Found 7 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM100152
(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)Show InChI InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
DrugBank MCE KEGG PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur (FUNDP)
Curated by ChEMBL
| Assay Description Inhibition of human DYRK1A kinase expressed in Escherichia coli cells |
J Med Chem 55: 6489-501 (2012)
Article DOI: 10.1021/jm300542e BindingDB Entry DOI: 10.7270/Q2GM88FB |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM50395379
(CHEMBL2164712 | US9168247, CV12)Show SMILES Cc1nccc2c3ccc(OCC4CCCCC4)cc3n(CC3CCCCC3)c12 Show InChI InChI=1S/C26H34N2O/c1-19-26-24(14-15-27-19)23-13-12-22(29-18-21-10-6-3-7-11-21)16-25(23)28(26)17-20-8-4-2-5-9-20/h12-16,20-21H,2-11,17-18H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur (FUNDP)
Curated by ChEMBL
| Assay Description Inhibition of DYRK1A kinase using RBER-CHKtide substrate by radiometric protein kinase assay |
J Med Chem 55: 6489-501 (2012)
Article DOI: 10.1021/jm300542e BindingDB Entry DOI: 10.7270/Q2GM88FB |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM50333423
(7-(Pyridin-3-ylmethoxy)-1-methyl-beta-carboline | ...)Show InChI InChI=1S/C18H15N3O/c1-12-18-16(6-8-20-12)15-5-4-14(9-17(15)21-18)22-11-13-3-2-7-19-10-13/h2-10,21H,11H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur (FUNDP)
Curated by ChEMBL
| Assay Description Inhibition of DYRK1A kinase using RBER-CHKtide substrate by radiometric protein kinase assay |
J Med Chem 55: 6489-501 (2012)
Article DOI: 10.1021/jm300542e BindingDB Entry DOI: 10.7270/Q2GM88FB |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM50333416
(7-(2-Methoxyethoxy)-1-methyl-beta-carboline | CHEM...)Show InChI InChI=1S/C15H16N2O2/c1-10-15-13(5-6-16-10)12-4-3-11(9-14(12)17-15)19-8-7-18-2/h3-6,9,17H,7-8H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur (FUNDP)
Curated by ChEMBL
| Assay Description Inhibition of DYRK1A kinase using RBER-CHKtide substrate by radiometric protein kinase assay |
J Med Chem 55: 6489-501 (2012)
Article DOI: 10.1021/jm300542e BindingDB Entry DOI: 10.7270/Q2GM88FB |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM50395380
(CHEMBL2164709 | US9168247, JR84)Show SMILES Cc1nccc2c3ccc(OCc4ccccc4)cc3n(Cc3ccccc3)c12 Show InChI InChI=1S/C26H22N2O/c1-19-26-24(14-15-27-19)23-13-12-22(29-18-21-10-6-3-7-11-21)16-25(23)28(26)17-20-8-4-2-5-9-20/h2-16H,17-18H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur (FUNDP)
Curated by ChEMBL
| Assay Description Inhibition of DYRK1A kinase using RBER-CHKtide substrate by radiometric protein kinase assay |
J Med Chem 55: 6489-501 (2012)
Article DOI: 10.1021/jm300542e BindingDB Entry DOI: 10.7270/Q2GM88FB |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM50395381
(CHEMBL2164716 | US9168247, JR95)Show SMILES Cc1[n+](Cc2ccccc2)ccc2c1n(Cc1ccccc1)c1cc(OCc3ccccc3)ccc21 Show InChI InChI=1S/C33H29N2O/c1-25-33-31(19-20-34(25)22-26-11-5-2-6-12-26)30-18-17-29(36-24-28-15-9-4-10-16-28)21-32(30)35(33)23-27-13-7-3-8-14-27/h2-21H,22-24H2,1H3/q+1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur (FUNDP)
Curated by ChEMBL
| Assay Description Inhibition of DYRK1A kinase using RBER-CHKtide substrate by radiometric protein kinase assay |
J Med Chem 55: 6489-501 (2012)
Article DOI: 10.1021/jm300542e BindingDB Entry DOI: 10.7270/Q2GM88FB |
More data for this Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM50395378
(CHEMBL2164696 | US9168247, CV24)Show SMILES Cc1[n+](Cc2ccccc2)ccc2c1n(CC1CCCCC1)c1cc(OCC3CCCCC3)ccc21 Show InChI InChI=1S/C33H41N2O/c1-25-33-31(19-20-34(25)22-26-11-5-2-6-12-26)30-18-17-29(36-24-28-15-9-4-10-16-28)21-32(30)35(33)23-27-13-7-3-8-14-27/h2,5-6,11-12,17-21,27-28H,3-4,7-10,13-16,22-24H2,1H3/q+1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur (FUNDP)
Curated by ChEMBL
| Assay Description Inhibition of DYRK1A kinase using RBER-CHKtide substrate by radiometric protein kinase assay |
J Med Chem 55: 6489-501 (2012)
Article DOI: 10.1021/jm300542e BindingDB Entry DOI: 10.7270/Q2GM88FB |
More data for this Ligand-Target Pair | |