Found 35 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254809
((R)-(7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropy...)Show SMILES CC1=Nc2ccnn2[C@@H](C1C(=O)N1CCN(CC1)c1ccc(F)cc1)c1ccc(Cl)c(Cl)c1 |r,t:1| Show InChI InChI=1S/C24H22Cl2FN5O/c1-15-22(24(33)31-12-10-30(11-13-31)18-5-3-17(27)4-6-18)23(32-21(29-15)8-9-28-32)16-2-7-19(25)20(26)14-16/h2-9,14,22-23H,10-13H2,1H3/t22?,23-/m1/s1 | PDB
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254617
(7-(3,4-dichlorophenyl)-5-methyl-N,N-dipropyl-4,7-d...)Show SMILES CCCN(CCC)C(=O)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C |c:26| Show InChI InChI=1S/C20H24Cl2N4O/c1-4-10-25(11-5-2)20(27)18-13(3)24-17-8-9-23-26(17)19(18)14-6-7-15(21)16(22)12-14/h6-9,12,18-19H,4-5,10-11H2,1-3H3 | PDB
UniProtKB/SwissProt
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| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254736
((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCN(CC1)c1ccccc1)c1ccc(Cl)c(Cl)c1 |t:1| Show InChI InChI=1S/C24H23Cl2N5O/c1-16-22(24(32)30-13-11-29(12-14-30)18-5-3-2-4-6-18)23(31-21(28-16)9-10-27-31)17-7-8-19(25)20(26)15-17/h2-10,15,22-23H,11-14H2,1H3 | PDB
UniProtKB/SwissProt
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PC sid
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| n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254698
(5-(1-cyclohexylvinyl)-4-(3,4-dimethylphenyl)-6-met...)Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCCCC1)c1ccc(Cl)c(Cl)c1 |t:1| Show InChI InChI=1S/C19H20Cl2N4O/c1-12-17(19(26)24-9-3-2-4-10-24)18(25-16(23-12)7-8-22-25)13-5-6-14(20)15(21)11-13/h5-8,11,17-18H,2-4,9-10H2,1H3 | PDB
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| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254656
(7-(3,4-dichlorophenyl)-5-methyl-N-phenethyl-4,7-di...)Show SMILES CC1=Nc2ccnn2C(C1C(=O)NCCc1ccccc1)c1ccc(Cl)c(Cl)c1 |t:1| Show InChI InChI=1S/C22H20Cl2N4O/c1-14-20(22(29)25-11-9-15-5-3-2-4-6-15)21(28-19(27-14)10-12-26-28)16-7-8-17(23)18(24)13-16/h2-8,10,12-13,20-21H,9,11H2,1H3,(H,25,29) | PDB
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| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254929
((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCN(CC1)c1ccc(F)cc1)c1ccc(Cl)c(Cl)c1 |t:1| Show InChI InChI=1S/C24H22Cl2FN5O/c1-15-22(24(33)31-12-10-30(11-13-31)18-5-3-17(27)4-6-18)23(32-21(29-15)8-9-28-32)16-2-7-19(25)20(26)14-16/h2-9,14,22-23H,10-13H2,1H3 | PDB
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| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254966
((7-(3,5-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCN(CC1)c1ccc(F)cc1)c1cc(Cl)cc(Cl)c1 |t:1| Show InChI InChI=1S/C24H22Cl2FN5O/c1-15-22(24(33)31-10-8-30(9-11-31)20-4-2-19(27)3-5-20)23(32-21(29-15)6-7-28-32)16-12-17(25)14-18(26)13-16/h2-7,12-14,22-23H,8-11H2,1H3 | PDB
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| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254737
((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCC(CC1)c1ccccc1)c1ccc(Cl)c(Cl)c1 |t:1| Show InChI InChI=1S/C25H24Cl2N4O/c1-16-23(25(32)30-13-10-18(11-14-30)17-5-3-2-4-6-17)24(31-22(29-16)9-12-28-31)19-7-8-20(26)21(27)15-19/h2-9,12,15,18,23-24H,10-11,13-14H2,1H3 | PDB
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| n/a | n/a | 159 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254850
((7-(benzofuran-2-yl)-5-methyl-4,7-dihydropyrazolo[...)Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCN(CC1)c1ccc(F)cc1)c1cc2ccccc2o1 |t:1| Show InChI InChI=1S/C26H24FN5O2/c1-17-24(26(33)31-14-12-30(13-15-31)20-8-6-19(27)7-9-20)25(32-23(29-17)10-11-28-32)22-16-18-4-2-3-5-21(18)34-22/h2-11,16,24-25H,12-15H2,1H3 | PDB
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PC sid
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| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254808
((S)-(7-(2,3-dichlorophenyl)-5-methyl-4,7-dihydropy...)Show SMILES CC1=Nc2ccnn2[C@@H](C1C(=O)N1CCN(CC1)c1ccc(F)cc1)c1cccc(Cl)c1Cl |r,t:1| Show InChI InChI=1S/C24H22Cl2FN5O/c1-15-21(24(33)31-13-11-30(12-14-31)17-7-5-16(27)6-8-17)23(32-20(29-15)9-10-28-32)18-3-2-4-19(25)22(18)26/h2-10,21,23H,11-14H2,1H3/t21?,23-/m1/s1 | PDB
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| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254655
(CHEMBL465086 | N-benzyl-7-(3,4-dichlorophenyl)-5-m...)Show SMILES CC1=Nc2ccnn2C(C1C(=O)NCc1ccccc1)c1ccc(Cl)c(Cl)c1 |t:1| Show InChI InChI=1S/C21H18Cl2N4O/c1-13-19(21(28)24-12-14-5-3-2-4-6-14)20(27-18(26-13)9-10-25-27)15-7-8-16(22)17(23)11-15/h2-11,19-20H,12H2,1H3,(H,24,28) | PDB
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| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254926
((7-(2,3-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCN(CC1)c1ccc(F)cc1)c1cccc(Cl)c1Cl |t:1| Show InChI InChI=1S/C24H22Cl2FN5O/c1-15-21(24(33)31-13-11-30(12-14-31)17-7-5-16(27)6-8-17)23(32-20(29-15)9-10-28-32)18-3-2-4-19(25)22(18)26/h2-10,21,23H,11-14H2,1H3 | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254654
(7-(3,4-dichlorophenyl)-5-methyl-N-phenyl-4,7-dihyd...)Show SMILES CC1=Nc2ccnn2C(C1C(=O)Nc1ccccc1)c1ccc(Cl)c(Cl)c1 |t:1| Show InChI InChI=1S/C20H16Cl2N4O/c1-12-18(20(27)25-14-5-3-2-4-6-14)19(26-17(24-12)9-10-23-26)13-7-8-15(21)16(22)11-13/h2-11,18-19H,1H3,(H,25,27) | PDB
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| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254890
((7-(3-chlorophenyl)-5-methyl-4,7-dihydropyrazolo[1...)Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCN(CC1)c1ccc(F)cc1)c1cccc(Cl)c1 |t:1| Show InChI InChI=1S/C24H23ClFN5O/c1-16-22(23(17-3-2-4-18(25)15-17)31-21(28-16)9-10-27-31)24(32)30-13-11-29(12-14-30)20-7-5-19(26)6-8-20/h2-10,15,22-23H,11-14H2,1H3 | PDB
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| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254699
(CHEMBL518718 | azepan-1-yl(7-(3,4-dichlorophenyl)-...)Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCCCCC1)c1ccc(Cl)c(Cl)c1 |t:1| Show InChI InChI=1S/C20H22Cl2N4O/c1-13-18(20(27)25-10-4-2-3-5-11-25)19(26-17(24-13)8-9-23-26)14-6-7-15(21)16(22)12-14/h6-9,12,18-19H,2-5,10-11H2,1H3 | PDB
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| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254778
((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)Show SMILES COC[C@@H]1CCCN1C(=O)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C |r,c:28| Show InChI InChI=1S/C20H22Cl2N4O2/c1-12-18(20(27)25-9-3-4-14(25)11-28-2)19(26-17(24-12)7-8-23-26)13-5-6-15(21)16(22)10-13/h5-8,10,14,18-19H,3-4,9,11H2,1-2H3/t14-,18?,19?/m0/s1 | PDB
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| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254849
((4-(4-fluorophenyl)piperazin-1-yl)(5-methyl-7-(3-m...)Show SMILES Cc1c(sc2ccccc12)C1C(C(=O)N2CCN(CC2)c2ccc(F)cc2)C(C)=Nc2ccnn12 |c:32| Show InChI InChI=1S/C27H26FN5OS/c1-17-21-5-3-4-6-22(21)35-26(17)25-24(18(2)30-23-11-12-29-33(23)25)27(34)32-15-13-31(14-16-32)20-9-7-19(28)8-10-20/h3-12,24-25H,13-16H2,1-2H3 | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254807
((7-(5-chlorothiophen-2-yl)-5-methyl-4,7-dihydropyr...)Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCN(CC1)c1ccc(F)cc1)c1ccc(Cl)s1 |t:1| Show InChI InChI=1S/C22H21ClFN5OS/c1-14-20(21(17-6-7-18(23)31-17)29-19(26-14)8-9-25-29)22(30)28-12-10-27(11-13-28)16-4-2-15(24)3-5-16/h2-9,20-21H,10-13H2,1H3 | PDB
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PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254927
((7-(2,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCN(CC1)c1ccc(F)cc1)c1ccc(Cl)cc1Cl |t:1| Show InChI InChI=1S/C24H22Cl2FN5O/c1-15-22(24(33)31-12-10-30(11-13-31)18-5-3-17(27)4-6-18)23(32-21(29-15)8-9-28-32)19-7-2-16(25)14-20(19)26/h2-9,14,22-23H,10-13H2,1H3 | PDB
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| n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254618
(CHEMBL520917 | N,N-dibutyl-7-(3,4-dichlorophenyl)-...)Show SMILES CCCCN(CCCC)C(=O)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C |c:28| Show InChI InChI=1S/C22H28Cl2N4O/c1-4-6-12-27(13-7-5-2)22(29)20-15(3)26-19-10-11-25-28(19)21(20)16-8-9-17(23)18(24)14-16/h8-11,14,20-21H,4-7,12-13H2,1-3H3 | PDB
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| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254998
((7-(3,5-dimethylphenyl)-5-methyl-4,7-dihydropyrazo...)Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCN(CC1)c1ccc(F)cc1)c1cc(C)cc(C)c1 |t:1| Show InChI InChI=1S/C26H28FN5O/c1-17-14-18(2)16-20(15-17)25-24(19(3)29-23-8-9-28-32(23)25)26(33)31-12-10-30(11-13-31)22-6-4-21(27)5-7-22/h4-9,14-16,24-25H,10-13H2,1-3H3 | PDB
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| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254616
(7-(3,4-dichlorophenyl)-N,N-diethyl-5-methyl-4,7-di...)Show SMILES CCN(CC)C(=O)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C |c:24| Show InChI InChI=1S/C18H20Cl2N4O/c1-4-23(5-2)18(25)16-11(3)22-15-8-9-21-24(15)17(16)12-6-7-13(19)14(20)10-12/h6-10,16-17H,4-5H2,1-3H3 | PDB
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| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254614
(CHEMBL481396 | N-butyl-7-(3,4-dichlorophenyl)-5-me...)Show SMILES CCCCNC(=O)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C |c:24| Show InChI InChI=1S/C18H20Cl2N4O/c1-3-4-8-21-18(25)16-11(2)23-15-7-9-22-24(15)17(16)12-5-6-13(19)14(20)10-12/h5-7,9-10,16-17H,3-4,8H2,1-2H3,(H,21,25) | PDB
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| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254891
((7-(4-chlorophenyl)-5-methyl-4,7-dihydropyrazolo[1...)Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCN(CC1)c1ccc(F)cc1)c1ccc(Cl)cc1 |t:1| Show InChI InChI=1S/C24H23ClFN5O/c1-16-22(23(17-2-4-18(25)5-3-17)31-21(28-16)10-11-27-31)24(32)30-14-12-29(13-15-30)20-8-6-19(26)7-9-20/h2-11,22-23H,12-15H2,1H3 | PDB
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| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254479
(7-(3,4-dichlorophenyl)-5-methyl-N-propyl-4,7-dihyd...)Show SMILES CCCNC(=O)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C |c:23| Show InChI InChI=1S/C17H18Cl2N4O/c1-3-7-20-17(24)15-10(2)22-14-6-8-21-23(14)16(15)11-4-5-12(18)13(19)9-11/h4-6,8-9,15-16H,3,7H2,1-2H3,(H,20,24) | PDB
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| n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254967
((4-(4-fluorophenyl)piperazin-1-yl)(5-methyl-7-m-to...)Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCN(CC1)c1ccc(F)cc1)c1cccc(C)c1 |t:1| Show InChI InChI=1S/C25H26FN5O/c1-17-4-3-5-19(16-17)24-23(18(2)28-22-10-11-27-31(22)24)25(32)30-14-12-29(13-15-30)21-8-6-20(26)7-9-21/h3-11,16,23-24H,12-15H2,1-2H3 | PDB
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| n/a | n/a | 540 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254653
(7-(3,4-dichlorophenyl)-5-methyl-N,N-dipentyl-4,7-d...)Show SMILES CCCCCN(CCCCC)C(=O)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C |c:30| Show InChI InChI=1S/C24H32Cl2N4O/c1-4-6-8-14-29(15-9-7-5-2)24(31)22-17(3)28-21-12-13-27-30(21)23(22)18-10-11-19(25)20(26)16-18/h10-13,16,22-23H,4-9,14-15H2,1-3H3 | PDB
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| n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254615
(7-(3,4-dichlorophenyl)-5-methyl-N-pentyl-4,7-dihyd...)Show SMILES CCCCCNC(=O)C1C(c2ccc(Cl)c(Cl)c2)n2nccc2N=C1C |c:25| Show InChI InChI=1S/C19H22Cl2N4O/c1-3-4-5-9-22-19(26)17-12(2)24-16-8-10-23-25(16)18(17)13-6-7-14(20)15(21)11-13/h6-8,10-11,17-18H,3-5,9H2,1-2H3,(H,22,26) | PDB
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| n/a | n/a | 590 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254437
((4-(4-fluorophenyl)piperazin-1-yl)(5-methyl-7-(nap...)Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCN(CC1)c1ccc(F)cc1)c1ccc2ccccc2c1 |t:1| Show InChI InChI=1S/C28H26FN5O/c1-19-26(28(35)33-16-14-32(15-17-33)24-10-8-23(29)9-11-24)27(34-25(31-19)12-13-30-34)22-7-6-20-4-2-3-5-21(20)18-22/h2-13,18,26-27H,14-17H2,1H3 | PDB
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| n/a | n/a | 650 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254697
((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCCC1)c1ccc(Cl)c(Cl)c1 |t:1| Show InChI InChI=1S/C18H18Cl2N4O/c1-11-16(18(25)23-8-2-3-9-23)17(24-15(22-11)6-7-21-24)12-4-5-13(19)14(20)10-12/h4-7,10,16-17H,2-3,8-9H2,1H3 | PDB
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| n/a | n/a | 660 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254997
((7-(3,4-dimethylphenyl)-5-methyl-4,7-dihydropyrazo...)Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCN(CC1)c1ccc(F)cc1)c1ccc(C)c(C)c1 |t:1| Show InChI InChI=1S/C26H28FN5O/c1-17-4-5-20(16-18(17)2)25-24(19(3)29-23-10-11-28-32(23)25)26(33)31-14-12-30(13-15-31)22-8-6-21(27)7-9-22/h4-11,16,24-25H,12-15H2,1-3H3 | PDB
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| n/a | n/a | 750 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254928
((7-(2,5-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCN(CC1)c1ccc(F)cc1)c1cc(Cl)ccc1Cl |t:1| Show InChI InChI=1S/C24H22Cl2FN5O/c1-15-22(24(33)31-12-10-30(11-13-31)18-5-3-17(27)4-6-18)23(32-21(29-15)8-9-28-32)19-14-16(25)2-7-20(19)26/h2-9,14,22-23H,10-13H2,1H3 | PDB
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| n/a | n/a | 820 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254696
(CHEMBL518717 | azetidin-1-yl(7-(3,4-dichlorophenyl...)Show SMILES CC1=Nc2ccnn2C(C1C(=O)N1CCC1)c1ccc(Cl)c(Cl)c1 |t:1| Show InChI InChI=1S/C17H16Cl2N4O/c1-10-15(17(24)22-7-2-8-22)16(23-14(21-10)5-6-20-23)11-3-4-12(18)13(19)9-11/h3-6,9,15-16H,2,7-8H2,1H3 | PDB
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| n/a | n/a | 970 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50254777
(CHEMBL481187 | ethyl 7-(2,3-dichlorophenyl)-5-meth...)Show SMILES CCOC(=O)C1C(c2cccc(Cl)c2Cl)n2nccc2N=C1C |c:22| Show InChI InChI=1S/C16H15Cl2N3O2/c1-3-23-16(22)13-9(2)20-12-7-8-19-21(12)15(13)10-5-4-6-11(17)14(10)18/h4-8,13,15H,3H2,1-2H3 | PDB
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PC cid
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UniChem
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| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily A member 5
(Homo sapiens (Human)) | BDBM50000778
((nifedipine) 2,6-Dimethyl-4-(2-nitro-phenyl)-1,4-d...)Show SMILES COC([O-])=C1C(C(C(=[OH+])OC)=C(C)N=C1C)c1ccccc1[N+]([O-])=O |w:2.2,c:13,t:10| Show InChI InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,20H,1-4H3 | PDB
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| n/a | n/a | 6.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp technique |
Bioorg Med Chem Lett 18: 6381-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.099
BindingDB Entry DOI: 10.7270/Q2WW7HH7 |
More data for this
Ligand-Target Pair | |
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