Found 49 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296807
(5-ethyl-2-(2-(4-methylpiperazin-1-yl)pyridin-3-yl)...)Show InChI InChI=1S/C20H22N4O2/c1-3-14-6-4-8-16-17(14)20(25)26-19(22-16)15-7-5-9-21-18(15)24-12-10-23(2)11-13-24/h4-9H,3,10-13H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8.10 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296805
(5-ethyl-2-(2-(4-(1-methylpiperidin-4-yl)piperazin-...)Show SMILES CCc1cccc2nc(oc(=O)c12)-c1cccnc1N1CCN(CC1)C1CCN(C)CC1 Show InChI InChI=1S/C25H31N5O2/c1-3-18-6-4-8-21-22(18)25(31)32-24(27-21)20-7-5-11-26-23(20)30-16-14-29(15-17-30)19-9-12-28(2)13-10-19/h4-8,11,19H,3,9-10,12-17H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296806
(1-(3-(5-ethyl-4-oxo-4H-benzo[d][1,3]oxazin-2-yl)py...)Show SMILES CCc1cccc2nc(oc(=O)c12)-c1cccnc1N1CCC(CC1)C(O)=O Show InChI InChI=1S/C21H21N3O4/c1-2-13-5-3-7-16-17(13)21(27)28-19(23-16)15-6-4-10-22-18(15)24-11-8-14(9-12-24)20(25)26/h3-7,10,14H,2,8-9,11-12H2,1H3,(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.60 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296826
(5-ethyl-2-(2-(4-(2-hydroxyethyl)piperazin-1-yl)pyr...)Show SMILES CCc1cc(OC)cc2nc(oc(=O)c12)-c1cccnc1N1CCN(CCO)CC1 Show InChI InChI=1S/C22H26N4O4/c1-3-15-13-16(29-2)14-18-19(15)22(28)30-21(24-18)17-5-4-6-23-20(17)26-9-7-25(8-10-26)11-12-27/h4-6,13-14,27H,3,7-12H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296830
(5-ethyl-7-methoxy-2-(2-(4-(2-methoxyethyl)piperazi...)Show SMILES CCc1cc(OC)cc2nc(oc(=O)c12)-c1cccnc1N1CCN(CCOC)CC1 Show InChI InChI=1S/C23H28N4O4/c1-4-16-14-17(30-3)15-19-20(16)23(28)31-22(25-19)18-6-5-7-24-21(18)27-10-8-26(9-11-27)12-13-29-2/h5-7,14-15H,4,8-13H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296834
((R)-1-(3-(5-ethyl-7-methoxy-4-oxo-4H-benzo[d][1,3]...)Show SMILES CCc1cc(OC)cc2nc(oc(=O)c12)-c1cccnc1N1CCC[C@H](C1)C(O)=O |r| Show InChI InChI=1S/C22H23N3O5/c1-3-13-10-15(29-2)11-17-18(13)22(28)30-20(24-17)16-7-4-8-23-19(16)25-9-5-6-14(12-25)21(26)27/h4,7-8,10-11,14H,3,5-6,9,12H2,1-2H3,(H,26,27)/t14-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296804
(5-ethyl-7-methoxy-2-(2-(4-methylpiperazin-1-yl)pyr...)Show SMILES CCc1cc(OC)cc2nc(oc(=O)c12)-c1cccnc1N1CCN(C)CC1 Show InChI InChI=1S/C21H24N4O3/c1-4-14-12-15(27-3)13-17-18(14)21(26)28-20(23-17)16-6-5-7-22-19(16)25-10-8-24(2)9-11-25/h5-7,12-13H,4,8-11H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296828
(5-ethyl-2-(2-(4-isobutylpiperazin-1-yl)pyridin-3-y...)Show SMILES CCc1cc(OC)cc2nc(oc(=O)c12)-c1cccnc1N1CCN(CC(C)C)CC1 Show InChI InChI=1S/C24H30N4O3/c1-5-17-13-18(30-4)14-20-21(17)24(29)31-23(26-20)19-7-6-8-25-22(19)28-11-9-27(10-12-28)15-16(2)3/h6-8,13-14,16H,5,9-12,15H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296824
(2-(2-(4-(2-(dimethylamino)ethyl)piperazin-1-yl)pyr...)Show SMILES CCc1cc(OC)cc2nc(oc(=O)c12)-c1cccnc1N1CCN(CCN(C)C)CC1 Show InChI InChI=1S/C24H31N5O3/c1-5-17-15-18(31-4)16-20-21(17)24(30)32-23(26-20)19-7-6-8-25-22(19)29-13-11-28(12-14-29)10-9-27(2)3/h6-8,15-16H,5,9-14H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296827
(5-ethyl-7-methoxy-2-(2-(4-(2-morpholinoethyl)piper...)Show SMILES CCc1cc(OC)cc2nc(oc(=O)c12)-c1cccnc1N1CCN(CCN2CCOCC2)CC1 Show InChI InChI=1S/C26H33N5O4/c1-3-19-17-20(33-2)18-22-23(19)26(32)35-25(28-22)21-5-4-6-27-24(21)31-11-9-29(10-12-31)7-8-30-13-15-34-16-14-30/h4-6,17-18H,3,7-16H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296835
(2-(4-(3-(5-ethyl-7-methoxy-4-oxo-4H-benzo[d][1,3]o...)Show SMILES CCc1cc(OC)cc2nc(oc(=O)c12)-c1cccnc1N1CCN(CC(O)=O)CC1 Show InChI InChI=1S/C22H24N4O5/c1-3-14-11-15(30-2)12-17-19(14)22(29)31-21(24-17)16-5-4-6-23-20(16)26-9-7-25(8-10-26)13-18(27)28/h4-6,11-12H,3,7-10,13H2,1-2H3,(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296825
(3-(4-(3-(5-ethyl-7-methoxy-4-oxo-4H-benzo[d][1,3]o...)Show SMILES CCc1cc(OC)cc2nc(oc(=O)c12)-c1cccnc1N1CCN(CCC#N)CC1 Show InChI InChI=1S/C23H25N5O3/c1-3-16-14-17(30-2)15-19-20(16)23(29)31-22(26-19)18-6-4-8-25-21(18)28-12-10-27(11-13-28)9-5-7-24/h4,6,8,14-15H,3,5,9-13H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296833
((S)-1-(3-(5-ethyl-7-methoxy-4-oxo-4H-benzo[d][1,3]...)Show SMILES CCc1cc(OC)cc2nc(oc(=O)c12)-c1cccnc1N1CCC[C@@H](C1)C(O)=O |r| Show InChI InChI=1S/C22H23N3O5/c1-3-13-10-15(29-2)11-17-18(13)22(28)30-20(24-17)16-7-4-8-23-19(16)25-9-5-6-14(12-25)21(26)27/h4,7-8,10-11,14H,3,5-6,9,12H2,1-2H3,(H,26,27)/t14-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296829
(2-(2-(4-butylpiperazin-1-yl)pyridin-3-yl)-5-ethyl-...)Show SMILES CCCCN1CCN(CC1)c1ncccc1-c1nc2cc(OC)cc(CC)c2c(=O)o1 Show InChI InChI=1S/C24H30N4O3/c1-4-6-10-27-11-13-28(14-12-27)22-19(8-7-9-25-22)23-26-20-16-18(30-3)15-17(5-2)21(20)24(29)31-23/h7-9,15-16H,4-6,10-14H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296802
(5-ethyl-7-methoxy-2-(2-(4-(1-methylpiperidin-4-yl)...)Show SMILES CCc1cc(OC)cc2nc(oc(=O)c12)-c1cccnc1N1CCN(CC1)C1CCN(C)CC1 Show InChI InChI=1S/C26H33N5O3/c1-4-18-16-20(33-3)17-22-23(18)26(32)34-25(28-22)21-6-5-9-27-24(21)31-14-12-30(13-15-31)19-7-10-29(2)11-8-19/h5-6,9,16-17,19H,4,7-8,10-15H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296831
(2-(2-(4-(cyclopropylmethyl)piperazin-1-yl)pyridin-...)Show SMILES CCc1cc(OC)cc2nc(oc(=O)c12)-c1cccnc1N1CCN(CC2CC2)CC1 Show InChI InChI=1S/C24H28N4O3/c1-3-17-13-18(30-2)14-20-21(17)24(29)31-23(26-20)19-5-4-8-25-22(19)28-11-9-27(10-12-28)15-16-6-7-16/h4-5,8,13-14,16H,3,6-7,9-12,15H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296803
(1-(3-(5-ethyl-7-methoxy-4-oxo-4H-benzo[d][1,3]oxaz...)Show SMILES CCc1cc(OC)cc2nc(oc(=O)c12)-c1cccnc1N1CCC(CC1)C(O)=O Show InChI InChI=1S/C22H23N3O5/c1-3-13-11-15(29-2)12-17-18(13)22(28)30-20(24-17)16-5-4-8-23-19(16)25-9-6-14(7-10-25)21(26)27/h4-5,8,11-12,14H,3,6-7,9-10H2,1-2H3,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296832
(2-(2-(4-cyclopentylpiperazin-1-yl)pyridin-3-yl)-5-...)Show SMILES CCc1cc(OC)cc2nc(oc(=O)c12)-c1cccnc1N1CCN(CC1)C1CCCC1 Show InChI InChI=1S/C25H30N4O3/c1-3-17-15-19(31-2)16-21-22(17)25(30)32-24(27-21)20-9-6-10-26-23(20)29-13-11-28(12-14-29)18-7-4-5-8-18/h6,9-10,15-16,18H,3-5,7-8,11-14H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296823
(5-methyl-2-(2-phenoxypyridin-3-yl)-4H-benzo[d][1,3...)Show InChI InChI=1S/C20H14N2O3/c1-13-7-5-11-16-17(13)20(23)25-19(22-16)15-10-6-12-21-18(15)24-14-8-3-2-4-9-14/h2-12H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 61 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296811
(2-(2-(1H-imidazol-1-yl)pyridin-3-yl)-5-methyl-4H-b...)Show InChI InChI=1S/C17H12N4O2/c1-11-4-2-6-13-14(11)17(22)23-16(20-13)12-5-3-7-19-15(12)21-9-8-18-10-21/h2-10H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296797
(7-methoxy-2-(2-(4-(1-methylpiperidin-4-yl)piperazi...)Show SMILES CCCc1cc(OC)cc2nc(oc(=O)c12)-c1cccnc1N1CCN(CC1)C1CCN(C)CC1 Show InChI InChI=1S/C27H35N5O3/c1-4-6-19-17-21(34-3)18-23-24(19)27(33)35-26(29-23)22-7-5-10-28-25(22)32-15-13-31(14-16-32)20-8-11-30(2)12-9-20/h5,7,10,17-18,20H,4,6,8-9,11-16H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 71 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296808
(5-methyl-2-(2-(4-(1-methylpiperidin-4-yl)piperazin...)Show SMILES CN1CCC(CC1)N1CCN(CC1)c1ncccc1-c1nc2cccc(C)c2c(=O)o1 Show InChI InChI=1S/C24H29N5O2/c1-17-5-3-7-20-21(17)24(30)31-23(26-20)19-6-4-10-25-22(19)29-15-13-28(14-16-29)18-8-11-27(2)12-9-18/h3-7,10,18H,8-9,11-16H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 74 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296809
(1-(3-(5-methyl-4-oxo-4H-benzo[d][1,3]oxazin-2-yl)p...)Show SMILES Cc1cccc2nc(oc(=O)c12)-c1cccnc1N1CCC(CC1)C(O)=O Show InChI InChI=1S/C20H19N3O4/c1-12-4-2-6-15-16(12)20(26)27-18(22-15)14-5-3-9-21-17(14)23-10-7-13(8-11-23)19(24)25/h2-6,9,13H,7-8,10-11H2,1H3,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296819
(2-(2-methoxypyridin-3-yl)-5-methyl-4H-benzo[d][1,3...)Show InChI InChI=1S/C15H12N2O3/c1-9-5-3-7-11-12(9)15(18)20-14(17-11)10-6-4-8-16-13(10)19-2/h3-8H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296818
(5-methyl-2-(2-methylpyridin-3-yl)-4H-benzo[d][1,3]...)Show InChI InChI=1S/C15H12N2O2/c1-9-5-3-7-12-13(9)15(18)19-14(17-12)11-6-4-8-16-10(11)2/h3-8H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 87 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296810
(5-methyl-2-(2-(4-methylpiperazin-1-yl)pyridin-3-yl...)Show InChI InChI=1S/C19H20N4O2/c1-13-5-3-7-15-16(13)19(24)25-18(21-15)14-6-4-8-20-17(14)23-11-9-22(2)10-12-23/h3-8H,9-12H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296812
(2-(2-((2-(dimethylamino)ethyl)(methyl)amino)pyridi...)Show InChI InChI=1S/C19H22N4O2/c1-13-7-5-9-15-16(13)19(24)25-18(21-15)14-8-6-10-20-17(14)23(4)12-11-22(2)3/h5-10H,11-12H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296840
(5-cyclopropyl-7-methoxy-2-(2-(4-(1-methylpiperidin...)Show SMILES COc1cc(C2CC2)c2c(c1)nc(oc2=O)-c1cccnc1N1CCN(CC1)C1CCN(C)CC1 Show InChI InChI=1S/C27H33N5O3/c1-30-10-7-19(8-11-30)31-12-14-32(15-13-31)25-21(4-3-9-28-25)26-29-23-17-20(34-2)16-22(18-5-6-18)24(23)27(33)35-26/h3-4,9,16-19H,5-8,10-15H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296793
(5-cyclopropyl-7-methoxy-2-(2-(4-methylpiperazin-1-...)Show SMILES COc1cc(C2CC2)c2c(c1)nc(oc2=O)-c1cccnc1N1CCN(C)CC1 Show InChI InChI=1S/C22H24N4O3/c1-25-8-10-26(11-9-25)20-16(4-3-7-23-20)21-24-18-13-15(28-2)12-17(14-5-6-14)19(18)22(27)29-21/h3-4,7,12-14H,5-6,8-11H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296794
(5-isopropyl-7-methoxy-2-(2-(4-(1-methylpiperidin-4...)Show SMILES COc1cc(C(C)C)c2c(c1)nc(oc2=O)-c1cccnc1N1CCN(CC1)C1CCN(C)CC1 Show InChI InChI=1S/C27H35N5O3/c1-18(2)22-16-20(34-4)17-23-24(22)27(33)35-26(29-23)21-6-5-9-28-25(21)32-14-12-31(13-15-32)19-7-10-30(3)11-8-19/h5-6,9,16-19H,7-8,10-15H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296792
(1-(3-(5-cyclopropyl-7-methoxy-4-oxo-4H-benzo[d][1,...)Show SMILES COc1cc(C2CC2)c2c(c1)nc(oc2=O)-c1cccnc1N1CCC(CC1)C(O)=O Show InChI InChI=1S/C23H23N3O5/c1-30-15-11-17(13-4-5-13)19-18(12-15)25-21(31-23(19)29)16-3-2-8-24-20(16)26-9-6-14(7-10-26)22(27)28/h2-3,8,11-14H,4-7,9-10H2,1H3,(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296839
(5-cyclobutyl-7-methoxy-2-(2-(4-methylpiperazin-1-y...)Show SMILES COc1cc(C2CCC2)c2c(c1)nc(oc2=O)-c1cccnc1N1CCN(C)CC1 Show InChI InChI=1S/C23H26N4O3/c1-26-9-11-27(12-10-26)21-17(7-4-8-24-21)22-25-19-14-16(29-2)13-18(15-5-3-6-15)20(19)23(28)30-22/h4,7-8,13-15H,3,5-6,9-12H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296816
(5-chloro-2-(2-phenoxypyridin-3-yl)-4H-benzo[d][1,3...)Show InChI InChI=1S/C19H11ClN2O3/c20-14-9-4-10-15-16(14)19(23)25-18(22-15)13-8-5-11-21-17(13)24-12-6-2-1-3-7-12/h1-11H | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296822
(5-methyl-2-(2-phenoxyphenyl)-4H-benzo[d][1,3]oxazi...)Show InChI InChI=1S/C21H15NO3/c1-14-8-7-12-17-19(14)21(23)25-20(22-17)16-11-5-6-13-18(16)24-15-9-3-2-4-10-15/h2-13H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296798
(1-(3-(7-methoxy-4-oxo-5-propyl-4H-benzo[d][1,3]oxa...)Show SMILES CCCc1cc(OC)cc2nc(oc(=O)c12)-c1cccnc1N1CCC(CC1)C(O)=O Show InChI InChI=1S/C23H25N3O5/c1-3-5-15-12-16(30-2)13-18-19(15)23(29)31-21(25-18)17-6-4-9-24-20(17)26-10-7-14(8-11-26)22(27)28/h4,6,9,12-14H,3,5,7-8,10-11H2,1-2H3,(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296796
(5-isopropyl-7-methoxy-2-(2-(4-methylpiperazin-1-yl...)Show SMILES COc1cc(C(C)C)c2c(c1)nc(oc2=O)-c1cccnc1N1CCN(C)CC1 Show InChI InChI=1S/C22H26N4O3/c1-14(2)17-12-15(28-4)13-18-19(17)22(27)29-21(24-18)16-6-5-7-23-20(16)26-10-8-25(3)9-11-26/h5-7,12-14H,8-11H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296799
(7-methoxy-2-(2-(4-methylpiperazin-1-yl)pyridin-3-y...)Show SMILES CCCc1cc(OC)cc2nc(oc(=O)c12)-c1cccnc1N1CCN(C)CC1 Show InChI InChI=1S/C22H26N4O3/c1-4-6-15-13-16(28-3)14-18-19(15)22(27)29-21(24-18)17-7-5-8-23-20(17)26-11-9-25(2)10-12-26/h5,7-8,13-14H,4,6,9-12H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296795
(1-(3-(5-isopropyl-7-methoxy-4-oxo-4H-benzo[d][1,3]...)Show SMILES COc1cc(C(C)C)c2c(c1)nc(oc2=O)-c1cccnc1N1CCC(CC1)C(O)=O Show InChI InChI=1S/C23H25N3O5/c1-13(2)17-11-15(30-3)12-18-19(17)23(29)31-21(25-18)16-5-4-8-24-20(16)26-9-6-14(7-10-26)22(27)28/h4-5,8,11-14H,6-7,9-10H2,1-3H3,(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296815
(5-methoxy-2-(2-phenoxypyridin-3-yl)-4H-benzo[d][1,...)Show InChI InChI=1S/C20H14N2O4/c1-24-16-11-5-10-15-17(16)20(23)26-19(22-15)14-9-6-12-21-18(14)25-13-7-3-2-4-8-13/h2-12H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296817
(5-methyl-2-(6-methylpyridin-3-yl)-4H-benzo[d][1,3]...)Show InChI InChI=1S/C15H12N2O2/c1-9-4-3-5-12-13(9)15(18)19-14(17-12)11-7-6-10(2)16-8-11/h3-8H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 710 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296837
(5-cyclobutyl-7-methoxy-2-(2-(4-(1-methylpiperidin-...)Show SMILES COc1cc(C2CCC2)c2c(c1)nc(oc2=O)-c1cccnc1N1CCN(CC1)C1CCN(C)CC1 Show InChI InChI=1S/C28H35N5O3/c1-31-11-8-20(9-12-31)32-13-15-33(16-14-32)26-22(7-4-10-29-26)27-30-24-18-21(35-2)17-23(19-5-3-6-19)25(24)28(34)36-27/h4,7,10,17-20H,3,5-6,8-9,11-16H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 850 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296820
(5-methyl-2-(pyridin-3-yl)-4H-benzo[d][1,3]oxazin-4...)Show InChI InChI=1S/C14H10N2O2/c1-9-4-2-6-11-12(9)14(17)18-13(16-11)10-5-3-7-15-8-10/h2-8H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296838
(1-(3-(5-cyclobutyl-7-methoxy-4-oxo-4H-benzo[d][1,3...)Show SMILES COc1cc(C2CCC2)c2c(c1)nc(oc2=O)-c1cccnc1N1CCC(CC1)C(O)=O Show InChI InChI=1S/C24H25N3O5/c1-31-16-12-18(14-4-2-5-14)20-19(13-16)26-22(32-24(20)30)17-6-3-9-25-21(17)27-10-7-15(8-11-27)23(28)29/h3,6,9,12-15H,2,4-5,7-8,10-11H2,1H3,(H,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296800
(7-(dimethylamino)-5-ethyl-2-(2-(4-(1-methylpiperid...)Show SMILES CCc1cc(cc2nc(oc(=O)c12)-c1cccnc1N1CCN(CC1)C1CCN(C)CC1)N(C)C Show InChI InChI=1S/C27H36N6O2/c1-5-19-17-21(30(2)3)18-23-24(19)27(34)35-26(29-23)22-7-6-10-28-25(22)33-15-13-32(14-16-33)20-8-11-31(4)12-9-20/h6-7,10,17-18,20H,5,8-9,11-16H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296801
(7-(dimethylamino)-5-ethyl-2-(2-(4-methylpiperazin-...)Show SMILES CCc1cc(cc2nc(oc(=O)c12)-c1cccnc1N1CCN(C)CC1)N(C)C Show InChI InChI=1S/C22H27N5O2/c1-5-15-13-16(25(2)3)14-18-19(15)22(28)29-21(24-18)17-7-6-8-23-20(17)27-11-9-26(4)10-12-27/h6-8,13-14H,5,9-12H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296814
(5-methyl-2-(2-(2-morpholinoethylamino)pyridin-3-yl...)Show InChI InChI=1S/C20H22N4O3/c1-14-4-2-6-16-17(14)20(25)27-19(23-16)15-5-3-7-21-18(15)22-8-9-24-10-12-26-13-11-24/h2-7H,8-13H2,1H3,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296813
(2-(2-(2-(dimethylamino)ethylamino)pyridin-3-yl)-5-...)Show InChI InChI=1S/C18H20N4O2/c1-12-6-4-8-14-15(12)18(23)24-17(21-14)13-7-5-9-19-16(13)20-10-11-22(2)3/h4-9H,10-11H2,1-3H3,(H,19,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296821
(2-(2-phenoxypyridin-3-yl)-4H-benzo[d][1,3]oxazin-4...)Show InChI InChI=1S/C19H12N2O3/c22-19-14-9-4-5-11-16(14)21-18(24-19)15-10-6-12-20-17(15)23-13-7-2-1-3-8-13/h1-12H | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 9.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM50296836
(5-tert-butyl-7-methoxy-2-(2-(4-methylpiperazin-1-y...)Show SMILES COc1cc(c2c(c1)nc(oc2=O)-c1cccnc1N1CCN(C)CC1)C(C)(C)C Show InChI InChI=1S/C23H28N4O3/c1-23(2,3)17-13-15(29-5)14-18-19(17)22(28)30-21(25-18)16-7-6-8-24-20(16)27-11-9-26(4)10-12-27/h6-8,13-14H,9-12H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ActivX Biosciences, Inc
Curated by ChEMBL
| Assay Description
Inhibition of human sputum neutrophil elastase by fluorescence based assay |
Bioorg Med Chem Lett 19: 4743-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.053
BindingDB Entry DOI: 10.7270/Q2M32VT3 |
More data for this
Ligand-Target Pair | |
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