Found 15 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Signal transducer and activator of transcription 6
(Homo sapiens (Human)) | BDBM50304425
(2-(4-morpholinophenylamino)-4-(2,3,6-trifluorobenz...)Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCOCC2)nc1NCc1c(F)ccc(F)c1F Show InChI InChI=1S/C22H21F3N6O2/c23-17-5-6-18(24)19(25)15(17)11-27-21-16(20(26)32)12-28-22(30-21)29-13-1-3-14(4-2-13)31-7-9-33-10-8-31/h1-6,12H,7-11H2,(H2,26,32)(H2,27,28,29,30) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assay |
Bioorg Med Chem 17: 6926-36 (2009)
Article DOI: 10.1016/j.bmc.2009.08.021
BindingDB Entry DOI: 10.7270/Q2RV0NS7 |
More data for this
Ligand-Target Pair | |
Signal transducer and activator of transcription 6
(Homo sapiens (Human)) | BDBM50304429
(2-[4-(4-{[7-(3,5-Difluorobenzyl)-7H-pyrrolo[2,3-d]...)Show SMILES NC(=O)CN1CCN(CC1)c1ccc(Nc2ncc3ccn(Cc4cc(F)cc(F)c4)c3n2)cc1 Show InChI InChI=1S/C25H25F2N7O/c26-19-11-17(12-20(27)13-19)15-34-6-5-18-14-29-25(31-24(18)34)30-21-1-3-22(4-2-21)33-9-7-32(8-10-33)16-23(28)35/h1-6,11-14H,7-10,15-16H2,(H2,28,35)(H,29,30,31) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assay |
Bioorg Med Chem 17: 6926-36 (2009)
Article DOI: 10.1016/j.bmc.2009.08.021
BindingDB Entry DOI: 10.7270/Q2RV0NS7 |
More data for this
Ligand-Target Pair | |
Signal transducer and activator of transcription 6
(Homo sapiens (Human)) | BDBM50304433
(7-(3,5-Difluorobenzyl)-N-[4-(4-methylpiperazin-1-y...)Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3ccn(Cc4cc(F)cc(F)c4)c3n2)cc1 Show InChI InChI=1S/C24H24F2N6/c1-30-8-10-31(11-9-30)22-4-2-21(3-5-22)28-24-27-15-18-6-7-32(23(18)29-24)16-17-12-19(25)14-20(26)13-17/h2-7,12-15H,8-11,16H2,1H3,(H,27,28,29) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assay |
Bioorg Med Chem 17: 6926-36 (2009)
Article DOI: 10.1016/j.bmc.2009.08.021
BindingDB Entry DOI: 10.7270/Q2RV0NS7 |
More data for this
Ligand-Target Pair | |
Signal transducer and activator of transcription 6
(Homo sapiens (Human)) | BDBM50304428
(2-[4-(4-{[7-(3,5-Difluorobenzyl)-7H-pyrrolo[2,3-d]...)Show SMILES CNC(=O)CN1CCN(CC1)c1ccc(Nc2ncc3ccn(Cc4cc(F)cc(F)c4)c3n2)cc1 Show InChI InChI=1S/C26H27F2N7O/c1-29-24(36)17-33-8-10-34(11-9-33)23-4-2-22(3-5-23)31-26-30-15-19-6-7-35(25(19)32-26)16-18-12-20(27)14-21(28)13-18/h2-7,12-15H,8-11,16-17H2,1H3,(H,29,36)(H,30,31,32) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assay |
Bioorg Med Chem 17: 6926-36 (2009)
Article DOI: 10.1016/j.bmc.2009.08.021
BindingDB Entry DOI: 10.7270/Q2RV0NS7 |
More data for this
Ligand-Target Pair | |
Signal transducer and activator of transcription 6
(Homo sapiens (Human)) | BDBM50304432
(2-[4-(4-{[7-(3,5-Difluorobenzyl)-7H-pyrrolo[2,3-d]...)Show SMILES OCCN1CCN(CC1)c1ccc(Nc2ncc3ncn(Cc4cc(F)cc(F)c4)c3n2)cc1 Show InChI InChI=1S/C24H25F2N7O/c25-18-11-17(12-19(26)13-18)15-33-16-28-22-14-27-24(30-23(22)33)29-20-1-3-21(4-2-20)32-7-5-31(6-8-32)9-10-34/h1-4,11-14,16,34H,5-10,15H2,(H,27,29,30) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assay |
Bioorg Med Chem 17: 6926-36 (2009)
Article DOI: 10.1016/j.bmc.2009.08.021
BindingDB Entry DOI: 10.7270/Q2RV0NS7 |
More data for this
Ligand-Target Pair | |
Signal transducer and activator of transcription 6
(Homo sapiens (Human)) | BDBM50244258
(4-(benzylamino)-2-(4-morpholinophenylamino)pyrimid...)Show SMILES NC(=O)c1cnc(Nc2ccc(cc2)N2CCOCC2)nc1NCc1ccccc1 Show InChI InChI=1S/C22H24N6O2/c23-20(29)19-15-25-22(27-21(19)24-14-16-4-2-1-3-5-16)26-17-6-8-18(9-7-17)28-10-12-30-13-11-28/h1-9,15H,10-14H2,(H2,23,29)(H2,24,25,26,27) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assay |
Bioorg Med Chem 17: 6926-36 (2009)
Article DOI: 10.1016/j.bmc.2009.08.021
BindingDB Entry DOI: 10.7270/Q2RV0NS7 |
More data for this
Ligand-Target Pair | |
Signal transducer and activator of transcription 6
(Homo sapiens (Human)) | BDBM50304434
(7-(3,5-Difluorobenzyl)-N-(4-piperazin-1-ylphenyl)-...)Show SMILES Fc1cc(F)cc(Cn2ccc3cnc(Nc4ccc(cc4)N4CCNCC4)nc23)c1 Show InChI InChI=1S/C23H22F2N6/c24-18-11-16(12-19(25)13-18)15-31-8-5-17-14-27-23(29-22(17)31)28-20-1-3-21(4-2-20)30-9-6-26-7-10-30/h1-5,8,11-14,26H,6-7,9-10,15H2,(H,27,28,29) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assay |
Bioorg Med Chem 17: 6926-36 (2009)
Article DOI: 10.1016/j.bmc.2009.08.021
BindingDB Entry DOI: 10.7270/Q2RV0NS7 |
More data for this
Ligand-Target Pair | |
Signal transducer and activator of transcription 6
(Homo sapiens (Human)) | BDBM50304430
(CHEMBL595488 | [4-(4-{[7-(3,5-Difluorobenzyl)-7H-p...)Show SMILES OC(=O)CN1CCN(CC1)c1ccc(Nc2ncc3ccn(Cc4cc(F)cc(F)c4)c3n2)cc1 Show InChI InChI=1S/C25H24F2N6O2/c26-19-11-17(12-20(27)13-19)15-33-6-5-18-14-28-25(30-24(18)33)29-21-1-3-22(4-2-21)32-9-7-31(8-10-32)16-23(34)35/h1-6,11-14H,7-10,15-16H2,(H,34,35)(H,28,29,30) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assay |
Bioorg Med Chem 17: 6926-36 (2009)
Article DOI: 10.1016/j.bmc.2009.08.021
BindingDB Entry DOI: 10.7270/Q2RV0NS7 |
More data for this
Ligand-Target Pair | |
Signal transducer and activator of transcription 6
(Homo sapiens (Human)) | BDBM50304431
(CHEMBL594821 | N-{4-[4-(2-Aminoethyl)piperazin-1-y...)Show SMILES NCCN1CCN(CC1)c1ccc(Nc2ncc3ccn(Cc4cc(F)cc(F)c4)c3n2)cc1 Show InChI InChI=1S/C25H27F2N7/c26-20-13-18(14-21(27)15-20)17-34-7-5-19-16-29-25(31-24(19)34)30-22-1-3-23(4-2-22)33-11-9-32(8-6-28)10-12-33/h1-5,7,13-16H,6,8-12,17,28H2,(H,29,30,31) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assay |
Bioorg Med Chem 17: 6926-36 (2009)
Article DOI: 10.1016/j.bmc.2009.08.021
BindingDB Entry DOI: 10.7270/Q2RV0NS7 |
More data for this
Ligand-Target Pair | |
Signal transducer and activator of transcription 6
(Homo sapiens (Human)) | BDBM50304435
(7-(3-Fluorobenzyl)-N-(4-morpholin-4-ylphenyl)-7Hpy...)Show SMILES Fc1cccc(Cn2ccc3cnc(Nc4ccc(cc4)N4CCOCC4)nc23)c1 Show InChI InChI=1S/C23H22FN5O/c24-19-3-1-2-17(14-19)16-29-9-8-18-15-25-23(27-22(18)29)26-20-4-6-21(7-5-20)28-10-12-30-13-11-28/h1-9,14-15H,10-13,16H2,(H,25,26,27) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assay |
Bioorg Med Chem 17: 6926-36 (2009)
Article DOI: 10.1016/j.bmc.2009.08.021
BindingDB Entry DOI: 10.7270/Q2RV0NS7 |
More data for this
Ligand-Target Pair | |
Signal transducer and activator of transcription 6
(Homo sapiens (Human)) | BDBM50304436
(7-(3,5-Difluorobenzyl)-N-(4-morpholin-4-ylphenyl)-...)Show SMILES Fc1cc(F)cc(Cn2ccc3cnc(Nc4ccc(cc4)N4CCOCC4)nc23)c1 Show InChI InChI=1S/C23H21F2N5O/c24-18-11-16(12-19(25)13-18)15-30-6-5-17-14-26-23(28-22(17)30)27-20-1-3-21(4-2-20)29-7-9-31-10-8-29/h1-6,11-14H,7-10,15H2,(H,26,27,28) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assay |
Bioorg Med Chem 17: 6926-36 (2009)
Article DOI: 10.1016/j.bmc.2009.08.021
BindingDB Entry DOI: 10.7270/Q2RV0NS7 |
More data for this
Ligand-Target Pair | |
Signal transducer and activator of transcription 6
(Homo sapiens (Human)) | BDBM50304437
(7-(2-Fluorobenzyl)-N-(4-morpholin-4-ylphenyl)-7Hpy...)Show SMILES Fc1ccccc1Cn1ccc2cnc(Nc3ccc(cc3)N3CCOCC3)nc12 Show InChI InChI=1S/C23H22FN5O/c24-21-4-2-1-3-18(21)16-29-10-9-17-15-25-23(27-22(17)29)26-19-5-7-20(8-6-19)28-11-13-30-14-12-28/h1-10,15H,11-14,16H2,(H,25,26,27) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assay |
Bioorg Med Chem 17: 6926-36 (2009)
Article DOI: 10.1016/j.bmc.2009.08.021
BindingDB Entry DOI: 10.7270/Q2RV0NS7 |
More data for this
Ligand-Target Pair | |
Signal transducer and activator of transcription 6
(Homo sapiens (Human)) | BDBM50304438
(7-Benzyl-N-(4-morpholin-4-ylphenyl)-7H-pyrrolo[2,3...)Show SMILES C(c1ccccc1)n1ccc2cnc(Nc3ccc(cc3)N3CCOCC3)nc12 Show InChI InChI=1S/C23H23N5O/c1-2-4-18(5-3-1)17-28-11-10-19-16-24-23(26-22(19)28)25-20-6-8-21(9-7-20)27-12-14-29-15-13-27/h1-11,16H,12-15,17H2,(H,24,25,26) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assay |
Bioorg Med Chem 17: 6926-36 (2009)
Article DOI: 10.1016/j.bmc.2009.08.021
BindingDB Entry DOI: 10.7270/Q2RV0NS7 |
More data for this
Ligand-Target Pair | |
Signal transducer and activator of transcription 6
(Homo sapiens (Human)) | BDBM50304427
(7-(4-Fluorobenzyl)-N-(4-morpholin-4-ylphenyl)-7Hpy...)Show SMILES Fc1ccc(Cn2ccc3cnc(Nc4ccc(cc4)N4CCOCC4)nc23)cc1 Show InChI InChI=1S/C23H22FN5O/c24-19-3-1-17(2-4-19)16-29-10-9-18-15-25-23(27-22(18)29)26-20-5-7-21(8-6-20)28-11-13-30-14-12-28/h1-10,15H,11-14,16H2,(H,25,26,27) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assay |
Bioorg Med Chem 17: 6926-36 (2009)
Article DOI: 10.1016/j.bmc.2009.08.021
BindingDB Entry DOI: 10.7270/Q2RV0NS7 |
More data for this
Ligand-Target Pair | |
Signal transducer and activator of transcription 6
(Homo sapiens (Human)) | BDBM50304426
(7-Benzyl-N-(4-morpholin-4-ylphenyl)-6,7-dihydro-5H...)Show SMILES C(N1CCc2cnc(Nc3ccc(cc3)N3CCOCC3)nc12)c1ccccc1 Show InChI InChI=1S/C23H25N5O/c1-2-4-18(5-3-1)17-28-11-10-19-16-24-23(26-22(19)28)25-20-6-8-21(9-7-20)27-12-14-29-15-13-27/h1-9,16H,10-15,17H2,(H,24,25,26) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc.
Curated by ChEMBL
| Assay Description
Inhibition of STAT6 in IL4-stimulated human FW4 reporter cells by luciferase assay |
Bioorg Med Chem 17: 6926-36 (2009)
Article DOI: 10.1016/j.bmc.2009.08.021
BindingDB Entry DOI: 10.7270/Q2RV0NS7 |
More data for this
Ligand-Target Pair | |
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