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PubMed code 19945877

Compile data set for download or QSAR
Found 50 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50305271
PNG
(5-[2-(4-Fluorophenyl)ethyl]-2,8-dimethyl-2,3,4,5-t...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(F)cc1
Show InChI InChI=1S/C21H23FN2/c1-15-3-8-20-18(13-15)19-14-23(2)11-10-21(19)24(20)12-9-16-4-6-17(22)7-5-16/h3-8,13H,9-12,14H2,1-2H3
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n/an/a 30n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50305268
PNG
(8-Fluoro-2-methyl-5-(2-p-tolylethyl)-2,3,4,5-tetra...)
Show SMILES CN1CCc2c(C1)c1cc(F)ccc1n2CCc1ccc(C)cc1
Show InChI InChI=1S/C21H23FN2/c1-15-3-5-16(6-4-15)9-12-24-20-8-7-17(22)13-18(20)19-14-23(2)11-10-21(19)24/h3-8,13H,9-12,14H2,1-2H3
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n/an/a 31n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50305266
PNG
(8-Fluoro-5-[2-(4-methoxyphenyl)ethyl]-2-methyl-2,3...)
Show SMILES COc1ccc(CCn2c3CCN(C)Cc3c3cc(F)ccc23)cc1
Show InChI InChI=1S/C21H23FN2O/c1-23-11-10-21-19(14-23)18-13-16(22)5-8-20(18)24(21)12-9-15-3-6-17(25-2)7-4-15/h3-8,13H,9-12,14H2,1-2H3
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n/an/a 32n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50305260
PNG
(2-Methyl-5-((Z)-styryl)-2,3,4,5-tetrahydro-1H-pyri...)
Show SMILES CN1CCc2c(C1)c1ccccc1n2\C=C/c1ccccc1
Show InChI InChI=1S/C20H20N2/c1-21-13-12-20-18(15-21)17-9-5-6-10-19(17)22(20)14-11-16-7-3-2-4-8-16/h2-11,14H,12-13,15H2,1H3/b14-11-
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n/an/a 33n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50305267
PNG
(8-Fluoro-2-methyl-5-[2-(4-trifluoromethylphenyl)et...)
Show SMILES CN1CCc2c(C1)c1cc(F)ccc1n2CCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H20F4N2/c1-26-10-9-20-18(13-26)17-12-16(22)6-7-19(17)27(20)11-8-14-2-4-15(5-3-14)21(23,24)25/h2-7,12H,8-11,13H2,1H3
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n/an/a 35n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50305263
PNG
(2,8-Dimethyl-5-phenethyl-2,3,4,5-tetrahydro-1H-pyr...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccccc1
Show InChI InChI=1S/C21H24N2/c1-16-8-9-20-18(14-16)19-15-22(2)12-11-21(19)23(20)13-10-17-6-4-3-5-7-17/h3-9,14H,10-13,15H2,1-2H3
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n/an/a 40n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50305262
PNG
(8-Fluoro-2-methyl-5-phenethyl-2,3,4,5-tetrahydro-1...)
Show SMILES CN1CCc2c(C1)c1cc(F)ccc1n2CCc1ccccc1
Show InChI InChI=1S/C20H21FN2/c1-22-11-10-20-18(14-22)17-13-16(21)7-8-19(17)23(20)12-9-15-5-3-2-4-6-15/h2-8,13H,9-12,14H2,1H3
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n/an/a 40n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50305269
PNG
(5-[2-(4-Methoxyphenyl)ethyl]-2,8-dimethyl-2,3,4,5-...)
Show SMILES COc1ccc(CCn2c3CCN(C)Cc3c3cc(C)ccc23)cc1
Show InChI InChI=1S/C22H26N2O/c1-16-4-9-21-19(14-16)20-15-23(2)12-11-22(20)24(21)13-10-17-5-7-18(25-3)8-6-17/h4-9,14H,10-13,15H2,1-3H3
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n/an/a 66n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50305265
PNG
(2-Methyl-5-phenethyl-8-trifluoromethyl-2,3,4,5-tet...)
Show SMILES CN1CCc2c(C1)c1cc(ccc1n2CCc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C21H21F3N2/c1-25-11-10-20-18(14-25)17-13-16(21(22,23)24)7-8-19(17)26(20)12-9-15-5-3-2-4-6-15/h2-8,13H,9-12,14H2,1H3
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n/an/a 68n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50305258
PNG
(2,8-Dimethyl-5-((Z)-styryl)-2,3,4,5-tetrahydro-1H-...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2\C=C/c1ccccc1
Show InChI InChI=1S/C21H22N2/c1-16-8-9-20-18(14-16)19-15-22(2)12-11-21(19)23(20)13-10-17-6-4-3-5-7-17/h3-10,13-14H,11-12,15H2,1-2H3/b13-10-
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n/an/a 70n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50305258
PNG
(2,8-Dimethyl-5-((Z)-styryl)-2,3,4,5-tetrahydro-1H-...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2\C=C/c1ccccc1
Show InChI InChI=1S/C21H22N2/c1-16-8-9-20-18(14-16)19-15-22(2)12-11-21(19)23(20)13-10-17-6-4-3-5-7-17/h3-10,13-14H,11-12,15H2,1-2H3/b13-10-
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n/an/a 87n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50305270
PNG
(2,8-Dimethyl-5-[2-(4-trifluoromethylphenyl)ethyl]-...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C22H23F3N2/c1-15-3-8-20-18(13-15)19-14-26(2)11-10-21(19)27(20)12-9-16-4-6-17(7-5-16)22(23,24)25/h3-8,13H,9-12,14H2,1-2H3
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n/an/a 98n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50305264
PNG
(8-Methoxy-2-methyl-5-phenethyl-2,3,4,5-tetrahydro-...)
Show SMILES COc1ccc2n(CCc3ccccc3)c3CCN(C)Cc3c2c1
Show InChI InChI=1S/C21H24N2O/c1-22-12-11-21-19(15-22)18-14-17(24-2)8-9-20(18)23(21)13-10-16-6-4-3-5-7-16/h3-9,14H,10-13,15H2,1-2H3
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n/an/a 104n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50305272
PNG
(2,8-Dimethyl-5-(2-p-tolylethyl)-2,3,4,5-tetrahydro...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)cc1
Show InChI InChI=1S/C22H26N2/c1-16-4-7-18(8-5-16)10-13-24-21-9-6-17(2)14-19(21)20-15-23(3)12-11-22(20)24/h4-9,14H,10-13,15H2,1-3H3
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n/an/a 112n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50305262
PNG
(8-Fluoro-2-methyl-5-phenethyl-2,3,4,5-tetrahydro-1...)
Show SMILES CN1CCc2c(C1)c1cc(F)ccc1n2CCc1ccccc1
Show InChI InChI=1S/C20H21FN2/c1-22-11-10-20-18(14-22)17-13-16(21)7-8-19(17)23(20)12-9-15-5-3-2-4-6-15/h2-8,13H,9-12,14H2,1H3
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n/an/a 131n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50305263
PNG
(2,8-Dimethyl-5-phenethyl-2,3,4,5-tetrahydro-1H-pyr...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccccc1
Show InChI InChI=1S/C21H24N2/c1-16-8-9-20-18(14-16)19-15-22(2)12-11-21(19)23(20)13-10-17-6-4-3-5-7-17/h3-9,14H,10-13,15H2,1-2H3
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n/an/a 146n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50305258
PNG
(2,8-Dimethyl-5-((Z)-styryl)-2,3,4,5-tetrahydro-1H-...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2\C=C/c1ccccc1
Show InChI InChI=1S/C21H22N2/c1-16-8-9-20-18(14-16)19-15-22(2)12-11-21(19)23(20)13-10-17-6-4-3-5-7-17/h3-10,13-14H,11-12,15H2,1-2H3/b13-10-
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n/an/a 154n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50305261
PNG
(CHEMBL589390 | Dimebolin)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)nc1
Show InChI InChI=1S/C21H25N3/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17/h4-7,12-13H,8-11,14H2,1-3H3
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n/an/a 158n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50305263
PNG
(2,8-Dimethyl-5-phenethyl-2,3,4,5-tetrahydro-1H-pyr...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccccc1
Show InChI InChI=1S/C21H24N2/c1-16-8-9-20-18(14-16)19-15-22(2)12-11-21(19)23(20)13-10-17-6-4-3-5-7-17/h3-9,14H,10-13,15H2,1-2H3
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n/an/a 158n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50305255
PNG
(25-[(Z)-2-(4-Fluorophenyl)vinyl]-2,8-dimethyl-2,3,...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2\C=C/c1ccc(F)cc1
Show InChI InChI=1S/C21H21FN2/c1-15-3-8-20-18(13-15)19-14-23(2)11-10-21(19)24(20)12-9-16-4-6-17(22)7-5-16/h3-9,12-13H,10-11,14H2,1-2H3/b12-9-
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n/an/a 180n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50305260
PNG
(2-Methyl-5-((Z)-styryl)-2,3,4,5-tetrahydro-1H-pyri...)
Show SMILES CN1CCc2c(C1)c1ccccc1n2\C=C/c1ccccc1
Show InChI InChI=1S/C20H20N2/c1-21-13-12-20-18(15-21)17-9-5-6-10-19(17)22(20)14-11-16-7-3-2-4-8-16/h2-11,14H,12-13,15H2,1H3/b14-11-
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n/an/a 181n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50305272
PNG
(2,8-Dimethyl-5-(2-p-tolylethyl)-2,3,4,5-tetrahydro...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)cc1
Show InChI InChI=1S/C22H26N2/c1-16-4-7-18(8-5-16)10-13-24-21-9-6-17(2)14-19(21)20-15-23(3)12-11-22(20)24/h4-9,14H,10-13,15H2,1-3H3
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n/an/a 276n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50305259
PNG
(2-Methyl-5-((E)-styryl)-2,3,4,5-tetrahydro-1H-pyri...)
Show SMILES CN1CCC2C(C1)c1ccccc1N2\C=C\c1ccccc1
Show InChI InChI=1S/C20H22N2/c1-21-13-12-20-18(15-21)17-9-5-6-10-19(17)22(20)14-11-16-7-3-2-4-8-16/h2-11,14,18,20H,12-13,15H2,1H3/b14-11+
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n/an/a 345n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as histamine-induced maximum intracellular calcium spike at phase 1 trea...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50305253
PNG
(5-[(Z)-2-(4-Methoxyphenyl)vinyl]-2,8-dimethyl-2,3,...)
Show SMILES COc1ccc(\C=C/n2c3CCN(C)Cc3c3cc(C)ccc23)cc1
Show InChI InChI=1S/C22H24N2O/c1-16-4-9-21-19(14-16)20-15-23(2)12-11-22(20)24(21)13-10-17-5-7-18(25-3)8-6-17/h4-10,13-14H,11-12,15H2,1-3H3/b13-10-
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n/an/a 550n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50305269
PNG
(5-[2-(4-Methoxyphenyl)ethyl]-2,8-dimethyl-2,3,4,5-...)
Show SMILES COc1ccc(CCn2c3CCN(C)Cc3c3cc(C)ccc23)cc1
Show InChI InChI=1S/C22H26N2O/c1-16-4-9-21-19(14-16)20-15-23(2)12-11-22(20)24(21)13-10-17-5-7-18(25-3)8-6-17/h4-9,14H,10-13,15H2,1-3H3
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n/an/a 666n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50305262
PNG
(8-Fluoro-2-methyl-5-phenethyl-2,3,4,5-tetrahydro-1...)
Show SMILES CN1CCc2c(C1)c1cc(F)ccc1n2CCc1ccccc1
Show InChI InChI=1S/C20H21FN2/c1-22-11-10-20-18(14-22)17-13-16(21)7-8-19(17)23(20)12-9-15-5-3-2-4-6-15/h2-8,13H,9-12,14H2,1H3
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n/an/a 692n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50305256
PNG
(2,8-Dimethyl-5-((Z)-2-p-tolylvinyl)-2,3,4,5-tetrah...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2\C=C/c1ccc(C)cc1
Show InChI InChI=1S/C22H24N2/c1-16-4-7-18(8-5-16)10-13-24-21-9-6-17(2)14-19(21)20-15-23(3)12-11-22(20)24/h4-10,13-14H,11-12,15H2,1-3H3/b13-10-
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n/an/a 910n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50305265
PNG
(2-Methyl-5-phenethyl-8-trifluoromethyl-2,3,4,5-tet...)
Show SMILES CN1CCc2c(C1)c1cc(ccc1n2CCc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C21H21F3N2/c1-25-11-10-20-18(14-25)17-13-16(21(22,23)24)7-8-19(17)26(20)12-9-15-5-3-2-4-6-15/h2-8,13H,9-12,14H2,1H3
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n/an/a 974n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50305271
PNG
(5-[2-(4-Fluorophenyl)ethyl]-2,8-dimethyl-2,3,4,5-t...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(F)cc1
Show InChI InChI=1S/C21H23FN2/c1-15-3-8-20-18(13-15)19-14-23(2)11-10-21(19)24(20)12-9-16-4-6-17(22)7-5-16/h3-8,13H,9-12,14H2,1-2H3
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n/an/a 977n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50305252
PNG
(8-Fluoro-2-methyl-5-((Z)-styryl)-2,3,4,5-tetrahydr...)
Show SMILES CN1CCc2c(C1)c1cc(F)ccc1n2\C=C/c1ccccc1
Show InChI InChI=1S/C20H19FN2/c1-22-11-10-20-18(14-22)17-13-16(21)7-8-19(17)23(20)12-9-15-5-3-2-4-6-15/h2-9,12-13H,10-11,14H2,1H3/b12-9-
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n/an/a 1.00E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50305264
PNG
(8-Methoxy-2-methyl-5-phenethyl-2,3,4,5-tetrahydro-...)
Show SMILES COc1ccc2n(CCc3ccccc3)c3CCN(C)Cc3c2c1
Show InChI InChI=1S/C21H24N2O/c1-22-12-11-21-19(15-22)18-14-17(24-2)8-9-20(18)23(21)13-10-16-6-4-3-5-7-16/h3-9,14H,10-13,15H2,1-2H3
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n/an/a 1.05E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50305273
PNG
(8-Fluoro-5-[2-(4-fluorophenyl)ethyl]-2-methyl-2,3,...)
Show SMILES CN1CCc2c(C1)c1cc(F)ccc1n2CCc1ccc(F)cc1
Show InChI InChI=1S/C20H20F2N2/c1-23-10-9-20-18(13-23)17-12-16(22)6-7-19(17)24(20)11-8-14-2-4-15(21)5-3-14/h2-7,12H,8-11,13H2,1H3
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n/an/a 1.13E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50305261
PNG
(CHEMBL589390 | Dimebolin)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)nc1
Show InChI InChI=1S/C21H25N3/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17/h4-7,12-13H,8-11,14H2,1-3H3
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PubMed
n/an/a 1.16E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50305249
PNG
(8-Fluoro-2-methyl-5-((Z)-2-p-tolylvinyl)-2,3,4,5-t...)
Show SMILES CN1CCc2c(C1)c1cc(F)ccc1n2\C=C/c1ccc(C)cc1
Show InChI InChI=1S/C21H21FN2/c1-15-3-5-16(6-4-15)9-12-24-20-8-7-17(22)13-18(20)19-14-23(2)11-10-21(19)24/h3-9,12-13H,10-11,14H2,1-2H3/b12-9-
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n/an/a 1.44E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50305276
PNG
(8-Fluoro-5-[(Z)-2-(4-methoxyphenyl)-vinyl]-2-methy...)
Show SMILES COc1ccc(\C=C/n2c3CCN(C)Cc3c3cc(F)ccc23)cc1
Show InChI InChI=1S/C21H21FN2O/c1-23-11-10-21-19(14-23)18-13-16(22)5-8-20(18)24(21)12-9-15-3-6-17(25-2)7-4-15/h3-9,12-13H,10-11,14H2,1-2H3/b12-9-
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n/an/a 1.50E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50305261
PNG
(CHEMBL589390 | Dimebolin)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)nc1
Show InChI InChI=1S/C21H25N3/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17/h4-7,12-13H,8-11,14H2,1-3H3
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n/an/a 1.58E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50305257
PNG
(2,8-Dimethyl-5-((E)-styryl)-2,3,4,5-tetrahydro-1H-...)
Show SMILES CN1CCC2C(C1)c1cc(C)ccc1N2\C=C\c1ccccc1
Show InChI InChI=1S/C21H24N2/c1-16-8-9-20-18(14-16)19-15-22(2)12-11-21(19)23(20)13-10-17-6-4-3-5-7-17/h3-10,13-14,19,21H,11-12,15H2,1-2H3/b13-10+
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n/an/a 1.68E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50305250
PNG
(8-Fluoro-2-methyl-5-((E)-styryl)-2,3,4,5-tetrahydr...)
Show SMILES CN1CCC2C(C1)c1cc(F)ccc1N2\C=C\c1ccccc1
Show InChI InChI=1S/C20H21FN2/c1-22-11-10-20-18(14-22)17-13-16(21)7-8-19(17)23(20)12-9-15-5-3-2-4-6-15/h2-9,12-13,18,20H,10-11,14H2,1H3/b12-9+
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n/an/a 1.75E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50305275
PNG
(8-Methyl-5-[(Z)-1-methyl-2-phenylvinyl]-2-methyl-2...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2\C(C)=C/c1ccccc1
Show InChI InChI=1S/C22H24N2/c1-16-9-10-21-19(13-16)20-15-23(3)12-11-22(20)24(21)17(2)14-18-7-5-4-6-8-18/h4-10,13-14H,11-12,15H2,1-3H3/b17-14-
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n/an/a 1.98E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50305259
PNG
(2-Methyl-5-((E)-styryl)-2,3,4,5-tetrahydro-1H-pyri...)
Show SMILES CN1CCC2C(C1)c1ccccc1N2\C=C\c1ccccc1
Show InChI InChI=1S/C20H22N2/c1-21-13-12-20-18(15-21)17-9-5-6-10-19(17)22(20)14-11-16-7-3-2-4-8-16/h2-11,14,18,20H,12-13,15H2,1H3/b14-11+
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n/an/a 2.13E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at histamine H1 receptor in human SK-N-SH cells assessed as reduction of histamine-induced intracellular calcium spike at phase 2...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50305268
PNG
(8-Fluoro-2-methyl-5-(2-p-tolylethyl)-2,3,4,5-tetra...)
Show SMILES CN1CCc2c(C1)c1cc(F)ccc1n2CCc1ccc(C)cc1
Show InChI InChI=1S/C21H23FN2/c1-15-3-5-16(6-4-15)9-12-24-20-8-7-17(22)13-18(20)19-14-23(2)11-10-21(19)24/h3-8,13H,9-12,14H2,1-2H3
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n/an/a 2.27E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50305266
PNG
(8-Fluoro-5-[2-(4-methoxyphenyl)ethyl]-2-methyl-2,3...)
Show SMILES COc1ccc(CCn2c3CCN(C)Cc3c3cc(F)ccc23)cc1
Show InChI InChI=1S/C21H23FN2O/c1-23-11-10-21-19(14-23)18-13-16(22)5-8-20(18)24(21)12-9-15-3-6-17(25-2)7-4-15/h3-8,13H,9-12,14H2,1-2H3
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n/an/a 2.35E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50305259
PNG
(2-Methyl-5-((E)-styryl)-2,3,4,5-tetrahydro-1H-pyri...)
Show SMILES CN1CCC2C(C1)c1ccccc1N2\C=C\c1ccccc1
Show InChI InChI=1S/C20H22N2/c1-21-13-12-20-18(15-21)17-9-5-6-10-19(17)22(20)14-11-16-7-3-2-4-8-16/h2-11,14,18,20H,12-13,15H2,1H3/b14-11+
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n/an/a 2.58E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50305254
PNG
(2,8-Dimethyl-5-[(Z)-2-(4-trifluoromethylphenyl)vin...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2\C=C/c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C22H21F3N2/c1-15-3-8-20-18(13-15)19-14-26(2)11-10-21(19)27(20)12-9-16-4-6-17(7-5-16)22(23,24)25/h3-9,12-13H,10-11,14H2,1-2H3/b12-9-
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n/an/a 2.81E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50305251
PNG
(8-Fluoro-5-[(Z)-2-(4-fluorophenyl)-vinyl]-2-methyl...)
Show SMILES CN1CCc2c(C1)c1cc(F)ccc1n2\C=C/c1ccc(F)cc1
Show InChI InChI=1S/C20H18F2N2/c1-23-10-9-20-18(13-23)17-12-16(22)6-7-19(17)24(20)11-8-14-2-4-15(21)5-3-14/h2-8,11-12H,9-10,13H2,1H3/b11-8-
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n/an/a 2.95E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50305274
PNG
(8-Fluoro-5-[(Z)-1-methyl-2-phenylvinyl]-2-methyl-2...)
Show SMILES CN1CCc2c(C1)c1cc(F)ccc1n2\C(C)=C/c1ccccc1
Show InChI InChI=1S/C21H21FN2/c1-15(12-16-6-4-3-5-7-16)24-20-9-8-17(22)13-18(20)19-14-23(2)11-10-21(19)24/h3-9,12-13H,10-11,14H2,1-2H3/b15-12-
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n/an/a 3.72E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50305270
PNG
(2,8-Dimethyl-5-[2-(4-trifluoromethylphenyl)ethyl]-...)
Show SMILES CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C22H23F3N2/c1-15-3-8-20-18(13-15)19-14-26(2)11-10-21(19)27(20)12-9-16-4-6-17(7-5-16)22(23,24)25/h3-8,13H,9-12,14H2,1-2H3
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n/an/a 4.07E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50305277
PNG
(8-Fluoro-2-methyl-5-[(Z)-2-(4-trifluoromethyl-phen...)
Show SMILES CN1CCc2c(C1)c1cc(F)ccc1n2\C=C/c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H18F4N2/c1-26-10-9-20-18(13-26)17-12-16(22)6-7-19(17)27(20)11-8-14-2-4-15(5-3-14)21(23,24)25/h2-8,11-12H,9-10,13H2,1H3/b11-8-
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n/an/a 5.58E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50305260
PNG
(2-Methyl-5-((Z)-styryl)-2,3,4,5-tetrahydro-1H-pyri...)
Show SMILES CN1CCc2c(C1)c1ccccc1n2\C=C/c1ccccc1
Show InChI InChI=1S/C20H20N2/c1-21-13-12-20-18(15-21)17-9-5-6-10-19(17)22(20)14-11-16-7-3-2-4-8-16/h2-11,14H,12-13,15H2,1H3/b14-11-
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n/an/a 5.73E+3n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50305267
PNG
(8-Fluoro-2-methyl-5-[2-(4-trifluoromethylphenyl)et...)
Show SMILES CN1CCc2c(C1)c1cc(F)ccc1n2CCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C21H20F4N2/c1-26-10-9-20-18(13-26)17-12-16(22)6-7-19(17)27(20)11-8-14-2-4-15(5-3-14)21(23,24)25/h2-7,12H,8-11,13H2,1H3
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n/an/a 2.07E+4n/an/an/an/an/an/a



Chemical Diversity Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant 5HT6 receptor expressed in HEK-293 cells assessed as inhibition of serotonin-induced increase in intracellul...

Bioorg Med Chem Lett 20: 78-82 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.037
BindingDB Entry DOI: 10.7270/Q25Q4W6C
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%