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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM50182010 (7-(pyridin-2-yl)-N-(2,4,6-trimethoxyphenyl)-7H-pyr...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet  | CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 5.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of recombinant GST tagged JAK2 after 60 mins by Caliper mobility shift assay | Bioorg Med Chem Lett 20: 1858-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.151 BindingDB Entry DOI: 10.7270/Q2PR7W4M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM50312975 (7-phenyl-N-(3,4,5-trimethoxyphenyl)benzo[d]oxazol-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of recombinant GST tagged JAK2 after 60 mins by Caliper mobility shift assay | Bioorg Med Chem Lett 20: 1858-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.151 BindingDB Entry DOI: 10.7270/Q2PR7W4M | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM50313807 (CHEMBL1093749 | N-methyl-4-(3-(3,4,5-trimethoxyphe...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents | PDB Article PubMed | n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of recombinant GST tagged JAK2 after 60 mins by Caliper mobility shift assay | Bioorg Med Chem Lett 20: 1858-60 (2010) Article DOI: 10.1016/j.bmcl.2010.01.151 BindingDB Entry DOI: 10.7270/Q2PR7W4M | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
