Reaction Details |
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Target | Neutrophil elastase |
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Ligand | BDBM50296808 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_582553 (CHEMBL1061649) |
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IC50 | 74±n/a nM |
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Citation | Shreder, KR; Cajica, J; Du, L; Fraser, A; Hu, Y; Kohno, Y; Lin, EC; Liu, SJ; Okerberg, E; Pham, L; Wu, J; Kozarich, JW Synthesis and optimization of 2-pyridin-3-yl-benzo[d][1,3]oxazin-4-one based inhibitors of human neutrophil elastase. Bioorg Med Chem Lett19:4743-6 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Neutrophil elastase |
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Name: | Neutrophil elastase |
Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
Type: | Enzyme |
Mol. Mass.: | 28532.38 |
Organism: | Homo sapiens (Human) |
Description: | P08246 |
Residue: | 267 |
Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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BDBM50296808 |
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n/a |
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Name | BDBM50296808 |
Synonyms: | 5-methyl-2-(2-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)pyridin-3-yl)-4H-benzo[d][1,3]oxazin-4-one | CHEMBL560589 |
Type | Small organic molecule |
Emp. Form. | C24H29N5O2 |
Mol. Mass. | 419.5194 |
SMILES | CN1CCC(CC1)N1CCN(CC1)c1ncccc1-c1nc2cccc(C)c2c(=O)o1 |
Structure |
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