| Reaction Details |
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 | Report a problem with these data |
| Target | Probable G-protein coupled receptor 142 |
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| Ligand | BDBM50395781 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_860250 (CHEMBL2169191) |
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| EC50 | 280±n/a nM |
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| Citation |  Du, X; Kim, YJ; Lai, S; Chen, X; Lizarzaburu, M; Turcotte, S; Fu, Z; Liu, Q; Zhang, Y; Motani, A; Oda, K; Okuyama, R; Nara, F; Murakoshi, M; Fu, A; Reagan, JD; Fan, P; Xiong, Y; Shen, W; Li, L; Houze, J; Medina, JC Phenylalanine derivatives as GPR142 agonists for the treatment of type II diabetes. Bioorg Med Chem Lett22:6218-23 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Probable G-protein coupled receptor 142 |
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| Name: | Probable G-protein coupled receptor 142 |
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| Synonyms: | G-protein coupled receptor PGR2 | GP142_HUMAN | GPR142 | PGR2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51127.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_985961 |
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| Residue: | 462 |
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| Sequence: | MSIMMLPMEQKIQWVPTSLQDITAVLGTEAYTEEDKSMVSHAQKSQHSCLSHSRWLRSPQ
VTGGSWDLRIRPSKDSSSFRQAQCLRKDPGANNHLESQGVRGTAGDADRELRGPSEKATA
GQPRVTLLPTPHVSGLSQEFESHWPEIAERSPCVAGVIPVIYYSVLLGLGLPVSLLTAVA
LARLATRTRRPSYYYLLALTASDIIIQVVIVFAGFLLQGAVLARQVPQAVVRTANILEFA
ANHASVWIAILLTVDRYTALCHPLHHRAASSPGRTRRAIAAVLSAALLTGIPFYWWLDMW
RDTDSPRTLDEVLKWAHCLTVYFIPCGVFLVTNSAIIHRLRRRGRSGLQPRVGKSTAILL
GITTLFTLLWAPRVFVMLYHMYVAPVHRDWRVHLALDVANMVAMLHTAANFGLYCFVSKT
FRATVRQVIHDAYLPCTLASQPEGMAAKPVMEPPGLPTGAEV
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| BDBM50395781 |
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| n/a |
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| Name | BDBM50395781 |
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| Synonyms: | CHEMBL2164854 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H34N6O2 |
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| Mol. Mass. | 522.6407 |
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| SMILES | CN(C)CCn1cc(cc(NC(=O)[C@H](Cc2ccccc2)NC2(CC2)c2ccccn2)c1=O)-c1ccncc1 |r| |
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| Structure | 
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