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PubMed code 22727371

Compile data set for download or QSAR
Found 22 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM82258
PNG
(CAS_114798-26-4 | Losartan | NSC_3961)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
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n/an/a 0.330n/an/an/an/an/an/a



School of Chemical Engineering& the Environment

Curated by ChEMBL


Assay Description
Inhibition of angiotensin AT1 receptor

Bioorg Med Chem 20: 4208-16 (2012)


Article DOI: 10.1016/j.bmc.2012.05.056
BindingDB Entry DOI: 10.7270/Q2GT5P7J
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50388737
PNG
(CHEMBL2058860)
Show SMILES CCCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(=O)NCC(C)c1ccccc1
Show InChI InChI=1S/C35H35N7O/c1-4-10-32-37-33-23(2)19-28(35(43)36-21-24(3)26-11-6-5-7-12-26)20-31(33)42(32)22-25-15-17-27(18-16-25)29-13-8-9-14-30(29)34-38-40-41-39-34/h5-9,11-20,24H,4,10,21-22H2,1-3H3,(H,36,43)(H,38,39,40,41)
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n/an/a 0.900n/an/an/an/an/an/a



School of Chemical Engineering& the Environment

Curated by ChEMBL


Assay Description
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting

Bioorg Med Chem 20: 4208-16 (2012)


Article DOI: 10.1016/j.bmc.2012.05.056
BindingDB Entry DOI: 10.7270/Q2GT5P7J
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50043280
PNG
(4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidaz...)
Show SMILES CCCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O)-c1nc2ccccc2n1C
Show InChI InChI=1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39)
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n/an/a 1n/an/an/an/an/an/a



School of Chemical Engineering& the Environment

Curated by ChEMBL


Assay Description
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting

Bioorg Med Chem 20: 4208-16 (2012)


Article DOI: 10.1016/j.bmc.2012.05.056
BindingDB Entry DOI: 10.7270/Q2GT5P7J
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50388736
PNG
(CHEMBL2058859)
Show SMILES CCCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C34H33N7O/c1-3-9-31-36-32-23(2)20-27(34(42)35-19-18-24-10-5-4-6-11-24)21-30(32)41(31)22-25-14-16-26(17-15-25)28-12-7-8-13-29(28)33-37-39-40-38-33/h4-8,10-17,20-21H,3,9,18-19,22H2,1-2H3,(H,35,42)(H,37,38,39,40)
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n/an/a 1.30n/an/an/an/an/an/a



School of Chemical Engineering& the Environment

Curated by ChEMBL


Assay Description
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting

Bioorg Med Chem 20: 4208-16 (2012)


Article DOI: 10.1016/j.bmc.2012.05.056
BindingDB Entry DOI: 10.7270/Q2GT5P7J
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50388738
PNG
(CHEMBL2058861)
Show SMILES CCCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(=O)NCCc1cccc(OC)c1
Show InChI InChI=1S/C35H35N7O2/c1-4-8-32-37-33-23(2)19-27(35(43)36-18-17-24-9-7-10-28(20-24)44-3)21-31(33)42(32)22-25-13-15-26(16-14-25)29-11-5-6-12-30(29)34-38-40-41-39-34/h5-7,9-16,19-21H,4,8,17-18,22H2,1-3H3,(H,36,43)(H,38,39,40,41)
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n/an/a 2.60n/an/an/an/an/an/a



School of Chemical Engineering& the Environment

Curated by ChEMBL


Assay Description
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting

Bioorg Med Chem 20: 4208-16 (2012)


Article DOI: 10.1016/j.bmc.2012.05.056
BindingDB Entry DOI: 10.7270/Q2GT5P7J
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50388741
PNG
(CHEMBL2058864)
Show SMILES CCCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(=O)NCCc1ccc(OC)c(OC)c1
Show InChI InChI=1S/C36H37N7O3/c1-5-8-33-38-34-23(2)19-27(36(44)37-18-17-24-13-16-31(45-3)32(20-24)46-4)21-30(34)43(33)22-25-11-14-26(15-12-25)28-9-6-7-10-29(28)35-39-41-42-40-35/h6-7,9-16,19-21H,5,8,17-18,22H2,1-4H3,(H,37,44)(H,39,40,41,42)
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n/an/a 3.70n/an/an/an/an/an/a



School of Chemical Engineering& the Environment

Curated by ChEMBL


Assay Description
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting

Bioorg Med Chem 20: 4208-16 (2012)


Article DOI: 10.1016/j.bmc.2012.05.056
BindingDB Entry DOI: 10.7270/Q2GT5P7J
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM82258
PNG
(CAS_114798-26-4 | Losartan | NSC_3961)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
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n/an/a 16.2n/an/an/an/an/an/a



School of Chemical Engineering& the Environment

Curated by ChEMBL


Assay Description
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting

Bioorg Med Chem 20: 4208-16 (2012)


Article DOI: 10.1016/j.bmc.2012.05.056
BindingDB Entry DOI: 10.7270/Q2GT5P7J
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50388732
PNG
(CHEMBL2058855)
Show SMILES CCCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(=O)NCc1ccccc1OC
Show InChI InChI=1S/C34H33N7O2/c1-4-9-31-36-32-22(2)18-26(34(42)35-20-25-10-5-8-13-30(25)43-3)19-29(32)41(31)21-23-14-16-24(17-15-23)27-11-6-7-12-28(27)33-37-39-40-38-33/h5-8,10-19H,4,9,20-21H2,1-3H3,(H,35,42)(H,37,38,39,40)
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n/an/a 19.7n/an/an/an/an/an/a



School of Chemical Engineering& the Environment

Curated by ChEMBL


Assay Description
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting

Bioorg Med Chem 20: 4208-16 (2012)


Article DOI: 10.1016/j.bmc.2012.05.056
BindingDB Entry DOI: 10.7270/Q2GT5P7J
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50388739
PNG
(CHEMBL2058862)
Show SMILES CCCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(=O)NCCc1ccc(OC)cc1
Show InChI InChI=1S/C35H35N7O2/c1-4-7-32-37-33-23(2)20-27(35(43)36-19-18-24-12-16-28(44-3)17-13-24)21-31(33)42(32)22-25-10-14-26(15-11-25)29-8-5-6-9-30(29)34-38-40-41-39-34/h5-6,8-17,20-21H,4,7,18-19,22H2,1-3H3,(H,36,43)(H,38,39,40,41)
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n/an/a 22.5n/an/an/an/an/an/a



School of Chemical Engineering& the Environment

Curated by ChEMBL


Assay Description
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting

Bioorg Med Chem 20: 4208-16 (2012)


Article DOI: 10.1016/j.bmc.2012.05.056
BindingDB Entry DOI: 10.7270/Q2GT5P7J
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50388730
PNG
(CHEMBL2058865)
Show SMILES CCCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(=O)NCCc1ccccc1F
Show InChI InChI=1S/C34H32FN7O/c1-3-8-31-37-32-22(2)19-26(34(43)36-18-17-25-9-4-7-12-29(25)35)20-30(32)42(31)21-23-13-15-24(16-14-23)27-10-5-6-11-28(27)33-38-40-41-39-33/h4-7,9-16,19-20H,3,8,17-18,21H2,1-2H3,(H,36,43)(H,38,39,40,41)
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n/an/a 37.6n/an/an/an/an/an/a



School of Chemical Engineering& the Environment

Curated by ChEMBL


Assay Description
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting

Bioorg Med Chem 20: 4208-16 (2012)


Article DOI: 10.1016/j.bmc.2012.05.056
BindingDB Entry DOI: 10.7270/Q2GT5P7J
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50388740
PNG
(CHEMBL2058863)
Show SMILES CCCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(=O)NCCc1cc(OC)ccc1OC
Show InChI InChI=1S/C36H37N7O3/c1-5-8-33-38-34-23(2)19-27(36(44)37-18-17-26-20-28(45-3)15-16-32(26)46-4)21-31(34)43(33)22-24-11-13-25(14-12-24)29-9-6-7-10-30(29)35-39-41-42-40-35/h6-7,9-16,19-21H,5,8,17-18,22H2,1-4H3,(H,37,44)(H,39,40,41,42)
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n/an/a 78n/an/an/an/an/an/a



School of Chemical Engineering& the Environment

Curated by ChEMBL


Assay Description
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting

Bioorg Med Chem 20: 4208-16 (2012)


Article DOI: 10.1016/j.bmc.2012.05.056
BindingDB Entry DOI: 10.7270/Q2GT5P7J
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50388733
PNG
(CHEMBL2058856)
Show SMILES CCCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(=O)NCc1cccc(OC)c1
Show InChI InChI=1S/C34H33N7O2/c1-4-8-31-36-32-22(2)17-26(34(42)35-20-24-9-7-10-27(18-24)43-3)19-30(32)41(31)21-23-13-15-25(16-14-23)28-11-5-6-12-29(28)33-37-39-40-38-33/h5-7,9-19H,4,8,20-21H2,1-3H3,(H,35,42)(H,37,38,39,40)
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n/an/a 78.3n/an/an/an/an/an/a



School of Chemical Engineering& the Environment

Curated by ChEMBL


Assay Description
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting

Bioorg Med Chem 20: 4208-16 (2012)


Article DOI: 10.1016/j.bmc.2012.05.056
BindingDB Entry DOI: 10.7270/Q2GT5P7J
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50388735
PNG
(CHEMBL2058858)
Show SMILES CCCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(=O)NCc1ccc(OC)c(OC)c1
Show InChI InChI=1S/C35H35N7O3/c1-5-8-32-37-33-22(2)17-26(35(43)36-20-24-13-16-30(44-3)31(18-24)45-4)19-29(33)42(32)21-23-11-14-25(15-12-23)27-9-6-7-10-28(27)34-38-40-41-39-34/h6-7,9-19H,5,8,20-21H2,1-4H3,(H,36,43)(H,38,39,40,41)
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n/an/a 96.8n/an/an/an/an/an/a



School of Chemical Engineering& the Environment

Curated by ChEMBL


Assay Description
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting

Bioorg Med Chem 20: 4208-16 (2012)


Article DOI: 10.1016/j.bmc.2012.05.056
BindingDB Entry DOI: 10.7270/Q2GT5P7J
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50388734
PNG
(CHEMBL2058857)
Show SMILES CCCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(=O)NCc1ccc(OC)cc1
Show InChI InChI=1S/C34H33N7O2/c1-4-7-31-36-32-22(2)18-26(34(42)35-20-23-12-16-27(43-3)17-13-23)19-30(32)41(31)21-24-10-14-25(15-11-24)28-8-5-6-9-29(28)33-37-39-40-38-33/h5-6,8-19H,4,7,20-21H2,1-3H3,(H,35,42)(H,37,38,39,40)
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n/an/a 119n/an/an/an/an/an/a



School of Chemical Engineering& the Environment

Curated by ChEMBL


Assay Description
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting

Bioorg Med Chem 20: 4208-16 (2012)


Article DOI: 10.1016/j.bmc.2012.05.056
BindingDB Entry DOI: 10.7270/Q2GT5P7J
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50043280
PNG
(4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidaz...)
Show SMILES CCCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O)-c1nc2ccccc2n1C
Show InChI InChI=1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39)
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n/an/a 150n/an/an/an/an/an/a



School of Chemical Engineering& the Environment

Curated by ChEMBL


Assay Description
Inhibition of angiotensin AT1 receptor

Bioorg Med Chem 20: 4208-16 (2012)


Article DOI: 10.1016/j.bmc.2012.05.056
BindingDB Entry DOI: 10.7270/Q2GT5P7J
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50388742
PNG
(CHEMBL2058866)
Show SMILES CCCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(=O)NCCc1ccc(F)cc1
Show InChI InChI=1S/C34H32FN7O/c1-3-6-31-37-32-22(2)19-26(34(43)36-18-17-23-11-15-27(35)16-12-23)20-30(32)42(31)21-24-9-13-25(14-10-24)28-7-4-5-8-29(28)33-38-40-41-39-33/h4-5,7-16,19-20H,3,6,17-18,21H2,1-2H3,(H,36,43)(H,38,39,40,41)
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n/an/a 209n/an/an/an/an/an/a



School of Chemical Engineering& the Environment

Curated by ChEMBL


Assay Description
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting

Bioorg Med Chem 20: 4208-16 (2012)


Article DOI: 10.1016/j.bmc.2012.05.056
BindingDB Entry DOI: 10.7270/Q2GT5P7J
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(Homo sapiens (Human))		BDBM50388731
PNG
(CHEMBL2058588)
Show SMILES CCCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C33H31N7O/c1-3-9-30-35-31-22(2)18-26(33(41)34-20-23-10-5-4-6-11-23)19-29(31)40(30)21-24-14-16-25(17-15-24)27-12-7-8-13-28(27)32-36-38-39-37-32/h4-8,10-19H,3,9,20-21H2,1-2H3,(H,34,41)(H,36,37,38,39)
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n/an/a 410n/an/an/an/an/an/a



School of Chemical Engineering& the Environment

Curated by ChEMBL


Assay Description
Displacement of [125I]Sar1Ile8-Ang2 from angiotensin AT1 receptor after 180 mins by gamma counting

Bioorg Med Chem 20: 4208-16 (2012)


Article DOI: 10.1016/j.bmc.2012.05.056
BindingDB Entry DOI: 10.7270/Q2GT5P7J
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(RABBIT)		BDBM82258
PNG
(CAS_114798-26-4 | Losartan | NSC_3961)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
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n/an/an/a 12.6n/an/an/an/an/a



School of Chemical Engineering& the Environment

Curated by ChEMBL


Assay Description
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post ...

Bioorg Med Chem 20: 4208-16 (2012)


Article DOI: 10.1016/j.bmc.2012.05.056
BindingDB Entry DOI: 10.7270/Q2GT5P7J
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(RABBIT)		BDBM50388738
PNG
(CHEMBL2058861)
Show SMILES CCCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(=O)NCCc1cccc(OC)c1
Show InChI InChI=1S/C35H35N7O2/c1-4-8-32-37-33-23(2)19-27(35(43)36-18-17-24-9-7-10-28(20-24)44-3)21-31(33)42(32)22-25-13-15-26(16-14-25)29-11-5-6-12-30(29)34-38-40-41-39-34/h5-7,9-16,19-21H,4,8,17-18,22H2,1-3H3,(H,36,43)(H,38,39,40,41)
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n/an/an/a 14.8n/an/an/an/an/a



School of Chemical Engineering& the Environment

Curated by ChEMBL


Assay Description
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post ...

Bioorg Med Chem 20: 4208-16 (2012)


Article DOI: 10.1016/j.bmc.2012.05.056
BindingDB Entry DOI: 10.7270/Q2GT5P7J
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(RABBIT)		BDBM50388736
PNG
(CHEMBL2058859)
Show SMILES CCCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C34H33N7O/c1-3-9-31-36-32-23(2)20-27(34(42)35-19-18-24-10-5-4-6-11-24)21-30(32)41(31)22-25-14-16-26(17-15-25)28-12-7-8-13-29(28)33-37-39-40-38-33/h4-8,10-17,20-21H,3,9,18-19,22H2,1-2H3,(H,35,42)(H,37,38,39,40)
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n/an/an/a 4.79n/an/an/an/an/a



School of Chemical Engineering& the Environment

Curated by ChEMBL


Assay Description
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post ...

Bioorg Med Chem 20: 4208-16 (2012)


Article DOI: 10.1016/j.bmc.2012.05.056
BindingDB Entry DOI: 10.7270/Q2GT5P7J
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(RABBIT)		BDBM50388737
PNG
(CHEMBL2058860)
Show SMILES CCCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(=O)NCC(C)c1ccccc1
Show InChI InChI=1S/C35H35N7O/c1-4-10-32-37-33-23(2)19-28(35(43)36-21-24(3)26-11-6-5-7-12-26)20-31(33)42(32)22-25-15-17-27(18-16-25)29-13-8-9-14-30(29)34-38-40-41-39-34/h5-9,11-20,24H,4,10,21-22H2,1-3H3,(H,36,43)(H,38,39,40,41)
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n/an/an/a 1.70n/an/an/an/an/a



School of Chemical Engineering& the Environment

Curated by ChEMBL


Assay Description
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post ...

Bioorg Med Chem 20: 4208-16 (2012)


Article DOI: 10.1016/j.bmc.2012.05.056
BindingDB Entry DOI: 10.7270/Q2GT5P7J
More data for this
Ligand-Target Pair
Type-1 angiotensin II receptor


(RABBIT)		BDBM50388741
PNG
(CHEMBL2058864)
Show SMILES CCCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(=O)NCCc1ccc(OC)c(OC)c1
Show InChI InChI=1S/C36H37N7O3/c1-5-8-33-38-34-23(2)19-27(36(44)37-18-17-24-13-16-31(45-3)32(20-24)46-4)21-30(34)43(33)22-25-11-14-26(15-12-25)28-9-6-7-10-29(28)35-39-41-42-40-35/h6-7,9-16,19-21H,5,8,17-18,22H2,1-4H3,(H,37,44)(H,39,40,41,42)
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n/an/an/a 1.82n/an/an/an/an/a



School of Chemical Engineering& the Environment

Curated by ChEMBL


Assay Description
Antagonist activity at AT1 receptor in Japanese white rabbit thoracic aorta assessed as inhibition of KCl-induced contraction incubated 30 mins post ...

Bioorg Med Chem 20: 4208-16 (2012)


Article DOI: 10.1016/j.bmc.2012.05.056
BindingDB Entry DOI: 10.7270/Q2GT5P7J
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%