| Reaction Details |
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 | Report a problem with these data |
| Target | Signal transducer and activator of transcription 6 |
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| Ligand | BDBM50304429 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_603163 (CHEMBL1042440) |
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| IC50 | 1.9±n/a nM |
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| Citation |  Nagashima, S; Hondo, T; Nagata, H; Ogiyama, T; Maeda, J; Hoshii, H; Kontani, T; Kuromitsu, S; Ohga, K; Orita, M; Ohno, K; Moritomo, A; Shiozuka, K; Furutani, M; Takeuchi, M; Ohta, M; Tsukamoto, S Novel 7H-pyrrolo[2,3-d]pyrimidine derivatives as potent and orally active STAT6 inhibitors. Bioorg Med Chem17:6926-36 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Signal transducer and activator of transcription 6 |
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| Name: | Signal transducer and activator of transcription 6 |
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| Synonyms: | STAT6 | STAT6_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 94129.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_881634 |
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| Residue: | 847 |
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| Sequence: | MSLWGLVSKMPPEKVQRLYVDFPQHLRHLLGDWLESQPWEFLVGSDAFCCNLASALLSDT
VQHLQASVGEQGEGSTILQHISTLESIYQRDPLKLVATFRQILQGEKKAVMEQFRHLPMP
FHWKQEELKFKTGLRRLQHRVGEIHLLREALQKGAEAGQVSLHSLIETPANGTGPSEALA
MLLQETTGELEAAKALVLKRIQIWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQ
EVGAAGGELEPKTRASLTGRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGLR
FLGAPAKPPLVRADMVTEKQARELSVPQGPGAGAESTGEIINNTVPLENSIPGNCCSALF
KNLLLKKIKRCERKGTESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHGNQDN
NAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQK
IFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIG
FISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDLSIR
SLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPE
LQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQVYPPHSHSIPPYQGLSPEESVNVLSAFQE
PHLQMPPSLGQMSLPFDQPHPQGLLPCQPQEHAVSSPDPLLCSDVTMVEDSCLSQPVTAF
PQGTWIGEDIFPPLLPPTEQDLTKLLLEGQGESGGGSLGAQPLLQPSHYGQSGISMSHMD
LRANPSW
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| BDBM50304429 |
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| n/a |
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| Name | BDBM50304429 |
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| Synonyms: | 2-[4-(4-{[7-(3,5-Difluorobenzyl)-7H-pyrrolo[2,3-d]-pyrimidin-2-yl]amino}phenyl)piperazin-1-yl]acetamide | AS-1810722 | CHEMBL595058 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H25F2N7O |
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| Mol. Mass. | 477.5091 |
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| SMILES | NC(=O)CN1CCN(CC1)c1ccc(Nc2ncc3ccn(Cc4cc(F)cc(F)c4)c3n2)cc1 |
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| Structure | 
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