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PubMed code 20143779

Compile data set for download or QSAR
Found 28 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50307793
PNG
(4-Acetamidophenyl 2-(4-(2-(trifluoromethyl)pyridin...)
Show SMILES CC(C(=O)Oc1ccc(NC(C)=O)cc1)c1ccc(Nc2ccnc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C23H20F3N3O3/c1-14(22(31)32-20-9-7-17(8-10-20)28-15(2)30)16-3-5-18(6-4-16)29-19-11-12-27-21(13-19)23(24,25)26/h3-14H,1-2H3,(H,27,29)(H,28,30)
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 160n/an/an/an/an/an/an/an/a



University of Cagliari

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate by time-dependent studies

J Med Chem 53: 2286-98 (2010)


Article DOI: 10.1021/jm901891p
BindingDB Entry DOI: 10.7270/Q2833S4K
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50307792
PNG
(4-Acetamidophenyl 2-(4-(2-(trifluoromethyl)pyridin...)
Show SMILES CC(=O)Nc1ccc(OC(=O)Cc2ccc(Nc3ccnc(c3)C(F)(F)F)cc2)cc1
Show InChI InChI=1S/C22H18F3N3O3/c1-14(29)27-16-6-8-19(9-7-16)31-21(30)12-15-2-4-17(5-3-15)28-18-10-11-26-20(13-18)22(23,24)25/h2-11,13H,12H2,1H3,(H,26,28)(H,27,29)
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 190n/an/an/an/an/an/an/an/a



University of Cagliari

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate by time-dependent studies

J Med Chem 53: 2286-98 (2010)


Article DOI: 10.1021/jm901891p
BindingDB Entry DOI: 10.7270/Q2833S4K
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50307793
PNG
(4-Acetamidophenyl 2-(4-(2-(trifluoromethyl)pyridin...)
Show SMILES CC(C(=O)Oc1ccc(NC(C)=O)cc1)c1ccc(Nc2ccnc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C23H20F3N3O3/c1-14(22(31)32-20-9-7-17(8-10-20)28-15(2)30)16-3-5-18(6-4-16)29-19-11-12-27-21(13-19)23(24,25)26/h3-14H,1-2H3,(H,27,29)(H,28,30)
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n/an/a 100n/an/an/an/an/an/a



University of Cagliari

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate by liquid scintillation spectroscopy

J Med Chem 53: 2286-98 (2010)


Article DOI: 10.1021/jm901891p
BindingDB Entry DOI: 10.7270/Q2833S4K
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50307792
PNG
(4-Acetamidophenyl 2-(4-(2-(trifluoromethyl)pyridin...)
Show SMILES CC(=O)Nc1ccc(OC(=O)Cc2ccc(Nc3ccnc(c3)C(F)(F)F)cc2)cc1
Show InChI InChI=1S/C22H18F3N3O3/c1-14(29)27-16-6-8-19(9-7-16)31-21(30)12-15-2-4-17(5-3-15)28-18-10-11-26-20(13-18)22(23,24)25/h2-11,13H,12H2,1H3,(H,26,28)(H,27,29)
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n/an/a 182n/an/an/an/an/an/a



University of Cagliari

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate by liquid scintillation spectroscopy

J Med Chem 53: 2286-98 (2010)


Article DOI: 10.1021/jm901891p
BindingDB Entry DOI: 10.7270/Q2833S4K
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50307796
PNG
(4-Acetamidophenyl 2-(2-(4-(2-(trifluoromethyl)pyri...)
Show SMILES CC(C(=O)NCC(=O)Oc1ccc(NC(C)=O)cc1)c1ccc(Nc2ccnc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C25H23F3N4O4/c1-15(24(35)30-14-23(34)36-21-9-7-18(8-10-21)31-16(2)33)17-3-5-19(6-4-17)32-20-11-12-29-22(13-20)25(26,27)28/h3-13,15H,14H2,1-2H3,(H,29,32)(H,30,35)(H,31,33)
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n/an/a 730n/an/an/an/an/an/a



University of Cagliari

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate by liquid scintillation spectroscopy

J Med Chem 53: 2286-98 (2010)


Article DOI: 10.1021/jm901891p
BindingDB Entry DOI: 10.7270/Q2833S4K
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50307799
PNG
(4-Acetamidophenyl 2-(4-(2-(trifluoromethyl)pyridin...)
Show SMILES CC(=O)Nc1ccc(OC(=O)CNC(=O)c2ccc(Nc3ccnc(c3)C(F)(F)F)cc2)cc1
Show InChI InChI=1S/C23H19F3N4O4/c1-14(31)29-16-6-8-19(9-7-16)34-21(32)13-28-22(33)15-2-4-17(5-3-15)30-18-10-11-27-20(12-18)23(24,25)26/h2-12H,13H2,1H3,(H,27,30)(H,28,33)(H,29,31)
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n/an/a 870n/an/an/an/an/an/a



University of Cagliari

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate by liquid scintillation spectroscopy

J Med Chem 53: 2286-98 (2010)


Article DOI: 10.1021/jm901891p
BindingDB Entry DOI: 10.7270/Q2833S4K
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50307794
PNG
(2-(4-isobutylphenyl)-N-(3-methylpyridin-2-yl)propa...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(=O)Nc1ncccc1C
Show InChI InChI=1S/C19H24N2O/c1-13(2)12-16-7-9-17(10-8-16)15(4)19(22)21-18-14(3)6-5-11-20-18/h5-11,13,15H,12H2,1-4H3,(H,20,21,22)
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n/an/a 1.32E+3n/an/an/an/an/an/a



University of Cagliari

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate by liquid scintillation spectroscopy

J Med Chem 53: 2286-98 (2010)


Article DOI: 10.1021/jm901891p
BindingDB Entry DOI: 10.7270/Q2833S4K
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50307795
PNG
(4-Acetamidophenyl 3-(4-(2-(trifluoromethyl)pyridin...)
Show SMILES CC(=O)Nc1ccc(OC(=O)CCc2ccc(Nc3ccnc(c3)C(F)(F)F)cc2)cc1
Show InChI InChI=1S/C23H20F3N3O3/c1-15(30)28-17-7-9-20(10-8-17)32-22(31)11-4-16-2-5-18(6-3-16)29-19-12-13-27-21(14-19)23(24,25)26/h2-3,5-10,12-14H,4,11H2,1H3,(H,27,29)(H,28,30)
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n/an/a 1.50E+3n/an/an/an/an/an/a



University of Cagliari

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate by liquid scintillation spectroscopy

J Med Chem 53: 2286-98 (2010)


Article DOI: 10.1021/jm901891p
BindingDB Entry DOI: 10.7270/Q2833S4K
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))		BDBM50307793
PNG
(4-Acetamidophenyl 2-(4-(2-(trifluoromethyl)pyridin...)
Show SMILES CC(C(=O)Oc1ccc(NC(C)=O)cc1)c1ccc(Nc2ccnc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C23H20F3N3O3/c1-14(22(31)32-20-9-7-17(8-10-20)28-15(2)30)16-3-5-18(6-4-16)29-19-11-12-27-21(13-19)23(24,25)26/h3-14H,1-2H3,(H,27,29)(H,28,30)
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n/an/a 1.90E+3n/an/an/an/an/an/a



University of Cagliari

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MGL

J Med Chem 53: 2286-98 (2010)


Article DOI: 10.1021/jm901891p
BindingDB Entry DOI: 10.7270/Q2833S4K
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))		BDBM50307792
PNG
(4-Acetamidophenyl 2-(4-(2-(trifluoromethyl)pyridin...)
Show SMILES CC(=O)Nc1ccc(OC(=O)Cc2ccc(Nc3ccnc(c3)C(F)(F)F)cc2)cc1
Show InChI InChI=1S/C22H18F3N3O3/c1-14(29)27-16-6-8-19(9-7-16)31-21(30)12-15-2-4-17(5-3-15)28-18-10-11-26-20(13-18)22(23,24)25/h2-11,13H,12H2,1H3,(H,26,28)(H,27,29)
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n/an/a 2.30E+3n/an/an/an/an/an/a



University of Cagliari

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MGL

J Med Chem 53: 2286-98 (2010)


Article DOI: 10.1021/jm901891p
BindingDB Entry DOI: 10.7270/Q2833S4K
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50307797
PNG
(4-Acetamidophenyl 2-(2-(4-(2-(trifluoromethyl)pyri...)
Show SMILES CC(=O)Nc1ccc(OC(=O)CNC(=O)Cc2ccc(Nc3ccnc(c3)C(F)(F)F)cc2)cc1
Show InChI InChI=1S/C24H21F3N4O4/c1-15(32)30-17-6-8-20(9-7-17)35-23(34)14-29-22(33)12-16-2-4-18(5-3-16)31-19-10-11-28-21(13-19)24(25,26)27/h2-11,13H,12,14H2,1H3,(H,28,31)(H,29,33)(H,30,32)
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n/an/a 2.57E+3n/an/an/an/an/an/a



University of Cagliari

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate by liquid scintillation spectroscopy

J Med Chem 53: 2286-98 (2010)


Article DOI: 10.1021/jm901891p
BindingDB Entry DOI: 10.7270/Q2833S4K
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50307802
PNG
(4-Acetamidophenyl 4-(2-(trifluoromethyl)pyridin-4-...)
Show SMILES CC(=O)Nc1ccc(OC(=O)c2ccc(Nc3ccnc(c3)C(F)(F)F)cc2)cc1
Show InChI InChI=1S/C21H16F3N3O3/c1-13(28)26-15-6-8-18(9-7-15)30-20(29)14-2-4-16(5-3-14)27-17-10-11-25-19(12-17)21(22,23)24/h2-12H,1H3,(H,25,27)(H,26,28)
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n/an/a 2.70E+3n/an/an/an/an/an/a



University of Cagliari

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate by liquid scintillation spectroscopy

J Med Chem 53: 2286-98 (2010)


Article DOI: 10.1021/jm901891p
BindingDB Entry DOI: 10.7270/Q2833S4K
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50307798
PNG
(4-Acetamidophenyl 2-(3-methyl-4-(2-(trifluoromethy...)
Show SMILES CC(=O)Nc1ccc(OC(=O)CNC(=O)c2ccc(Nc3ccnc(c3)C(F)(F)F)c(C)c2)cc1
Show InChI InChI=1S/C24H21F3N4O4/c1-14-11-16(3-8-20(14)31-18-9-10-28-21(12-18)24(25,26)27)23(34)29-13-22(33)35-19-6-4-17(5-7-19)30-15(2)32/h3-12H,13H2,1-2H3,(H,28,31)(H,29,34)(H,30,32)
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n/an/a 2.95E+3n/an/an/an/an/an/a



University of Cagliari

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate by liquid scintillation spectroscopy

J Med Chem 53: 2286-98 (2010)


Article DOI: 10.1021/jm901891p
BindingDB Entry DOI: 10.7270/Q2833S4K
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50307809
PNG
(4-Acetamidophenyl 5-chloro-2-(2-(trifluoromethyl)p...)
Show SMILES CC(=O)Nc1ccc(OC(=O)c2cc(Cl)ccc2Nc2ccnc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H15ClF3N3O3/c1-12(29)27-14-3-5-16(6-4-14)31-20(30)17-10-13(22)2-7-18(17)28-15-8-9-26-19(11-15)21(23,24)25/h2-11H,1H3,(H,26,28)(H,27,29)
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n/an/a 4.30E+3n/an/an/an/an/an/a



University of Cagliari

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate by liquid scintillation spectroscopy

J Med Chem 53: 2286-98 (2010)


Article DOI: 10.1021/jm901891p
BindingDB Entry DOI: 10.7270/Q2833S4K
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50307801
PNG
(4-Acetamidophenyl 3-methyl-4-(2-(trifluoromethyl)p...)
Show SMILES CC(=O)Nc1ccc(OC(=O)c2ccc(Nc3ccnc(c3)C(F)(F)F)c(C)c2)cc1
Show InChI InChI=1S/C22H18F3N3O3/c1-13-11-15(21(30)31-18-6-4-16(5-7-18)27-14(2)29)3-8-19(13)28-17-9-10-26-20(12-17)22(23,24)25/h3-12H,1-2H3,(H,26,28)(H,27,29)
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n/an/a 4.60E+3n/an/an/an/an/an/a



University of Cagliari

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate by liquid scintillation spectroscopy

J Med Chem 53: 2286-98 (2010)


Article DOI: 10.1021/jm901891p
BindingDB Entry DOI: 10.7270/Q2833S4K
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50307806
PNG
(4-Acetamidophenyl 2-(3-(trifluoromethyl)phenylamin...)
Show SMILES CC(=O)Nc1ccc(OC(=O)c2ccccc2Nc2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C22H17F3N2O3/c1-14(28)26-16-9-11-18(12-10-16)30-21(29)19-7-2-3-8-20(19)27-17-6-4-5-15(13-17)22(23,24)25/h2-13,27H,1H3,(H,26,28)
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n/an/a 8.70E+3n/an/an/an/an/an/a



University of Cagliari

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate by liquid scintillation spectroscopy

J Med Chem 53: 2286-98 (2010)


Article DOI: 10.1021/jm901891p
BindingDB Entry DOI: 10.7270/Q2833S4K
More data for this
Ligand-Target Pair
Monoglyceride lipase


(Homo sapiens (Human))		BDBM50307796
PNG
(4-Acetamidophenyl 2-(2-(4-(2-(trifluoromethyl)pyri...)
Show SMILES CC(C(=O)NCC(=O)Oc1ccc(NC(C)=O)cc1)c1ccc(Nc2ccnc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C25H23F3N4O4/c1-15(24(35)30-14-23(34)36-21-9-7-18(8-10-21)31-16(2)33)17-3-5-19(6-4-17)32-20-11-12-29-22(13-20)25(26,27)28/h3-13,15H,14H2,1-2H3,(H,29,32)(H,30,35)(H,31,33)
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n/an/a 1.80E+4n/an/an/an/an/an/a



University of Cagliari

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MGL

J Med Chem 53: 2286-98 (2010)


Article DOI: 10.1021/jm901891p
BindingDB Entry DOI: 10.7270/Q2833S4K
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50307800
PNG
(4-Acetamidophenyl 4-((2-(trifluoromethyl)pyridin-4...)
Show SMILES CC(=O)Nc1ccc(OC(=O)c2ccc(Cc3ccnc(c3)C(F)(F)F)cc2)cc1
Show InChI InChI=1S/C22H17F3N2O3/c1-14(28)27-18-6-8-19(9-7-18)30-21(29)17-4-2-15(3-5-17)12-16-10-11-26-20(13-16)22(23,24)25/h2-11,13H,12H2,1H3,(H,27,28)
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n/an/a 2.20E+4n/an/an/an/an/an/a



University of Cagliari

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate by liquid scintillation spectroscopy

J Med Chem 53: 2286-98 (2010)


Article DOI: 10.1021/jm901891p
BindingDB Entry DOI: 10.7270/Q2833S4K
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50307807
PNG
(4-Acetamidophenyl 4-chloro-2-(2-(trifluoromethyl)p...)
Show SMILES CC(=O)Nc1ccc(OC(=O)c2ccc(Cl)cc2Nc2ccnc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H15ClF3N3O3/c1-12(29)27-14-3-5-16(6-4-14)31-20(30)17-7-2-13(22)10-18(17)28-15-8-9-26-19(11-15)21(23,24)25/h2-11H,1H3,(H,26,28)(H,27,29)
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n/an/a 3.10E+4n/an/an/an/an/an/a



University of Cagliari

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate by liquid scintillation spectroscopy

J Med Chem 53: 2286-98 (2010)


Article DOI: 10.1021/jm901891p
BindingDB Entry DOI: 10.7270/Q2833S4K
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50307808
PNG
(4-Acetamidophenyl 5-methyl-2-(2-(trifluoromethyl)p...)
Show SMILES CC(=O)Nc1ccc(OC(=O)c2cc(C)ccc2Nc2ccnc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C22H18F3N3O3/c1-13-3-8-19(28-16-9-10-26-20(12-16)22(23,24)25)18(11-13)21(30)31-17-6-4-15(5-7-17)27-14(2)29/h3-12H,1-2H3,(H,26,28)(H,27,29)
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n/an/a 3.80E+4n/an/an/an/an/an/a



University of Cagliari

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate by liquid scintillation spectroscopy

J Med Chem 53: 2286-98 (2010)


Article DOI: 10.1021/jm901891p
BindingDB Entry DOI: 10.7270/Q2833S4K
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50307803
PNG
(4-Acetamidophenyl 3-(2-(trifluoromethyl)pyridin-4-...)
Show SMILES CC(=O)Nc1ccc(OC(=O)c2cccc(Nc3ccnc(c3)C(F)(F)F)c2)cc1
Show InChI InChI=1S/C21H16F3N3O3/c1-13(28)26-15-5-7-18(8-6-15)30-20(29)14-3-2-4-16(11-14)27-17-9-10-25-19(12-17)21(22,23)24/h2-12H,1H3,(H,25,27)(H,26,28)
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n/an/a 4.70E+4n/an/an/an/an/an/a



University of Cagliari

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate by liquid scintillation spectroscopy

J Med Chem 53: 2286-98 (2010)


Article DOI: 10.1021/jm901891p
BindingDB Entry DOI: 10.7270/Q2833S4K
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50307805
PNG
(4-Acetamidophenyl 2-(2-(trifluoromethyl)pyridin-4-...)
Show SMILES CC(=O)Nc1ccc(OC(=O)c2cccnc2Nc2ccnc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C20H15F3N4O3/c1-12(28)26-13-4-6-15(7-5-13)30-19(29)16-3-2-9-25-18(16)27-14-8-10-24-17(11-14)20(21,22)23/h2-11H,1H3,(H,26,28)(H,24,25,27)
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n/an/a 5.80E+4n/an/an/an/an/an/a



University of Cagliari

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate by liquid scintillation spectroscopy

J Med Chem 53: 2286-98 (2010)


Article DOI: 10.1021/jm901891p
BindingDB Entry DOI: 10.7270/Q2833S4K
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50307810
PNG
(4-Acetamidophenyl 2-(2-(trifluoromethyl)pyridin-4-...)
Show SMILES CC(=O)Nc1ccc(OC(=O)c2ccccc2Nc2ccnc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H16F3N3O3/c1-13(28)26-14-6-8-16(9-7-14)30-20(29)17-4-2-3-5-18(17)27-15-10-11-25-19(12-15)21(22,23)24/h2-12H,1H3,(H,25,27)(H,26,28)
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n/an/a 6.40E+4n/an/an/an/an/an/a



University of Cagliari

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate by liquid scintillation spectroscopy

J Med Chem 53: 2286-98 (2010)


Article DOI: 10.1021/jm901891p
BindingDB Entry DOI: 10.7270/Q2833S4K
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50009859
PNG
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O
Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
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n/an/a 2.40E+5n/an/an/an/a7.4n/a



University of Cagliari

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate at pH 7.4 by liquid scintillation spectroscopy

J Med Chem 53: 2286-98 (2010)


Article DOI: 10.1021/jm901891p
BindingDB Entry DOI: 10.7270/Q2833S4K
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50009859
PNG
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O
Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
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n/an/a 2.63E+5n/an/an/an/an/an/a



University of Cagliari

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate by liquid scintillation spectroscopy

J Med Chem 53: 2286-98 (2010)


Article DOI: 10.1021/jm901891p
BindingDB Entry DOI: 10.7270/Q2833S4K
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM26197
PNG
(CHEMBL112 | N-(4-hydroxyphenyl)acetamide | Norco |...)
Show SMILES CC(=O)Nc1ccc(O)cc1
Show InChI InChI=1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Cagliari

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate by liquid scintillation spectroscopy

J Med Chem 53: 2286-98 (2010)


Article DOI: 10.1021/jm901891p
BindingDB Entry DOI: 10.7270/Q2833S4K
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50307804
PNG
(4-Acetamidophenyl 2-(3-(trifluoromethyl)phenylamin...)
Show SMILES CC(=O)Nc1ccc(OC(=O)c2cccnc2Nc2cccc(c2)C(F)(F)F)cc1
Show InChI InChI=1S/C21H16F3N3O3/c1-13(28)26-15-7-9-17(10-8-15)30-20(29)18-6-3-11-25-19(18)27-16-5-2-4-14(12-16)21(22,23)24/h2-12H,1H3,(H,25,27)(H,26,28)
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n/an/a>3.00E+5n/an/an/an/an/an/a



University of Cagliari

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate by liquid scintillation spectroscopy

J Med Chem 53: 2286-98 (2010)


Article DOI: 10.1021/jm901891p
BindingDB Entry DOI: 10.7270/Q2833S4K
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50009859
PNG
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O
Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
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n/an/a>5.00E+5n/an/an/an/a9.0n/a



University of Cagliari

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate at pH 9.0 by liquid scintillation spectroscopy

J Med Chem 53: 2286-98 (2010)


Article DOI: 10.1021/jm901891p
BindingDB Entry DOI: 10.7270/Q2833S4K
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%