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PubMed code 22926069

Compile data set for download or QSAR
Found 28 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Probable G-protein coupled receptor 142


(Mus musculus)		BDBM50395775
PNG
(CHEMBL2164857)
Show SMILES CNc1cc(ccn1)-c1nnc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)s1 |r|
Show InChI InChI=1S/C21H21N7OS2/c1-22-18-10-15(7-8-23-18)20-27-28-21(31-20)26-19(29)17(9-14-5-3-2-4-6-14)24-11-16-12-30-13-25-16/h2-8,10,12-13,17,24H,9,11H2,1H3,(H,22,23)(H,26,28,29)/t17-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Partial agonist activity at mouse GPR142 expressed in HEK293 cells

Bioorg Med Chem Lett 22: 6218-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50395796
PNG
(CHEMBL2164838)
Show SMILES Cn1ccc(CN[C@@H](Cc2ccccc2)C(=O)Nc2cc(c[nH]c2=O)-c2ccncc2)n1 |r|
Show InChI InChI=1S/C24H24N6O2/c1-30-12-9-20(29-30)16-26-21(13-17-5-3-2-4-6-17)24(32)28-22-14-19(15-27-23(22)31)18-7-10-25-11-8-18/h2-12,14-15,21,26H,13,16H2,1H3,(H,27,31)(H,28,32)/t21-/m0/s1
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n/an/an/an/a 210n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting

Bioorg Med Chem Lett 22: 6218-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50395789
PNG
(CHEMBL2164845)
Show SMILES O=C(Nc1cc(c[nH]c1=O)-c1ccncc1)[C@H](Cc1ccccc1)NC[C@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C24H25N5O3/c30-22-7-6-19(28-22)15-26-20(12-16-4-2-1-3-5-16)24(32)29-21-13-18(14-27-23(21)31)17-8-10-25-11-9-17/h1-5,8-11,13-14,19-20,26H,6-7,12,15H2,(H,27,31)(H,28,30)(H,29,32)/t19-,20+/m1/s1
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n/an/an/an/a 2.23E+3n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting

Bioorg Med Chem Lett 22: 6218-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50395793
PNG
(CHEMBL2164841)
Show SMILES O=C(Nc1cc(c[nH]c1=O)-c1ccncc1)[C@H](Cc1ccccc1)NCCc1ccccn1 |r|
Show InChI InChI=1S/C26H25N5O2/c32-25-24(17-21(18-30-25)20-9-13-27-14-10-20)31-26(33)23(16-19-6-2-1-3-7-19)29-15-11-22-8-4-5-12-28-22/h1-10,12-14,17-18,23,29H,11,15-16H2,(H,30,32)(H,31,33)/t23-/m0/s1
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n/an/an/an/a 1.32E+3n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting

Bioorg Med Chem Lett 22: 6218-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50395797
PNG
(CHEMBL2164837)
Show SMILES O=C(Nc1cc(c[nH]c1=O)-c1ccncc1)[C@H](Cc1ccccc1)NCc1cnc[nH]1 |r|
Show InChI InChI=1S/C23H22N6O2/c30-22-21(11-18(12-27-22)17-6-8-24-9-7-17)29-23(31)20(10-16-4-2-1-3-5-16)26-14-19-13-25-15-28-19/h1-9,11-13,15,20,26H,10,14H2,(H,25,28)(H,27,30)(H,29,31)/t20-/m0/s1
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n/an/an/an/a 110n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting

Bioorg Med Chem Lett 22: 6218-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50395780
PNG
(CHEMBL2164855)
Show SMILES COc1ncc(cc1NC(=O)[C@H](Cc1ccccc1)NC1(CC1)c1ccccn1)-c1ccncc1 |r|
Show InChI InChI=1S/C28H27N5O2/c1-35-27-24(18-22(19-31-27)21-10-15-29-16-11-21)32-26(34)23(17-20-7-3-2-4-8-20)33-28(12-13-28)25-9-5-6-14-30-25/h2-11,14-16,18-19,23,33H,12-13,17H2,1H3,(H,32,34)/t23-/m0/s1
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n/an/an/an/a 350n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting

Bioorg Med Chem Lett 22: 6218-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50395788
PNG
(CHEMBL2164846)
Show SMILES C[C@H](N[C@@H](Cc1ccccc1)C(=O)Nc1cc(c[nH]c1=O)-c1ccncc1)c1ccccn1 |r|
Show InChI InChI=1S/C26H25N5O2/c1-18(22-9-5-6-12-28-22)30-23(15-19-7-3-2-4-8-19)26(33)31-24-16-21(17-29-25(24)32)20-10-13-27-14-11-20/h2-14,16-18,23,30H,15H2,1H3,(H,29,32)(H,31,33)/t18-,23-/m0/s1
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n/an/an/an/a 220n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting

Bioorg Med Chem Lett 22: 6218-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50395795
PNG
(CHEMBL2164839)
Show SMILES O=C(Nc1cc(c[nH]c1=O)-c1ccncc1)[C@H](Cc1ccccc1)NCc1ccccn1 |r|
Show InChI InChI=1S/C25H23N5O2/c31-24-23(15-20(16-29-24)19-9-12-26-13-10-19)30-25(32)22(14-18-6-2-1-3-7-18)28-17-21-8-4-5-11-27-21/h1-13,15-16,22,28H,14,17H2,(H,29,31)(H,30,32)/t22-/m0/s1
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n/an/an/an/a 95n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting

Bioorg Med Chem Lett 22: 6218-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50395775
PNG
(CHEMBL2164857)
Show SMILES CNc1cc(ccn1)-c1nnc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)s1 |r|
Show InChI InChI=1S/C21H21N7OS2/c1-22-18-10-15(7-8-23-18)20-27-28-21(31-20)26-19(29)17(9-14-5-3-2-4-6-14)24-11-16-12-30-13-25-16/h2-8,10,12-13,17,24H,9,11H2,1H3,(H,22,23)(H,26,28,29)/t17-/m0/s1
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n/an/an/an/a 36n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting

Bioorg Med Chem Lett 22: 6218-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50395782
PNG
(CHEMBL2164853)
Show SMILES OC(=O)Cn1cc(cc(NC(=O)[C@H](Cc2ccccc2)NC2(CC2)c2ccccn2)c1=O)-c1ccncc1 |r|
Show InChI InChI=1S/C29H27N5O4/c35-26(36)19-34-18-22(21-9-14-30-15-10-21)17-24(28(34)38)32-27(37)23(16-20-6-2-1-3-7-20)33-29(11-12-29)25-8-4-5-13-31-25/h1-10,13-15,17-18,23,33H,11-12,16,19H2,(H,32,37)(H,35,36)/t23-/m0/s1
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n/an/an/an/a 260n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting

Bioorg Med Chem Lett 22: 6218-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50395786
PNG
(CHEMBL2164848)
Show SMILES CCC(N[C@@H](Cc1ccccc1)C(=O)Nc1cc(c[nH]c1=O)-c1ccncc1)c1ccccn1 |r|
Show InChI InChI=1S/C27H27N5O2/c1-2-22(23-10-6-7-13-29-23)31-24(16-19-8-4-3-5-9-19)27(34)32-25-17-21(18-30-26(25)33)20-11-14-28-15-12-20/h3-15,17-18,22,24,31H,2,16H2,1H3,(H,30,33)(H,32,34)/t22?,24-/m0/s1
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n/an/an/an/a 730n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting

Bioorg Med Chem Lett 22: 6218-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50395787
PNG
(CHEMBL2164847)
Show SMILES C[C@@H](N[C@@H](Cc1ccccc1)C(=O)Nc1cc(c[nH]c1=O)-c1ccncc1)c1ccccn1 |r|
Show InChI InChI=1S/C26H25N5O2/c1-18(22-9-5-6-12-28-22)30-23(15-19-7-3-2-4-8-19)26(33)31-24-16-21(17-29-25(24)32)20-10-13-27-14-11-20/h2-14,16-18,23,30H,15H2,1H3,(H,29,32)(H,31,33)/t18-,23+/m1/s1
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n/an/an/an/a 6.00E+3n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting

Bioorg Med Chem Lett 22: 6218-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50395790
PNG
(CHEMBL2164844)
Show SMILES O=C(Nc1cc(c[nH]c1=O)-c1ccncc1)[C@H](Cc1ccccc1)NCCC1CCOCC1 |r|
Show InChI InChI=1S/C26H30N4O3/c31-25-24(17-22(18-29-25)21-7-11-27-12-8-21)30-26(32)23(16-20-4-2-1-3-5-20)28-13-6-19-9-14-33-15-10-19/h1-5,7-8,11-12,17-19,23,28H,6,9-10,13-16H2,(H,29,31)(H,30,32)/t23-/m0/s1
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n/an/an/an/a 1.06E+3n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting

Bioorg Med Chem Lett 22: 6218-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50395791
PNG
(CHEMBL2164843)
Show SMILES O=C(Nc1cc(c[nH]c1=O)-c1ccncc1)[C@H](Cc1ccccc1)NC[C@H]1CCCO1 |r|
Show InChI InChI=1S/C24H26N4O3/c29-23-22(14-19(15-27-23)18-8-10-25-11-9-18)28-24(30)21(13-17-5-2-1-3-6-17)26-16-20-7-4-12-31-20/h1-3,5-6,8-11,14-15,20-21,26H,4,7,12-13,16H2,(H,27,29)(H,28,30)/t20-,21+/m1/s1
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n/an/an/an/a 390n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting

Bioorg Med Chem Lett 22: 6218-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50395781
PNG
(CHEMBL2164854)
Show SMILES CN(C)CCn1cc(cc(NC(=O)[C@H](Cc2ccccc2)NC2(CC2)c2ccccn2)c1=O)-c1ccncc1 |r|
Show InChI InChI=1S/C31H34N6O2/c1-36(2)18-19-37-22-25(24-11-16-32-17-12-24)21-27(30(37)39)34-29(38)26(20-23-8-4-3-5-9-23)35-31(13-14-31)28-10-6-7-15-33-28/h3-12,15-17,21-22,26,35H,13-14,18-20H2,1-2H3,(H,34,38)/t26-/m0/s1
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n/an/an/an/a 280n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting

Bioorg Med Chem Lett 22: 6218-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50395792
PNG
(CHEMBL2164842)
Show SMILES O=C(Nc1cc(c[nH]c1=O)-c1ccncc1)[C@H](Cc1ccccc1)NCC1CCS(=O)(=O)CC1 |r|
Show InChI InChI=1S/C25H28N4O4S/c30-24-23(15-21(17-28-24)20-6-10-26-11-7-20)29-25(31)22(14-18-4-2-1-3-5-18)27-16-19-8-12-34(32,33)13-9-19/h1-7,10-11,15,17,19,22,27H,8-9,12-14,16H2,(H,28,30)(H,29,31)/t22-/m0/s1
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n/an/an/an/a 2.00E+4n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting

Bioorg Med Chem Lett 22: 6218-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50395798
PNG
(CHEMBL2164836)
Show SMILES Cc1cc(CN[C@@H](Cc2ccccc2)C(=O)Nc2cc(c[nH]c2=O)-c2ccncc2)no1 |r|
Show InChI InChI=1S/C24H23N5O3/c1-16-11-20(29-32-16)15-26-21(12-17-5-3-2-4-6-17)24(31)28-22-13-19(14-27-23(22)30)18-7-9-25-10-8-18/h2-11,13-14,21,26H,12,15H2,1H3,(H,27,30)(H,28,31)/t21-/m0/s1
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n/an/an/an/a 2.20E+3n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting

Bioorg Med Chem Lett 22: 6218-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Mus musculus)		BDBM50395776
PNG
(CHEMBL2164850)
Show SMILES O=C(Nc1cc(c[nH]c1=O)-c1ccncc1)[C@H](Cc1ccccc1)NC1(CC1)c1ccccn1 |r|
Show InChI InChI=1S/C27H25N5O2/c33-25-22(17-21(18-30-25)20-9-14-28-15-10-20)31-26(34)23(16-19-6-2-1-3-7-19)32-27(11-12-27)24-8-4-5-13-29-24/h1-10,13-15,17-18,23,32H,11-12,16H2,(H,30,33)(H,31,34)/t23-/m0/s1
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n/an/an/an/a 1.80n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR142 expressed in HEK293 cells by inositol phosphate accumulation assay

Bioorg Med Chem Lett 22: 6218-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50395777
PNG
(CHEMBL2164859)
Show SMILES O=C(Nc1nnc(s1)-c1cncs1)[C@H](Cc1ccccc1)NCc1cscn1 |r|
Show InChI InChI=1S/C18H16N6OS3/c25-16(22-18-24-23-17(28-18)15-8-19-10-27-15)14(6-12-4-2-1-3-5-12)20-7-13-9-26-11-21-13/h1-5,8-11,14,20H,6-7H2,(H,22,24,25)/t14-/m0/s1
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n/an/an/an/a 390n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting

Bioorg Med Chem Lett 22: 6218-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50395779
PNG
(CHEMBL2164856)
Show SMILES O=C(Nc1nnc(s1)-c1ccncc1)[C@H](Cc1ccccc1)NCc1cscn1 |r|
Show InChI InChI=1S/C20H18N6OS2/c27-18(24-20-26-25-19(29-20)15-6-8-21-9-7-15)17(10-14-4-2-1-3-5-14)22-11-16-12-28-13-23-16/h1-9,12-13,17,22H,10-11H2,(H,24,26,27)/t17-/m0/s1
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n/an/an/an/a 86n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting

Bioorg Med Chem Lett 22: 6218-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50395776
PNG
(CHEMBL2164850)
Show SMILES O=C(Nc1cc(c[nH]c1=O)-c1ccncc1)[C@H](Cc1ccccc1)NC1(CC1)c1ccccn1 |r|
Show InChI InChI=1S/C27H25N5O2/c33-25-22(17-21(18-30-25)20-9-14-28-15-10-20)31-26(34)23(16-19-6-2-1-3-7-19)32-27(11-12-27)24-8-4-5-13-29-24/h1-10,13-15,17-18,23,32H,11-12,16H2,(H,30,33)(H,31,34)/t23-/m0/s1
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n/an/an/an/a 54n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting

Bioorg Med Chem Lett 22: 6218-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50395794
PNG
(CHEMBL2164840)
Show SMILES O=C(Nc1cc(c[nH]c1=O)-c1ccncc1)[C@H](Cc1ccccc1)NCc1ncccn1 |r|
Show InChI InChI=1S/C24H22N6O2/c31-23-21(14-19(15-29-23)18-7-11-25-12-8-18)30-24(32)20(13-17-5-2-1-3-6-17)28-16-22-26-9-4-10-27-22/h1-12,14-15,20,28H,13,16H2,(H,29,31)(H,30,32)/t20-/m0/s1
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n/an/an/an/a 440n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting

Bioorg Med Chem Lett 22: 6218-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50395778
PNG
(CHEMBL2164858)
Show SMILES Cn1cncc1-c1nnc(NC(=O)[C@H](Cc2ccccc2)NCc2cscn2)s1 |r|
Show InChI InChI=1S/C19H19N7OS2/c1-26-11-20-9-16(26)18-24-25-19(29-18)23-17(27)15(7-13-5-3-2-4-6-13)21-8-14-10-28-12-22-14/h2-6,9-12,15,21H,7-8H2,1H3,(H,23,25,27)/t15-/m0/s1
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n/an/an/an/a 180n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting

Bioorg Med Chem Lett 22: 6218-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390593
PNG
(CHEMBL2069573)
Show SMILES O=C(Nc1cc(c[nH]c1=O)-c1ccncc1)[C@H](Cc1ccccc1)NCc1cscn1 |r|
Show InChI InChI=1S/C23H21N5O2S/c29-22-21(11-18(12-26-22)17-6-8-24-9-7-17)28-23(30)20(10-16-4-2-1-3-5-16)25-13-19-14-31-15-27-19/h1-9,11-12,14-15,20,25H,10,13H2,(H,26,29)(H,28,30)/t20-/m0/s1
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n/an/an/an/a 930n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting

Bioorg Med Chem Lett 22: 6218-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50390577
PNG
(CHEMBL2069482)
Show SMILES N[C@@H](Cc1ccccc1)C(=O)Nc1cc(c[nH]c1=O)-c1ccncc1 |r|
Show InChI InChI=1S/C19H18N4O2/c20-16(10-13-4-2-1-3-5-13)18(24)23-17-11-15(12-22-19(17)25)14-6-8-21-9-7-14/h1-9,11-12,16H,10,20H2,(H,22,25)(H,23,24)/t16-/m0/s1
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n/an/an/an/a 4.80E+3n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting

Bioorg Med Chem Lett 22: 6218-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50395784
PNG
(CHEMBL2164851)
Show SMILES O=C(Nc1cc(c[nH]c1=O)-c1ccncc1)[C@H](Cc1ccccc1)NC1(CC1)c1ncccn1 |r|
Show InChI InChI=1S/C26H24N6O2/c33-23-21(16-20(17-30-23)19-7-13-27-14-8-19)31-24(34)22(15-18-5-2-1-3-6-18)32-26(9-10-26)25-28-11-4-12-29-25/h1-8,11-14,16-17,22,32H,9-10,15H2,(H,30,33)(H,31,34)/t22-/m0/s1
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n/an/an/an/a 99n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting

Bioorg Med Chem Lett 22: 6218-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50395783
PNG
(CHEMBL2164852)
Show SMILES Cc1nc(cs1)C1(CC1)N[C@@H](Cc1ccccc1)C(=O)Nc1cc(c[nH]c1=O)-c1ccncc1 |r|
Show InChI InChI=1S/C26H25N5O2S/c1-17-29-23(16-34-17)26(9-10-26)31-22(13-18-5-3-2-4-6-18)25(33)30-21-14-20(15-28-24(21)32)19-7-11-27-12-8-19/h2-8,11-12,14-16,22,31H,9-10,13H2,1H3,(H,28,32)(H,30,33)/t22-/m0/s1
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n/an/an/an/a 200n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting

Bioorg Med Chem Lett 22: 6218-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R
More data for this
Ligand-Target Pair
Probable G-protein coupled receptor 142


(Homo sapiens (Human))		BDBM50395785
PNG
(CHEMBL2164849)
Show SMILES CC(C)(N[C@@H](Cc1ccccc1)C(=O)Nc1cc(c[nH]c1=O)-c1ccncc1)c1ccccn1 |r|
Show InChI InChI=1S/C27H27N5O2/c1-27(2,24-10-6-7-13-29-24)32-23(16-19-8-4-3-5-9-19)26(34)31-22-17-21(18-30-25(22)33)20-11-14-28-15-12-20/h3-15,17-18,23,32H,16H2,1-2H3,(H,30,33)(H,31,34)/t23-/m0/s1
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n/an/an/an/a 9.45E+3n/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Agonist activity at human GPR142 expressed in HEK293 cells assessed as inositol phosphate accumulation after 1 hr by scintillation counting

Bioorg Med Chem Lett 22: 6218-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.08.015
BindingDB Entry DOI: 10.7270/Q2CN751R
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%