| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM50296793 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_582553 (CHEMBL1061649) |
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| IC50 | 120±n/a nM |
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| Citation |  Shreder, KR; Cajica, J; Du, L; Fraser, A; Hu, Y; Kohno, Y; Lin, EC; Liu, SJ; Okerberg, E; Pham, L; Wu, J; Kozarich, JW Synthesis and optimization of 2-pyridin-3-yl-benzo[d][1,3]oxazin-4-one based inhibitors of human neutrophil elastase. Bioorg Med Chem Lett19:4743-6 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM50296793 |
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| n/a |
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| Name | BDBM50296793 |
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| Synonyms: | 5-cyclopropyl-7-methoxy-2-(2-(4-methylpiperazin-1-yl)pyridin-3-yl)-4H-benzo[d][1,3]oxazin-4-one | CHEMBL549582 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24N4O3 |
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| Mol. Mass. | 392.451 |
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| SMILES | COc1cc(C2CC2)c2c(c1)nc(oc2=O)-c1cccnc1N1CCN(C)CC1 |
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| Structure | 
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