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PubMed code 19833514

Compile data set for download or QSAR
Found 104 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50302961
PNG
((R)-3-amino-1-((S)-2-(3-(1-(methylsulfonyl)azetidi...)
Show SMILES CS(=O)(=O)N1CC(C1)c1noc(n1)[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H24F3N5O4S/c1-33(30,31)27-9-12(10-27)19-25-20(32-26-19)17-3-2-4-28(17)18(29)7-13(24)5-11-6-15(22)16(23)8-14(11)21/h6,8,12-13,17H,2-5,7,9-10,24H2,1H3/t13-,17+/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP4 transfected in Pichia methanolica expression system after 10 mins by continuous fluorimetric assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50302972
PNG
((R)-3-amino-1-((S)-2-(5-(3-methyloxetan-3-yl)-1,2,...)
Show SMILES CC1(COC1)c1nc(no1)[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H23F3N4O3/c1-20(9-29-10-20)19-25-18(26-30-19)16-3-2-4-27(16)17(28)7-12(24)5-11-6-14(22)15(23)8-13(11)21/h6,8,12,16H,2-5,7,9-10,24H2,1H3/t12-,16+/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP4 transfected in Pichia methanolica expression system after 10 mins by continuous fluorimetric assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50302958
PNG
((R)-3-amino-1-((S)-2-(3-(1-(trifluoromethyl)cyclop...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)C1(CC1)C(F)(F)F)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H20F6N4O2/c21-12-9-14(23)13(22)7-10(12)6-11(27)8-16(31)30-5-1-2-15(30)17-28-18(29-32-17)19(3-4-19)20(24,25)26/h7,9,11,15H,1-6,8,27H2/t11-,15+/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP4 transfected in Pichia methanolica expression system after 10 mins by continuous fluorimetric assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50302956
PNG
((R)-3-amino-1-((S)-2-(3-tert-butyl-1,2,4-oxadiazol...)
Show SMILES CC(C)(C)c1noc(n1)[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H25F3N4O2/c1-20(2,3)19-25-18(29-26-19)16-5-4-6-27(16)17(28)9-12(24)7-11-8-14(22)15(23)10-13(11)21/h8,10,12,16H,4-7,9,24H2,1-3H3/t12-,16+/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP4 transfected in Pichia methanolica expression system after 10 mins by continuous fluorimetric assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50302964
PNG
((R)-3-amino-1-((S)-2-(3-(pyrazin-2-yl)-1,2,4-oxadi...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)-c1cnccn1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H19F3N6O2/c21-13-9-15(23)14(22)7-11(13)6-12(24)8-18(30)29-5-1-2-17(29)20-27-19(28-31-20)16-10-25-3-4-26-16/h3-4,7,9-10,12,17H,1-2,5-6,8,24H2/t12-,17+/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP4 transfected in Pichia methanolica expression system after 10 mins by continuous fluorimetric assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50302966
PNG
((R)-3-amino-1-((S)-2-(3-(3,5-difluoropyridin-2-yl)...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)-c1ncc(F)cc1F)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C21H18F5N5O2/c22-11-6-16(26)19(28-9-11)20-29-21(33-30-20)17-2-1-3-31(17)18(32)7-12(27)4-10-5-14(24)15(25)8-13(10)23/h5-6,8-9,12,17H,1-4,7,27H2/t12-,17+/m1/s1
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n/an/a 3n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP4 transfected in Pichia methanolica expression system after 10 mins by continuous fluorimetric assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50302957
PNG
((R)-3-amino-1-((S)-2-(3-(cyclopropylmethyl)-1,2,4-...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(CC2CC2)no1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H23F3N4O2/c21-14-10-16(23)15(22)8-12(14)7-13(24)9-19(28)27-5-1-2-17(27)20-25-18(26-29-20)6-11-3-4-11/h8,10-11,13,17H,1-7,9,24H2/t13-,17+/m1/s1
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n/an/a 3n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP4 transfected in Pichia methanolica expression system after 10 mins by continuous fluorimetric assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50302959
PNG
((R)-3-amino-1-((S)-2-(3-morpholino-1,2,4-oxadiazol...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)N1CCOCC1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H24F3N5O3/c21-14-11-16(23)15(22)9-12(14)8-13(24)10-18(29)28-3-1-2-17(28)19-25-20(26-31-19)27-4-6-30-7-5-27/h9,11,13,17H,1-8,10,24H2/t13-,17+/m1/s1
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n/an/a 4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP4 transfected in Pichia methanolica expression system after 10 mins by continuous fluorimetric assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50302965
PNG
((R)-3-amino-1-((S)-2-(3-(pyrimidin-2-yl)-1,2,4-oxa...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)-c1ncccn1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H19F3N6O2/c21-13-10-15(23)14(22)8-11(13)7-12(24)9-17(30)29-6-1-3-16(29)20-27-19(28-31-20)18-25-4-2-5-26-18/h2,4-5,8,10,12,16H,1,3,6-7,9,24H2/t12-,16+/m1/s1
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n/an/a 4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP4 transfected in Pichia methanolica expression system after 10 mins by continuous fluorimetric assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50302960
PNG
((R)-3-amino-1-((S)-2-(3-(pyrrolidin-1-yl)-1,2,4-ox...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)N1CCCC1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H24F3N5O2/c21-14-11-16(23)15(22)9-12(14)8-13(24)10-18(29)28-7-3-4-17(28)19-25-20(26-30-19)27-5-1-2-6-27/h9,11,13,17H,1-8,10,24H2/t13-,17+/m1/s1
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n/an/a 4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP4 transfected in Pichia methanolica expression system after 10 mins by continuous fluorimetric assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50302962
PNG
((R)-1-((S)-2-(3-(1-acetylazetidin-3-yl)-1,2,4-oxad...)
Show SMILES CC(=O)N1CC(C1)c1noc(n1)[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C21H24F3N5O3/c1-11(30)28-9-13(10-28)20-26-21(32-27-20)18-3-2-4-29(18)19(31)7-14(25)5-12-6-16(23)17(24)8-15(12)22/h6,8,13-14,18H,2-5,7,9-10,25H2,1H3/t14-,18+/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP4 transfected in Pichia methanolica expression system after 10 mins by continuous fluorimetric assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50302955
PNG
((R)-3-amino-1-((S)-2-(3-cyclopropyl-1,2,4-oxadiazo...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)C1CC1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C19H21F3N4O2/c20-13-9-15(22)14(21)7-11(13)6-12(23)8-17(27)26-5-1-2-16(26)19-24-18(25-28-19)10-3-4-10/h7,9-10,12,16H,1-6,8,23H2/t12-,16+/m1/s1
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n/an/a 7n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP4 transfected in Pichia methanolica expression system after 10 mins by continuous fluorimetric assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50302963
PNG
((R)-3-amino-1-((S)-2-(3-(pyridin-2-yl)-1,2,4-oxadi...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)-c1ccccn1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C21H20F3N5O2/c22-14-11-16(24)15(23)9-12(14)8-13(25)10-19(30)29-7-3-5-18(29)21-27-20(28-31-21)17-4-1-2-6-26-17/h1-2,4,6,9,11,13,18H,3,5,7-8,10,25H2/t13-,18+/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP4 transfected in Pichia methanolica expression system after 10 mins by continuous fluorimetric assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50302968
PNG
((R)-3-amino-1-((S)-2-(5-(1-(trifluoromethyl)cyclop...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1noc(n1)C1(CC1)C(F)(F)F)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H20F6N4O2/c21-12-9-14(23)13(22)7-10(12)6-11(27)8-16(31)30-5-1-2-15(30)17-28-18(32-29-17)19(3-4-19)20(24,25)26/h7,9,11,15H,1-6,8,27H2/t11-,15+/m1/s1
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n/an/a 11n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP4 transfected in Pichia methanolica expression system after 10 mins by continuous fluorimetric assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50302971
PNG
((R)-3-amino-1-((S)-2-(5-(2-fluoropropan-2-yl)-1,2,...)
Show SMILES CC(C)(F)c1nc(no1)[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C19H22F4N4O2/c1-19(2,23)18-25-17(26-29-18)15-4-3-5-27(15)16(28)8-11(24)6-10-7-13(21)14(22)9-12(10)20/h7,9,11,15H,3-6,8,24H2,1-2H3/t11-,15+/m1/s1
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n/an/a 16n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP4 transfected in Pichia methanolica expression system after 10 mins by continuous fluorimetric assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50302967
PNG
((R)-3-amino-1-((S)-2-(5-cyclopropyl-1,2,4-oxadiazo...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1noc(n1)C1CC1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C19H21F3N4O2/c20-13-9-15(22)14(21)7-11(13)6-12(23)8-17(27)26-5-1-2-16(26)18-24-19(28-25-18)10-3-4-10/h7,9-10,12,16H,1-6,8,23H2/t12-,16+/m1/s1
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n/an/a 17n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP4 transfected in Pichia methanolica expression system after 10 mins by continuous fluorimetric assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50302969
PNG
((R)-3-amino-1-((S)-2-(5-(1-hydroxycyclopropyl)-1,2...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1noc(n1)C1(O)CC1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C19H21F3N4O3/c20-12-9-14(22)13(21)7-10(12)6-11(23)8-16(27)26-5-1-2-15(26)17-24-18(29-25-17)19(28)3-4-19/h7,9,11,15,28H,1-6,8,23H2/t11-,15+/m1/s1
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n/an/a 17n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP4 transfected in Pichia methanolica expression system after 10 mins by continuous fluorimetric assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50302970
PNG
((R)-3-amino-1-((S)-2-(5-(1-fluorocyclopropyl)-1,2,...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1noc(n1)C1(F)CC1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C19H20F4N4O2/c20-12-9-14(22)13(21)7-10(12)6-11(24)8-16(28)27-5-1-2-15(27)17-25-18(29-26-17)19(23)3-4-19/h7,9,11,15H,1-6,8,24H2/t11-,15+/m1/s1
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n/an/a 22n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP4 transfected in Pichia methanolica expression system after 10 mins by continuous fluorimetric assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50302974
PNG
((R)-3-amino-1-((S)-2-(1-(pyridin-2-yl)-1H-1,2,4-tr...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1ncn(n1)-c1ccccn1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C21H21F3N6O/c22-15-11-17(24)16(23)9-13(15)8-14(25)10-20(31)29-7-3-4-18(29)21-27-12-30(28-21)19-5-1-2-6-26-19/h1-2,5-6,9,11-12,14,18H,3-4,7-8,10,25H2/t14-,18+/m1/s1
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n/an/a 28n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP4 transfected in Pichia methanolica expression system after 10 mins by continuous fluorimetric assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50302948
PNG
((R)-1-(2-fluorophenyl)-4-((S)-2-(3-phenyl-1,2,4-ox...)
Show SMILES N[C@@H](CCN1CCC[C@H]1c1nc(no1)-c1ccccc1)Cc1ccccc1F |r|
Show InChI InChI=1S/C22H25FN4O/c23-19-10-5-4-9-17(19)15-18(24)12-14-27-13-6-11-20(27)22-25-21(26-28-22)16-7-2-1-3-8-16/h1-5,7-10,18,20H,6,11-15,24H2/t18-,20-/m0/s1
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n/an/a 31n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP4 transfected in Pichia methanolica expression system after 10 mins by continuous fluorimetric assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50302973
PNG
((R)-3-amino-1-((S)-2-(5-tert-butyl-1,2,4-oxadiazol...)
Show SMILES CC(C)(C)c1nc(no1)[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H25F3N4O2/c1-20(2,3)19-25-18(26-29-19)16-5-4-6-27(16)17(28)9-12(24)7-11-8-14(22)15(23)10-13(11)21/h8,10,12,16H,4-7,9,24H2,1-3H3/t12-,16+/m1/s1
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n/an/a 32n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP4 transfected in Pichia methanolica expression system after 10 mins by continuous fluorimetric assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50302950
PNG
((R)-1-(2-fluorophenyl)-4-((S)-2-(1-phenyl-1H-1,2,4...)
Show SMILES N[C@@H](CCN1CCC[C@H]1c1ncn(n1)-c1ccccc1)Cc1ccccc1F |r|
Show InChI InChI=1S/C22H26FN5/c23-20-10-5-4-7-17(20)15-18(24)12-14-27-13-6-11-21(27)22-25-16-28(26-22)19-8-2-1-3-9-19/h1-5,7-10,16,18,21H,6,11-15,24H2/t18-,21-/m0/s1
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n/an/a 62n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP4 transfected in Pichia methanolica expression system after 10 mins by continuous fluorimetric assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50302952
PNG
((R)-1-(2-fluorophenyl)-4-((S)-2-(4-phenyloxazol-2-...)
Show SMILES N[C@@H](CCN1CCC[C@H]1c1nc(co1)-c1ccccc1)Cc1ccccc1F |r|
Show InChI InChI=1S/C23H26FN3O/c24-20-10-5-4-9-18(20)15-19(25)12-14-27-13-6-11-22(27)23-26-21(16-28-23)17-7-2-1-3-8-17/h1-5,7-10,16,19,22H,6,11-15,25H2/t19-,22-/m0/s1
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n/an/a 76n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP4 transfected in Pichia methanolica expression system after 10 mins by continuous fluorimetric assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50302947
PNG
(CHEMBL567263 | N-(((S)-1-((R)-3-amino-4-(2-fluorop...)
Show SMILES N[C@@H](CCN1CCC[C@H]1CNC(=O)c1ccccc1)Cc1ccccc1F |r|
Show InChI InChI=1S/C22H28FN3O/c23-21-11-5-4-9-18(21)15-19(24)12-14-26-13-6-10-20(26)16-25-22(27)17-7-2-1-3-8-17/h1-5,7-9,11,19-20H,6,10,12-16,24H2,(H,25,27)/t19-,20-/m0/s1
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n/an/a 90n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP4 transfected in Pichia methanolica expression system after 10 mins by continuous fluorimetric assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50302949
PNG
((R)-1-(2-fluorophenyl)-4-((S)-2-(5-phenyl-1,2,4-ox...)
Show SMILES N[C@@H](CCN1CCC[C@H]1c1noc(n1)-c1ccccc1)Cc1ccccc1F |r|
Show InChI InChI=1S/C22H25FN4O/c23-19-10-5-4-9-17(19)15-18(24)12-14-27-13-6-11-20(27)21-25-22(28-26-21)16-7-2-1-3-8-16/h1-5,7-10,18,20H,6,11-15,24H2/t18-,20-/m0/s1
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n/an/a 90n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP4 transfected in Pichia methanolica expression system after 10 mins by continuous fluorimetric assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50302951
PNG
((R)-1-(2-fluorophenyl)-4-((S)-2-(5-phenyl-1,3,4-ox...)
Show SMILES N[C@@H](CCN1CCC[C@H]1c1nnc(o1)-c1ccccc1)Cc1ccccc1F |r|
Show InChI InChI=1S/C22H25FN4O/c23-19-10-5-4-9-17(19)15-18(24)12-14-27-13-6-11-20(27)22-26-25-21(28-22)16-7-2-1-3-8-16/h1-5,7-10,18,20H,6,11-15,24H2/t18-,20-/m0/s1
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n/an/a 120n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP4 transfected in Pichia methanolica expression system after 10 mins by continuous fluorimetric assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50302954
PNG
((R)-1-(2-fluorophenyl)-4-((S)-2-(1-phenyl-1H-1,2,3...)
Show SMILES N[C@@H](CCN1CCC[C@H]1c1cn(nn1)-c1ccccc1)Cc1ccccc1F |r|
Show InChI InChI=1S/C22H26FN5/c23-20-10-5-4-7-17(20)15-18(24)12-14-27-13-6-11-22(27)21-16-28(26-25-21)19-8-2-1-3-9-19/h1-5,7-10,16,18,22H,6,11-15,24H2/t18-,22-/m0/s1
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n/an/a 130n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP4 transfected in Pichia methanolica expression system after 10 mins by continuous fluorimetric assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))		BDBM50302953
PNG
((R)-1-(2-fluorophenyl)-4-((S)-2-(1-phenyl-1H-pyraz...)
Show SMILES N[C@@H](CCN1CCC[C@H]1c1ccn(n1)-c1ccccc1)Cc1ccccc1F |r|
Show InChI InChI=1S/C23H27FN4/c24-21-10-5-4-7-18(21)17-19(25)12-15-27-14-6-11-23(27)22-13-16-28(26-22)20-8-2-1-3-9-20/h1-5,7-10,13,16,19,23H,6,11-12,14-15,17,25H2/t19-,23-/m0/s1
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n/an/a 180n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant DPP4 transfected in Pichia methanolica expression system after 10 mins by continuous fluorimetric assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM50302963
PNG
((R)-3-amino-1-((S)-2-(3-(pyridin-2-yl)-1,2,4-oxadi...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)-c1ccccn1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C21H20F3N5O2/c22-14-11-16(24)15(23)9-12(14)8-13(25)10-19(30)29-7-3-5-18(29)21-27-20(28-31-21)17-4-1-2-6-26-17/h1-2,4,6,9,11,13,18H,3,5,7-8,10,25H2/t13-,18+/m1/s1
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n/an/a 886n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of DPP7

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50302963
PNG
((R)-3-amino-1-((S)-2-(3-(pyridin-2-yl)-1,2,4-oxadi...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)-c1ccccn1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C21H20F3N5O2/c22-14-11-16(24)15(23)9-12(14)8-13(25)10-19(30)29-7-3-5-18(29)21-27-20(28-31-21)17-4-1-2-6-26-17/h1-2,4,6,9,11,13,18H,3,5,7-8,10,25H2/t13-,18+/m1/s1
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n/an/a 910n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP9 expressed in baculovirus system after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50302964
PNG
((R)-3-amino-1-((S)-2-(3-(pyrazin-2-yl)-1,2,4-oxadi...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)-c1cnccn1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H19F3N6O2/c21-13-9-15(23)14(22)7-11(13)6-12(24)8-18(30)29-5-1-2-17(29)20-27-19(28-31-20)16-10-25-3-4-26-16/h3-4,7,9-10,12,17H,1-2,5-6,8,24H2/t12-,17+/m1/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP9 expressed in baculovirus system after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM50302966
PNG
((R)-3-amino-1-((S)-2-(3-(3,5-difluoropyridin-2-yl)...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)-c1ncc(F)cc1F)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C21H18F5N5O2/c22-11-6-16(26)19(28-9-11)20-29-21(33-30-20)17-2-1-3-31(17)18(32)7-12(27)4-10-5-14(24)15(25)8-13(10)23/h5-6,8-9,12,17H,1-4,7,27H2/t12-,17+/m1/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of DPP7

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM50302965
PNG
((R)-3-amino-1-((S)-2-(3-(pyrimidin-2-yl)-1,2,4-oxa...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)-c1ncccn1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H19F3N6O2/c21-13-10-15(23)14(22)8-11(13)7-12(24)9-17(30)29-6-1-3-16(29)20-27-19(28-31-20)18-25-4-2-5-26-18/h2,4-5,8,10,12,16H,1,3,6-7,9,24H2/t12-,16+/m1/s1
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n/an/a 2.20E+3n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of DPP7

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM50302964
PNG
((R)-3-amino-1-((S)-2-(3-(pyrazin-2-yl)-1,2,4-oxadi...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)-c1cnccn1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H19F3N6O2/c21-13-9-15(23)14(22)7-11(13)6-12(24)8-18(30)29-5-1-2-17(29)20-27-19(28-31-20)16-10-25-3-4-26-16/h3-4,7,9-10,12,17H,1-2,5-6,8,24H2/t12-,17+/m1/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of DPP7

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50302963
PNG
((R)-3-amino-1-((S)-2-(3-(pyridin-2-yl)-1,2,4-oxadi...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)-c1ccccn1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C21H20F3N5O2/c22-14-11-16(24)15(23)9-12(14)8-13(25)10-19(30)29-7-3-5-18(29)21-27-20(28-31-21)17-4-1-2-6-26-17/h1-2,4,6,9,11,13,18H,3,5,7-8,10,25H2/t13-,18+/m1/s1
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n/an/a 2.50E+3n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 expressed in baculovirus system after 15 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM50302958
PNG
((R)-3-amino-1-((S)-2-(3-(1-(trifluoromethyl)cyclop...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)C1(CC1)C(F)(F)F)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H20F6N4O2/c21-12-9-14(23)13(22)7-10(12)6-11(27)8-16(31)30-5-1-2-15(30)17-28-18(29-32-17)19(3-4-19)20(24,25)26/h7,9,11,15H,1-6,8,27H2/t11-,15+/m1/s1
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n/an/a 2.80E+3n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of DPP7

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM50302960
PNG
((R)-3-amino-1-((S)-2-(3-(pyrrolidin-1-yl)-1,2,4-ox...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)N1CCCC1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H24F3N5O2/c21-14-11-16(23)15(22)9-12(14)8-13(24)10-18(29)28-7-3-4-17(28)19-25-20(26-30-19)27-5-1-2-6-27/h9,11,13,17H,1-8,10,24H2/t13-,17+/m1/s1
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n/an/a 3.20E+3n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of DPP7

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM50302955
PNG
((R)-3-amino-1-((S)-2-(3-cyclopropyl-1,2,4-oxadiazo...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)C1CC1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C19H21F3N4O2/c20-13-9-15(22)14(21)7-11(13)6-12(23)8-17(27)26-5-1-2-16(26)19-24-18(25-28-19)10-3-4-10/h7,9-10,12,16H,1-6,8,23H2/t12-,16+/m1/s1
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n/an/a 3.80E+3n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of DPP7

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM50302961
PNG
((R)-3-amino-1-((S)-2-(3-(1-(methylsulfonyl)azetidi...)
Show SMILES CS(=O)(=O)N1CC(C1)c1noc(n1)[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H24F3N5O4S/c1-33(30,31)27-9-12(10-27)19-25-20(32-26-19)17-3-2-4-28(17)18(29)7-13(24)5-11-6-15(22)16(23)8-14(11)21/h6,8,12-13,17H,2-5,7,9-10,24H2,1H3/t13-,17+/m1/s1
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n/an/a 3.80E+3n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of DPP7

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50302966
PNG
((R)-3-amino-1-((S)-2-(3-(3,5-difluoropyridin-2-yl)...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)-c1ncc(F)cc1F)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C21H18F5N5O2/c22-11-6-16(26)19(28-9-11)20-29-21(33-30-20)17-2-1-3-31(17)18(32)7-12(27)4-10-5-14(24)15(25)8-13(10)23/h5-6,8-9,12,17H,1-4,7,27H2/t12-,17+/m1/s1
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n/an/a 3.90E+3n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP9 expressed in baculovirus system after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM50302957
PNG
((R)-3-amino-1-((S)-2-(3-(cyclopropylmethyl)-1,2,4-...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(CC2CC2)no1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H23F3N4O2/c21-14-10-16(23)15(22)8-12(14)7-13(24)9-19(28)27-5-1-2-17(27)20-25-18(26-29-20)6-11-3-4-11/h8,10-11,13,17H,1-7,9,24H2/t13-,17+/m1/s1
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n/an/a 4.00E+3n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of DPP7

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50302964
PNG
((R)-3-amino-1-((S)-2-(3-(pyrazin-2-yl)-1,2,4-oxadi...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)-c1cnccn1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H19F3N6O2/c21-13-9-15(23)14(22)7-11(13)6-12(24)8-18(30)29-5-1-2-17(29)20-27-19(28-31-20)16-10-25-3-4-26-16/h3-4,7,9-10,12,17H,1-2,5-6,8,24H2/t12-,17+/m1/s1
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n/an/a 4.50E+3n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 expressed in baculovirus system after 15 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50302959
PNG
((R)-3-amino-1-((S)-2-(3-morpholino-1,2,4-oxadiazol...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)N1CCOCC1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H24F3N5O3/c21-14-11-16(23)15(22)9-12(14)8-13(24)10-18(29)28-3-1-2-17(28)19-25-20(26-31-19)27-4-6-30-7-5-27/h9,11,13,17H,1-8,10,24H2/t13-,17+/m1/s1
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n/an/a 4.80E+3n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP9 expressed in baculovirus system after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50302965
PNG
((R)-3-amino-1-((S)-2-(3-(pyrimidin-2-yl)-1,2,4-oxa...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)-c1ncccn1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H19F3N6O2/c21-13-10-15(23)14(22)8-11(13)7-12(24)9-17(30)29-6-1-3-16(29)20-27-19(28-31-20)18-25-4-2-5-26-18/h2,4-5,8,10,12,16H,1,3,6-7,9,24H2/t12-,16+/m1/s1
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n/an/a 5.10E+3n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP9 expressed in baculovirus system after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM50302959
PNG
((R)-3-amino-1-((S)-2-(3-morpholino-1,2,4-oxadiazol...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)N1CCOCC1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H24F3N5O3/c21-14-11-16(23)15(22)9-12(14)8-13(24)10-18(29)28-3-1-2-17(28)19-25-20(26-31-19)27-4-6-30-7-5-27/h9,11,13,17H,1-8,10,24H2/t13-,17+/m1/s1
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n/an/a 5.60E+3n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of DPP7

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50302960
PNG
((R)-3-amino-1-((S)-2-(3-(pyrrolidin-1-yl)-1,2,4-ox...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)N1CCCC1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H24F3N5O2/c21-14-11-16(23)15(22)9-12(14)8-13(24)10-18(29)28-7-3-4-17(28)19-25-20(26-30-19)27-5-1-2-6-27/h9,11,13,17H,1-8,10,24H2/t13-,17+/m1/s1
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n/an/a 6.60E+3n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP9 expressed in baculovirus system after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM50302956
PNG
((R)-3-amino-1-((S)-2-(3-tert-butyl-1,2,4-oxadiazol...)
Show SMILES CC(C)(C)c1noc(n1)[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H25F3N4O2/c1-20(2,3)19-25-18(29-26-19)16-5-4-6-27(16)17(28)9-12(24)7-11-8-14(22)15(23)10-13(11)21/h8,10,12,16H,4-7,9,24H2,1-3H3/t12-,16+/m1/s1
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n/an/a 7.00E+3n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of DPP7

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50302958
PNG
((R)-3-amino-1-((S)-2-(3-(1-(trifluoromethyl)cyclop...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)C1(CC1)C(F)(F)F)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H20F6N4O2/c21-12-9-14(23)13(22)7-10(12)6-11(27)8-16(31)30-5-1-2-15(30)17-28-18(29-32-17)19(3-4-19)20(24,25)26/h7,9,11,15H,1-6,8,27H2/t11-,15+/m1/s1
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n/an/a 7.40E+3n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP9 expressed in baculovirus system after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50302958
PNG
((R)-3-amino-1-((S)-2-(3-(1-(trifluoromethyl)cyclop...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)C1(CC1)C(F)(F)F)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H20F6N4O2/c21-12-9-14(23)13(22)7-10(12)6-11(27)8-16(31)30-5-1-2-15(30)17-28-18(29-32-17)19(3-4-19)20(24,25)26/h7,9,11,15H,1-6,8,27H2/t11-,15+/m1/s1
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n/an/a 8.20E+3n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 expressed in baculovirus system after 15 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50302961
PNG
((R)-3-amino-1-((S)-2-(3-(1-(methylsulfonyl)azetidi...)
Show SMILES CS(=O)(=O)N1CC(C1)c1noc(n1)[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H24F3N5O4S/c1-33(30,31)27-9-12(10-27)19-25-20(32-26-19)17-3-2-4-28(17)18(29)7-13(24)5-11-6-15(22)16(23)8-14(11)21/h6,8,12-13,17H,2-5,7,9-10,24H2,1H3/t13-,17+/m1/s1
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n/an/a 8.20E+3n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP9 expressed in baculovirus system after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50302962
PNG
((R)-1-((S)-2-(3-(1-acetylazetidin-3-yl)-1,2,4-oxad...)
Show SMILES CC(=O)N1CC(C1)c1noc(n1)[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C21H24F3N5O3/c1-11(30)28-9-13(10-28)20-26-21(32-27-20)18-3-2-4-29(18)19(31)7-14(25)5-12-6-16(23)17(24)8-15(12)22/h6,8,13-14,18H,2-5,7,9-10,25H2,1H3/t14-,18+/m1/s1
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n/an/a 9.80E+3n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP9 expressed in baculovirus system after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM50302968
PNG
((R)-3-amino-1-((S)-2-(5-(1-(trifluoromethyl)cyclop...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1noc(n1)C1(CC1)C(F)(F)F)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H20F6N4O2/c21-12-9-14(23)13(22)7-10(12)6-11(27)8-16(31)30-5-1-2-15(30)17-28-18(32-29-17)19(3-4-19)20(24,25)26/h7,9,11,15H,1-6,8,27H2/t11-,15+/m1/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of DPP7

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50302966
PNG
((R)-3-amino-1-((S)-2-(3-(3,5-difluoropyridin-2-yl)...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)-c1ncc(F)cc1F)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C21H18F5N5O2/c22-11-6-16(26)19(28-9-11)20-29-21(33-30-20)17-2-1-3-31(17)18(32)7-12(27)4-10-5-14(24)15(25)8-13(10)23/h5-6,8-9,12,17H,1-4,7,27H2/t12-,17+/m1/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 expressed in baculovirus system after 15 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM50302967
PNG
((R)-3-amino-1-((S)-2-(5-cyclopropyl-1,2,4-oxadiazo...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1noc(n1)C1CC1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C19H21F3N4O2/c20-13-9-15(22)14(21)7-11(13)6-12(23)8-17(27)26-5-1-2-16(26)18-24-19(28-25-18)10-3-4-10/h7,9-10,12,16H,1-6,8,23H2/t12-,16+/m1/s1
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n/an/a 1.10E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of DPP7

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50302957
PNG
((R)-3-amino-1-((S)-2-(3-(cyclopropylmethyl)-1,2,4-...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(CC2CC2)no1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H23F3N4O2/c21-14-10-16(23)15(22)8-12(14)7-13(24)9-19(28)27-5-1-2-17(27)20-25-18(26-29-20)6-11-3-4-11/h8,10-11,13,17H,1-7,9,24H2/t13-,17+/m1/s1
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n/an/a 1.10E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP9 expressed in baculovirus system after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50302967
PNG
((R)-3-amino-1-((S)-2-(5-cyclopropyl-1,2,4-oxadiazo...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1noc(n1)C1CC1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C19H21F3N4O2/c20-13-9-15(22)14(21)7-11(13)6-12(23)8-17(27)26-5-1-2-16(26)18-24-19(28-25-18)10-3-4-10/h7,9-10,12,16H,1-6,8,23H2/t12-,16+/m1/s1
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n/an/a 1.20E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP9 expressed in baculovirus system after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50302961
PNG
((R)-3-amino-1-((S)-2-(3-(1-(methylsulfonyl)azetidi...)
Show SMILES CS(=O)(=O)N1CC(C1)c1noc(n1)[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H24F3N5O4S/c1-33(30,31)27-9-12(10-27)19-25-20(32-26-19)17-3-2-4-28(17)18(29)7-13(24)5-11-6-15(22)16(23)8-14(11)21/h6,8,12-13,17H,2-5,7,9-10,24H2,1H3/t13-,17+/m1/s1
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n/an/a 1.30E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 expressed in baculovirus system after 15 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50302970
PNG
((R)-3-amino-1-((S)-2-(5-(1-fluorocyclopropyl)-1,2,...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1noc(n1)C1(F)CC1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C19H20F4N4O2/c20-12-9-14(22)13(21)7-10(12)6-11(24)8-16(28)27-5-1-2-15(27)17-25-18(29-26-17)19(23)3-4-19/h7,9,11,15H,1-6,8,24H2/t11-,15+/m1/s1
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n/an/a 1.40E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP9 expressed in baculovirus system after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM50302970
PNG
((R)-3-amino-1-((S)-2-(5-(1-fluorocyclopropyl)-1,2,...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1noc(n1)C1(F)CC1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C19H20F4N4O2/c20-12-9-14(22)13(21)7-10(12)6-11(24)8-16(28)27-5-1-2-15(27)17-25-18(29-26-17)19(23)3-4-19/h7,9,11,15H,1-6,8,24H2/t11-,15+/m1/s1
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n/an/a 1.40E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of DPP7

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))		BDBM50302963
PNG
((R)-3-amino-1-((S)-2-(3-(pyridin-2-yl)-1,2,4-oxadi...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)-c1ccccn1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C21H20F3N5O2/c22-14-11-16(24)15(23)9-12(14)8-13(25)10-19(30)29-7-3-5-18(29)21-27-20(28-31-21)17-4-1-2-6-26-17/h1-2,4,6,9,11,13,18H,3,5,7-8,10,25H2/t13-,18+/m1/s1
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n/an/a 1.50E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM50302971
PNG
((R)-3-amino-1-((S)-2-(5-(2-fluoropropan-2-yl)-1,2,...)
Show SMILES CC(C)(F)c1nc(no1)[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C19H22F4N4O2/c1-19(2,23)18-25-17(26-29-18)15-4-3-5-27(15)16(28)8-11(24)6-10-7-13(21)14(22)9-12(10)20/h7,9,11,15H,3-6,8,24H2,1-2H3/t11-,15+/m1/s1
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n/an/a 1.60E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of DPP7

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM50302962
PNG
((R)-1-((S)-2-(3-(1-acetylazetidin-3-yl)-1,2,4-oxad...)
Show SMILES CC(=O)N1CC(C1)c1noc(n1)[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C21H24F3N5O3/c1-11(30)28-9-13(10-28)20-26-21(32-27-20)18-3-2-4-29(18)19(31)7-14(25)5-12-6-16(23)17(24)8-15(12)22/h6,8,13-14,18H,2-5,7,9-10,25H2,1H3/t14-,18+/m1/s1
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n/an/a 1.70E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of DPP7

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50302968
PNG
((R)-3-amino-1-((S)-2-(5-(1-(trifluoromethyl)cyclop...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1noc(n1)C1(CC1)C(F)(F)F)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H20F6N4O2/c21-12-9-14(23)13(22)7-10(12)6-11(27)8-16(31)30-5-1-2-15(30)17-28-18(32-29-17)19(3-4-19)20(24,25)26/h7,9,11,15H,1-6,8,27H2/t11-,15+/m1/s1
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n/an/a 1.70E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP9 expressed in baculovirus system after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50302955
PNG
((R)-3-amino-1-((S)-2-(3-cyclopropyl-1,2,4-oxadiazo...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)C1CC1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C19H21F3N4O2/c20-13-9-15(22)14(21)7-11(13)6-12(23)8-17(27)26-5-1-2-16(26)19-24-18(25-28-19)10-3-4-10/h7,9-10,12,16H,1-6,8,23H2/t12-,16+/m1/s1
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n/an/a 1.70E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP9 expressed in baculovirus system after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50302962
PNG
((R)-1-((S)-2-(3-(1-acetylazetidin-3-yl)-1,2,4-oxad...)
Show SMILES CC(=O)N1CC(C1)c1noc(n1)[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C21H24F3N5O3/c1-11(30)28-9-13(10-28)20-26-21(32-27-20)18-3-2-4-29(18)19(31)7-14(25)5-12-6-16(23)17(24)8-15(12)22/h6,8,13-14,18H,2-5,7,9-10,25H2,1H3/t14-,18+/m1/s1
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n/an/a 1.80E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 expressed in baculovirus system after 15 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50302969
PNG
((R)-3-amino-1-((S)-2-(5-(1-hydroxycyclopropyl)-1,2...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1noc(n1)C1(O)CC1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C19H21F3N4O3/c20-12-9-14(22)13(21)7-10(12)6-11(23)8-16(27)26-5-1-2-15(26)17-24-18(29-25-17)19(28)3-4-19/h7,9,11,15,28H,1-6,8,23H2/t11-,15+/m1/s1
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n/an/a 1.90E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP9 expressed in baculovirus system after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50302959
PNG
((R)-3-amino-1-((S)-2-(3-morpholino-1,2,4-oxadiazol...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)N1CCOCC1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H24F3N5O3/c21-14-11-16(23)15(22)9-12(14)8-13(24)10-18(29)28-3-1-2-17(28)19-25-20(26-31-19)27-4-6-30-7-5-27/h9,11,13,17H,1-8,10,24H2/t13-,17+/m1/s1
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n/an/a 2.10E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 expressed in baculovirus system after 15 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50302967
PNG
((R)-3-amino-1-((S)-2-(5-cyclopropyl-1,2,4-oxadiazo...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1noc(n1)C1CC1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C19H21F3N4O2/c20-13-9-15(22)14(21)7-11(13)6-12(23)8-17(27)26-5-1-2-16(26)18-24-19(28-25-18)10-3-4-10/h7,9-10,12,16H,1-6,8,23H2/t12-,16+/m1/s1
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n/an/a 2.30E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 expressed in baculovirus system after 15 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM50302969
PNG
((R)-3-amino-1-((S)-2-(5-(1-hydroxycyclopropyl)-1,2...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1noc(n1)C1(O)CC1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C19H21F3N4O3/c20-12-9-14(22)13(21)7-10(12)6-11(23)8-16(27)26-5-1-2-15(26)17-24-18(29-25-17)19(28)3-4-19/h7,9,11,15,28H,1-6,8,23H2/t11-,15+/m1/s1
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n/an/a 2.30E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of DPP7

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50302956
PNG
((R)-3-amino-1-((S)-2-(3-tert-butyl-1,2,4-oxadiazol...)
Show SMILES CC(C)(C)c1noc(n1)[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H25F3N4O2/c1-20(2,3)19-25-18(29-26-19)16-5-4-6-27(16)17(28)9-12(24)7-11-8-14(22)15(23)10-13(11)21/h8,10,12,16H,4-7,9,24H2,1-3H3/t12-,16+/m1/s1
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n/an/a 2.40E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP9 expressed in baculovirus system after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50302973
PNG
((R)-3-amino-1-((S)-2-(5-tert-butyl-1,2,4-oxadiazol...)
Show SMILES CC(C)(C)c1nc(no1)[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H25F3N4O2/c1-20(2,3)19-25-18(26-29-19)16-5-4-6-27(16)17(28)9-12(24)7-11-8-14(22)15(23)10-13(11)21/h8,10,12,16H,4-7,9,24H2,1-3H3/t12-,16+/m1/s1
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n/an/a 2.50E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 expressed in baculovirus system after 15 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50302955
PNG
((R)-3-amino-1-((S)-2-(3-cyclopropyl-1,2,4-oxadiazo...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)C1CC1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C19H21F3N4O2/c20-13-9-15(22)14(21)7-11(13)6-12(23)8-17(27)26-5-1-2-16(26)19-24-18(25-28-19)10-3-4-10/h7,9-10,12,16H,1-6,8,23H2/t12-,16+/m1/s1
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n/an/a 2.60E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 expressed in baculovirus system after 15 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50302968
PNG
((R)-3-amino-1-((S)-2-(5-(1-(trifluoromethyl)cyclop...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1noc(n1)C1(CC1)C(F)(F)F)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H20F6N4O2/c21-12-9-14(23)13(22)7-10(12)6-11(27)8-16(31)30-5-1-2-15(30)17-28-18(32-29-17)19(3-4-19)20(24,25)26/h7,9,11,15H,1-6,8,27H2/t11-,15+/m1/s1
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n/an/a 2.60E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 expressed in baculovirus system after 15 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50302960
PNG
((R)-3-amino-1-((S)-2-(3-(pyrrolidin-1-yl)-1,2,4-ox...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)N1CCCC1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H24F3N5O2/c21-14-11-16(23)15(22)9-12(14)8-13(24)10-18(29)28-7-3-4-17(28)19-25-20(26-30-19)27-5-1-2-6-27/h9,11,13,17H,1-8,10,24H2/t13-,17+/m1/s1
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n/an/a 2.70E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 expressed in baculovirus system after 15 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50302972
PNG
((R)-3-amino-1-((S)-2-(5-(3-methyloxetan-3-yl)-1,2,...)
Show SMILES CC1(COC1)c1nc(no1)[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H23F3N4O3/c1-20(9-29-10-20)19-25-18(26-30-19)16-3-2-4-27(16)17(28)7-12(24)5-11-6-14(22)15(23)8-13(11)21/h6,8,12,16H,2-5,7,9-10,24H2,1H3/t12-,16+/m1/s1
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n/an/a 2.70E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP9 expressed in baculovirus system after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50302971
PNG
((R)-3-amino-1-((S)-2-(5-(2-fluoropropan-2-yl)-1,2,...)
Show SMILES CC(C)(F)c1nc(no1)[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C19H22F4N4O2/c1-19(2,23)18-25-17(26-29-18)15-4-3-5-27(15)16(28)8-11(24)6-10-7-13(21)14(22)9-12(10)20/h7,9,11,15H,3-6,8,24H2,1-2H3/t11-,15+/m1/s1
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n/an/a 2.70E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP9 expressed in baculovirus system after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))		BDBM50302968
PNG
((R)-3-amino-1-((S)-2-(5-(1-(trifluoromethyl)cyclop...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1noc(n1)C1(CC1)C(F)(F)F)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H20F6N4O2/c21-12-9-14(23)13(22)7-10(12)6-11(27)8-16(31)30-5-1-2-15(30)17-28-18(32-29-17)19(3-4-19)20(24,25)26/h7,9,11,15H,1-6,8,27H2/t11-,15+/m1/s1
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n/an/a 3.30E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50302965
PNG
((R)-3-amino-1-((S)-2-(3-(pyrimidin-2-yl)-1,2,4-oxa...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)-c1ncccn1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H19F3N6O2/c21-13-10-15(23)14(22)8-11(13)7-12(24)9-17(30)29-6-1-3-16(29)20-27-19(28-31-20)18-25-4-2-5-26-18/h2,4-5,8,10,12,16H,1,3,6-7,9,24H2/t12-,16+/m1/s1
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n/an/a 3.40E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 expressed in baculovirus system after 15 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50302969
PNG
((R)-3-amino-1-((S)-2-(5-(1-hydroxycyclopropyl)-1,2...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1noc(n1)C1(O)CC1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C19H21F3N4O3/c20-12-9-14(22)13(21)7-10(12)6-11(23)8-16(27)26-5-1-2-15(26)17-24-18(29-25-17)19(28)3-4-19/h7,9,11,15,28H,1-6,8,23H2/t11-,15+/m1/s1
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n/an/a 3.50E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 expressed in baculovirus system after 15 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 9


(Homo sapiens (Human))		BDBM50302973
PNG
((R)-3-amino-1-((S)-2-(5-tert-butyl-1,2,4-oxadiazol...)
Show SMILES CC(C)(C)c1nc(no1)[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H25F3N4O2/c1-20(2,3)19-25-18(26-29-19)16-5-4-6-27(16)17(28)9-12(24)7-11-8-14(22)15(23)10-13(11)21/h8,10,12,16H,4-7,9,24H2,1-3H3/t12-,16+/m1/s1
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n/an/a 3.60E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP9 expressed in baculovirus system after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM50302973
PNG
((R)-3-amino-1-((S)-2-(5-tert-butyl-1,2,4-oxadiazol...)
Show SMILES CC(C)(C)c1nc(no1)[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H25F3N4O2/c1-20(2,3)19-25-18(26-29-19)16-5-4-6-27(16)17(28)9-12(24)7-11-8-14(22)15(23)10-13(11)21/h8,10,12,16H,4-7,9,24H2,1-3H3/t12-,16+/m1/s1
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n/an/a 3.60E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of DPP7

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50302957
PNG
((R)-3-amino-1-((S)-2-(3-(cyclopropylmethyl)-1,2,4-...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(CC2CC2)no1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H23F3N4O2/c21-14-10-16(23)15(22)8-12(14)7-13(24)9-19(28)27-5-1-2-17(27)20-25-18(26-29-20)6-11-3-4-11/h8,10-11,13,17H,1-7,9,24H2/t13-,17+/m1/s1
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n/an/a 3.70E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 expressed in baculovirus system after 15 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 2


(Homo sapiens (Human))		BDBM50302972
PNG
((R)-3-amino-1-((S)-2-(5-(3-methyloxetan-3-yl)-1,2,...)
Show SMILES CC1(COC1)c1nc(no1)[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H23F3N4O3/c1-20(9-29-10-20)19-25-18(26-30-19)16-3-2-4-27(16)17(28)7-12(24)5-11-6-14(22)15(23)8-13(11)21/h6,8,12,16H,2-5,7,9-10,24H2,1H3/t12-,16+/m1/s1
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n/an/a 3.80E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of DPP7

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))		BDBM50302956
PNG
((R)-3-amino-1-((S)-2-(3-tert-butyl-1,2,4-oxadiazol...)
Show SMILES CC(C)(C)c1noc(n1)[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H25F3N4O2/c1-20(2,3)19-25-18(29-26-19)16-5-4-6-27(16)17(28)9-12(24)7-11-8-14(22)15(23)10-13(11)21/h8,10,12,16H,4-7,9,24H2,1-3H3/t12-,16+/m1/s1
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n/an/a 3.90E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50302970
PNG
((R)-3-amino-1-((S)-2-(5-(1-fluorocyclopropyl)-1,2,...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1noc(n1)C1(F)CC1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C19H20F4N4O2/c20-12-9-14(22)13(21)7-10(12)6-11(24)8-16(28)27-5-1-2-15(27)17-25-18(29-26-17)19(23)3-4-19/h7,9,11,15H,1-6,8,24H2/t11-,15+/m1/s1
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n/an/a 4.10E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 expressed in baculovirus system after 15 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50302971
PNG
((R)-3-amino-1-((S)-2-(5-(2-fluoropropan-2-yl)-1,2,...)
Show SMILES CC(C)(F)c1nc(no1)[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C19H22F4N4O2/c1-19(2,23)18-25-17(26-29-18)15-4-3-5-27(15)16(28)8-11(24)6-10-7-13(21)14(22)9-12(10)20/h7,9,11,15H,3-6,8,24H2,1-2H3/t11-,15+/m1/s1
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n/an/a 4.10E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 expressed in baculovirus system after 15 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))		BDBM50302961
PNG
((R)-3-amino-1-((S)-2-(3-(1-(methylsulfonyl)azetidi...)
Show SMILES CS(=O)(=O)N1CC(C1)c1noc(n1)[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H24F3N5O4S/c1-33(30,31)27-9-12(10-27)19-25-20(32-26-19)17-3-2-4-28(17)18(29)7-13(24)5-11-6-15(22)16(23)8-14(11)21/h6,8,12-13,17H,2-5,7,9-10,24H2,1H3/t13-,17+/m1/s1
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n/an/a 4.30E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))		BDBM50302969
PNG
((R)-3-amino-1-((S)-2-(5-(1-hydroxycyclopropyl)-1,2...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1noc(n1)C1(O)CC1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C19H21F3N4O3/c20-12-9-14(22)13(21)7-10(12)6-11(23)8-16(27)26-5-1-2-15(26)17-24-18(29-25-17)19(28)3-4-19/h7,9,11,15,28H,1-6,8,23H2/t11-,15+/m1/s1
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n/an/a 4.50E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))		BDBM50302965
PNG
((R)-3-amino-1-((S)-2-(3-(pyrimidin-2-yl)-1,2,4-oxa...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)-c1ncccn1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H19F3N6O2/c21-13-10-15(23)14(22)8-11(13)7-12(24)9-17(30)29-6-1-3-16(29)20-27-19(28-31-20)18-25-4-2-5-26-18/h2,4-5,8,10,12,16H,1,3,6-7,9,24H2/t12-,16+/m1/s1
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n/an/a 4.80E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50302956
PNG
((R)-3-amino-1-((S)-2-(3-tert-butyl-1,2,4-oxadiazol...)
Show SMILES CC(C)(C)c1noc(n1)[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H25F3N4O2/c1-20(2,3)19-25-18(29-26-19)16-5-4-6-27(16)17(28)9-12(24)7-11-8-14(22)15(23)10-13(11)21/h8,10,12,16H,4-7,9,24H2,1-3H3/t12-,16+/m1/s1
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n/an/a 5.20E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 expressed in baculovirus system after 15 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))		BDBM50302955
PNG
((R)-3-amino-1-((S)-2-(3-cyclopropyl-1,2,4-oxadiazo...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)C1CC1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C19H21F3N4O2/c20-13-9-15(22)14(21)7-11(13)6-12(23)8-17(27)26-5-1-2-16(26)19-24-18(25-28-19)10-3-4-10/h7,9-10,12,16H,1-6,8,23H2/t12-,16+/m1/s1
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n/an/a 5.70E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))		BDBM50302958
PNG
((R)-3-amino-1-((S)-2-(3-(1-(trifluoromethyl)cyclop...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)C1(CC1)C(F)(F)F)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H20F6N4O2/c21-12-9-14(23)13(22)7-10(12)6-11(27)8-16(31)30-5-1-2-15(30)17-28-18(29-32-17)19(3-4-19)20(24,25)26/h7,9,11,15H,1-6,8,27H2/t11-,15+/m1/s1
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n/an/a 6.10E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))		BDBM50302962
PNG
((R)-1-((S)-2-(3-(1-acetylazetidin-3-yl)-1,2,4-oxad...)
Show SMILES CC(=O)N1CC(C1)c1noc(n1)[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C21H24F3N5O3/c1-11(30)28-9-13(10-28)20-26-21(32-27-20)18-3-2-4-29(18)19(31)7-14(25)5-12-6-16(23)17(24)8-15(12)22/h6,8,13-14,18H,2-5,7,9-10,25H2,1H3/t14-,18+/m1/s1
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n/an/a 6.50E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))		BDBM50302970
PNG
((R)-3-amino-1-((S)-2-(5-(1-fluorocyclopropyl)-1,2,...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1noc(n1)C1(F)CC1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C19H20F4N4O2/c20-12-9-14(22)13(21)7-10(12)6-11(24)8-16(28)27-5-1-2-15(27)17-25-18(29-26-17)19(23)3-4-19/h7,9,11,15H,1-6,8,24H2/t11-,15+/m1/s1
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n/an/a 7.20E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 8


(Homo sapiens (Human))		BDBM50302972
PNG
((R)-3-amino-1-((S)-2-(5-(3-methyloxetan-3-yl)-1,2,...)
Show SMILES CC1(COC1)c1nc(no1)[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H23F3N4O3/c1-20(9-29-10-20)19-25-18(26-30-19)16-3-2-4-27(16)17(28)7-12(24)5-11-6-14(22)15(23)8-13(11)21/h6,8,12,16H,2-5,7,9-10,24H2,1H3/t12-,16+/m1/s1
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n/an/a 7.20E+4n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human DPP8 expressed in baculovirus system after 15 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))		BDBM50302966
PNG
((R)-3-amino-1-((S)-2-(3-(3,5-difluoropyridin-2-yl)...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)-c1ncc(F)cc1F)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C21H18F5N5O2/c22-11-6-16(26)19(28-9-11)20-29-21(33-30-20)17-2-1-3-31(17)18(32)7-12(27)4-10-5-14(24)15(25)8-13(10)23/h5-6,8-9,12,17H,1-4,7,27H2/t12-,17+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))		BDBM50302967
PNG
((R)-3-amino-1-((S)-2-(5-cyclopropyl-1,2,4-oxadiazo...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1noc(n1)C1CC1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C19H21F3N4O2/c20-13-9-15(22)14(21)7-11(13)6-12(23)8-17(27)26-5-1-2-16(26)18-24-19(28-25-18)10-3-4-10/h7,9-10,12,16H,1-6,8,23H2/t12-,16+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))		BDBM50302972
PNG
((R)-3-amino-1-((S)-2-(5-(3-methyloxetan-3-yl)-1,2,...)
Show SMILES CC1(COC1)c1nc(no1)[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H23F3N4O3/c1-20(9-29-10-20)19-25-18(26-30-19)16-3-2-4-27(16)17(28)7-12(24)5-11-6-14(22)15(23)8-13(11)21/h6,8,12,16H,2-5,7,9-10,24H2,1H3/t12-,16+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))		BDBM50302957
PNG
((R)-3-amino-1-((S)-2-(3-(cyclopropylmethyl)-1,2,4-...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(CC2CC2)no1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H23F3N4O2/c21-14-10-16(23)15(22)8-12(14)7-13(24)9-19(28)27-5-1-2-17(27)20-25-18(26-29-20)6-11-3-4-11/h8,10-11,13,17H,1-7,9,24H2/t13-,17+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))		BDBM50302964
PNG
((R)-3-amino-1-((S)-2-(3-(pyrazin-2-yl)-1,2,4-oxadi...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)-c1cnccn1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H19F3N6O2/c21-13-9-15(23)14(22)7-11(13)6-12(24)8-18(30)29-5-1-2-17(29)20-27-19(28-31-20)16-10-25-3-4-26-16/h3-4,7,9-10,12,17H,1-2,5-6,8,24H2/t12-,17+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))		BDBM50302971
PNG
((R)-3-amino-1-((S)-2-(5-(2-fluoropropan-2-yl)-1,2,...)
Show SMILES CC(C)(F)c1nc(no1)[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C19H22F4N4O2/c1-19(2,23)18-25-17(26-29-18)15-4-3-5-27(15)16(28)8-11(24)6-10-7-13(21)14(22)9-12(10)20/h7,9,11,15H,3-6,8,24H2,1-2H3/t11-,15+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))		BDBM50302973
PNG
((R)-3-amino-1-((S)-2-(5-tert-butyl-1,2,4-oxadiazol...)
Show SMILES CC(C)(C)c1nc(no1)[C@@H]1CCCN1C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H25F3N4O2/c1-20(2,3)19-25-18(26-29-19)16-5-4-6-27(16)17(28)9-12(24)7-11-8-14(22)15(23)10-13(11)21/h8,10,12,16H,4-7,9,24H2,1-3H3/t12-,16+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))		BDBM50302960
PNG
((R)-3-amino-1-((S)-2-(3-(pyrrolidin-1-yl)-1,2,4-ox...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)N1CCCC1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H24F3N5O2/c21-14-11-16(23)15(22)9-12(14)8-13(24)10-18(29)28-7-3-4-17(28)19-25-20(26-30-19)27-5-1-2-6-27/h9,11,13,17H,1-8,10,24H2/t13-,17+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))		BDBM50302959
PNG
((R)-3-amino-1-((S)-2-(3-morpholino-1,2,4-oxadiazol...)
Show SMILES N[C@@H](CC(=O)N1CCC[C@H]1c1nc(no1)N1CCOCC1)Cc1cc(F)c(F)cc1F |r|
Show InChI InChI=1S/C20H24F3N5O3/c21-14-11-16(23)15(22)9-12(14)8-13(24)10-18(29)28-3-1-2-17(28)19-25-20(26-31-19)27-4-6-30-7-5-27/h9,11,13,17H,1-8,10,24H2/t13-,17+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Santhera Pharmaceuticals (Switzerland) Ltd

Curated by ChEMBL


Assay Description
Inhibition of human POP expressed in Escherichia coli after 30 mins by continuous fluorescent assay

Bioorg Med Chem Lett 19: 6340-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.078
BindingDB Entry DOI: 10.7270/Q2WS8TB2
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%