Found 15 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50355883
(CHEMBL1910022)Show SMILES C[C@H](NC(=O)c1cccc2CCc3ccc(cc3Oc12)C(F)(F)F)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C25H20F3NO4/c1-14(15-5-9-18(10-6-15)24(31)32)29-23(30)20-4-2-3-17-8-7-16-11-12-19(25(26,27)28)13-21(16)33-22(17)20/h2-6,9-14H,7-8H2,1H3,(H,29,30)(H,31,32)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Rottapharm Madaus
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGE2 from human EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 21: 6336-40 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.102
BindingDB Entry DOI: 10.7270/Q29Z95B1 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50355879
(CHEMBL1910023)Show SMILES OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1cccc2CCc3ccc(cc3Oc12)C(F)(F)F Show InChI InChI=1S/C26H20F3NO4/c27-26(28,29)19-11-6-15-4-5-16-2-1-3-20(22(16)34-21(15)14-19)23(31)30-25(12-13-25)18-9-7-17(8-10-18)24(32)33/h1-3,6-11,14H,4-5,12-13H2,(H,30,31)(H,32,33) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Rottapharm Madaus
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGE2 from human EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 21: 6336-40 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.102
BindingDB Entry DOI: 10.7270/Q29Z95B1 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50355882
(CHEMBL591666)Show SMILES C[C@H](NC(=O)c1cc(Cl)ccc1Oc1ccc(F)cc1)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C22H17ClFNO4/c1-13(14-2-4-15(5-3-14)22(27)28)25-21(26)19-12-16(23)6-11-20(19)29-18-9-7-17(24)8-10-18/h2-13H,1H3,(H,25,26)(H,27,28)/t13-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Rottapharm Madaus
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGE2 from human EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 21: 6336-40 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.102
BindingDB Entry DOI: 10.7270/Q29Z95B1 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50355882
(CHEMBL591666)Show SMILES C[C@H](NC(=O)c1cc(Cl)ccc1Oc1ccc(F)cc1)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C22H17ClFNO4/c1-13(14-2-4-15(5-3-14)22(27)28)25-21(26)19-12-16(23)6-11-20(19)29-18-9-7-17(24)8-10-18/h2-13H,1H3,(H,25,26)(H,27,28)/t13-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Rottapharm Madaus
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by bead-based proximity ... |
Bioorg Med Chem Lett 21: 6336-40 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.102
BindingDB Entry DOI: 10.7270/Q29Z95B1 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50355883
(CHEMBL1910022)Show SMILES C[C@H](NC(=O)c1cccc2CCc3ccc(cc3Oc12)C(F)(F)F)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C25H20F3NO4/c1-14(15-5-9-18(10-6-15)24(31)32)29-23(30)20-4-2-3-17-8-7-16-11-12-19(25(26,27)28)13-21(16)33-22(17)20/h2-6,9-14H,7-8H2,1H3,(H,29,30)(H,31,32)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Rottapharm Madaus
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by bead-based proximity ... |
Bioorg Med Chem Lett 21: 6336-40 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.102
BindingDB Entry DOI: 10.7270/Q29Z95B1 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50355881
(CHEMBL1910025)Show SMILES OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1cccc2CCc3cc(ccc3Oc12)C(F)(F)F Show InChI InChI=1S/C26H20F3NO4/c27-26(28,29)19-10-11-21-17(14-19)5-4-15-2-1-3-20(22(15)34-21)23(31)30-25(12-13-25)18-8-6-16(7-9-18)24(32)33/h1-3,6-11,14H,4-5,12-13H2,(H,30,31)(H,32,33) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Rottapharm Madaus
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGE2 from human EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 21: 6336-40 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.102
BindingDB Entry DOI: 10.7270/Q29Z95B1 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50355881
(CHEMBL1910025)Show SMILES OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1cccc2CCc3cc(ccc3Oc12)C(F)(F)F Show InChI InChI=1S/C26H20F3NO4/c27-26(28,29)19-10-11-21-17(14-19)5-4-15-2-1-3-20(22(15)34-21)23(31)30-25(12-13-25)18-8-6-16(7-9-18)24(32)33/h1-3,6-11,14H,4-5,12-13H2,(H,30,31)(H,32,33) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Rottapharm Madaus
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by bead-based proximity ... |
Bioorg Med Chem Lett 21: 6336-40 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.102
BindingDB Entry DOI: 10.7270/Q29Z95B1 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50355880
(CHEMBL1910024)Show SMILES C[C@H](NC(=O)c1cccc2CCc3cc(ccc3Oc12)C(F)(F)F)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C25H20F3NO4/c1-14(15-5-8-17(9-6-15)24(31)32)29-23(30)20-4-2-3-16-7-10-18-13-19(25(26,27)28)11-12-21(18)33-22(16)20/h2-6,8-9,11-14H,7,10H2,1H3,(H,29,30)(H,31,32)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Rottapharm Madaus
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by bead-based proximity ... |
Bioorg Med Chem Lett 21: 6336-40 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.102
BindingDB Entry DOI: 10.7270/Q29Z95B1 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50355880
(CHEMBL1910024)Show SMILES C[C@H](NC(=O)c1cccc2CCc3cc(ccc3Oc12)C(F)(F)F)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C25H20F3NO4/c1-14(15-5-8-17(9-6-15)24(31)32)29-23(30)20-4-2-3-16-7-10-18-13-19(25(26,27)28)11-12-21(18)33-22(16)20/h2-6,8-9,11-14H,7,10H2,1H3,(H,29,30)(H,31,32)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Rottapharm Madaus
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGE2 from human EP4 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 21: 6336-40 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.102
BindingDB Entry DOI: 10.7270/Q29Z95B1 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM50355879
(CHEMBL1910023)Show SMILES OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1cccc2CCc3ccc(cc3Oc12)C(F)(F)F Show InChI InChI=1S/C26H20F3NO4/c27-26(28,29)19-11-6-15-4-5-16-2-1-3-20(22(16)34-21(15)14-19)23(31)30-25(12-13-25)18-9-7-17(8-10-18)24(32)33/h1-3,6-11,14H,4-5,12-13H2,(H,30,31)(H,32,33) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Rottapharm Madaus
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 21: 6336-40 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.102
BindingDB Entry DOI: 10.7270/Q29Z95B1 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM50355883
(CHEMBL1910022)Show SMILES C[C@H](NC(=O)c1cccc2CCc3ccc(cc3Oc12)C(F)(F)F)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C25H20F3NO4/c1-14(15-5-9-18(10-6-15)24(31)32)29-23(30)20-4-2-3-17-8-7-16-11-12-19(25(26,27)28)13-21(16)33-22(17)20/h2-6,9-14H,7-8H2,1H3,(H,29,30)(H,31,32)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Rottapharm Madaus
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 21: 6336-40 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.102
BindingDB Entry DOI: 10.7270/Q29Z95B1 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM50355882
(CHEMBL591666)Show SMILES C[C@H](NC(=O)c1cc(Cl)ccc1Oc1ccc(F)cc1)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C22H17ClFNO4/c1-13(14-2-4-15(5-3-14)22(27)28)25-21(26)19-12-16(23)6-11-20(19)29-18-9-7-17(24)8-10-18/h2-13H,1H3,(H,25,26)(H,27,28)/t13-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Rottapharm Madaus
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 21: 6336-40 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.102
BindingDB Entry DOI: 10.7270/Q29Z95B1 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM50355880
(CHEMBL1910024)Show SMILES C[C@H](NC(=O)c1cccc2CCc3cc(ccc3Oc12)C(F)(F)F)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C25H20F3NO4/c1-14(15-5-8-17(9-6-15)24(31)32)29-23(30)20-4-2-3-16-7-10-18-13-19(25(26,27)28)11-12-21(18)33-22(16)20/h2-6,8-9,11-14H,7,10H2,1H3,(H,29,30)(H,31,32)/t14-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Rottapharm Madaus
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 21: 6336-40 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.102
BindingDB Entry DOI: 10.7270/Q29Z95B1 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50355879
(CHEMBL1910023)Show SMILES OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1cccc2CCc3ccc(cc3Oc12)C(F)(F)F Show InChI InChI=1S/C26H20F3NO4/c27-26(28,29)19-11-6-15-4-5-16-2-1-3-20(22(16)34-21(15)14-19)23(31)30-25(12-13-25)18-9-7-17(8-10-18)24(32)33/h1-3,6-11,14H,4-5,12-13H2,(H,30,31)(H,32,33) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Rottapharm Madaus
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by bead-based proximity ... |
Bioorg Med Chem Lett 21: 6336-40 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.102
BindingDB Entry DOI: 10.7270/Q29Z95B1 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM50355881
(CHEMBL1910025)Show SMILES OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1cccc2CCc3cc(ccc3Oc12)C(F)(F)F Show InChI InChI=1S/C26H20F3NO4/c27-26(28,29)19-10-11-21-17(14-19)5-4-15-2-1-3-20(22(15)34-21)23(31)30-25(12-13-25)18-8-6-16(7-9-18)24(32)33/h1-3,6-11,14H,4-5,12-13H2,(H,30,31)(H,32,33) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Rottapharm Madaus
Curated by ChEMBL
| Assay Description
Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 21: 6336-40 (2011)
Article DOI: 10.1016/j.bmcl.2011.08.102
BindingDB Entry DOI: 10.7270/Q29Z95B1 |
More data for this
Ligand-Target Pair | |
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