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PubMed code 23411075

Compile data set for download or QSAR
Found 37 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431484
PNG
(CHEMBL2348660)
Show SMILES Fc1ccccc1NC(C(=O)N1CCC[C@H]1c1ccccc1F)c1cc2ccccc2s1 |r|
Show InChI InChI=1S/C26H22F2N2OS/c27-19-10-3-2-9-18(19)22-13-7-15-30(22)26(31)25(29-21-12-5-4-11-20(21)28)24-16-17-8-1-6-14-23(17)32-24/h1-6,8-12,14,16,22,25,29H,7,13,15H2/t22-,25?/m0/s1
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n/an/a 3n/an/an/an/an/an/a



Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431489
PNG
(CHEMBL2348666)
Show SMILES Fc1ccccc1NC(C(=O)N1CCC[C@H]1c1ccccc1)c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C25H22F4N2O/c26-20-9-4-5-10-21(20)30-23(18-12-14-19(15-13-18)25(27,28)29)24(32)31-16-6-11-22(31)17-7-2-1-3-8-17/h1-5,7-10,12-15,22-23,30H,6,11,16H2/t22-,23?/m0/s1
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Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431488
PNG
(CHEMBL2348665)
Show SMILES Fc1ccccc1NC(C(=O)N1CCC[C@@H]1c1ccccc1)c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C25H22F4N2O/c26-20-9-4-5-10-21(20)30-23(18-12-14-19(15-13-18)25(27,28)29)24(32)31-16-6-11-22(31)17-7-2-1-3-8-17/h1-5,7-10,12-15,22-23,30H,6,11,16H2/t22-,23?/m1/s1
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Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431473
PNG
(CHEMBL2348325)
Show SMILES Fc1ccccc1N[C@H](C(=O)N1CCC[C@H]1c1ccccc1F)c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C25H21F5N2O/c26-19-7-2-1-6-18(19)22-10-5-15-32(22)24(33)23(31-21-9-4-3-8-20(21)27)16-11-13-17(14-12-16)25(28,29)30/h1-4,6-9,11-14,22-23,31H,5,10,15H2/t22-,23-/m0/s1
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Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431477
PNG
(CHEMBL2348329)
Show SMILES Fc1ccccc1NC(C(=O)N1CCC[C@H]1c1ccccc1F)c1ccc(cc1)-c1cccnc1 |r|
Show InChI InChI=1S/C29H25F2N3O/c30-24-9-2-1-8-23(24)27-12-6-18-34(27)29(35)28(33-26-11-4-3-10-25(26)31)21-15-13-20(14-16-21)22-7-5-17-32-19-22/h1-5,7-11,13-17,19,27-28,33H,6,12,18H2/t27-,28?/m0/s1
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Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431472
PNG
(CHEMBL2348324)
Show SMILES Fc1ccccc1N[C@@H](C(=O)N1CCC[C@H]1c1ccccc1F)c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C25H21F5N2O/c26-19-7-2-1-6-18(19)22-10-5-15-32(22)24(33)23(31-21-9-4-3-8-20(21)27)16-11-13-17(14-12-16)25(28,29)30/h1-4,6-9,11-14,22-23,31H,5,10,15H2/t22-,23+/m0/s1
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Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431492
PNG
(CHEMBL2348671)
Show SMILES Fc1ccccc1NC(C(=O)N1CCCC1c1cccnc1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H21F4N3O/c25-19-6-1-2-7-20(19)30-22(16-9-11-18(12-10-16)24(26,27)28)23(32)31-14-4-8-21(31)17-5-3-13-29-15-17/h1-3,5-7,9-13,15,21-22,30H,4,8,14H2
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Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431483
PNG
(CHEMBL2346684)
Show SMILES Fc1ccccc1NC(C(=O)N1CCCC1c1ccccn1)c1cc2ccccc2s1
Show InChI InChI=1S/C25H22FN3OS/c26-18-9-2-3-10-19(18)28-24(23-16-17-8-1-4-13-22(17)31-23)25(30)29-15-7-12-21(29)20-11-5-6-14-27-20/h1-6,8-11,13-14,16,21,24,28H,7,12,15H2
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Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431472
PNG
(CHEMBL2348324)
Show SMILES Fc1ccccc1N[C@@H](C(=O)N1CCC[C@H]1c1ccccc1F)c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C25H21F5N2O/c26-19-7-2-1-6-18(19)22-10-5-15-32(22)24(33)23(31-21-9-4-3-8-20(21)27)16-11-13-17(14-12-16)25(28,29)30/h1-4,6-9,11-14,22-23,31H,5,10,15H2/t22-,23+/m0/s1
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Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431498
PNG
(CHEMBL2348677)
Show SMILES Fc1cccc(c1)C1CCCN1C(=O)C(Nc1ccccc1F)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C25H21F5N2O/c26-19-6-3-5-17(15-19)22-9-4-14-32(22)24(33)23(31-21-8-2-1-7-20(21)27)16-10-12-18(13-11-16)25(28,29)30/h1-3,5-8,10-13,15,22-23,31H,4,9,14H2
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Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431478
PNG
(CHEMBL2348655)
Show SMILES Fc1ccccc1NC(C(=O)N1CCC[C@H]1c1ccccc1F)c1ccc(Br)cc1 |r|
Show InChI InChI=1S/C24H21BrF2N2O/c25-17-13-11-16(12-14-17)23(28-21-9-4-3-8-20(21)27)24(30)29-15-5-10-22(29)18-6-1-2-7-19(18)26/h1-4,6-9,11-14,22-23,28H,5,10,15H2/t22-,23?/m0/s1
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Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431475
PNG
(CHEMBL2348327)
Show SMILES Fc1ccccc1NC(C(=O)N1CCCC1c1ccccc1F)c1ccc(cc1)-c1cncnc1
Show InChI InChI=1S/C28H24F2N4O/c29-23-7-2-1-6-22(23)26-10-5-15-34(26)28(35)27(33-25-9-4-3-8-24(25)30)20-13-11-19(12-14-20)21-16-31-18-32-17-21/h1-4,6-9,11-14,16-18,26-27,33H,5,10,15H2
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Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431486
PNG
(CHEMBL2348662)
Show SMILES Fc1ccccc1NC(C(=O)N1CCC[C@H]1c1ccccc1Cl)c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C25H21ClF4N2O/c26-19-7-2-1-6-18(19)22-10-5-15-32(22)24(33)23(31-21-9-4-3-8-20(21)27)16-11-13-17(14-12-16)25(28,29)30/h1-4,6-9,11-14,22-23,31H,5,10,15H2/t22-,23?/m0/s1
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Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431494
PNG
(CHEMBL2348672)
Show SMILES COc1ccccc1C1CCCN1C(=O)C(Nc1ccccc1F)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C26H24F4N2O2/c1-34-23-11-5-2-7-19(23)22-10-6-16-32(22)25(33)24(31-21-9-4-3-8-20(21)27)17-12-14-18(15-13-17)26(28,29)30/h2-5,7-9,11-15,22,24,31H,6,10,16H2,1H3
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Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431479
PNG
(CHEMBL2348656)
Show SMILES Fc1ccccc1NC(C(=O)N1CCC[C@H]1c1ccccc1F)c1ccc2OCCc2c1 |r|
Show InChI InChI=1S/C26H24F2N2O2/c27-20-7-2-1-6-19(20)23-10-5-14-30(23)26(31)25(29-22-9-4-3-8-21(22)28)18-11-12-24-17(16-18)13-15-32-24/h1-4,6-9,11-12,16,23,25,29H,5,10,13-15H2/t23-,25?/m0/s1
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Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431486
PNG
(CHEMBL2348662)
Show SMILES Fc1ccccc1NC(C(=O)N1CCC[C@H]1c1ccccc1Cl)c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C25H21ClF4N2O/c26-19-7-2-1-6-18(19)22-10-5-15-32(22)24(33)23(31-21-9-4-3-8-20(21)27)16-11-13-17(14-12-16)25(28,29)30/h1-4,6-9,11-14,22-23,31H,5,10,15H2/t22-,23?/m0/s1
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Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431491
PNG
(CHEMBL2348669)
Show SMILES Fc1ccccc1NC(C(=O)N1CCCC1c1ccncc1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H21F4N3O/c25-19-4-1-2-5-20(19)30-22(17-7-9-18(10-8-17)24(26,27)28)23(32)31-15-3-6-21(31)16-11-13-29-14-12-16/h1-2,4-5,7-14,21-22,30H,3,6,15H2
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Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431493
PNG
(CHEMBL2348670)
Show SMILES Fc1ccccc1NC(C(=O)N1CCCC1c1ccccn1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H21F4N3O/c25-18-6-1-2-7-19(18)30-22(16-10-12-17(13-11-16)24(26,27)28)23(32)31-15-5-9-21(31)20-8-3-4-14-29-20/h1-4,6-8,10-14,21-22,30H,5,9,15H2
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Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431482
PNG
(CHEMBL2348659)
Show SMILES Fc1ccccc1NC(C(=O)N1CCCC1c1cccnc1)c1cc2ccccc2s1
Show InChI InChI=1S/C25H22FN3OS/c26-19-9-2-3-10-20(19)28-24(23-15-17-7-1-4-12-22(17)31-23)25(30)29-14-6-11-21(29)18-8-5-13-27-16-18/h1-5,7-10,12-13,15-16,21,24,28H,6,11,14H2
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n/an/a 25n/an/an/an/an/an/a



Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431476
PNG
(CHEMBL2348328)
Show SMILES Fc1ccccc1NC(C(=O)N1CCCC1c1ccccc1F)c1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C29H25F2N3O/c30-24-7-2-1-6-23(24)27-10-5-19-34(27)29(35)28(33-26-9-4-3-8-25(26)31)22-13-11-20(12-14-22)21-15-17-32-18-16-21/h1-4,6-9,11-18,27-28,33H,5,10,19H2
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n/an/a 25n/an/an/an/an/an/a



Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431502
PNG
(CHEMBL2348683)
Show SMILES Fc1ccccc1C1CCCN1C(=O)C(Nc1ccccc1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C25H22F4N2O/c26-21-10-5-4-9-20(21)22-11-6-16-31(22)24(32)23(30-19-7-2-1-3-8-19)17-12-14-18(15-13-17)25(27,28)29/h1-5,7-10,12-15,22-23,30H,6,11,16H2
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n/an/a 30n/an/an/an/an/an/a



Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431485
PNG
(CHEMBL2348661)
Show SMILES OC(=O)c1cccc(c1)[C@@H]1CCCN1C(=O)C(Nc1ccccc1F)c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C26H22F4N2O3/c27-20-7-1-2-8-21(20)31-23(16-10-12-19(13-11-16)26(28,29)30)24(33)32-14-4-9-22(32)17-5-3-6-18(15-17)25(34)35/h1-3,5-8,10-13,15,22-23,31H,4,9,14H2,(H,34,35)/t22-,23?/m0/s1
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n/an/a 33n/an/an/an/an/an/a



Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431501
PNG
(CHEMBL2348682)
Show SMILES COc1ccccc1C1CCCN1C(=O)C(Nc1ccccc1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C26H25F3N2O2/c1-33-23-12-6-5-10-21(23)22-11-7-17-31(22)25(32)24(30-20-8-3-2-4-9-20)18-13-15-19(16-14-18)26(27,28)29/h2-6,8-10,12-16,22,24,30H,7,11,17H2,1H3
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n/an/a 33n/an/an/an/an/an/a



Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431497
PNG
(CHEMBL2348676)
Show SMILES Fc1ccc(cc1)C1CCCN1C(=O)C(Nc1ccccc1F)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C25H21F5N2O/c26-19-13-9-16(10-14-19)22-6-3-15-32(22)24(33)23(31-21-5-2-1-4-20(21)27)17-7-11-18(12-8-17)25(28,29)30/h1-2,4-5,7-14,22-23,31H,3,6,15H2
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n/an/a 37n/an/an/an/an/an/a



Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431485
PNG
(CHEMBL2348661)
Show SMILES OC(=O)c1cccc(c1)[C@@H]1CCCN1C(=O)C(Nc1ccccc1F)c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C26H22F4N2O3/c27-20-7-1-2-8-21(20)31-23(16-10-12-19(13-11-16)26(28,29)30)24(33)32-14-4-9-22(32)17-5-3-6-18(15-17)25(34)35/h1-3,5-8,10-13,15,22-23,31H,4,9,14H2,(H,34,35)/t22-,23?/m0/s1
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n/an/a 40n/an/an/an/an/an/a



Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431480
PNG
(CHEMBL2348657)
Show SMILES OC(=O)c1ccc(cc1)C1CCCN1C(=O)C(Nc1ccccc1F)c1cc2ccccc2s1
Show InChI InChI=1S/C27H23FN2O3S/c28-20-7-2-3-8-21(20)29-25(24-16-19-6-1-4-10-23(19)34-24)26(31)30-15-5-9-22(30)17-11-13-18(14-12-17)27(32)33/h1-4,6-8,10-14,16,22,25,29H,5,9,15H2,(H,32,33)
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n/an/a 41n/an/an/an/an/an/a



Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431500
PNG
(CHEMBL2348681)
Show SMILES FC(F)(F)c1ccc(cc1)C(Nc1ccccc1)C(=O)N1CCC[C@H]1c1ccccc1Cl |r|
Show InChI InChI=1S/C25H22ClF3N2O/c26-21-10-5-4-9-20(21)22-11-6-16-31(22)24(32)23(30-19-7-2-1-3-8-19)17-12-14-18(15-13-17)25(27,28)29/h1-5,7-10,12-15,22-23,30H,6,11,16H2/t22-,23?/m0/s1
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n/an/a 41n/an/an/an/an/an/a



Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431488
PNG
(CHEMBL2348665)
Show SMILES Fc1ccccc1NC(C(=O)N1CCC[C@@H]1c1ccccc1)c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C25H22F4N2O/c26-20-9-4-5-10-21(20)30-23(18-12-14-19(15-13-18)25(27,28)29)24(32)31-16-6-11-22(31)17-7-2-1-3-8-17/h1-5,7-10,12-15,22-23,30H,6,11,16H2/t22-,23?/m1/s1
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n/an/a 43n/an/an/an/an/an/a



Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431487
PNG
(CHEMBL2348663)
Show SMILES Fc1ccccc1NC(C(=O)N1CCC[C@@H]1c1ccccc1F)c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C25H21F5N2O/c26-19-7-2-1-6-18(19)22-10-5-15-32(22)24(33)23(31-21-9-4-3-8-20(21)27)16-11-13-17(14-12-16)25(28,29)30/h1-4,6-9,11-14,22-23,31H,5,10,15H2/t22-,23?/m1/s1
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n/an/a 44n/an/an/an/an/an/a



Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431472
PNG
(CHEMBL2348324)
Show SMILES Fc1ccccc1N[C@@H](C(=O)N1CCC[C@H]1c1ccccc1F)c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C25H21F5N2O/c26-19-7-2-1-6-18(19)22-10-5-15-32(22)24(33)23(31-21-9-4-3-8-20(21)27)16-11-13-17(14-12-16)25(28,29)30/h1-4,6-9,11-14,22-23,31H,5,10,15H2/t22-,23+/m0/s1
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n/an/a 45n/an/an/an/an/an/a



Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431474
PNG
(CHEMBL2348326)
Show SMILES OC(=O)c1ccc(cc1)-c1ccc(cc1)C(Nc1ccccc1F)C(=O)N1CCC[C@H]1c1ccccc1F |r|
Show InChI InChI=1S/C31H26F2N2O3/c32-25-7-2-1-6-24(25)28-10-5-19-35(28)30(36)29(34-27-9-4-3-8-26(27)33)22-15-11-20(12-16-22)21-13-17-23(18-14-21)31(37)38/h1-4,6-9,11-18,28-29,34H,5,10,19H2,(H,37,38)/t28-,29?/m0/s1
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n/an/a 56n/an/an/an/an/an/a



Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431503
PNG
(CHEMBL2348684)
Show SMILES FC(F)(F)c1ccc(cc1)C(Nc1ccccc1)C(=O)N1CCCC1c1ccccc1
Show InChI InChI=1S/C25H23F3N2O/c26-25(27,28)20-15-13-19(14-16-20)23(29-21-10-5-2-6-11-21)24(31)30-17-7-12-22(30)18-8-3-1-4-9-18/h1-6,8-11,13-16,22-23,29H,7,12,17H2
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n/an/a 60n/an/an/an/an/an/a



Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431490
PNG
(CHEMBL2348667)
Show SMILES OC(=O)c1ccc(cc1)C1CCCN1C(=O)C(Nc1ccccc1F)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C26H22F4N2O3/c27-20-4-1-2-5-21(20)31-23(17-11-13-19(14-12-17)26(28,29)30)24(33)32-15-3-6-22(32)16-7-9-18(10-8-16)25(34)35/h1-2,4-5,7-14,22-23,31H,3,6,15H2,(H,34,35)
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n/an/a 66n/an/an/an/an/an/a



Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431495
PNG
(CHEMBL2348673)
Show SMILES Fc1ccc(NC(C(=O)N2CCCC2c2ccccc2Cl)c2ccc(cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C25H21ClF4N2O/c26-21-5-2-1-4-20(21)22-6-3-15-32(22)24(33)23(31-19-13-11-18(27)12-14-19)16-7-9-17(10-8-16)25(28,29)30/h1-2,4-5,7-14,22-23,31H,3,6,15H2
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n/an/a 73n/an/an/an/an/an/a



Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431481
PNG
(CHEMBL2348658)
Show SMILES OC(=O)c1cccc(c1)C1CCCN1C(=O)C(Nc1ccccc1F)c1cc2ccccc2s1
Show InChI InChI=1S/C27H23FN2O3S/c28-20-10-2-3-11-21(20)29-25(24-16-18-7-1-4-13-23(18)34-24)26(31)30-14-6-12-22(30)17-8-5-9-19(15-17)27(32)33/h1-5,7-11,13,15-16,22,25,29H,6,12,14H2,(H,32,33)
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n/an/a 78n/an/an/an/an/an/a



Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431496
PNG
(CHEMBL2348674)
Show SMILES Fc1cccc(NC(C(=O)N2CCCC2c2ccccc2Cl)c2ccc(cc2)C(F)(F)F)c1
Show InChI InChI=1S/C25H21ClF4N2O/c26-21-8-2-1-7-20(21)22-9-4-14-32(22)24(33)23(31-19-6-3-5-18(27)15-19)16-10-12-17(13-11-16)25(28,29)30/h1-3,5-8,10-13,15,22-23,31H,4,9,14H2
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n/an/a 138n/an/an/an/an/an/a



Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
Transient receptor potential M8 protein


(Canis lupus familiaris (Dog))		BDBM50431499
PNG
(CHEMBL2348680)
Show SMILES FC(F)(F)c1ccc(cc1)C(Nc1ccccc1)C(=O)N1CCC[C@@H]1c1ccccc1Cl |r|
Show InChI InChI=1S/C25H22ClF3N2O/c26-21-10-5-4-9-20(21)22-11-6-16-31(22)24(32)23(30-19-7-2-1-3-8-19)17-12-14-18(15-13-17)25(27,28)29/h1-5,7-10,12-15,22-23,30H,6,11,16H2/t22-,23?/m1/s1
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n/an/a 168n/an/an/an/an/an/a



Janssen Research& Development, L.L.C.

Curated by ChEMBL


Assay Description
Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...

Bioorg Med Chem Lett 23: 2234-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.062
BindingDB Entry DOI: 10.7270/Q2959JWT
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%