Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (Homo sapiens (Human)) | BDBM50347446 (CHEMBL1802095) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bar-Ilan University Curated by ChEMBL | Assay Description Inhibition of human NPP1 expressed in COS7 cells assessed as production of p-nitrophenol using pnp-TMP as the substrate after 15 mins by malachite gr... | J Med Chem 53: 8485-97 (2010) Article DOI: 10.1021/jm100597c BindingDB Entry DOI: 10.7270/Q22V2GF7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (Homo sapiens (Human)) | BDBM50347447 (CHEMBL1802096) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bar-Ilan University Curated by ChEMBL | Assay Description Inhibition of human NPP1 expressed in COS7 cells assessed as production of p-nitrophenol using pnp-TMP as the substrate after 15 mins by malachite gr... | J Med Chem 53: 8485-97 (2010) Article DOI: 10.1021/jm100597c BindingDB Entry DOI: 10.7270/Q22V2GF7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (Homo sapiens (Human)) | BDBM50347445 (CHEMBL1802094) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bar-Ilan University Curated by ChEMBL | Assay Description Inhibition of human NPP1 expressed in COS7 cells assessed as production of p-nitrophenol using pnp-TMP as the substrate after 15 mins by malachite gr... | J Med Chem 53: 8485-97 (2010) Article DOI: 10.1021/jm100597c BindingDB Entry DOI: 10.7270/Q22V2GF7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (Homo sapiens (Human)) | BDBM50347445 (CHEMBL1802094) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bar-Ilan University Curated by ChEMBL | Assay Description Inhibition of human NPP1 expressed in COS7 cells assessed as enzyme-substrate-inhibitor dissociation constant using pnp-TMP as the substrate after 15... | J Med Chem 53: 8485-97 (2010) Article DOI: 10.1021/jm100597c BindingDB Entry DOI: 10.7270/Q22V2GF7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (Homo sapiens (Human)) | BDBM50347448 (CHEMBL1802097) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 5.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bar-Ilan University Curated by ChEMBL | Assay Description Inhibition of human NPP1 expressed in COS7 cells assessed as production of p-nitrophenol using pnp-TMP as the substrate after 15 mins by malachite gr... | J Med Chem 53: 8485-97 (2010) Article DOI: 10.1021/jm100597c BindingDB Entry DOI: 10.7270/Q22V2GF7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (Homo sapiens (Human)) | BDBM50347448 (CHEMBL1802097) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 8.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bar-Ilan University Curated by ChEMBL | Assay Description Inhibition of human NPP1 expressed in COS7 cells assessed as enzyme-substrate-inhibitor dissociation constant using pnp-TMP as the substrate after 15... | J Med Chem 53: 8485-97 (2010) Article DOI: 10.1021/jm100597c BindingDB Entry DOI: 10.7270/Q22V2GF7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (Homo sapiens (Human)) | BDBM50347446 (CHEMBL1802095) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.45E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bar-Ilan University Curated by ChEMBL | Assay Description Inhibition of human NPP1 expressed in COS7 cells assessed as enzyme-substrate-inhibitor dissociation constant using pnp-TMP as the substrate after 15... | J Med Chem 53: 8485-97 (2010) Article DOI: 10.1021/jm100597c BindingDB Entry DOI: 10.7270/Q22V2GF7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (Homo sapiens (Human)) | BDBM50347447 (CHEMBL1802096) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.47E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bar-Ilan University Curated by ChEMBL | Assay Description Inhibition of human NPP1 expressed in COS7 cells assessed as enzyme-substrate-inhibitor dissociation constant using pnp-TMP as the substrate after 15... | J Med Chem 53: 8485-97 (2010) Article DOI: 10.1021/jm100597c BindingDB Entry DOI: 10.7270/Q22V2GF7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (Homo sapiens (Human)) | BDBM50347446 (CHEMBL1802095) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bar-Ilan University Curated by ChEMBL | Assay Description Inhibition of human NPP1 expressed in COS7 cells assessed as production of p-nitrophenol using pnp-TMP as the substrate after 15 mins by malachite gr... | J Med Chem 53: 8485-97 (2010) Article DOI: 10.1021/jm100597c BindingDB Entry DOI: 10.7270/Q22V2GF7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (Homo sapiens (Human)) | BDBM50347447 (CHEMBL1802096) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bar-Ilan University Curated by ChEMBL | Assay Description Inhibition of human NPP1 expressed in COS7 cells assessed as production of p-nitrophenol using pnp-TMP as the substrate after 15 mins by malachite gr... | J Med Chem 53: 8485-97 (2010) Article DOI: 10.1021/jm100597c BindingDB Entry DOI: 10.7270/Q22V2GF7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (Homo sapiens (Human)) | BDBM50347448 (CHEMBL1802097) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bar-Ilan University Curated by ChEMBL | Assay Description Inhibition of human NPP1 expressed in COS7 cells assessed as production of p-nitrophenol using pnp-TMP as the substrate after 15 mins by malachite gr... | J Med Chem 53: 8485-97 (2010) Article DOI: 10.1021/jm100597c BindingDB Entry DOI: 10.7270/Q22V2GF7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (Homo sapiens (Human)) | BDBM50347445 (CHEMBL1802094) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bar-Ilan University Curated by ChEMBL | Assay Description Inhibition of human NPP1 expressed in COS7 cells assessed as production of p-nitrophenol using pnp-TMP as the substrate after 15 mins by malachite gr... | J Med Chem 53: 8485-97 (2010) Article DOI: 10.1021/jm100597c BindingDB Entry DOI: 10.7270/Q22V2GF7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2Y purinoceptor 11 (Homo sapiens (Human)) | BDBM2 (({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a |
Bar-Ilan University Curated by ChEMBL | Assay Description Agonist activity at GFP tagged-human P2Y11 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluoresce... | J Med Chem 53: 8485-97 (2010) Article DOI: 10.1021/jm100597c BindingDB Entry DOI: 10.7270/Q22V2GF7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2Y purinoceptor 1 (Homo sapiens (Human)) | BDBM50347447 (CHEMBL1802096) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a |
Bar-Ilan University Curated by ChEMBL | Assay Description Agonist activity at GFP tagged-human P2Y1 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluorescen... | J Med Chem 53: 8485-97 (2010) Article DOI: 10.1021/jm100597c BindingDB Entry DOI: 10.7270/Q22V2GF7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2Y purinoceptor 1 (Homo sapiens (Human)) | BDBM50347445 (CHEMBL1802094) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 300 | n/a | n/a | n/a | n/a |
Bar-Ilan University Curated by ChEMBL | Assay Description Agonist activity at GFP tagged-human P2Y1 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluorescen... | J Med Chem 53: 8485-97 (2010) Article DOI: 10.1021/jm100597c BindingDB Entry DOI: 10.7270/Q22V2GF7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2Y purinoceptor 11 (Homo sapiens (Human)) | BDBM50347445 (CHEMBL1802094) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a |
Bar-Ilan University Curated by ChEMBL | Assay Description Agonist activity at GFP tagged-human P2Y11 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluoresce... | J Med Chem 53: 8485-97 (2010) Article DOI: 10.1021/jm100597c BindingDB Entry DOI: 10.7270/Q22V2GF7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2Y purinoceptor 1 (Homo sapiens (Human)) | BDBM2 (({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 150 | n/a | n/a | n/a | n/a |
Bar-Ilan University Curated by ChEMBL | Assay Description Agonist activity at GFP tagged-human P2Y1 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluorescen... | J Med Chem 53: 8485-97 (2010) Article DOI: 10.1021/jm100597c BindingDB Entry DOI: 10.7270/Q22V2GF7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2Y purinoceptor 1 (Homo sapiens (Human)) | BDBM50347448 (CHEMBL1802097) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a |
Bar-Ilan University Curated by ChEMBL | Assay Description Agonist activity at GFP tagged-human P2Y1 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluorescen... | J Med Chem 53: 8485-97 (2010) Article DOI: 10.1021/jm100597c BindingDB Entry DOI: 10.7270/Q22V2GF7 | |||||||||||
More data for this Ligand-Target Pair |