Reaction Details |
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Target | Prostaglandin E2 receptor EP4 subtype |
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Ligand | BDBM50355880 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_775626 (CHEMBL1913310) |
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IC50 | 42±n/a nM |
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Citation | Stasi, LP; Bhimani, K; Borriello, M; Canciani, L; Caselli, G; Colace, F; Ferioli, C; Kaswala, M; Mennuni, L; Piepoli, T; Pucci, S; Salvi, M; Shirsath, V; Zanelli, T; Zerbi, S Synthesis, pharmacophore modeling and in vitro activity of 10,11-dihydrodibenzo[b,f]oxepine-4-carboxamide derivatives as novel and potent antagonists of the prostaglandin EP4 receptor. Bioorg Med Chem Lett21:6336-40 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Prostaglandin E2 receptor EP4 subtype |
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Name: | Prostaglandin E2 receptor EP4 subtype |
Synonyms: | PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor |
Type: | Enzyme |
Mol. Mass.: | 53134.53 |
Organism: | Homo sapiens (Human) |
Description: | P35408 |
Residue: | 488 |
Sequence: | MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG
LAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLA
INHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTA
HAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRG
HPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQP
SLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSG
QHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPG
MGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSET
LNLSEKCI
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BDBM50355880 |
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n/a |
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Name | BDBM50355880 |
Synonyms: | CHEMBL1910024 |
Type | Small organic molecule |
Emp. Form. | C25H20F3NO4 |
Mol. Mass. | 455.4258 |
SMILES | C[C@H](NC(=O)c1cccc2CCc3cc(ccc3Oc12)C(F)(F)F)c1ccc(cc1)C(O)=O |r| |
Structure |
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