.35,-.04,;-5.43,-1.58,)| Show InChI InChI=1S/C22H20N2O4/c1-27-20(25)14-6-7-17-18(12-14)24-19(23-17)13-8-10-22(11-9-13)16-5-3-2-4-15(16)21(26)28-22/h2-7,12-13H,8-11H2,1H3,(H,23,24)/t13-,22- | KEGG
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| n/a | n/a | 7.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant NPYY5 receptor expressed in mouse LMtk cells |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50264393
(CHEMBL522788 | trans-4-(5,6-Dichloro-1H-benzoimida...)Show SMILES Clc1cc2nc([nH]c2cc1Cl)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:14.19,wD:11.12,(4.78,-12.44,;3.5,-13.28,;2.13,-12.59,;.86,-13.42,;-.63,-13.02,;-1.46,-14.3,;-.5,-15.5,;.93,-14.95,;2.29,-15.65,;3.58,-14.82,;4.95,-15.51,;-3,-14.38,;-3.84,-13.08,;-5.38,-13.17,;-6.08,-14.54,;-5.24,-15.83,;-3.7,-15.76,;-6.78,-15.91,;-8.31,-15.67,;-9.39,-16.76,;-8.55,-14.15,;-9.84,-13.31,;-9.76,-11.77,;-8.37,-11.07,;-7.08,-11.91,;-7.17,-13.45,)| Show InChI InChI=1S/C20H16Cl2N2O2/c21-14-9-16-17(10-15(14)22)24-18(23-16)11-5-7-20(8-6-11)13-4-2-1-3-12(13)19(25)26-20/h1-4,9-11H,5-8H2,(H,23,24)/t11-,20- | KEGG
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| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant NPYY5 receptor expressed in mouse LMtk cells |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50264443
(CHEMBL522609 | trans-4-(5-[1,3,4]Oxadiazol-2-yl-1H...)Show SMILES O=C1O[C@]2(CC[C@@H](CC2)c2nc3cc(ccc3[nH]2)-c2nnco2)c2ccccc12 |r,wU:3.2,wD:6.9,(17.43,-17.87,;18.52,-16.79,;20.05,-17.03,;20.75,-15.65,;21.46,-14.28,;22.99,-14.19,;23.84,-15.49,;23.13,-16.87,;21.59,-16.95,;25.37,-15.42,;26.21,-14.13,;27.7,-14.53,;28.98,-13.7,;30.34,-14.39,;30.42,-15.93,;29.13,-16.76,;27.77,-16.06,;26.34,-16.62,;31.63,-13.55,;33.06,-14.09,;34.02,-12.9,;33.18,-11.61,;31.7,-12.01,;19.66,-14.56,;19.75,-13.02,;18.45,-12.17,;17.07,-12.88,;16.99,-14.42,;18.28,-15.26,)| Show InChI InChI=1S/C22H18N4O3/c27-21-15-3-1-2-4-16(15)22(29-21)9-7-13(8-10-22)19-24-17-6-5-14(11-18(17)25-19)20-26-23-12-28-20/h1-6,11-13H,7-10H2,(H,24,25)/t13-,22- | KEGG
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| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant NPYY5 receptor expressed in mouse LMtk cells |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50264324
(CHEMBL490608 | trans-2-(3'-Oxo-3'H-spiro[cyclohex-...)Show SMILES O=C1O[C@]2(CC[C@@H](CC2)c2nc3ccc(cc3[nH]2)C#N)c2ccccc12 |r,wU:3.2,wD:6.9,(11.19,-2.35,;12.28,-1.27,;13.8,-1.51,;14.5,-.13,;15.21,1.24,;16.75,1.33,;17.59,.03,;16.89,-1.35,;15.35,-1.43,;19.13,.1,;20.09,-1.1,;21.53,-.54,;22.89,-1.24,;24.17,-.41,;24.09,1.13,;22.73,1.82,;21.45,.99,;19.97,1.39,;25.38,1.96,;26.66,2.8,;13.42,.96,;13.5,2.5,;12.21,3.35,;10.82,2.64,;10.74,1.1,;12.03,.26,)| Show InChI InChI=1S/C21H17N3O2/c22-12-13-5-6-17-18(11-13)24-19(23-17)14-7-9-21(10-8-14)16-4-2-1-3-15(16)20(25)26-21/h1-6,11,14H,7-10H2,(H,23,24)/t14-,21- | KEGG
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| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant NPYY5 receptor expressed in mouse LMtk cells |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50264325
(CHEMBL523964 | trans-4-(5-Chloro-1H-benzoimidazol-...)Show SMILES Clc1ccc2nc([nH]c2c1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:13.18,wD:10.11,(5.41,-11.46,;4.13,-12.3,;4.21,-13.84,;2.93,-14.67,;1.56,-13.97,;.13,-14.53,;-.83,-13.33,;.01,-12.04,;1.49,-12.44,;2.77,-11.61,;-2.37,-13.4,;-3.21,-12.1,;-4.75,-12.19,;-5.45,-13.56,;-4.61,-14.86,;-3.07,-14.78,;-6.15,-14.94,;-7.68,-14.7,;-8.76,-15.78,;-7.92,-13.17,;-9.21,-12.33,;-9.13,-10.79,;-7.74,-10.09,;-6.45,-10.93,;-6.54,-12.47,)| Show InChI InChI=1S/C20H17ClN2O2/c21-13-5-6-16-17(11-13)23-18(22-16)12-7-9-20(10-8-12)15-4-2-1-3-14(15)19(24)25-20/h1-6,11-12H,7-10H2,(H,22,23)/t12-,20- | KEGG
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PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant NPYY5 receptor expressed in mouse LMtk cells |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50264327
(CHEMBL523943 | trans-4-(5-Bromo-1H-benzoimidazol-2...)Show SMILES Brc1ccc2nc([nH]c2c1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:13.18,wD:10.11,(6.71,-24.17,;5.42,-25,;5.51,-26.54,;4.22,-27.37,;2.86,-26.67,;1.43,-27.23,;.46,-26.03,;1.3,-24.75,;2.79,-25.14,;4.06,-24.31,;-1.07,-26.11,;-1.91,-24.81,;-3.45,-24.89,;-4.15,-26.26,;-3.31,-27.56,;-1.77,-27.48,;-4.85,-27.64,;-6.38,-27.4,;-7.46,-28.48,;-6.62,-25.87,;-7.91,-25.03,;-7.83,-23.49,;-6.45,-22.79,;-5.15,-23.63,;-5.24,-25.18,)| Show InChI InChI=1S/C20H17BrN2O2/c21-13-5-6-16-17(11-13)23-18(22-16)12-7-9-20(10-8-12)15-4-2-1-3-14(15)19(24)25-20/h1-6,11-12H,7-10H2,(H,22,23)/t12-,20- | KEGG
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UniChem
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PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant NPYY5 receptor expressed in mouse LMtk cells |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50264326
(CHEMBL452726 | trans-4-(5-Trifluoromethyl-1H-benzo...)Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:16.21,wD:13.14,(27.85,-10.82,;26.53,-11.6,;25.72,-10.3,;27.35,-12.91,;25.24,-12.44,;25.33,-13.98,;24.04,-14.81,;22.68,-14.12,;21.25,-14.67,;20.28,-13.47,;21.12,-12.18,;22.6,-12.58,;23.88,-11.75,;18.74,-13.55,;17.9,-12.24,;16.36,-12.33,;15.66,-13.7,;16.5,-15,;18.04,-14.92,;14.96,-15.08,;13.43,-14.84,;12.34,-15.93,;13.19,-13.31,;11.9,-12.47,;11.98,-10.93,;13.36,-10.22,;14.66,-11.07,;14.57,-12.61,)| Show InChI InChI=1S/C21H17F3N2O2/c22-21(23,24)13-5-6-16-17(11-13)26-18(25-16)12-7-9-20(10-8-12)15-4-2-1-3-14(15)19(27)28-20/h1-6,11-12H,7-10H2,(H,25,26)/t12-,20- | KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant NPYY5 receptor expressed in mouse LMtk cells |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50264295
(CHEMBL491020 | trans-4-(1H-Benzoimidazol-2-yl)-spi...)Show SMILES O=C1O[C@]2(CC[C@@H](CC2)c2nc3ccccc3[nH]2)c2ccccc12 |r,wU:3.2,wD:6.9,(-8.26,-2.86,;-7.17,-1.78,;-5.65,-2.02,;-4.94,-.64,;-4.24,.73,;-2.7,.81,;-1.86,-.49,;-2.56,-1.86,;-4.11,-1.94,;-.33,-.41,;.51,.87,;1.99,.47,;3.27,1.3,;4.63,.62,;4.71,-.92,;3.43,-1.75,;2.07,-1.05,;.64,-1.61,;-6.03,.44,;-5.95,1.98,;-7.24,2.83,;-8.62,2.13,;-8.7,.59,;-7.41,-.25,)| Show InChI InChI=1S/C20H18N2O2/c23-19-14-5-1-2-6-15(14)20(24-19)11-9-13(10-12-20)18-21-16-7-3-4-8-17(16)22-18/h1-8,13H,9-12H2,(H,21,22)/t13-,20- | KEGG
UniProtKB/SwissProt
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 91 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant NPYY5 receptor expressed in mouse LMtk cells |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50264396
(CHEMBL489806 | trans-4-(5,6-Dichloro-1-methyl-1H-b...)Show SMILES Cn1c(nc2cc(Cl)c(Cl)cc12)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:15.20,wD:12.13,(23.12,-31.22,;23.52,-29.73,;22.55,-28.53,;23.39,-27.25,;24.88,-27.65,;26.16,-26.82,;27.52,-27.51,;28.8,-26.67,;27.6,-29.05,;28.97,-29.74,;26.31,-29.88,;24.95,-29.18,;21.02,-28.61,;20.18,-27.31,;18.64,-27.4,;17.94,-28.77,;18.78,-30.06,;20.32,-29.99,;17.23,-30.14,;15.71,-29.9,;14.62,-30.99,;15.47,-28.38,;14.18,-27.54,;14.26,-26,;15.64,-25.29,;16.93,-26.14,;16.85,-27.68,)| Show InChI InChI=1S/C21H18Cl2N2O2/c1-25-18-11-16(23)15(22)10-17(18)24-19(25)12-6-8-21(9-7-12)14-5-3-2-4-13(14)20(26)27-21/h2-5,10-12H,6-9H2,1H3/t12-,21- | KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
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UniChem
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| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant NPYY5 receptor expressed in mouse LMtk cells |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50264528
(CHEMBL483239 | cis-4-[5-(5-Methyl-[1,3,4]oxadiazol...)Show SMILES Cc1nnc(o1)-c1ccc2[nH]c(nc2c1)[C@H]1CC[C@]2(CC1)OC(=O)c1ccccc21 |r,wU:15.17,18.24,(32.84,2.64,;32.3,1.2,;33.14,-.08,;32.17,-1.28,;30.74,-.73,;30.81,.8,;29.45,-1.57,;29.54,-3.11,;28.25,-3.94,;26.89,-3.24,;25.45,-3.8,;24.48,-2.59,;25.33,-1.31,;26.81,-1.71,;28.09,-.88,;22.95,-2.67,;22.25,-4.05,;20.7,-4.13,;19.86,-2.83,;20.57,-1.46,;22.11,-1.37,;19.16,-4.21,;17.63,-3.97,;16.55,-5.05,;17.39,-2.44,;16.1,-1.6,;16.18,-.06,;17.57,.65,;18.86,-.2,;18.78,-1.74,)| Show InChI InChI=1S/C23H20N4O3/c1-13-26-27-21(29-13)15-6-7-18-19(12-15)25-20(24-18)14-8-10-23(11-9-14)17-5-3-2-4-16(17)22(28)30-23/h2-7,12,14H,8-11H2,1H3,(H,24,25)/t14-,23+ | KEGG
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant NPYY5 receptor expressed in mouse LMtk cells |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 5
(Homo sapiens (Human)) | BDBM50264495
(CHEMBL489609 | cis-6-Chloro-2-(3'-oxo-3'H-spiro[cy...)Show SMILES COC(=O)c1cc2[nH]c(nc2cc1Cl)[C@H]1CC[C@]2(CC1)OC(=O)c1ccccc21 |r,wU:14.15,17.22,(8.36,-3.53,;6.99,-2.83,;5.7,-3.67,;5.78,-5.2,;4.33,-2.97,;3.04,-3.8,;1.68,-3.11,;.24,-3.66,;-.72,-2.46,;.12,-1.18,;1.6,-1.57,;2.88,-.74,;4.24,-1.43,;5.53,-.59,;-2.26,-2.54,;-2.96,-3.91,;-4.5,-3.99,;-5.34,-2.69,;-4.64,-1.32,;-3.1,-1.24,;-6.05,-4.07,;-7.57,-3.83,;-8.66,-4.92,;-7.82,-2.3,;-9.11,-1.46,;-9.03,.08,;-7.64,.78,;-6.35,-.06,;-6.43,-1.61,)| Show InChI InChI=1S/C22H19ClN2O4/c1-28-20(26)14-10-17-18(11-16(14)23)25-19(24-17)12-6-8-22(9-7-12)15-5-3-2-4-13(15)21(27)29-22/h2-5,10-12H,6-9H2,1H3,(H,24,25)/t12-,22+ | KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
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UniChem
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| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]PYY from human recombinant NPYY5 receptor expressed in mouse LMtk cells |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50264444
(CHEMBL490427 | trans-4-[5-(5-Methyl-[1,3,4]oxadiaz...)Show SMILES Cc1nnc(o1)-c1ccc2[nH]c(nc2c1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:18.24,wD:15.17,(6.6,-22.73,;6.06,-24.16,;6.9,-25.45,;5.93,-26.65,;4.5,-26.1,;4.57,-24.56,;3.21,-26.94,;3.29,-28.48,;2.01,-29.31,;.64,-28.62,;-.79,-29.17,;-1.76,-27.97,;-.92,-26.69,;.57,-27.08,;1.85,-26.25,;-3.29,-28.05,;-4.13,-26.75,;-5.67,-26.83,;-6.38,-28.2,;-5.54,-29.5,;-3.99,-29.42,;-7.08,-29.58,;-8.61,-29.34,;-9.69,-30.43,;-8.85,-27.81,;-10.14,-26.97,;-10.06,-25.43,;-8.67,-24.73,;-7.38,-25.57,;-7.47,-27.12,)| Show InChI InChI=1S/C23H20N4O3/c1-13-26-27-21(29-13)15-6-7-18-19(12-15)25-20(24-18)14-8-10-23(11-9-14)17-5-3-2-4-16(17)22(28)30-23/h2-7,12,14H,8-11H2,1H3,(H,24,25)/t14-,23- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of NPYY4 receptor (unknown origin) |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50264494
(CHEMBL521750 | trans-4-[5-(2-Methyl-2H-tetrazol-5-...)Show SMILES Cn1nnc(n1)-c1ccc2[nH]c(nc2c1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:18.24,wD:15.17,(29.77,-38.49,;29.22,-39.92,;30.06,-41.21,;29.1,-42.41,;27.66,-41.87,;27.74,-40.33,;26.37,-42.71,;26.46,-44.24,;25.17,-45.08,;23.81,-44.38,;22.38,-44.93,;21.41,-43.73,;22.25,-42.45,;23.73,-42.85,;25.01,-42.02,;19.87,-43.81,;19.03,-42.51,;17.49,-42.6,;16.79,-43.97,;17.63,-45.26,;19.17,-45.19,;16.08,-45.34,;14.56,-45.1,;13.47,-46.19,;14.32,-43.57,;13.03,-42.73,;13.1,-41.19,;14.49,-40.49,;15.78,-41.34,;15.7,-42.88,)| Show InChI InChI=1S/C22H20N6O2/c1-28-26-20(25-27-28)14-6-7-17-18(12-14)24-19(23-17)13-8-10-22(11-9-13)16-5-3-2-4-15(16)21(29)30-22/h2-7,12-13H,8-11H2,1H3,(H,23,24)/t13-,22- | PDB
Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of NPYY2 receptor (unknown origin) |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50264494
(CHEMBL521750 | trans-4-[5-(2-Methyl-2H-tetrazol-5-...)Show SMILES Cn1nnc(n1)-c1ccc2[nH]c(nc2c1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:18.24,wD:15.17,(29.77,-38.49,;29.22,-39.92,;30.06,-41.21,;29.1,-42.41,;27.66,-41.87,;27.74,-40.33,;26.37,-42.71,;26.46,-44.24,;25.17,-45.08,;23.81,-44.38,;22.38,-44.93,;21.41,-43.73,;22.25,-42.45,;23.73,-42.85,;25.01,-42.02,;19.87,-43.81,;19.03,-42.51,;17.49,-42.6,;16.79,-43.97,;17.63,-45.26,;19.17,-45.19,;16.08,-45.34,;14.56,-45.1,;13.47,-46.19,;14.32,-43.57,;13.03,-42.73,;13.1,-41.19,;14.49,-40.49,;15.78,-41.34,;15.7,-42.88,)| Show InChI InChI=1S/C22H20N6O2/c1-28-26-20(25-27-28)14-6-7-17-18(12-14)24-19(23-17)13-8-10-22(11-9-13)16-5-3-2-4-15(16)21(29)30-22/h2-7,12-13H,8-11H2,1H3,(H,23,24)/t13-,22- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of NPYY4 receptor (unknown origin) |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50264444
(CHEMBL490427 | trans-4-[5-(5-Methyl-[1,3,4]oxadiaz...)Show SMILES Cc1nnc(o1)-c1ccc2[nH]c(nc2c1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:18.24,wD:15.17,(6.6,-22.73,;6.06,-24.16,;6.9,-25.45,;5.93,-26.65,;4.5,-26.1,;4.57,-24.56,;3.21,-26.94,;3.29,-28.48,;2.01,-29.31,;.64,-28.62,;-.79,-29.17,;-1.76,-27.97,;-.92,-26.69,;.57,-27.08,;1.85,-26.25,;-3.29,-28.05,;-4.13,-26.75,;-5.67,-26.83,;-6.38,-28.2,;-5.54,-29.5,;-3.99,-29.42,;-7.08,-29.58,;-8.61,-29.34,;-9.69,-30.43,;-8.85,-27.81,;-10.14,-26.97,;-10.06,-25.43,;-8.67,-24.73,;-7.38,-25.57,;-7.47,-27.12,)| Show InChI InChI=1S/C23H20N4O3/c1-13-26-27-21(29-13)15-6-7-18-19(12-15)25-20(24-18)14-8-10-23(11-9-14)17-5-3-2-4-16(17)22(28)30-23/h2-7,12,14H,8-11H2,1H3,(H,24,25)/t14-,23- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of NPYY1 receptor (unknown origin) |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50264444
(CHEMBL490427 | trans-4-[5-(5-Methyl-[1,3,4]oxadiaz...)Show SMILES Cc1nnc(o1)-c1ccc2[nH]c(nc2c1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:18.24,wD:15.17,(6.6,-22.73,;6.06,-24.16,;6.9,-25.45,;5.93,-26.65,;4.5,-26.1,;4.57,-24.56,;3.21,-26.94,;3.29,-28.48,;2.01,-29.31,;.64,-28.62,;-.79,-29.17,;-1.76,-27.97,;-.92,-26.69,;.57,-27.08,;1.85,-26.25,;-3.29,-28.05,;-4.13,-26.75,;-5.67,-26.83,;-6.38,-28.2,;-5.54,-29.5,;-3.99,-29.42,;-7.08,-29.58,;-8.61,-29.34,;-9.69,-30.43,;-8.85,-27.81,;-10.14,-26.97,;-10.06,-25.43,;-8.67,-24.73,;-7.38,-25.57,;-7.47,-27.12,)| Show InChI InChI=1S/C23H20N4O3/c1-13-26-27-21(29-13)15-6-7-18-19(12-15)25-20(24-18)14-8-10-23(11-9-14)17-5-3-2-4-16(17)22(28)30-23/h2-7,12,14H,8-11H2,1H3,(H,24,25)/t14-,23- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of NPYY2 receptor (unknown origin) |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50264492
(CHEMBL522589 | trans-4-[5-(5-Methyl-[1,2,4]oxadiaz...)Show SMILES Cc1nc(no1)-c1ccc2[nH]c(nc2c1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:18.24,wD:15.17,(20.48,-8.99,;19.93,-10.43,;18.44,-10.83,;18.37,-12.37,;19.8,-12.91,;20.77,-11.72,;17.08,-13.21,;17.16,-14.75,;15.88,-15.58,;14.52,-14.88,;13.08,-15.44,;12.11,-14.24,;12.96,-12.95,;14.44,-13.35,;15.72,-12.52,;10.58,-14.32,;9.74,-13.01,;8.2,-13.1,;7.49,-14.47,;8.33,-15.77,;9.88,-15.69,;6.79,-15.85,;5.26,-15.61,;4.18,-16.7,;5.02,-14.08,;3.73,-13.24,;3.81,-11.7,;5.2,-10.99,;6.49,-11.84,;6.41,-13.38,)| Show InChI InChI=1S/C23H20N4O3/c1-13-24-21(27-30-13)15-6-7-18-19(12-15)26-20(25-18)14-8-10-23(11-9-14)17-5-3-2-4-16(17)22(28)29-23/h2-7,12,14H,8-11H2,1H3,(H,25,26)/t14-,23- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of NPYY2 receptor (unknown origin) |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50264492
(CHEMBL522589 | trans-4-[5-(5-Methyl-[1,2,4]oxadiaz...)Show SMILES Cc1nc(no1)-c1ccc2[nH]c(nc2c1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:18.24,wD:15.17,(20.48,-8.99,;19.93,-10.43,;18.44,-10.83,;18.37,-12.37,;19.8,-12.91,;20.77,-11.72,;17.08,-13.21,;17.16,-14.75,;15.88,-15.58,;14.52,-14.88,;13.08,-15.44,;12.11,-14.24,;12.96,-12.95,;14.44,-13.35,;15.72,-12.52,;10.58,-14.32,;9.74,-13.01,;8.2,-13.1,;7.49,-14.47,;8.33,-15.77,;9.88,-15.69,;6.79,-15.85,;5.26,-15.61,;4.18,-16.7,;5.02,-14.08,;3.73,-13.24,;3.81,-11.7,;5.2,-10.99,;6.49,-11.84,;6.41,-13.38,)| Show InChI InChI=1S/C23H20N4O3/c1-13-24-21(27-30-13)15-6-7-18-19(12-15)26-20(25-18)14-8-10-23(11-9-14)17-5-3-2-4-16(17)22(28)29-23/h2-7,12,14H,8-11H2,1H3,(H,25,26)/t14-,23- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of NPYY1 receptor (unknown origin) |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 4
(Homo sapiens (Human)) | BDBM50264492
(CHEMBL522589 | trans-4-[5-(5-Methyl-[1,2,4]oxadiaz...)Show SMILES Cc1nc(no1)-c1ccc2[nH]c(nc2c1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:18.24,wD:15.17,(20.48,-8.99,;19.93,-10.43,;18.44,-10.83,;18.37,-12.37,;19.8,-12.91,;20.77,-11.72,;17.08,-13.21,;17.16,-14.75,;15.88,-15.58,;14.52,-14.88,;13.08,-15.44,;12.11,-14.24,;12.96,-12.95,;14.44,-13.35,;15.72,-12.52,;10.58,-14.32,;9.74,-13.01,;8.2,-13.1,;7.49,-14.47,;8.33,-15.77,;9.88,-15.69,;6.79,-15.85,;5.26,-15.61,;4.18,-16.7,;5.02,-14.08,;3.73,-13.24,;3.81,-11.7,;5.2,-10.99,;6.49,-11.84,;6.41,-13.38,)| Show InChI InChI=1S/C23H20N4O3/c1-13-24-21(27-30-13)15-6-7-18-19(12-15)26-20(25-18)14-8-10-23(11-9-14)17-5-3-2-4-16(17)22(28)29-23/h2-7,12,14H,8-11H2,1H3,(H,25,26)/t14-,23- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of NPYY4 receptor (unknown origin) |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50264494
(CHEMBL521750 | trans-4-[5-(2-Methyl-2H-tetrazol-5-...)Show SMILES Cn1nnc(n1)-c1ccc2[nH]c(nc2c1)[C@H]1CC[C@@]2(CC1)OC(=O)c1ccccc21 |r,wU:18.24,wD:15.17,(29.77,-38.49,;29.22,-39.92,;30.06,-41.21,;29.1,-42.41,;27.66,-41.87,;27.74,-40.33,;26.37,-42.71,;26.46,-44.24,;25.17,-45.08,;23.81,-44.38,;22.38,-44.93,;21.41,-43.73,;22.25,-42.45,;23.73,-42.85,;25.01,-42.02,;19.87,-43.81,;19.03,-42.51,;17.49,-42.6,;16.79,-43.97,;17.63,-45.26,;19.17,-45.19,;16.08,-45.34,;14.56,-45.1,;13.47,-46.19,;14.32,-43.57,;13.03,-42.73,;13.1,-41.19,;14.49,-40.49,;15.78,-41.34,;15.7,-42.88,)| Show InChI InChI=1S/C22H20N6O2/c1-28-26-20(25-27-28)14-6-7-17-18(12-14)24-19(23-17)13-8-10-22(11-9-13)16-5-3-2-4-15(16)21(29)30-22/h2-7,12-13H,8-11H2,1H3,(H,23,24)/t13-,22- | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Banyu Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of NPYY1 receptor (unknown origin) |
Bioorg Med Chem Lett 18: 4997-5001 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.021
BindingDB Entry DOI: 10.7270/Q25H7G2P |
More data for this
Ligand-Target Pair | |
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