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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human)) | BDBM27216 ((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet  | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Universite de Lyon | Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]... | J Med Chem 52: 655-63 (2009) Article DOI: 10.1021/jm801340z BindingDB Entry DOI: 10.7270/Q2WQ024J | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM27217 ((2R)-2-{[4-(benzylamino)-8-(propan-2-yl)pyrazolo[1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | DrugBank PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Universite de Lyon | Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]... | J Med Chem 52: 655-63 (2009) Article DOI: 10.1021/jm801340z BindingDB Entry DOI: 10.7270/Q2WQ024J | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| Cyclin-T1/Cyclin-dependent kinase 9 (Homo sapiens (Human)) | BDBM27217 ((2R)-2-{[4-(benzylamino)-8-(propan-2-yl)pyrazolo[1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | DrugBank PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 43 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Universite de Lyon | Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]... | J Med Chem 52: 655-63 (2009) Article DOI: 10.1021/jm801340z BindingDB Entry DOI: 10.7270/Q2WQ024J | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human)) | BDBM27218 ((2R)-2-({4-[(3-chlorophenyl)amino]-8-(propan-2-yl)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Universite de Lyon | Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]... | J Med Chem 52: 655-63 (2009) Article DOI: 10.1021/jm801340z BindingDB Entry DOI: 10.7270/Q2WQ024J | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM27218 ((2R)-2-({4-[(3-chlorophenyl)amino]-8-(propan-2-yl)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Universite de Lyon | Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]... | J Med Chem 52: 655-63 (2009) Article DOI: 10.1021/jm801340z BindingDB Entry DOI: 10.7270/Q2WQ024J | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human)) | BDBM27217 ((2R)-2-{[4-(benzylamino)-8-(propan-2-yl)pyrazolo[1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | DrugBank PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 70 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Universite de Lyon | Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]... | J Med Chem 52: 655-63 (2009) Article DOI: 10.1021/jm801340z BindingDB Entry DOI: 10.7270/Q2WQ024J | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM27216 ((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 70 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Universite de Lyon | Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]... | J Med Chem 52: 655-63 (2009) Article DOI: 10.1021/jm801340z BindingDB Entry DOI: 10.7270/Q2WQ024J | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
| Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human)) | BDBM27217 ((2R)-2-{[4-(benzylamino)-8-(propan-2-yl)pyrazolo[1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | DrugBank PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 73 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Universite de Lyon | Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]... | J Med Chem 52: 655-63 (2009) Article DOI: 10.1021/jm801340z BindingDB Entry DOI: 10.7270/Q2WQ024J | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human)) | BDBM27216 ((2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 75 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Universite de Lyon | Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]... | J Med Chem 52: 655-63 (2009) Article DOI: 10.1021/jm801340z BindingDB Entry DOI: 10.7270/Q2WQ024J | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human)) | BDBM27218 ((2R)-2-({4-[(3-chlorophenyl)amino]-8-(propan-2-yl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 80 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Universite de Lyon | Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]... | J Med Chem 52: 655-63 (2009) Article DOI: 10.1021/jm801340z BindingDB Entry DOI: 10.7270/Q2WQ024J | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human)) | BDBM27220 ((2S)-2-{[4-(benzylamino)-8-(propan-2-yl)pyrazolo[1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 130 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Universite de Lyon | Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]... | J Med Chem 52: 655-63 (2009) Article DOI: 10.1021/jm801340z BindingDB Entry DOI: 10.7270/Q2WQ024J | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclin-T1/Cyclin-dependent kinase 9 (Homo sapiens (Human)) | BDBM27219 ((2R)-2-{[4-(benzylamino)-7-(propan-2-yl)imidazo[1,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Universite de Lyon | Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]... | J Med Chem 52: 655-63 (2009) Article DOI: 10.1021/jm801340z BindingDB Entry DOI: 10.7270/Q2WQ024J | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM27219 ((2R)-2-{[4-(benzylamino)-7-(propan-2-yl)imidazo[1,...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 220 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Universite de Lyon | Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]... | J Med Chem 52: 655-63 (2009) Article DOI: 10.1021/jm801340z BindingDB Entry DOI: 10.7270/Q2WQ024J | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM7533 ((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 220 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Universite de Lyon | Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]... | J Med Chem 52: 655-63 (2009) Article DOI: 10.1021/jm801340z BindingDB Entry DOI: 10.7270/Q2WQ024J | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Cyclin-T1/Cyclin-dependent kinase 9 (Homo sapiens (Human)) | BDBM7533 ((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 230 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Universite de Lyon | Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]... | J Med Chem 52: 655-63 (2009) Article DOI: 10.1021/jm801340z BindingDB Entry DOI: 10.7270/Q2WQ024J | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human)) | BDBM7533 ((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 270 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Universite de Lyon | Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]... | J Med Chem 52: 655-63 (2009) Article DOI: 10.1021/jm801340z BindingDB Entry DOI: 10.7270/Q2WQ024J | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Cyclin-dependent kinase 5 activator 1 [99-307] (Homo sapiens (Human)) | BDBM27219 ((2R)-2-{[4-(benzylamino)-7-(propan-2-yl)imidazo[1,...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 320 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Universite de Lyon | Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]... | J Med Chem 52: 655-63 (2009) Article DOI: 10.1021/jm801340z BindingDB Entry DOI: 10.7270/Q2WQ024J | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human)) | BDBM7533 ((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 330 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Universite de Lyon | Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]... | J Med Chem 52: 655-63 (2009) Article DOI: 10.1021/jm801340z BindingDB Entry DOI: 10.7270/Q2WQ024J | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human)) | BDBM27219 ((2R)-2-{[4-(benzylamino)-7-(propan-2-yl)imidazo[1,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 400 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Universite de Lyon | Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]... | J Med Chem 52: 655-63 (2009) Article DOI: 10.1021/jm801340z BindingDB Entry DOI: 10.7270/Q2WQ024J | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM27217 ((2R)-2-{[4-(benzylamino)-8-(propan-2-yl)pyrazolo[1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | DrugBank PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Universite de Lyon | Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]... | J Med Chem 52: 655-63 (2009) Article DOI: 10.1021/jm801340z BindingDB Entry DOI: 10.7270/Q2WQ024J | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM27219 ((2R)-2-{[4-(benzylamino)-7-(propan-2-yl)imidazo[1,...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 600 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Universite de Lyon | Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]... | J Med Chem 52: 655-63 (2009) Article DOI: 10.1021/jm801340z BindingDB Entry DOI: 10.7270/Q2WQ024J | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM7533 ((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 800 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Universite de Lyon | Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]... | J Med Chem 52: 655-63 (2009) Article DOI: 10.1021/jm801340z BindingDB Entry DOI: 10.7270/Q2WQ024J | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclin-H/Cyclin-dependent kinase 7 (Homo sapiens (Human)) | BDBM27218 ((2R)-2-({4-[(3-chlorophenyl)amino]-8-(propan-2-yl)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Universite de Lyon | Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]... | J Med Chem 52: 655-63 (2009) Article DOI: 10.1021/jm801340z BindingDB Entry DOI: 10.7270/Q2WQ024J | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cyclin-T1/Cyclin-dependent kinase 9 (Homo sapiens (Human)) | BDBM27218 ((2R)-2-({4-[(3-chlorophenyl)amino]-8-(propan-2-yl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Universite de Lyon | Assay Description In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 15 uM ATP/ [gamma-33P]... | J Med Chem 52: 655-63 (2009) Article DOI: 10.1021/jm801340z BindingDB Entry DOI: 10.7270/Q2WQ024J | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
