Reaction Details |
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Target | Transient receptor potential M8 protein |
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Ligand | BDBM50431495 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_952739 (CHEMBL2350718) |
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IC50 | 73±n/a nM |
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Citation | Zhu, B; Xia, M; Xu, X; Ludovici, DW; Tennakoon, M; Youngman, MA; Matthews, JM; Dax, SL; Colburn, RW; Qin, N; Hutchinson, TL; Lubin, ML; Brandt, MR; Stone, DJ; Flores, CM; Macielag, MJ Arylglycine derivatives as potent transient receptor potential melastatin 8 (TRPM8) antagonists. Bioorg Med Chem Lett23:2234-7 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Transient receptor potential M8 protein |
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Name: | Transient receptor potential M8 protein |
Synonyms: | Cold-menthol receptor (TRPM8) | TRPM8 Receptor | Transient receptor potential M8 protein | Transient receptor potential M8 protein (TRPM8) | Transient receptor potential melastatin subfamily, type 8 (TRPM8) |
Type: | Enzyme |
Mol. Mass.: | 127589.43 |
Organism: | Canis lupus familiaris (Dog) |
Description: | Q1A7N1 |
Residue: | 1104 |
Sequence: | MSFEGARLSMRNRRNGTLDSTRTLYSSTSRSTDVSYSESDLVNFIQANFKKRECVFFTKD
SKATENVCKCGYAQSQHIEGTQINSNEKWNYKKHTKEFPTDAFGDIQFETLGKKGKYIRL
SCDTDAETLYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWIL
TGGTHYGLMKYIGEVVRDNTISRNSEENIVAIGIAAWGMVSNRDTLLRNCDAEGYFSAQY
IMDDFKRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTIQDSNYGGKIP
IVCFAQGGGRETLKAINTSIKSKIPCVVVEGSGQIADVIASLVEVEDVLTSSVVKEKLVR
FLPRTVSRLPEEETESWIKWLKEILESSHLLTVIKMEEAGDEIVSNAISYALYKAFSTNE
QDKDNWNGQLKLLLEWNQLDLANEEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLEN
GLNLRKFLTNDVLTELFSNHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRGFRKEDR
SSRDDIDVELHDVSPITRHPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKT
LAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELA
VEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGFVSFRKKPIDKH
KKILWYYVAFFTSPFVVFAWNVVFYIAFLLLFAYVLLMDFHSVPHSPELVLYALVFVLFC
DEVRQWYMNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHPSNKTSLYSGRVIFCLDYIIFT
LRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEHRWRWIF
RSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLV
CIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCNRLNIPFPFVVFAY
FYMVVKKCFGCCCREKHAEPSACCFRNEDNETLAWEGVMKENYLVKINTKANDTSQEMRH
RFRQLDTKINDLKGLLKEIANKIK
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BDBM50431495 |
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n/a |
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Name | BDBM50431495 |
Synonyms: | CHEMBL2348673 |
Type | Small organic molecule |
Emp. Form. | C25H21ClF4N2O |
Mol. Mass. | 476.894 |
SMILES | Fc1ccc(NC(C(=O)N2CCCC2c2ccccc2Cl)c2ccc(cc2)C(F)(F)F)cc1 |
Structure |
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