Found 37 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Cyclin-T1/Cyclin-dependent kinase 9
(Homo sapiens (Human)) | BDBM7266
(14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)Show InChI InChI=1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant CDK9/cyclin T expressed in insect cells assessed as incorporation of [gamma-33P]-ATP in to pRB fragment (773 to 928) ... |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Cyclin-T1/Cyclin-dependent kinase 9
(Homo sapiens (Human)) | BDBM50346235
(9-azapaullone | CHEMBL1782168)Show InChI InChI=1S/C15H11N3O/c19-14-7-10-11-8-16-6-5-13(11)18-15(10)9-3-1-2-4-12(9)17-14/h1-6,8,18H,7H2,(H,17,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant CDK9/cyclin T expressed in insect cells assessed as incorporation of [gamma-33P]-ATP in to pRB fragment (773 to 928) ... |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Cyclin-T1/Cyclin-dependent kinase 9
(Homo sapiens (Human)) | BDBM50346237
(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)Show SMILES [O-][n+]1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI InChI=1S/C15H11N3O2/c19-14-7-10-11-8-18(20)6-5-13(11)17-15(10)9-3-1-2-4-12(9)16-14/h1-6,8,17H,7H2,(H,16,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant CDK9/cyclin T expressed in insect cells assessed as incorporation of [gamma-33P]-ATP in to pRB fragment (773 to 928) ... |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1
(Homo sapiens (Human)) | BDBM7266
(14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)Show InChI InChI=1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of CDK1/cyclin B |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Cyclin-A2/Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM7266
(14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)Show InChI InChI=1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 780 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant CDK2/cyclin A assessed as incorporation of [gamma-33P]-ATP into histone H1 substrate after 30 mins by scintillation c... |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Cyclin-T1/Cyclin-dependent kinase 9
(Homo sapiens (Human)) | BDBM7287
(8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,17}]octad...)Show InChI InChI=1S/C16H12N2O/c19-15-9-12-10-5-1-3-7-13(10)18-16(12)11-6-2-4-8-14(11)17-15/h1-8,18H,9H2,(H,17,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 810 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant CDK9/cyclin T expressed in insect cells assessed as incorporation of [gamma-33P]-ATP in to pRB fragment (773 to 928) ... |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 5 activator 1
(Homo sapiens (Human)) | BDBM7266
(14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)Show InChI InChI=1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant CDK5/p25 assessed as incorporation of [gamma-33P]-ATP into histone H1 substrate after 30 mins by scintillation counti... |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Cyclin-A2/Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50346235
(9-azapaullone | CHEMBL1782168)Show InChI InChI=1S/C15H11N3O/c19-14-7-10-11-8-16-6-5-13(11)18-15(10)9-3-1-2-4-12(9)17-14/h1-6,8,18H,7H2,(H,17,19) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant CDK2/cyclin A assessed as incorporation of [gamma-33P]-ATP into histone H1 substrate after 30 mins by scintillation c... |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Cyclin-A2/Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM7287
(8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,17}]octad...)Show InChI InChI=1S/C16H12N2O/c19-15-9-12-10-5-1-3-7-13(10)18-16(12)11-6-2-4-8-14(11)17-15/h1-8,18H,9H2,(H,17,19) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant CDK2/cyclin A assessed as incorporation of [gamma-33P]-ATP into histone H1 substrate after 30 mins by scintillation c... |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 5 activator 1
(Homo sapiens (Human)) | BDBM50346235
(9-azapaullone | CHEMBL1782168)Show InChI InChI=1S/C15H11N3O/c19-14-7-10-11-8-16-6-5-13(11)18-15(10)9-3-1-2-4-12(9)17-14/h1-6,8,18H,7H2,(H,17,19) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant CDK5/p25 assessed as incorporation of [gamma-33P]-ATP into histone H1 substrate after 30 mins by scintillation counti... |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 5 activator 1
(Homo sapiens (Human)) | BDBM7287
(8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,17}]octad...)Show InChI InChI=1S/C16H12N2O/c19-15-9-12-10-5-1-3-7-13(10)18-16(12)11-6-2-4-8-14(11)17-15/h1-8,18H,9H2,(H,17,19) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant CDK5/p25 assessed as incorporation of [gamma-33P]-ATP into histone H1 substrate after 30 mins by scintillation counti... |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Cyclin-A2/Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50346237
(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)Show SMILES [O-][n+]1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI InChI=1S/C15H11N3O2/c19-14-7-10-11-8-18(20)6-5-13(11)17-15(10)9-3-1-2-4-12(9)16-14/h1-6,8,17H,7H2,(H,16,19) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant CDK2/cyclin A assessed as incorporation of [gamma-33P]-ATP into histone H1 substrate after 30 mins by scintillation c... |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1
(Homo sapiens (Human)) | BDBM7287
(8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,17}]octad...)Show InChI InChI=1S/C16H12N2O/c19-15-9-12-10-5-1-3-7-13(10)18-16(12)11-6-2-4-8-14(11)17-15/h1-8,18H,9H2,(H,17,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of CDK1/cyclin B |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 5 activator 1
(Homo sapiens (Human)) | BDBM50346237
(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)Show SMILES [O-][n+]1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI InChI=1S/C15H11N3O2/c19-14-7-10-11-8-18(20)6-5-13(11)17-15(10)9-3-1-2-4-12(9)16-14/h1-6,8,17H,7H2,(H,16,19) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant CDK5/p25 assessed as incorporation of [gamma-33P]-ATP into histone H1 substrate after 30 mins by scintillation counti... |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Cyclin-T1/Cyclin-dependent kinase 9
(Homo sapiens (Human)) | BDBM50346236
(9-Benzyl-6-oxo-5,6,7,12-tetrahydro-5,12-diaza-9-az...)Show SMILES O=C1Cc2c([nH+]c3ccn(Cc4ccccc4)cc23)-c2ccccc2N1 Show InChI InChI=1S/C22H17N3O/c26-21-12-17-18-14-25(13-15-6-2-1-3-7-15)11-10-20(18)24-22(17)16-8-4-5-9-19(16)23-21/h1-11,14H,12-13H2,(H,23,26)/p+1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant CDK9/cyclin T expressed in insect cells assessed as incorporation of [gamma-33P]-ATP in to pRB fragment (773 to 928) ... |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Glycogen synthase kinase 3
(Plasmodium falciparum (isolate 3D7)) | BDBM50346237
(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)Show SMILES [O-][n+]1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI InChI=1S/C15H11N3O2/c19-14-7-10-11-8-18(20)6-5-13(11)17-15(10)9-3-1-2-4-12(9)16-14/h1-6,8,17H,7H2,(H,16,19) | KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of Plasmodium falciparum GSK3 |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(RAT) | BDBM7287
(8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,17}]octad...)Show InChI InChI=1S/C16H12N2O/c19-15-9-12-10-5-1-3-7-13(10)18-16(12)11-6-2-4-8-14(11)17-15/h1-8,18H,9H2,(H,17,19) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli assessed as assessed as incorporation of [gamma-33P]-ATP into myelin bas... |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Casein kinase I isoform alpha
(Sus scrofa) | BDBM50346235
(9-azapaullone | CHEMBL1782168)Show InChI InChI=1S/C15H11N3O/c19-14-7-10-11-8-16-6-5-13(11)18-15(10)9-3-1-2-4-12(9)17-14/h1-6,8,18H,7H2,(H,17,19) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of porcine brain CK1 assessed as incorporation of [gamma-33P]-ATP into RRKHAAIGpSAYSITA substrate after 30 mins by scintillation counting |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Glycogen synthase kinase 3
(Plasmodium falciparum (isolate 3D7)) | BDBM50346236
(9-Benzyl-6-oxo-5,6,7,12-tetrahydro-5,12-diaza-9-az...)Show SMILES O=C1Cc2c([nH+]c3ccn(Cc4ccccc4)cc23)-c2ccccc2N1 Show InChI InChI=1S/C22H17N3O/c26-21-12-17-18-14-25(13-15-6-2-1-3-7-15)11-10-20(18)24-22(17)16-8-4-5-9-19(16)23-21/h1-11,14H,12-13H2,(H,23,26)/p+1 | KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of Plasmodium falciparum GSK3 |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Glycogen synthase kinase 3
(Plasmodium falciparum (isolate 3D7)) | BDBM7287
(8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,17}]octad...)Show InChI InChI=1S/C16H12N2O/c19-15-9-12-10-5-1-3-7-13(10)18-16(12)11-6-2-4-8-14(11)17-15/h1-8,18H,9H2,(H,17,19) | KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
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Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of Plasmodium falciparum GSK3 |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Glycogen synthase kinase 3
(Plasmodium falciparum (isolate 3D7)) | BDBM7266
(14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)Show InChI InChI=1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20) | KEGG
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Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of Plasmodium falciparum GSK3 |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(RAT) | BDBM50346237
(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)Show SMILES [O-][n+]1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI InChI=1S/C15H11N3O2/c19-14-7-10-11-8-18(20)6-5-13(11)17-15(10)9-3-1-2-4-12(9)16-14/h1-6,8,17H,7H2,(H,16,19) | PDB
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Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli assessed as assessed as incorporation of [gamma-33P]-ATP into myelin bas... |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Casein kinase I isoform alpha
(Sus scrofa) | BDBM50346236
(9-Benzyl-6-oxo-5,6,7,12-tetrahydro-5,12-diaza-9-az...)Show SMILES O=C1Cc2c([nH+]c3ccn(Cc4ccccc4)cc23)-c2ccccc2N1 Show InChI InChI=1S/C22H17N3O/c26-21-12-17-18-14-25(13-15-6-2-1-3-7-15)11-10-20(18)24-22(17)16-8-4-5-9-19(16)23-21/h1-11,14H,12-13H2,(H,23,26)/p+1 | PDB
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Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of porcine brain CK1 assessed as incorporation of [gamma-33P]-ATP into RRKHAAIGpSAYSITA substrate after 30 mins by scintillation counting |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(RAT) | BDBM50346235
(9-azapaullone | CHEMBL1782168)Show InChI InChI=1S/C15H11N3O/c19-14-7-10-11-8-16-6-5-13(11)18-15(10)9-3-1-2-4-12(9)17-14/h1-6,8,18H,7H2,(H,17,19) | PDB
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Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli assessed as assessed as incorporation of [gamma-33P]-ATP into myelin bas... |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Dual specificity protein kinase CLK1
(Homo sapiens (Human)) | BDBM50346237
(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)Show SMILES [O-][n+]1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI InChI=1S/C15H11N3O2/c19-14-7-10-11-8-18(20)6-5-13(11)17-15(10)9-3-1-2-4-12(9)16-14/h1-6,8,17H,7H2,(H,16,19) | PDB
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Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of CLK1 |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Casein kinase I isoform alpha
(Sus scrofa) | BDBM7287
(8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,17}]octad...)Show InChI InChI=1S/C16H12N2O/c19-15-9-12-10-5-1-3-7-13(10)18-16(12)11-6-2-4-8-14(11)17-15/h1-8,18H,9H2,(H,17,19) | PDB
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Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of porcine brain CK1 assessed as incorporation of [gamma-33P]-ATP into RRKHAAIGpSAYSITA substrate after 30 mins by scintillation counting |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(RAT) | BDBM50346236
(9-Benzyl-6-oxo-5,6,7,12-tetrahydro-5,12-diaza-9-az...)Show SMILES O=C1Cc2c([nH+]c3ccn(Cc4ccccc4)cc23)-c2ccccc2N1 Show InChI InChI=1S/C22H17N3O/c26-21-12-17-18-14-25(13-15-6-2-1-3-7-15)11-10-20(18)24-22(17)16-8-4-5-9-19(16)23-21/h1-11,14H,12-13H2,(H,23,26)/p+1 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli assessed as assessed as incorporation of [gamma-33P]-ATP into myelin bas... |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Dual specificity protein kinase CLK1
(Homo sapiens (Human)) | BDBM50346236
(9-Benzyl-6-oxo-5,6,7,12-tetrahydro-5,12-diaza-9-az...)Show SMILES O=C1Cc2c([nH+]c3ccn(Cc4ccccc4)cc23)-c2ccccc2N1 Show InChI InChI=1S/C22H17N3O/c26-21-12-17-18-14-25(13-15-6-2-1-3-7-15)11-10-20(18)24-22(17)16-8-4-5-9-19(16)23-21/h1-11,14H,12-13H2,(H,23,26)/p+1 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of CLK1 |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Dual specificity protein kinase CLK1
(Homo sapiens (Human)) | BDBM50346235
(9-azapaullone | CHEMBL1782168)Show InChI InChI=1S/C15H11N3O/c19-14-7-10-11-8-16-6-5-13(11)18-15(10)9-3-1-2-4-12(9)17-14/h1-6,8,18H,7H2,(H,17,19) | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of CLK1 |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Glycogen synthase kinase 3
(Plasmodium falciparum (isolate 3D7)) | BDBM50346235
(9-azapaullone | CHEMBL1782168)Show InChI InChI=1S/C15H11N3O/c19-14-7-10-11-8-16-6-5-13(11)18-15(10)9-3-1-2-4-12(9)17-14/h1-6,8,18H,7H2,(H,17,19) | KEGG
UniProtKB/TrEMBL
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| CHEMBL
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of Plasmodium falciparum GSK3 |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Cyclin-dependent kinase 5 activator 1
(Homo sapiens (Human)) | BDBM50346236
(9-Benzyl-6-oxo-5,6,7,12-tetrahydro-5,12-diaza-9-az...)Show SMILES O=C1Cc2c([nH+]c3ccn(Cc4ccccc4)cc23)-c2ccccc2N1 Show InChI InChI=1S/C22H17N3O/c26-21-12-17-18-14-25(13-15-6-2-1-3-7-15)11-10-20(18)24-22(17)16-8-4-5-9-19(16)23-21/h1-11,14H,12-13H2,(H,23,26)/p+1 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant CDK5/p25 assessed as incorporation of [gamma-33P]-ATP into histone H1 substrate after 30 mins by scintillation counti... |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Dual specificity protein kinase CLK1
(Homo sapiens (Human)) | BDBM7266
(14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)Show InChI InChI=1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20) | PDB
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Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of CLK1 |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Casein kinase I isoform alpha
(Sus scrofa) | BDBM7266
(14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)Show InChI InChI=1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20) | PDB
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Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of porcine brain CK1 assessed as incorporation of [gamma-33P]-ATP into RRKHAAIGpSAYSITA substrate after 30 mins by scintillation counting |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Casein kinase I isoform alpha
(Sus scrofa) | BDBM50346237
(9-Oxy-5,12-dihydro-7H-5,9,12-triaza-dibenzo[a,e]az...)Show SMILES [O-][n+]1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 Show InChI InChI=1S/C15H11N3O2/c19-14-7-10-11-8-18(20)6-5-13(11)17-15(10)9-3-1-2-4-12(9)16-14/h1-6,8,17H,7H2,(H,16,19) | PDB
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Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of porcine brain CK1 assessed as incorporation of [gamma-33P]-ATP into RRKHAAIGpSAYSITA substrate after 30 mins by scintillation counting |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Cyclin-A2/Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM50346236
(9-Benzyl-6-oxo-5,6,7,12-tetrahydro-5,12-diaza-9-az...)Show SMILES O=C1Cc2c([nH+]c3ccn(Cc4ccccc4)cc23)-c2ccccc2N1 Show InChI InChI=1S/C22H17N3O/c26-21-12-17-18-14-25(13-15-6-2-1-3-7-15)11-10-20(18)24-22(17)16-8-4-5-9-19(16)23-21/h1-11,14H,12-13H2,(H,23,26)/p+1 | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant CDK2/cyclin A assessed as incorporation of [gamma-33P]-ATP into histone H1 substrate after 30 mins by scintillation c... |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(RAT) | BDBM7266
(14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)Show InChI InChI=1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20) | PDB
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Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli assessed as assessed as incorporation of [gamma-33P]-ATP into myelin bas... |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
Dual specificity protein kinase CLK1
(Homo sapiens (Human)) | BDBM7287
(8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,17}]octad...)Show InChI InChI=1S/C16H12N2O/c19-15-9-12-10-5-1-3-7-13(10)18-16(12)11-6-2-4-8-14(11)17-15/h1-8,18H,9H2,(H,17,19) | PDB
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Trinity College
Curated by ChEMBL
| Assay Description
Inhibition of CLK1 |
Bioorg Med Chem Lett 20: 4940-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.06.024
BindingDB Entry DOI: 10.7270/Q21836T2 |
More data for this
Ligand-Target Pair | |
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