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PubMed code 19469479

Compile data set for download or QSAR
Found 44 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Gamma-aminobutyric acid receptor subunit alpha-1


(Rattus norvegicus (Rat))		BDBM50268784
PNG
((R)-N-(2,3-dihydro-1H-inden-1-yl)-2-(5-nitro-1H-in...)
Show SMILES [O-][N+](=O)c1ccc2[nH]cc(C(=O)C(=O)N[C@@H]3CCc4ccccc34)c2c1 |r|
Show InChI InChI=1S/C19H15N3O4/c23-18(15-10-20-16-8-6-12(22(25)26)9-14(15)16)19(24)21-17-7-5-11-3-1-2-4-13(11)17/h1-4,6,8-10,17,20H,5,7H2,(H,21,24)/t17-/m1/s1
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 9n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha1beta2gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5


(RAT)		BDBM50000766
PNG
(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)
Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccccc1 |c:10|
Show InChI InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
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 9.80n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha5beta3gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1


(Rattus norvegicus (Rat))		BDBM50000766
PNG
(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)
Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccccc1 |c:10|
Show InChI InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
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 11n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha1beta2gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1


(Rattus norvegicus (Rat))		BDBM50101427
PNG
((R)-2-(5-nitro-1H-indol-3-yl)-2-oxo-N-(1-phenyleth...)
Show SMILES C[C@@H](NC(=O)C(=O)c1c[nH]c2ccc(cc12)[N+]([O-])=O)c1ccccc1 |r|
Show InChI InChI=1S/C18H15N3O4/c1-11(12-5-3-2-4-6-12)20-18(23)17(22)15-10-19-16-8-7-13(21(24)25)9-14(15)16/h2-11,19H,1H3,(H,20,23)/t11-/m1/s1
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 14n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha1beta2gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Rattus norvegicus (Rat))		BDBM50000766
PNG
(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)
Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccccc1 |c:10|
Show InChI InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
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 15n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha2beta2gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1


(Rattus norvegicus (Rat))		BDBM50101429
PNG
(2-(1H-Indol-3-yl)-N-(4-nitro-benzyl)-2-oxo-acetami...)
Show SMILES [O-][N+](=O)c1ccc(CNC(=O)C(=O)c2c[nH]c3ccccc23)cc1
Show InChI InChI=1S/C17H13N3O4/c21-16(14-10-18-15-4-2-1-3-13(14)15)17(22)19-9-11-5-7-12(8-6-11)20(23)24/h1-8,10,18H,9H2,(H,19,22)
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 16n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha1beta2gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Rattus norvegicus (Rat))		BDBM50268893
PNG
((R/S)-N-(5-methoxy-2,3-dihydro-1H-inden-1-yl)-2-(5...)
Show SMILES COc1ccc2C(CCc2c1)NC(=O)C(=O)c1c[nH]c2ccc(cc12)[N+]([O-])=O
Show InChI InChI=1S/C20H17N3O5/c1-28-13-4-5-14-11(8-13)2-6-18(14)22-20(25)19(24)16-10-21-17-7-3-12(23(26)27)9-15(16)17/h3-5,7-10,18,21H,2,6H2,1H3,(H,22,25)
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 28n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha1beta2gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5


(RAT)		BDBM26266
PNG
(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)
Show SMILES CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1
Show InChI InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3
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 35n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha5beta3gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Rattus norvegicus (Rat))		BDBM50055247
PNG
(CHEMBL75306 | N-(4-Methoxy-benzyl)-2-(5-nitro-1H-i...)
Show SMILES COc1ccc(CNC(=O)C(=O)c2c[nH]c3ccc(cc23)[N+]([O-])=O)cc1
Show InChI InChI=1S/C18H15N3O5/c1-26-13-5-2-11(3-6-13)9-20-18(23)17(22)15-10-19-16-7-4-12(21(24)25)8-14(15)16/h2-8,10,19H,9H2,1H3,(H,20,23)
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 42n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha1beta2gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Rattus norvegicus (Rat))		BDBM26266
PNG
(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)
Show SMILES CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1
Show InChI InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3
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 50n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha1beta2gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-5


(RAT)		BDBM50101429
PNG
(2-(1H-Indol-3-yl)-N-(4-nitro-benzyl)-2-oxo-acetami...)
Show SMILES [O-][N+](=O)c1ccc(CNC(=O)C(=O)c2c[nH]c3ccccc23)cc1
Show InChI InChI=1S/C17H13N3O4/c21-16(14-10-18-15-4-2-1-3-13(14)15)17(22)19-9-11-5-7-12(8-6-11)20(23)24/h1-8,10,18H,9H2,(H,19,22)
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 58n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha5beta3gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Rattus norvegicus (Rat))		BDBM50268784
PNG
((R)-N-(2,3-dihydro-1H-inden-1-yl)-2-(5-nitro-1H-in...)
Show SMILES [O-][N+](=O)c1ccc2[nH]cc(C(=O)C(=O)N[C@@H]3CCc4ccccc34)c2c1 |r|
Show InChI InChI=1S/C19H15N3O4/c23-18(15-10-20-16-8-6-12(22(25)26)9-14(15)16)19(24)21-17-7-5-11-3-1-2-4-13(11)17/h1-4,6,8-10,17,20H,5,7H2,(H,21,24)/t17-/m1/s1
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 85n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha2beta2gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5


(RAT)		BDBM50268784
PNG
((R)-N-(2,3-dihydro-1H-inden-1-yl)-2-(5-nitro-1H-in...)
Show SMILES [O-][N+](=O)c1ccc2[nH]cc(C(=O)C(=O)N[C@@H]3CCc4ccccc34)c2c1 |r|
Show InChI InChI=1S/C19H15N3O4/c23-18(15-10-20-16-8-6-12(22(25)26)9-14(15)16)19(24)21-17-7-5-11-3-1-2-4-13(11)17/h1-4,6,8-10,17,20H,5,7H2,(H,21,24)/t17-/m1/s1
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 95n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha5beta3gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Rattus norvegicus (Rat))		BDBM50055244
PNG
(CHEMBL127135 | N-(4-Fluoro-benzyl)-2-(1H-indol-3-y...)
Show SMILES Fc1ccc(CNC(=O)C(=O)c2c[nH]c3ccccc23)cc1
Show InChI InChI=1S/C17H13FN2O2/c18-12-7-5-11(6-8-12)9-20-17(22)16(21)14-10-19-15-4-2-1-3-13(14)15/h1-8,10,19H,9H2,(H,20,22)
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 118n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha2beta2gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Rattus norvegicus (Rat))		BDBM50101427
PNG
((R)-2-(5-nitro-1H-indol-3-yl)-2-oxo-N-(1-phenyleth...)
Show SMILES C[C@@H](NC(=O)C(=O)c1c[nH]c2ccc(cc12)[N+]([O-])=O)c1ccccc1 |r|
Show InChI InChI=1S/C18H15N3O4/c1-11(12-5-3-2-4-6-12)20-18(23)17(22)15-10-19-16-8-7-13(21(24)25)9-14(15)16/h2-11,19H,1H3,(H,20,23)/t11-/m1/s1
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 121n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha2beta2gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5


(RAT)		BDBM50055247
PNG
(CHEMBL75306 | N-(4-Methoxy-benzyl)-2-(5-nitro-1H-i...)
Show SMILES COc1ccc(CNC(=O)C(=O)c2c[nH]c3ccc(cc23)[N+]([O-])=O)cc1
Show InChI InChI=1S/C18H15N3O5/c1-26-13-5-2-11(3-6-13)9-20-18(23)17(22)15-10-19-16-7-4-12(21(24)25)8-14(15)16/h2-8,10,19H,9H2,1H3,(H,20,23)
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 126n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha5beta3gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5


(RAT)		BDBM50055244
PNG
(CHEMBL127135 | N-(4-Fluoro-benzyl)-2-(1H-indol-3-y...)
Show SMILES Fc1ccc(CNC(=O)C(=O)c2c[nH]c3ccccc23)cc1
Show InChI InChI=1S/C17H13FN2O2/c18-12-7-5-11(6-8-12)9-20-17(22)16(21)14-10-19-15-4-2-1-3-13(14)15/h1-8,10,19H,9H2,(H,20,22)
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 163n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha5beta3gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Rattus norvegicus (Rat))		BDBM50268786
PNG
((R/S)-N-(5-fluoro-2,3-dihydro-1H-inden-1-yl)-2-(5-...)
Show SMILES [O-][N+](=O)c1ccc2[nH]cc(C(=O)C(=O)NC3CCc4cc(F)ccc34)c2c1
Show InChI InChI=1S/C19H14FN3O4/c20-11-2-4-13-10(7-11)1-5-17(13)22-19(25)18(24)15-9-21-16-6-3-12(23(26)27)8-14(15)16/h2-4,6-9,17,21H,1,5H2,(H,22,25)
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 195n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha1beta2gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Rattus norvegicus (Rat))		BDBM50055265
PNG
(2-(1H-Indol-3-yl)-N-(4-methoxy-benzyl)-2-oxo-aceta...)
Show SMILES COc1ccc(CNC(=O)C(=O)c2c[nH]c3ccccc23)cc1
Show InChI InChI=1S/C18H16N2O3/c1-23-13-8-6-12(7-9-13)10-20-18(22)17(21)15-11-19-16-5-3-2-4-14(15)16/h2-9,11,19H,10H2,1H3,(H,20,22)
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 195n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha1beta2gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Rattus norvegicus (Rat))		BDBM50268787
PNG
((R/S)-2-(5-nitro-1H-indol-3-yl)-N-(5-nitro-2,3-dih...)
Show SMILES [O-][N+](=O)c1ccc2C(CCc2c1)NC(=O)C(=O)c1c[nH]c2ccc(cc12)[N+]([O-])=O
Show InChI InChI=1S/C19H14N4O6/c24-18(15-9-20-16-6-3-12(23(28)29)8-14(15)16)19(25)21-17-5-1-10-7-11(22(26)27)2-4-13(10)17/h2-4,6-9,17,20H,1,5H2,(H,21,25)
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 200n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha1beta2gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Rattus norvegicus (Rat))		BDBM50101429
PNG
(2-(1H-Indol-3-yl)-N-(4-nitro-benzyl)-2-oxo-acetami...)
Show SMILES [O-][N+](=O)c1ccc(CNC(=O)C(=O)c2c[nH]c3ccccc23)cc1
Show InChI InChI=1S/C17H13N3O4/c21-16(14-10-18-15-4-2-1-3-13(14)15)17(22)19-9-11-5-7-12(8-6-11)20(23)24/h1-8,10,18H,9H2,(H,19,22)
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 210n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha2beta2gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Rattus norvegicus (Rat))		BDBM50268744
PNG
((R)-N-(2,3-dihydro-1H-inden-1-yl)-2-(1H-indol-3-yl...)
Show SMILES O=C(N[C@@H]1CCc2ccccc12)C(=O)c1c[nH]c2ccccc12 |r|
Show InChI InChI=1S/C19H16N2O2/c22-18(15-11-20-16-8-4-3-7-14(15)16)19(23)21-17-10-9-12-5-1-2-6-13(12)17/h1-8,11,17,20H,9-10H2,(H,21,23)/t17-/m1/s1
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 225n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha1beta2gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Rattus norvegicus (Rat))		BDBM50268893
PNG
((R/S)-N-(5-methoxy-2,3-dihydro-1H-inden-1-yl)-2-(5...)
Show SMILES COc1ccc2C(CCc2c1)NC(=O)C(=O)c1c[nH]c2ccc(cc12)[N+]([O-])=O
Show InChI InChI=1S/C20H17N3O5/c1-28-13-4-5-14-11(8-13)2-6-18(14)22-20(25)19(24)16-10-21-17-7-3-12(23(26)27)9-15(16)17/h3-5,7-10,18,21H,2,6H2,1H3,(H,22,25)
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 231n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha2beta2gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5


(RAT)		BDBM50101427
PNG
((R)-2-(5-nitro-1H-indol-3-yl)-2-oxo-N-(1-phenyleth...)
Show SMILES C[C@@H](NC(=O)C(=O)c1c[nH]c2ccc(cc12)[N+]([O-])=O)c1ccccc1 |r|
Show InChI InChI=1S/C18H15N3O4/c1-11(12-5-3-2-4-6-12)20-18(23)17(22)15-10-19-16-8-7-13(21(24)25)9-14(15)16/h2-11,19H,1H3,(H,20,23)/t11-/m1/s1
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 239n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha5beta3gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Rattus norvegicus (Rat))		BDBM50055244
PNG
(CHEMBL127135 | N-(4-Fluoro-benzyl)-2-(1H-indol-3-y...)
Show SMILES Fc1ccc(CNC(=O)C(=O)c2c[nH]c3ccccc23)cc1
Show InChI InChI=1S/C17H13FN2O2/c18-12-7-5-11(6-8-12)9-20-17(22)16(21)14-10-19-15-4-2-1-3-13(14)15/h1-8,10,19H,9H2,(H,20,22)
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 245n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha1beta2gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Rattus norvegicus (Rat))		BDBM50268892
PNG
((R/S)-2-(1H-indol-3-yl)-N-(5-methoxy-2,3-dihydro-1...)
Show SMILES COc1ccc2C(CCc2c1)NC(=O)C(=O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C20H18N2O3/c1-25-13-7-8-14-12(10-13)6-9-18(14)22-20(24)19(23)16-11-21-17-5-3-2-4-15(16)17/h2-5,7-8,10-11,18,21H,6,9H2,1H3,(H,22,24)
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 246n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha1beta2gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5


(RAT)		BDBM50268893
PNG
((R/S)-N-(5-methoxy-2,3-dihydro-1H-inden-1-yl)-2-(5...)
Show SMILES COc1ccc2C(CCc2c1)NC(=O)C(=O)c1c[nH]c2ccc(cc12)[N+]([O-])=O
Show InChI InChI=1S/C20H17N3O5/c1-28-13-4-5-14-11(8-13)2-6-18(14)22-20(25)19(24)16-10-21-17-7-3-12(23(26)27)9-15(16)17/h3-5,7-10,18,21H,2,6H2,1H3,(H,22,25)
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 252n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha5beta3gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Rattus norvegicus (Rat))		BDBM50101423
PNG
(2-(5-nitro-1H-indol-3-yl)-N-(4-nitrobenzyl)-2-oxoa...)
Show SMILES [O-][N+](=O)c1ccc(CNC(=O)C(=O)c2c[nH]c3ccc(cc23)[N+]([O-])=O)cc1
Show InChI InChI=1S/C17H12N4O6/c22-16(14-9-18-15-6-5-12(21(26)27)7-13(14)15)17(23)19-8-10-1-3-11(4-2-10)20(24)25/h1-7,9,18H,8H2,(H,19,23)
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 293n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha1beta2gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Rattus norvegicus (Rat))		BDBM50268787
PNG
((R/S)-2-(5-nitro-1H-indol-3-yl)-N-(5-nitro-2,3-dih...)
Show SMILES [O-][N+](=O)c1ccc2C(CCc2c1)NC(=O)C(=O)c1c[nH]c2ccc(cc12)[N+]([O-])=O
Show InChI InChI=1S/C19H14N4O6/c24-18(15-9-20-16-6-3-12(23(28)29)8-14(15)16)19(25)21-17-5-1-10-7-11(22(26)27)2-4-13(10)17/h2-4,6-9,17,20H,1,5H2,(H,21,25)
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 513n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha2beta2gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Rattus norvegicus (Rat))		BDBM50268892
PNG
((R/S)-2-(1H-indol-3-yl)-N-(5-methoxy-2,3-dihydro-1...)
Show SMILES COc1ccc2C(CCc2c1)NC(=O)C(=O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C20H18N2O3/c1-25-13-7-8-14-12(10-13)6-9-18(14)22-20(24)19(23)16-11-21-17-5-3-2-4-15(16)17/h2-5,7-8,10-11,18,21H,6,9H2,1H3,(H,22,24)
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 690n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha2beta2gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5


(RAT)		BDBM50268787
PNG
((R/S)-2-(5-nitro-1H-indol-3-yl)-N-(5-nitro-2,3-dih...)
Show SMILES [O-][N+](=O)c1ccc2C(CCc2c1)NC(=O)C(=O)c1c[nH]c2ccc(cc12)[N+]([O-])=O
Show InChI InChI=1S/C19H14N4O6/c24-18(15-9-20-16-6-3-12(23(28)29)8-14(15)16)19(25)21-17-5-1-10-7-11(22(26)27)2-4-13(10)17/h2-4,6-9,17,20H,1,5H2,(H,21,25)
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 749n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha5beta3gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Rattus norvegicus (Rat))		BDBM26266
PNG
(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)
Show SMILES CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1
Show InChI InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3
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 765n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha2beta2gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-2


(Rattus norvegicus (Rat))		BDBM50268786
PNG
((R/S)-N-(5-fluoro-2,3-dihydro-1H-inden-1-yl)-2-(5-...)
Show SMILES [O-][N+](=O)c1ccc2[nH]cc(C(=O)C(=O)NC3CCc4cc(F)ccc34)c2c1
Show InChI InChI=1S/C19H14FN3O4/c20-11-2-4-13-10(7-11)1-5-17(13)22-19(25)18(24)15-9-21-16-6-3-12(23(26)27)8-14(15)16/h2-4,6-9,17,21H,1,5H2,(H,22,25)
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 810n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha2beta2gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Rattus norvegicus (Rat))		BDBM50101422
PNG
((R)-2-(1H-indol-3-yl)-2-oxo-N-(1-phenylethyl)aceta...)
Show SMILES C[C@@H](NC(=O)C(=O)c1c[nH]c2ccccc12)c1ccccc1 |r|
Show InChI InChI=1S/C18H16N2O2/c1-12(13-7-3-2-4-8-13)20-18(22)17(21)15-11-19-16-10-6-5-9-14(15)16/h2-12,19H,1H3,(H,20,22)/t12-/m1/s1
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 1.15E+3n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha1beta2gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5


(RAT)		BDBM50268786
PNG
((R/S)-N-(5-fluoro-2,3-dihydro-1H-inden-1-yl)-2-(5-...)
Show SMILES [O-][N+](=O)c1ccc2[nH]cc(C(=O)C(=O)NC3CCc4cc(F)ccc34)c2c1
Show InChI InChI=1S/C19H14FN3O4/c20-11-2-4-13-10(7-11)1-5-17(13)22-19(25)18(24)15-9-21-16-6-3-12(23(26)27)8-14(15)16/h2-4,6-9,17,21H,1,5H2,(H,22,25)
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 1.42E+3n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha5beta3gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Rattus norvegicus (Rat))		BDBM50101422
PNG
((R)-2-(1H-indol-3-yl)-2-oxo-N-(1-phenylethyl)aceta...)
Show SMILES C[C@@H](NC(=O)C(=O)c1c[nH]c2ccccc12)c1ccccc1 |r|
Show InChI InChI=1S/C18H16N2O2/c1-12(13-7-3-2-4-8-13)20-18(22)17(21)15-11-19-16-10-6-5-9-14(15)16/h2-12,19H,1H3,(H,20,22)/t12-/m1/s1
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 1.55E+3n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha2beta2gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Rattus norvegicus (Rat))		BDBM50055247
PNG
(CHEMBL75306 | N-(4-Methoxy-benzyl)-2-(5-nitro-1H-i...)
Show SMILES COc1ccc(CNC(=O)C(=O)c2c[nH]c3ccc(cc23)[N+]([O-])=O)cc1
Show InChI InChI=1S/C18H15N3O5/c1-26-13-5-2-11(3-6-13)9-20-18(23)17(22)15-10-19-16-7-4-12(21(24)25)8-14(15)16/h2-8,10,19H,9H2,1H3,(H,20,23)
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 1.65E+3n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha2beta2gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Rattus norvegicus (Rat))		BDBM50055265
PNG
(2-(1H-Indol-3-yl)-N-(4-methoxy-benzyl)-2-oxo-aceta...)
Show SMILES COc1ccc(CNC(=O)C(=O)c2c[nH]c3ccccc23)cc1
Show InChI InChI=1S/C18H16N2O3/c1-23-13-8-6-12(7-9-13)10-20-18(22)17(21)15-11-19-16-5-3-2-4-14(15)16/h2-9,11,19H,10H2,1H3,(H,20,22)
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 1.95E+3n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha2beta2gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1


(Rattus norvegicus (Rat))		BDBM50268785
PNG
((R/S)-N-(5-fluoro-2,3-dihydro-1H-inden-1-yl)-2-(1H...)
Show SMILES Fc1ccc2C(CCc2c1)NC(=O)C(=O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C19H15FN2O2/c20-12-6-7-13-11(9-12)5-8-17(13)22-19(24)18(23)15-10-21-16-4-2-1-3-14(15)16/h1-4,6-7,9-10,17,21H,5,8H2,(H,22,24)
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 2.05E+3n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha1beta2gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5


(RAT)		BDBM50268744
PNG
((R)-N-(2,3-dihydro-1H-inden-1-yl)-2-(1H-indol-3-yl...)
Show SMILES O=C(N[C@@H]1CCc2ccccc12)C(=O)c1c[nH]c2ccccc12 |r|
Show InChI InChI=1S/C19H16N2O2/c22-18(15-11-20-16-8-4-3-7-14(15)16)19(23)21-17-10-9-12-5-1-2-6-13(12)17/h1-8,11,17,20H,9-10H2,(H,21,23)/t17-/m1/s1
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 2.16E+3n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha5beta3gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5


(RAT)		BDBM50101423
PNG
(2-(5-nitro-1H-indol-3-yl)-N-(4-nitrobenzyl)-2-oxoa...)
Show SMILES [O-][N+](=O)c1ccc(CNC(=O)C(=O)c2c[nH]c3ccc(cc23)[N+]([O-])=O)cc1
Show InChI InChI=1S/C17H12N4O6/c22-16(14-9-18-15-6-5-12(21(26)27)7-13(14)15)17(23)19-8-10-1-3-11(4-2-10)20(24)25/h1-7,9,18H,8H2,(H,19,23)
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 2.22E+3n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha5beta3gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Rattus norvegicus (Rat))		BDBM50101423
PNG
(2-(5-nitro-1H-indol-3-yl)-N-(4-nitrobenzyl)-2-oxoa...)
Show SMILES [O-][N+](=O)c1ccc(CNC(=O)C(=O)c2c[nH]c3ccc(cc23)[N+]([O-])=O)cc1
Show InChI InChI=1S/C17H12N4O6/c22-16(14-9-18-15-6-5-12(21(26)27)7-13(14)15)17(23)19-8-10-1-3-11(4-2-10)20(24)25/h1-7,9,18H,8H2,(H,19,23)
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 2.98E+3n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha2beta2gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-2


(Rattus norvegicus (Rat))		BDBM50268744
PNG
((R)-N-(2,3-dihydro-1H-inden-1-yl)-2-(1H-indol-3-yl...)
Show SMILES O=C(N[C@@H]1CCc2ccccc12)C(=O)c1c[nH]c2ccccc12 |r|
Show InChI InChI=1S/C19H16N2O2/c22-18(15-11-20-16-8-4-3-7-14(15)16)19(23)21-17-10-9-12-5-1-2-6-13(12)17/h1-8,11,17,20H,9-10H2,(H,21,23)/t17-/m1/s1
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 3.10E+3n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha2beta2gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-5


(RAT)		BDBM50101422
PNG
((R)-2-(1H-indol-3-yl)-2-oxo-N-(1-phenylethyl)aceta...)
Show SMILES C[C@@H](NC(=O)C(=O)c1c[nH]c2ccccc12)c1ccccc1 |r|
Show InChI InChI=1S/C18H16N2O2/c1-12(13-7-3-2-4-8-13)20-18(22)17(21)15-11-19-16-10-6-5-9-14(15)16/h2-12,19H,1H3,(H,20,22)/t12-/m1/s1
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 5.50E+3n/an/an/an/an/an/an/an/a



Universita di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]flumazenil from rat GABA-Aalpha5beta3gamma2 receptor expressed in HEK293 cells

J Med Chem 52: 3723-34 (2009)


Article DOI: 10.1021/jm9001154
BindingDB Entry DOI: 10.7270/Q2N58M89
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%