Affinity Data by PubMed id=20494587

PubMed code 20494587

Found 24 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Thermolysin (Bacillus thermoproteolyticus)	BDBM50321113 (3-Phenyl-2-(trifluoromethyl)quinazolin-4(3H)-one \|...) Show SMILES FC(F)(F)c1nc2ccccc2c(=O)n1-c1ccccc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	11.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Troms£ Curated by ChEMBL					Assay Description Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.5 to 2 mM substrate FaGLa				Bioorg Med Chem 18: 4317-27 (2010) Article DOI: 10.1016/j.bmc.2010.04.083 BindingDB Entry DOI: 10.7270/Q2QV3MP9
University of Troms£ Curated by ChEMBL					More data for this Ligand-Target Pair
Thermolysin (Bacillus thermoproteolyticus)	BDBM50321123 (3-(Isopropylideneamino)-2,2-dimethyl-2,3-dihydroqu...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	243	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Troms£ Curated by ChEMBL					Assay Description Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.5 to 2 mM substrate FaGLa				Bioorg Med Chem 18: 4317-27 (2010) Article DOI: 10.1016/j.bmc.2010.04.083 BindingDB Entry DOI: 10.7270/Q2QV3MP9
University of Troms£ Curated by ChEMBL					More data for this Ligand-Target Pair
Thermolysin (Bacillus thermoproteolyticus)	BDBM50321122 (2-Ethylquinazolin-4(3H)-one \| CHEMBL1163173) Show SMILES Clc1ccc(cc1)-c1nc2ccccc2c(=O)[nH]1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.25E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Troms£ Curated by ChEMBL					Assay Description Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.5 to 2 mM substrate FaGLa				Bioorg Med Chem 18: 4317-27 (2010) Article DOI: 10.1016/j.bmc.2010.04.083 BindingDB Entry DOI: 10.7270/Q2QV3MP9
University of Troms£ Curated by ChEMBL					More data for this Ligand-Target Pair
Thermolysin (Bacillus thermoproteolyticus)	BDBM50321112 (3-Amino-2-(trifluoromethyl)quinazolin-4(3H)-one \| ...) Show SMILES Nn1c(nc2ccccc2c1=O)C(F)(F)F Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	3.79E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Troms£ Curated by ChEMBL					Assay Description Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.5 to 2 mM substrate FaGLa				Bioorg Med Chem 18: 4317-27 (2010) Article DOI: 10.1016/j.bmc.2010.04.083 BindingDB Entry DOI: 10.7270/Q2QV3MP9
University of Troms£ Curated by ChEMBL					More data for this Ligand-Target Pair
Thermolysin (Bacillus thermoproteolyticus)	BDBM50321118 (3-({(1E)-[4-(Dimethylamino)phenyl]methylene}amino)...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.20E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Troms£ Curated by ChEMBL					Assay Description Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.5 to 2 mM substrate FaGLa				Bioorg Med Chem 18: 4317-27 (2010) Article DOI: 10.1016/j.bmc.2010.04.083 BindingDB Entry DOI: 10.7270/Q2QV3MP9
University of Troms£ Curated by ChEMBL					More data for this Ligand-Target Pair
Thermolysin (Bacillus thermoproteolyticus)	BDBM50321114 (3-Amino-2-methylquinazolin-4(3H)-one \| CHEMBL11631...) Show SMILES Cc1nc2ccccc2c(=O)n1N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	5.49E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Troms£ Curated by ChEMBL					Assay Description Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.5 to 2 mM substrate FaGLa				Bioorg Med Chem 18: 4317-27 (2010) Article DOI: 10.1016/j.bmc.2010.04.083 BindingDB Entry DOI: 10.7270/Q2QV3MP9
University of Troms£ Curated by ChEMBL					More data for this Ligand-Target Pair
Thermolysin (Bacillus thermoproteolyticus)	BDBM50321115 (2-(4-Methylphenyl)-3-(1,3-thiazol-2-yl)quinazolin-...) Show SMILES Cc1ccc(cc1)-c1nc2ccccc2c(=O)n1-c1nccs1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	5.93E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Troms£ Curated by ChEMBL					Assay Description Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.5 to 2 mM substrate FaGLa				Bioorg Med Chem 18: 4317-27 (2010) Article DOI: 10.1016/j.bmc.2010.04.083 BindingDB Entry DOI: 10.7270/Q2QV3MP9
University of Troms£ Curated by ChEMBL					More data for this Ligand-Target Pair
Thermolysin (Bacillus thermoproteolyticus)	BDBM50321119 (3-({(1E)-[4-(Dimethylamino)phenyl]methylene}amino)...) Show SMILES CC1Nc2ccccc2C(=O)N1\N=C\c1ccc(cc1)N(C)C Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.83E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Troms£ Curated by ChEMBL					Assay Description Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.5 to 2 mM substrate FaGLa				Bioorg Med Chem 18: 4317-27 (2010) Article DOI: 10.1016/j.bmc.2010.04.083 BindingDB Entry DOI: 10.7270/Q2QV3MP9
University of Troms£ Curated by ChEMBL					More data for this Ligand-Target Pair
Thermolysin (Bacillus thermoproteolyticus)	BDBM50321116 (3-Amino-2-(4-nitrophenyl)quinazolin-4(3H)-one \| CH...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	3.12E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Troms£ Curated by ChEMBL					Assay Description Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.5 to 2 mM substrate FaGLa				Bioorg Med Chem 18: 4317-27 (2010) Article DOI: 10.1016/j.bmc.2010.04.083 BindingDB Entry DOI: 10.7270/Q2QV3MP9
University of Troms£ Curated by ChEMBL					More data for this Ligand-Target Pair
Thermolysin (Bacillus thermoproteolyticus)	BDBM50321120 (3-{[(1E)-(3-Chlorophenyl)methylene]amino}-2-phenyl...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Troms£ Curated by ChEMBL					Assay Description Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.5 to 2 mM substrate FaGLa				Bioorg Med Chem 18: 4317-27 (2010) Article DOI: 10.1016/j.bmc.2010.04.083 BindingDB Entry DOI: 10.7270/Q2QV3MP9
University of Troms£ Curated by ChEMBL					More data for this Ligand-Target Pair
Thermolysin (Bacillus thermoproteolyticus)	BDBM50321117 (3-Amino-2-(4-chlorophenyl)quinazolin-4(3H)-one \| C...) Show SMILES Nn1c(nc2ccccc2c1=O)-c1ccc(Cl)cc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	1.01E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Troms£ Curated by ChEMBL					Assay Description Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.5 to 2 mM substrate FaGLa				Bioorg Med Chem 18: 4317-27 (2010) Article DOI: 10.1016/j.bmc.2010.04.083 BindingDB Entry DOI: 10.7270/Q2QV3MP9
University of Troms£ Curated by ChEMBL					More data for this Ligand-Target Pair
Thermolysin (Bacillus thermoproteolyticus)	BDBM50321121 (CHEMBL1163684 \| EthanimidicacidN-[4-oxo-2-phenyl-3...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	1.06E+8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Troms£ Curated by ChEMBL					Assay Description Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.5 to 2 mM substrate FaGLa				Bioorg Med Chem 18: 4317-27 (2010) Article DOI: 10.1016/j.bmc.2010.04.083 BindingDB Entry DOI: 10.7270/Q2QV3MP9
University of Troms£ Curated by ChEMBL					More data for this Ligand-Target Pair
Thermolysin (Bacillus thermoproteolyticus)	BDBM50321113 (3-Phenyl-2-(trifluoromethyl)quinazolin-4(3H)-one \|...) Show SMILES FC(F)(F)c1nc2ccccc2c(=O)n1-c1ccccc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Troms£ Curated by ChEMBL					Assay Description Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLa				Bioorg Med Chem 18: 4317-27 (2010) Article DOI: 10.1016/j.bmc.2010.04.083 BindingDB Entry DOI: 10.7270/Q2QV3MP9
University of Troms£ Curated by ChEMBL					More data for this Ligand-Target Pair
Thermolysin (Bacillus thermoproteolyticus)	BDBM50321123 (3-(Isopropylideneamino)-2,2-dimethyl-2,3-dihydroqu...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	248	n/a	n/a	n/a	n/a	n/a	n/a
University of Troms£ Curated by ChEMBL					Assay Description Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLa				Bioorg Med Chem 18: 4317-27 (2010) Article DOI: 10.1016/j.bmc.2010.04.083 BindingDB Entry DOI: 10.7270/Q2QV3MP9
University of Troms£ Curated by ChEMBL					More data for this Ligand-Target Pair
Thermolysin (Bacillus thermoproteolyticus)	BDBM50321122 (2-Ethylquinazolin-4(3H)-one \| CHEMBL1163173) Show SMILES Clc1ccc(cc1)-c1nc2ccccc2c(=O)[nH]1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.25E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Troms£ Curated by ChEMBL					Assay Description Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLa				Bioorg Med Chem 18: 4317-27 (2010) Article DOI: 10.1016/j.bmc.2010.04.083 BindingDB Entry DOI: 10.7270/Q2QV3MP9
University of Troms£ Curated by ChEMBL					More data for this Ligand-Target Pair
Thermolysin (Bacillus thermoproteolyticus)	BDBM50321112 (3-Amino-2-(trifluoromethyl)quinazolin-4(3H)-one \| ...) Show SMILES Nn1c(nc2ccccc2c1=O)C(F)(F)F Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.79E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Troms£ Curated by ChEMBL					Assay Description Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLa				Bioorg Med Chem 18: 4317-27 (2010) Article DOI: 10.1016/j.bmc.2010.04.083 BindingDB Entry DOI: 10.7270/Q2QV3MP9
University of Troms£ Curated by ChEMBL					More data for this Ligand-Target Pair
Thermolysin (Bacillus thermoproteolyticus)	BDBM50321118 (3-({(1E)-[4-(Dimethylamino)phenyl]methylene}amino)...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Troms£ Curated by ChEMBL					Assay Description Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLa				Bioorg Med Chem 18: 4317-27 (2010) Article DOI: 10.1016/j.bmc.2010.04.083 BindingDB Entry DOI: 10.7270/Q2QV3MP9
University of Troms£ Curated by ChEMBL					More data for this Ligand-Target Pair
Thermolysin (Bacillus thermoproteolyticus)	BDBM50321114 (3-Amino-2-methylquinazolin-4(3H)-one \| CHEMBL11631...) Show SMILES Cc1nc2ccccc2c(=O)n1N Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.49E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Troms£ Curated by ChEMBL					Assay Description Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLa				Bioorg Med Chem 18: 4317-27 (2010) Article DOI: 10.1016/j.bmc.2010.04.083 BindingDB Entry DOI: 10.7270/Q2QV3MP9
University of Troms£ Curated by ChEMBL					More data for this Ligand-Target Pair
Thermolysin (Bacillus thermoproteolyticus)	BDBM50321115 (2-(4-Methylphenyl)-3-(1,3-thiazol-2-yl)quinazolin-...) Show SMILES Cc1ccc(cc1)-c1nc2ccccc2c(=O)n1-c1nccs1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.69E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Troms£ Curated by ChEMBL					Assay Description Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLa				Bioorg Med Chem 18: 4317-27 (2010) Article DOI: 10.1016/j.bmc.2010.04.083 BindingDB Entry DOI: 10.7270/Q2QV3MP9
University of Troms£ Curated by ChEMBL					More data for this Ligand-Target Pair
Thermolysin (Bacillus thermoproteolyticus)	BDBM50321121 (CHEMBL1163684 \| EthanimidicacidN-[4-oxo-2-phenyl-3...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.23E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Troms£ Curated by ChEMBL					Assay Description Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLa				Bioorg Med Chem 18: 4317-27 (2010) Article DOI: 10.1016/j.bmc.2010.04.083 BindingDB Entry DOI: 10.7270/Q2QV3MP9
University of Troms£ Curated by ChEMBL					More data for this Ligand-Target Pair
Thermolysin (Bacillus thermoproteolyticus)	BDBM50321119 (3-({(1E)-[4-(Dimethylamino)phenyl]methylene}amino)...) Show SMILES CC1Nc2ccccc2C(=O)N1\N=C\c1ccc(cc1)N(C)C Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.83E+6	n/a	n/a	n/a	n/a	n/a	n/a
University of Troms£ Curated by ChEMBL					Assay Description Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLa				Bioorg Med Chem 18: 4317-27 (2010) Article DOI: 10.1016/j.bmc.2010.04.083 BindingDB Entry DOI: 10.7270/Q2QV3MP9
University of Troms£ Curated by ChEMBL					More data for this Ligand-Target Pair
Thermolysin (Bacillus thermoproteolyticus)	BDBM50321116 (3-Amino-2-(4-nitrophenyl)quinazolin-4(3H)-one \| CH...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.12E+6	n/a	n/a	n/a	n/a	n/a	n/a
University of Troms£ Curated by ChEMBL					Assay Description Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLa				Bioorg Med Chem 18: 4317-27 (2010) Article DOI: 10.1016/j.bmc.2010.04.083 BindingDB Entry DOI: 10.7270/Q2QV3MP9
University of Troms£ Curated by ChEMBL					More data for this Ligand-Target Pair
Thermolysin (Bacillus thermoproteolyticus)	BDBM50321120 (3-{[(1E)-(3-Chlorophenyl)methylene]amino}-2-phenyl...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
University of Troms£ Curated by ChEMBL					Assay Description Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLa				Bioorg Med Chem 18: 4317-27 (2010) Article DOI: 10.1016/j.bmc.2010.04.083 BindingDB Entry DOI: 10.7270/Q2QV3MP9
University of Troms£ Curated by ChEMBL					More data for this Ligand-Target Pair
Thermolysin (Bacillus thermoproteolyticus)	BDBM50321117 (3-Amino-2-(4-chlorophenyl)quinazolin-4(3H)-one \| C...) Show SMILES Nn1c(nc2ccccc2c1=O)-c1ccc(Cl)cc1 Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.27E+7	n/a	n/a	n/a	n/a	n/a	n/a
University of Troms£ Curated by ChEMBL					Assay Description Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLa				Bioorg Med Chem 18: 4317-27 (2010) Article DOI: 10.1016/j.bmc.2010.04.083 BindingDB Entry DOI: 10.7270/Q2QV3MP9
University of Troms£ Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%