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PubMed code 22408714

Compile data set for download or QSAR
Found 23 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM50386391
PNG
(CHEMBL1411333)
Show SMILES CCCC(=O)Nc1cccc(NC(=O)c2ccccc2Br)c1
Show InChI InChI=1S/C17H17BrN2O2/c1-2-6-16(21)19-12-7-5-8-13(11-12)20-17(22)14-9-3-4-10-15(14)18/h3-5,7-11H,2,6H2,1H3,(H,19,21)(H,20,22)
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n/an/a 260n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of SFLLRN-NH2-stimulated PAR1-mediated platelet activation in platelet-rich human plasma assessed as surface expression of P-selectin afte...

ACS Med Chem Lett 3: 232-237 (2012)


Article DOI: 10.1021/ml2002696
BindingDB Entry DOI: 10.7270/Q2Q52QP8
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM50386409
PNG
(CHEMBL2047299)
Show SMILES CC(C)CC(=O)Nc1cccc(NC(=O)c2ccccc2Br)c1
Show InChI InChI=1S/C18H19BrN2O2/c1-12(2)10-17(22)20-13-6-5-7-14(11-13)21-18(23)15-8-3-4-9-16(15)19/h3-9,11-12H,10H2,1-2H3,(H,20,22)(H,21,23)
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n/an/a 290n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of SFLLRN-NH2-stimulated PAR1-mediated platelet activation in platelet-rich human plasma assessed as surface expression of P-selectin afte...

ACS Med Chem Lett 3: 232-237 (2012)


Article DOI: 10.1021/ml2002696
BindingDB Entry DOI: 10.7270/Q2Q52QP8
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM50386408
PNG
(CHEMBL2047297)
Show SMILES CCCCNc1cccc(NC(=O)c2ccccc2Br)c1
Show InChI InChI=1S/C17H19BrN2O/c1-2-3-11-19-13-7-6-8-14(12-13)20-17(21)15-9-4-5-10-16(15)18/h4-10,12,19H,2-3,11H2,1H3,(H,20,21)
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n/an/a 340n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of SFLLRN-NH2-stimulated PAR1-mediated platelet activation in platelet-rich human plasma assessed as surface expression of P-selectin afte...

ACS Med Chem Lett 3: 232-237 (2012)


Article DOI: 10.1021/ml2002696
BindingDB Entry DOI: 10.7270/Q2Q52QP8
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM50386400
PNG
(CHEMBL2049115)
Show SMILES CCCC(=O)Nc1cccc(NC(=O)c2cc(Cl)ccc2Br)c1
Show InChI InChI=1S/C17H16BrClN2O2/c1-2-4-16(22)20-12-5-3-6-13(10-12)21-17(23)14-9-11(19)7-8-15(14)18/h3,5-10H,2,4H2,1H3,(H,20,22)(H,21,23)
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n/an/a 380n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of SFLLRN-NH2-stimulated PAR1-mediated platelet activation in platelet-rich human plasma assessed as surface expression of P-selectin afte...

ACS Med Chem Lett 3: 232-237 (2012)


Article DOI: 10.1021/ml2002696
BindingDB Entry DOI: 10.7270/Q2Q52QP8
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM50386398
PNG
(CHEMBL2049113)
Show SMILES CCCC(=O)Nc1cccc(NC(=O)c2ccc(F)cc2Br)c1
Show InChI InChI=1S/C17H16BrFN2O2/c1-2-4-16(22)20-12-5-3-6-13(10-12)21-17(23)14-8-7-11(19)9-15(14)18/h3,5-10H,2,4H2,1H3,(H,20,22)(H,21,23)
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n/an/a 390n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of SFLLRN-NH2-stimulated PAR1-mediated platelet activation in platelet-rich human plasma assessed as surface expression of P-selectin afte...

ACS Med Chem Lett 3: 232-237 (2012)


Article DOI: 10.1021/ml2002696
BindingDB Entry DOI: 10.7270/Q2Q52QP8
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM50386397
PNG
(CHEMBL2049112)
Show SMILES CCCC(=O)Nc1cccc(NC(=O)c2cc(C)ccc2Br)c1
Show InChI InChI=1S/C18H19BrN2O2/c1-3-5-17(22)20-13-6-4-7-14(11-13)21-18(23)15-10-12(2)8-9-16(15)19/h4,6-11H,3,5H2,1-2H3,(H,20,22)(H,21,23)
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n/an/a 480n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of SFLLRN-NH2-stimulated PAR1-mediated platelet activation in platelet-rich human plasma assessed as surface expression of P-selectin afte...

ACS Med Chem Lett 3: 232-237 (2012)


Article DOI: 10.1021/ml2002696
BindingDB Entry DOI: 10.7270/Q2Q52QP8
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM50386406
PNG
(CHEMBL1718628)
Show SMILES Brc1ccccc1C(=O)Nc1cccc(NC(=O)C2CCCC2)c1
Show InChI InChI=1S/C19H19BrN2O2/c20-17-11-4-3-10-16(17)19(24)22-15-9-5-8-14(12-15)21-18(23)13-6-1-2-7-13/h3-5,8-13H,1-2,6-7H2,(H,21,23)(H,22,24)
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n/an/a 520n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of SFLLRN-NH2-stimulated PAR1-mediated platelet activation in platelet-rich human plasma assessed as surface expression of P-selectin afte...

ACS Med Chem Lett 3: 232-237 (2012)


Article DOI: 10.1021/ml2002696
BindingDB Entry DOI: 10.7270/Q2Q52QP8
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM50386394
PNG
(CHEMBL2048423)
Show SMILES CCCC(=O)Nc1cccc(NC(=O)c2ccccc2CC)c1
Show InChI InChI=1S/C19H22N2O2/c1-3-8-18(22)20-15-10-7-11-16(13-15)21-19(23)17-12-6-5-9-14(17)4-2/h5-7,9-13H,3-4,8H2,1-2H3,(H,20,22)(H,21,23)
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n/an/a 520n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of SFLLRN-NH2-stimulated PAR1-mediated platelet activation in platelet-rich human plasma assessed as surface expression of P-selectin afte...

ACS Med Chem Lett 3: 232-237 (2012)


Article DOI: 10.1021/ml2002696
BindingDB Entry DOI: 10.7270/Q2Q52QP8
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM50386399
PNG
(CHEMBL2049114)
Show SMILES CCCC(=O)Nc1cccc(NC(=O)c2cc(F)ccc2Br)c1
Show InChI InChI=1S/C17H16BrFN2O2/c1-2-4-16(22)20-12-5-3-6-13(10-12)21-17(23)14-9-11(19)7-8-15(14)18/h3,5-10H,2,4H2,1H3,(H,20,22)(H,21,23)
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n/an/a 600n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of SFLLRN-NH2-stimulated PAR1-mediated platelet activation in platelet-rich human plasma assessed as surface expression of P-selectin afte...

ACS Med Chem Lett 3: 232-237 (2012)


Article DOI: 10.1021/ml2002696
BindingDB Entry DOI: 10.7270/Q2Q52QP8
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM50386395
PNG
(CHEMBL2048425)
Show SMILES CCCC(=O)Nc1cccc(NC(=O)c2ccccc2OC(F)(F)F)c1
Show InChI InChI=1S/C18H17F3N2O3/c1-2-6-16(24)22-12-7-5-8-13(11-12)23-17(25)14-9-3-4-10-15(14)26-18(19,20)21/h3-5,7-11H,2,6H2,1H3,(H,22,24)(H,23,25)
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n/an/a 710n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of SFLLRN-NH2-stimulated PAR1-mediated platelet activation in platelet-rich human plasma assessed as surface expression of P-selectin afte...

ACS Med Chem Lett 3: 232-237 (2012)


Article DOI: 10.1021/ml2002696
BindingDB Entry DOI: 10.7270/Q2Q52QP8
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM50386393
PNG
(CHEMBL1721173)
Show SMILES CCCC(=O)Nc1cccc(NC(=O)c2ccccc2C)c1
Show InChI InChI=1S/C18H20N2O2/c1-3-7-17(21)19-14-9-6-10-15(12-14)20-18(22)16-11-5-4-8-13(16)2/h4-6,8-12H,3,7H2,1-2H3,(H,19,21)(H,20,22)
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n/an/a 770n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of SFLLRN-NH2-stimulated PAR1-mediated platelet activation in platelet-rich human plasma assessed as surface expression of P-selectin afte...

ACS Med Chem Lett 3: 232-237 (2012)


Article DOI: 10.1021/ml2002696
BindingDB Entry DOI: 10.7270/Q2Q52QP8
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM50386389
PNG
(CHEMBL1729550)
Show SMILES CCCC(=O)Nc1cccc(NC(=O)c2ccccc2F)c1
Show InChI InChI=1S/C17H17FN2O2/c1-2-6-16(21)19-12-7-5-8-13(11-12)20-17(22)14-9-3-4-10-15(14)18/h3-5,7-11H,2,6H2,1H3,(H,19,21)(H,20,22)
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n/an/a 970n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of SFLLRN-NH2-stimulated PAR1-mediated platelet activation in platelet-rich human plasma assessed as surface expression of P-selectin afte...

ACS Med Chem Lett 3: 232-237 (2012)


Article DOI: 10.1021/ml2002696
BindingDB Entry DOI: 10.7270/Q2Q52QP8
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM50386390
PNG
(CHEMBL1734760)
Show SMILES CCCC(=O)Nc1cccc(NC(=O)c2ccccc2Cl)c1
Show InChI InChI=1S/C17H17ClN2O2/c1-2-6-16(21)19-12-7-5-8-13(11-12)20-17(22)14-9-3-4-10-15(14)18/h3-5,7-11H,2,6H2,1H3,(H,19,21)(H,20,22)
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n/an/a 1.10E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of SFLLRN-NH2-stimulated PAR1-mediated platelet activation in platelet-rich human plasma assessed as surface expression of P-selectin afte...

ACS Med Chem Lett 3: 232-237 (2012)


Article DOI: 10.1021/ml2002696
BindingDB Entry DOI: 10.7270/Q2Q52QP8
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM50386410
PNG
(CHEMBL2047300)
Show SMILES CC(C)CC(=O)Nc1cccc(NC(=O)c2ccccc2C)c1
Show InChI InChI=1S/C19H22N2O2/c1-13(2)11-18(22)20-15-8-6-9-16(12-15)21-19(23)17-10-5-4-7-14(17)3/h4-10,12-13H,11H2,1-3H3,(H,20,22)(H,21,23)
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n/an/a 1.12E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of SFLLRN-NH2-stimulated PAR1-mediated platelet activation in platelet-rich human plasma assessed as surface expression of P-selectin afte...

ACS Med Chem Lett 3: 232-237 (2012)


Article DOI: 10.1021/ml2002696
BindingDB Entry DOI: 10.7270/Q2Q52QP8
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM50386392
PNG
(CHEMBL2048420)
Show SMILES CCCC(=O)Nc1cccc(NC(=O)c2ccccc2C(F)(F)F)c1
Show InChI InChI=1S/C18H17F3N2O2/c1-2-6-16(24)22-12-7-5-8-13(11-12)23-17(25)14-9-3-4-10-15(14)18(19,20)21/h3-5,7-11H,2,6H2,1H3,(H,22,24)(H,23,25)
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n/an/a 1.29E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of SFLLRN-NH2-stimulated PAR1-mediated platelet activation in platelet-rich human plasma assessed as surface expression of P-selectin afte...

ACS Med Chem Lett 3: 232-237 (2012)


Article DOI: 10.1021/ml2002696
BindingDB Entry DOI: 10.7270/Q2Q52QP8
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM50386405
PNG
(CHEMBL2049121)
Show SMILES CC(C)C(=O)Nc1cccc(NC(=O)c2ccccc2Br)c1
Show InChI InChI=1S/C17H17BrN2O2/c1-11(2)16(21)19-12-6-5-7-13(10-12)20-17(22)14-8-3-4-9-15(14)18/h3-11H,1-2H3,(H,19,21)(H,20,22)
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n/an/a 1.41E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of SFLLRN-NH2-stimulated PAR1-mediated platelet activation in platelet-rich human plasma assessed as surface expression of P-selectin afte...

ACS Med Chem Lett 3: 232-237 (2012)


Article DOI: 10.1021/ml2002696
BindingDB Entry DOI: 10.7270/Q2Q52QP8
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM50386404
PNG
(CHEMBL1332325)
Show SMILES CCC(=O)Nc1cccc(NC(=O)c2ccccc2Br)c1
Show InChI InChI=1S/C16H15BrN2O2/c1-2-15(20)18-11-6-5-7-12(10-11)19-16(21)13-8-3-4-9-14(13)17/h3-10H,2H2,1H3,(H,18,20)(H,19,21)
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n/an/a 1.68E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of SFLLRN-NH2-stimulated PAR1-mediated platelet activation in platelet-rich human plasma assessed as surface expression of P-selectin afte...

ACS Med Chem Lett 3: 232-237 (2012)


Article DOI: 10.1021/ml2002696
BindingDB Entry DOI: 10.7270/Q2Q52QP8
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM50386411
PNG
(CHEMBL2047284)
Show SMILES CCCNC(=O)c1cccc(NC(=O)c2ccccc2Cl)c1
Show InChI InChI=1S/C17H17ClN2O2/c1-2-10-19-16(21)12-6-5-7-13(11-12)20-17(22)14-8-3-4-9-15(14)18/h3-9,11H,2,10H2,1H3,(H,19,21)(H,20,22)
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n/an/a 1.80E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of SFLLRN-NH2-stimulated PAR1-mediated platelet activation in platelet-rich human plasma assessed as surface expression of P-selectin afte...

ACS Med Chem Lett 3: 232-237 (2012)


Article DOI: 10.1021/ml2002696
BindingDB Entry DOI: 10.7270/Q2Q52QP8
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM50386396
PNG
(CHEMBL2048430)
Show SMILES CCCC(=O)Nc1cccc(NC(=O)c2cccc(c2)-c2ccccc2)c1
Show InChI InChI=1S/C23H22N2O2/c1-2-8-22(26)24-20-13-7-14-21(16-20)25-23(27)19-12-6-11-18(15-19)17-9-4-3-5-10-17/h3-7,9-16H,2,8H2,1H3,(H,24,26)(H,25,27)
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n/an/a 2.20E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of SFLLRN-NH2-stimulated PAR1-mediated platelet activation in platelet-rich human plasma assessed as surface expression of P-selectin afte...

ACS Med Chem Lett 3: 232-237 (2012)


Article DOI: 10.1021/ml2002696
BindingDB Entry DOI: 10.7270/Q2Q52QP8
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM50386401
PNG
(CHEMBL2049116)
Show SMILES CCCC(=O)Nc1cccc(NC(=O)c2c(Cl)cccc2Br)c1
Show InChI InChI=1S/C17H16BrClN2O2/c1-2-5-15(22)20-11-6-3-7-12(10-11)21-17(23)16-13(18)8-4-9-14(16)19/h3-4,6-10H,2,5H2,1H3,(H,20,22)(H,21,23)
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n/an/a 2.28E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of SFLLRN-NH2-stimulated PAR1-mediated platelet activation in platelet-rich human plasma assessed as surface expression of P-selectin afte...

ACS Med Chem Lett 3: 232-237 (2012)


Article DOI: 10.1021/ml2002696
BindingDB Entry DOI: 10.7270/Q2Q52QP8
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM50386407
PNG
(CHEMBL2047286)
Show SMILES CCOC(=O)Nc1cccc(NC(=O)c2ccccc2Br)c1
Show InChI InChI=1S/C16H15BrN2O3/c1-2-22-16(21)19-12-7-5-6-11(10-12)18-15(20)13-8-3-4-9-14(13)17/h3-10H,2H2,1H3,(H,18,20)(H,19,21)
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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.64E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of SFLLRN-NH2-stimulated PAR1-mediated platelet activation in platelet-rich human plasma assessed as surface expression of P-selectin afte...

ACS Med Chem Lett 3: 232-237 (2012)


Article DOI: 10.1021/ml2002696
BindingDB Entry DOI: 10.7270/Q2Q52QP8
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM50386403
PNG
(CHEMBL2049118)
Show SMILES CCCC(=O)Nc1cccc(NC(=O)c2c(C)cccc2C)c1
Show InChI InChI=1S/C19H22N2O2/c1-4-7-17(22)20-15-10-6-11-16(12-15)21-19(23)18-13(2)8-5-9-14(18)3/h5-6,8-12H,4,7H2,1-3H3,(H,20,22)(H,21,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
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CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of SFLLRN-NH2-stimulated PAR1-mediated platelet activation in platelet-rich human plasma assessed as surface expression of P-selectin afte...

ACS Med Chem Lett 3: 232-237 (2012)


Article DOI: 10.1021/ml2002696
BindingDB Entry DOI: 10.7270/Q2Q52QP8
More data for this
Ligand-Target Pair
Proteinase-activated receptor 1


(Homo sapiens (Human))		BDBM50386402
PNG
(CHEMBL2049117)
Show SMILES CCCC(=O)Nc1cccc(NC(=O)c2cccc(Cl)c2Cl)c1
Show InChI InChI=1S/C17H16Cl2N2O2/c1-2-5-15(22)20-11-6-3-7-12(10-11)21-17(23)13-8-4-9-14(18)16(13)19/h3-4,6-10H,2,5H2,1H3,(H,20,22)(H,21,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.12E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of SFLLRN-NH2-stimulated PAR1-mediated platelet activation in platelet-rich human plasma assessed as surface expression of P-selectin afte...

ACS Med Chem Lett 3: 232-237 (2012)


Article DOI: 10.1021/ml2002696
BindingDB Entry DOI: 10.7270/Q2Q52QP8
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%