Found 3 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50401017
(CHEMBL2203658)Show SMILES CN(C)CCCNc1nc(nc2ccccc12)-c1ccc(Cl)cc1NC(=O)CCN1CCN(C)CC1 Show InChI InChI=1S/C27H36ClN7O/c1-33(2)13-6-12-29-26-21-7-4-5-8-23(21)31-27(32-26)22-10-9-20(28)19-24(22)30-25(36)11-14-35-17-15-34(3)16-18-35/h4-5,7-10,19H,6,11-18H2,1-3H3,(H,30,36)(H,29,31,32) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University
Curated by ChEMBL
| Assay Description
Inhibition of human telomerase in cell free system after 1 min by TRAP-LIG assay |
Eur J Med Chem 47: 299-311 (2012)
Article DOI: 10.1016/j.ejmech.2011.10.057
BindingDB Entry DOI: 10.7270/Q2V40WCF |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50401016
(CHEMBL2203643)Show SMILES CN(C)CCCNc1nc(nc2ccccc12)-c1ccc(Cl)cc1NC(=O)CCCN1CCN(C)CC1 Show InChI InChI=1S/C28H38ClN7O/c1-34(2)14-7-13-30-27-22-8-4-5-9-24(22)32-28(33-27)23-12-11-21(29)20-25(23)31-26(37)10-6-15-36-18-16-35(3)17-19-36/h4-5,8-9,11-12,20H,6-7,10,13-19H2,1-3H3,(H,31,37)(H,30,32,33) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University
Curated by ChEMBL
| Assay Description
Inhibition of human telomerase in cell free system after 1 min by TRAP-LIG assay |
Eur J Med Chem 47: 299-311 (2012)
Article DOI: 10.1016/j.ejmech.2011.10.057
BindingDB Entry DOI: 10.7270/Q2V40WCF |
More data for this
Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50401018
(CHEMBL2203649)Show SMILES CN(C)CCCNc1nc(nc2ccccc12)-c1ccc(Cl)cc1NC(=O)CN1CCN(C)CC1 Show InChI InChI=1S/C26H34ClN7O/c1-32(2)12-6-11-28-25-20-7-4-5-8-22(20)30-26(31-25)21-10-9-19(27)17-23(21)29-24(35)18-34-15-13-33(3)14-16-34/h4-5,7-10,17H,6,11-16,18H2,1-3H3,(H,29,35)(H,28,30,31) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.93E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University
Curated by ChEMBL
| Assay Description
Inhibition of human telomerase in cell free system after 1 min by TRAP-LIG assay |
Eur J Med Chem 47: 299-311 (2012)
Article DOI: 10.1016/j.ejmech.2011.10.057
BindingDB Entry DOI: 10.7270/Q2V40WCF |
More data for this
Ligand-Target Pair | |
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