| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prolyl endopeptidase |
|---|
| Ligand | BDBM50302967 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_596527 (CHEMBL1039015) |
|---|
| IC50 | >100000±n/a nM |
|---|
| Citation |  Nordhoff, S; Bulat, S; Cerezo-Gálvez, S; Hill, O; Hoffmann-Enger, B; López-Canet, M; Rosenbaum, C; Rummey, C; Thiemann, M; Matassa, VG; Edwards, PJ; Feurer, A The design of potent and selective inhibitors of DPP-4: optimization of ADME properties by amide replacements. Bioorg Med Chem Lett19:6340-5 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prolyl endopeptidase |
|---|
| Name: | Prolyl endopeptidase |
|---|
| Synonyms: | PE | PEP | POP | PPCE_HUMAN | PREP | Post-proline cleaving enzyme | Prolyl oligopeptidase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 80688.50 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P48147 |
|---|
| Residue: | 710 |
|---|
| Sequence: | MLSLQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIR
GLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILS
DDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTH
DGKGMFYNSYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAEL
SDDGRYVLLSIREGCDPVNRLWYCDLQQESSGIAGILKWVKLIDNFEGEYDYVTNEGTVF
TFKTNRQSPNYRVINIDFRDPEESKWKVLVPEHEKDVLEWIACVRSNFLVLCYLHDVKNI
LQLHDLTTGALLKTFPLDVGSIVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPR
VFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISI
TPNYSVSRLIFVRHMGGILAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKE
GYTSPKRLTINGGSNGGLLVAACANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYG
CSDSKQHFEWLVKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIV
GRSRKQSNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNVDWIP
|
|
|
|---|
| BDBM50302967 |
|---|
| n/a |
|---|
| Name | BDBM50302967 |
|---|
| Synonyms: | (R)-3-amino-1-((S)-2-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)pyrrolidin-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one | CHEMBL566419 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H21F3N4O2 |
|---|
| Mol. Mass. | 394.3908 |
|---|
| SMILES | N[C@@H](CC(=O)N1CCC[C@H]1c1noc(n1)C1CC1)Cc1cc(F)c(F)cc1F |r| |
|---|
| Structure | 
|
|---|
Search and Browse
