Compile Data Set for Download or QSAR

Found 164 hits with Last Name = 'ludovici' and Initial = 'dw'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50179206 (3-trifluoromethyl-N-(6,7-dimethoxy-2,4-dihydroinde...) Show SMILES COc1cc2Cc3c(Nc4cccc(c4)C(F)(F)F)[nH]nc3-c2cc1OC Show InChI InChI=1S/C19H16F3N3O2/c1-26-15-7-10-6-14-17(13(10)9-16(15)27-2)24-25-18(14)23-12-5-3-4-11(8-12)19(20,21)22/h3-5,7-9H,6H2,1-2H3,(H2,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Antiproliferative activity against PDGF-BB stimulated HCASMC				J Med Chem 48: 8163-73 (2005) Article DOI: 10.1021/jm050680m BindingDB Entry DOI: 10.7270/Q2W095HW
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50179212 (3-chloro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...) Show SMILES COc1cc2Cc3c(Nc4cccc(Cl)c4)[nH]nc3-c2cc1OC Show InChI InChI=1S/C18H16ClN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibitory activity against PDGFRbeta kinase				J Med Chem 48: 8163-73 (2005) Article DOI: 10.1021/jm050680m BindingDB Entry DOI: 10.7270/Q2W095HW
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50179207 (3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...) Show SMILES COc1cc2Cc3c(Nc4cccc(F)c4)[nH]nc3-c2cc1OC Show InChI InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Antiproliferative activity against PDGF-BB stimulated HCASMC				J Med Chem 48: 8163-73 (2005) Article DOI: 10.1021/jm050680m BindingDB Entry DOI: 10.7270/Q2W095HW
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM50431484 (CHEMBL2348660) Show SMILES Fc1ccccc1NC(C(=O)N1CCC[C@H]1c1ccccc1F)c1cc2ccccc2s1 |r| Show InChI InChI=1S/C26H22F2N2OS/c27-19-10-3-2-9-18(19)22-13-7-15-30(22)26(31)25(29-21-12-5-4-11-20(21)28)24-16-17-8-1-6-14-23(17)32-24/h1-6,8-12,14,16,22,25,29H,7,13,15H2/t22-,25?/m0/s1	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...				Bioorg Med Chem Lett 23: 2234-7 (2013) Article DOI: 10.1016/j.bmcl.2013.01.062 BindingDB Entry DOI: 10.7270/Q2959JWT
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50179207 (3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...) Show SMILES COc1cc2Cc3c(Nc4cccc(F)c4)[nH]nc3-c2cc1OC Show InChI InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibitory activity against PDGFRbeta kinase				J Med Chem 48: 8163-73 (2005) Article DOI: 10.1021/jm050680m BindingDB Entry DOI: 10.7270/Q2W095HW
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM50431488 (CHEMBL2348665) Show SMILES Fc1ccccc1NC(C(=O)N1CCC[C@@H]1c1ccccc1)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C25H22F4N2O/c26-20-9-4-5-10-21(20)30-23(18-12-14-19(15-13-18)25(27,28)29)24(32)31-16-6-11-22(31)17-7-2-1-3-8-17/h1-5,7-10,12-15,22-23,30H,6,11,16H2/t22-,23?/m1/s1	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...				Bioorg Med Chem Lett 23: 2234-7 (2013) Article DOI: 10.1016/j.bmcl.2013.01.062 BindingDB Entry DOI: 10.7270/Q2959JWT
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM50431489 (CHEMBL2348666) Show SMILES Fc1ccccc1NC(C(=O)N1CCC[C@H]1c1ccccc1)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C25H22F4N2O/c26-20-9-4-5-10-21(20)30-23(18-12-14-19(15-13-18)25(27,28)29)24(32)31-16-6-11-22(31)17-7-2-1-3-8-17/h1-5,7-10,12-15,22-23,30H,6,11,16H2/t22-,23?/m0/s1	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...				Bioorg Med Chem Lett 23: 2234-7 (2013) Article DOI: 10.1016/j.bmcl.2013.01.062 BindingDB Entry DOI: 10.7270/Q2959JWT
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50179211 (3-bromo-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]p...) Show SMILES COc1cc2Cc3c(Nc4cccc(Br)c4)[nH]nc3-c2cc1OC Show InChI InChI=1S/C18H16BrN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibitory activity against PDGFRbeta kinase				J Med Chem 48: 8163-73 (2005) Article DOI: 10.1021/jm050680m BindingDB Entry DOI: 10.7270/Q2W095HW
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM50431473 (CHEMBL2348325) Show SMILES Fc1ccccc1N[C@H](C(=O)N1CCC[C@H]1c1ccccc1F)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C25H21F5N2O/c26-19-7-2-1-6-18(19)22-10-5-15-32(22)24(33)23(31-21-9-4-3-8-20(21)27)16-11-13-17(14-12-16)25(28,29)30/h1-4,6-9,11-14,22-23,31H,5,10,15H2/t22-,23-/m0/s1	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...				Bioorg Med Chem Lett 23: 2234-7 (2013) Article DOI: 10.1016/j.bmcl.2013.01.062 BindingDB Entry DOI: 10.7270/Q2959JWT
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM50431477 (CHEMBL2348329) Show SMILES Fc1ccccc1NC(C(=O)N1CCC[C@H]1c1ccccc1F)c1ccc(cc1)-c1cccnc1 |r| Show InChI InChI=1S/C29H25F2N3O/c30-24-9-2-1-8-23(24)27-12-6-18-34(27)29(35)28(33-26-11-4-3-10-25(26)31)21-15-13-20(14-16-21)22-7-5-17-32-19-22/h1-5,7-11,13-17,19,27-28,33H,6,12,18H2/t27-,28?/m0/s1	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...				Bioorg Med Chem Lett 23: 2234-7 (2013) Article DOI: 10.1016/j.bmcl.2013.01.062 BindingDB Entry DOI: 10.7270/Q2959JWT
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM50431492 (CHEMBL2348671) Show SMILES Fc1ccccc1NC(C(=O)N1CCCC1c1cccnc1)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C24H21F4N3O/c25-19-6-1-2-7-20(19)30-22(16-9-11-18(12-10-16)24(26,27)28)23(32)31-14-4-8-21(31)17-5-3-13-29-15-17/h1-3,5-7,9-13,15,21-22,30H,4,8,14H2	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...				Bioorg Med Chem Lett 23: 2234-7 (2013) Article DOI: 10.1016/j.bmcl.2013.01.062 BindingDB Entry DOI: 10.7270/Q2959JWT
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM50431472 (CHEMBL2348324) Show SMILES Fc1ccccc1N[C@@H](C(=O)N1CCC[C@H]1c1ccccc1F)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C25H21F5N2O/c26-19-7-2-1-6-18(19)22-10-5-15-32(22)24(33)23(31-21-9-4-3-8-20(21)27)16-11-13-17(14-12-16)25(28,29)30/h1-4,6-9,11-14,22-23,31H,5,10,15H2/t22-,23+/m0/s1	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...				Bioorg Med Chem Lett 23: 2234-7 (2013) Article DOI: 10.1016/j.bmcl.2013.01.062 BindingDB Entry DOI: 10.7270/Q2959JWT
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM50431472 (CHEMBL2348324) Show SMILES Fc1ccccc1N[C@@H](C(=O)N1CCC[C@H]1c1ccccc1F)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C25H21F5N2O/c26-19-7-2-1-6-18(19)22-10-5-15-32(22)24(33)23(31-21-9-4-3-8-20(21)27)16-11-13-17(14-12-16)25(28,29)30/h1-4,6-9,11-14,22-23,31H,5,10,15H2/t22-,23+/m0/s1	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...				Bioorg Med Chem Lett 23: 2234-7 (2013) Article DOI: 10.1016/j.bmcl.2013.01.062 BindingDB Entry DOI: 10.7270/Q2959JWT
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM50431483 (CHEMBL2346684) Show SMILES Fc1ccccc1NC(C(=O)N1CCCC1c1ccccn1)c1cc2ccccc2s1 Show InChI InChI=1S/C25H22FN3OS/c26-18-9-2-3-10-19(18)28-24(23-16-17-8-1-4-13-22(17)31-23)25(30)29-15-7-12-21(29)20-11-5-6-14-27-20/h1-6,8-11,13-14,16,21,24,28H,7,12,15H2	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...				Bioorg Med Chem Lett 23: 2234-7 (2013) Article DOI: 10.1016/j.bmcl.2013.01.062 BindingDB Entry DOI: 10.7270/Q2959JWT
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM50431478 (CHEMBL2348655) Show SMILES Fc1ccccc1NC(C(=O)N1CCC[C@H]1c1ccccc1F)c1ccc(Br)cc1 |r| Show InChI InChI=1S/C24H21BrF2N2O/c25-17-13-11-16(12-14-17)23(28-21-9-4-3-8-20(21)27)24(30)29-15-5-10-22(29)18-6-1-2-7-19(18)26/h1-4,6-9,11-14,22-23,28H,5,10,15H2/t22-,23?/m0/s1	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...				Bioorg Med Chem Lett 23: 2234-7 (2013) Article DOI: 10.1016/j.bmcl.2013.01.062 BindingDB Entry DOI: 10.7270/Q2959JWT
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM50431498 (CHEMBL2348677) Show SMILES Fc1cccc(c1)C1CCCN1C(=O)C(Nc1ccccc1F)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C25H21F5N2O/c26-19-6-3-5-17(15-19)22-9-4-14-32(22)24(33)23(31-21-8-2-1-7-20(21)27)16-10-12-18(13-11-16)25(28,29)30/h1-3,5-8,10-13,15,22-23,31H,4,9,14H2	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...				Bioorg Med Chem Lett 23: 2234-7 (2013) Article DOI: 10.1016/j.bmcl.2013.01.062 BindingDB Entry DOI: 10.7270/Q2959JWT
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50179210 ((7-methoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)ph...) Show SMILES COc1ccc2Cc3c(Nc4ccccc4)[nH]nc3-c2c1 Show InChI InChI=1S/C17H15N3O/c1-21-13-8-7-11-9-15-16(14(11)10-13)19-20-17(15)18-12-5-3-2-4-6-12/h2-8,10H,9H2,1H3,(H2,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Antiproliferative activity against PDGF-BB stimulated HCASMC				J Med Chem 48: 8163-73 (2005) Article DOI: 10.1021/jm050680m BindingDB Entry DOI: 10.7270/Q2W095HW
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50179209 ((6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-y...) Show SMILES COc1cc2Cc3c(Nc4ccccc4)[nH]nc3-c2cc1OC Show InChI InChI=1S/C18H17N3O2/c1-22-15-9-11-8-14-17(13(11)10-16(15)23-2)20-21-18(14)19-12-6-4-3-5-7-12/h3-7,9-10H,8H2,1-2H3,(H2,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibitory activity against PDGFRbeta kinase				J Med Chem 48: 8163-73 (2005) Article DOI: 10.1021/jm050680m BindingDB Entry DOI: 10.7270/Q2W095HW
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50179209 ((6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-y...) Show SMILES COc1cc2Cc3c(Nc4ccccc4)[nH]nc3-c2cc1OC Show InChI InChI=1S/C18H17N3O2/c1-22-15-9-11-8-14-17(13(11)10-16(15)23-2)20-21-18(14)19-12-6-4-3-5-7-12/h3-7,9-10H,8H2,1-2H3,(H2,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibitory activity against PDGFRbeta kinase				J Med Chem 48: 8163-73 (2005) Article DOI: 10.1021/jm050680m BindingDB Entry DOI: 10.7270/Q2W095HW
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50179204 (3-methoxy-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c...) Show SMILES COc1cccc(Nc2[nH]nc-3c2Cc2cc(OC)c(OC)cc-32)c1 Show InChI InChI=1S/C19H19N3O3/c1-23-13-6-4-5-12(9-13)20-19-15-7-11-8-16(24-2)17(25-3)10-14(11)18(15)21-22-19/h4-6,8-10H,7H2,1-3H3,(H2,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibitory activity against PDGFRbeta kinase				J Med Chem 48: 8163-73 (2005) Article DOI: 10.1021/jm050680m BindingDB Entry DOI: 10.7270/Q2W095HW
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50179204 (3-methoxy-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c...) Show SMILES COc1cccc(Nc2[nH]nc-3c2Cc2cc(OC)c(OC)cc-32)c1 Show InChI InChI=1S/C19H19N3O3/c1-23-13-6-4-5-12(9-13)20-19-15-7-11-8-16(24-2)17(25-3)10-14(11)18(15)21-22-19/h4-6,8-10H,7H2,1-3H3,(H2,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibitory activity against PDGFRbeta kinase				J Med Chem 48: 8163-73 (2005) Article DOI: 10.1021/jm050680m BindingDB Entry DOI: 10.7270/Q2W095HW
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM50431475 (CHEMBL2348327) Show SMILES Fc1ccccc1NC(C(=O)N1CCCC1c1ccccc1F)c1ccc(cc1)-c1cncnc1 Show InChI InChI=1S/C28H24F2N4O/c29-23-7-2-1-6-22(23)26-10-5-15-34(26)28(35)27(33-25-9-4-3-8-24(25)30)20-13-11-19(12-14-20)21-16-31-18-32-17-21/h1-4,6-9,11-14,16-18,26-27,33H,5,10,15H2	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...				Bioorg Med Chem Lett 23: 2234-7 (2013) Article DOI: 10.1016/j.bmcl.2013.01.062 BindingDB Entry DOI: 10.7270/Q2959JWT
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50179216 (3-carbomethoxy-N-(6,7-dimethoxy-2,4-dihydroindeno[...) Show SMILES COC(=O)c1cccc(Nc2[nH]nc-3c2Cc2cc(OC)c(OC)cc-32)c1 Show InChI InChI=1S/C20H19N3O4/c1-25-16-9-12-8-15-18(14(12)10-17(16)26-2)22-23-19(15)21-13-6-4-5-11(7-13)20(24)27-3/h4-7,9-10H,8H2,1-3H3,(H2,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Antiproliferative activity against PDGF-BB stimulated HCASMC				J Med Chem 48: 8163-73 (2005) Article DOI: 10.1021/jm050680m BindingDB Entry DOI: 10.7270/Q2W095HW
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM50431486 (CHEMBL2348662) Show SMILES Fc1ccccc1NC(C(=O)N1CCC[C@H]1c1ccccc1Cl)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C25H21ClF4N2O/c26-19-7-2-1-6-18(19)22-10-5-15-32(22)24(33)23(31-21-9-4-3-8-20(21)27)16-11-13-17(14-12-16)25(28,29)30/h1-4,6-9,11-14,22-23,31H,5,10,15H2/t22-,23?/m0/s1	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...				Bioorg Med Chem Lett 23: 2234-7 (2013) Article DOI: 10.1016/j.bmcl.2013.01.062 BindingDB Entry DOI: 10.7270/Q2959JWT
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50179216 (3-carbomethoxy-N-(6,7-dimethoxy-2,4-dihydroindeno[...) Show SMILES COC(=O)c1cccc(Nc2[nH]nc-3c2Cc2cc(OC)c(OC)cc-32)c1 Show InChI InChI=1S/C20H19N3O4/c1-25-16-9-12-8-15-18(14(12)10-17(16)26-2)22-23-19(15)21-13-6-4-5-11(7-13)20(24)27-3/h4-7,9-10H,8H2,1-3H3,(H2,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Antiproliferative activity against PDGF-BB stimulated HCASMC				J Med Chem 48: 8163-73 (2005) Article DOI: 10.1021/jm050680m BindingDB Entry DOI: 10.7270/Q2W095HW
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50179217 (3-methyl-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...) Show SMILES COc1cc2Cc3c(Nc4cccc(C)c4)[nH]nc3-c2cc1OC Show InChI InChI=1S/C19H19N3O2/c1-11-5-4-6-13(7-11)20-19-15-8-12-9-16(23-2)17(24-3)10-14(12)18(15)21-22-19/h4-7,9-10H,8H2,1-3H3,(H2,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibitory activity against PDGFRbeta kinase				J Med Chem 48: 8163-73 (2005) Article DOI: 10.1021/jm050680m BindingDB Entry DOI: 10.7270/Q2W095HW
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM50431494 (CHEMBL2348672) Show SMILES COc1ccccc1C1CCCN1C(=O)C(Nc1ccccc1F)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C26H24F4N2O2/c1-34-23-11-5-2-7-19(23)22-10-6-16-32(22)25(33)24(31-21-9-4-3-8-20(21)27)17-12-14-18(15-13-17)26(28,29)30/h2-5,7-9,11-15,22,24,31H,6,10,16H2,1H3	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...				Bioorg Med Chem Lett 23: 2234-7 (2013) Article DOI: 10.1016/j.bmcl.2013.01.062 BindingDB Entry DOI: 10.7270/Q2959JWT
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM50431479 (CHEMBL2348656) Show SMILES Fc1ccccc1NC(C(=O)N1CCC[C@H]1c1ccccc1F)c1ccc2OCCc2c1 |r| Show InChI InChI=1S/C26H24F2N2O2/c27-20-7-2-1-6-19(20)23-10-5-14-30(23)26(31)25(29-22-9-4-3-8-21(22)28)18-11-12-24-17(16-18)13-15-32-24/h1-4,6-9,11-12,16,23,25,29H,5,10,13-15H2/t23-,25?/m0/s1	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...				Bioorg Med Chem Lett 23: 2234-7 (2013) Article DOI: 10.1016/j.bmcl.2013.01.062 BindingDB Entry DOI: 10.7270/Q2959JWT
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM50431486 (CHEMBL2348662) Show SMILES Fc1ccccc1NC(C(=O)N1CCC[C@H]1c1ccccc1Cl)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C25H21ClF4N2O/c26-19-7-2-1-6-18(19)22-10-5-15-32(22)24(33)23(31-21-9-4-3-8-20(21)27)16-11-13-17(14-12-16)25(28,29)30/h1-4,6-9,11-14,22-23,31H,5,10,15H2/t22-,23?/m0/s1	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...				Bioorg Med Chem Lett 23: 2234-7 (2013) Article DOI: 10.1016/j.bmcl.2013.01.062 BindingDB Entry DOI: 10.7270/Q2959JWT
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50179208 (6,7-dimethoxy-3-phenyl-1,4-dihydroindeno[1,2-c]pyr...) Show SMILES COc1cc2Cc3c([nH]nc3-c3ccccc3)-c2cc1OC Show InChI InChI=1S/C18H16N2O2/c1-21-15-9-12-8-14-17(11-6-4-3-5-7-11)19-20-18(14)13(12)10-16(15)22-2/h3-7,9-10H,8H2,1-2H3,(H,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibitory activity against PDGFRbeta kinase				J Med Chem 48: 8163-73 (2005) Article DOI: 10.1021/jm050680m BindingDB Entry DOI: 10.7270/Q2W095HW
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50179208 (6,7-dimethoxy-3-phenyl-1,4-dihydroindeno[1,2-c]pyr...) Show SMILES COc1cc2Cc3c([nH]nc3-c3ccccc3)-c2cc1OC Show InChI InChI=1S/C18H16N2O2/c1-21-15-9-12-8-14-17(11-6-4-3-5-7-11)19-20-18(14)13(12)10-16(15)22-2/h3-7,9-10H,8H2,1-2H3,(H,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibitory activity against PDGFRbeta kinase				J Med Chem 48: 8163-73 (2005) Article DOI: 10.1021/jm050680m BindingDB Entry DOI: 10.7270/Q2W095HW
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50179210 ((7-methoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)ph...) Show SMILES COc1ccc2Cc3c(Nc4ccccc4)[nH]nc3-c2c1 Show InChI InChI=1S/C17H15N3O/c1-21-13-8-7-11-9-15-16(14(11)10-13)19-20-17(15)18-12-5-3-2-4-6-12/h2-8,10H,9H2,1H3,(H2,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibitory activity against PDGFRbeta kinase				J Med Chem 48: 8163-73 (2005) Article DOI: 10.1021/jm050680m BindingDB Entry DOI: 10.7270/Q2W095HW
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM50431491 (CHEMBL2348669) Show SMILES Fc1ccccc1NC(C(=O)N1CCCC1c1ccncc1)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C24H21F4N3O/c25-19-4-1-2-5-20(19)30-22(17-7-9-18(10-8-17)24(26,27)28)23(32)31-15-3-6-21(31)16-11-13-29-14-12-16/h1-2,4-5,7-14,21-22,30H,3,6,15H2	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...				Bioorg Med Chem Lett 23: 2234-7 (2013) Article DOI: 10.1016/j.bmcl.2013.01.062 BindingDB Entry DOI: 10.7270/Q2959JWT
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM50179207 (3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...) Show SMILES COc1cc2Cc3c(Nc4cccc(F)c4)[nH]nc3-c2cc1OC Show InChI InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibitory activity against c-ABL				J Med Chem 48: 8163-73 (2005) Article DOI: 10.1021/jm050680m BindingDB Entry DOI: 10.7270/Q2W095HW
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM50431476 (CHEMBL2348328) Show SMILES Fc1ccccc1NC(C(=O)N1CCCC1c1ccccc1F)c1ccc(cc1)-c1ccncc1 Show InChI InChI=1S/C29H25F2N3O/c30-24-7-2-1-6-23(24)27-10-5-19-34(27)29(35)28(33-26-9-4-3-8-25(26)31)22-13-11-20(12-14-22)21-15-17-32-18-16-21/h1-4,6-9,11-18,27-28,33H,5,10,19H2	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...				Bioorg Med Chem Lett 23: 2234-7 (2013) Article DOI: 10.1016/j.bmcl.2013.01.062 BindingDB Entry DOI: 10.7270/Q2959JWT
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM50431482 (CHEMBL2348659) Show SMILES Fc1ccccc1NC(C(=O)N1CCCC1c1cccnc1)c1cc2ccccc2s1 Show InChI InChI=1S/C25H22FN3OS/c26-19-9-2-3-10-20(19)28-24(23-15-17-7-1-4-12-22(17)31-23)25(30)29-14-6-11-21(29)18-8-5-13-27-16-18/h1-5,7-10,12-13,15-16,21,24,28H,6,11,14H2	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...				Bioorg Med Chem Lett 23: 2234-7 (2013) Article DOI: 10.1016/j.bmcl.2013.01.062 BindingDB Entry DOI: 10.7270/Q2959JWT
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM50431493 (CHEMBL2348670) Show SMILES Fc1ccccc1NC(C(=O)N1CCCC1c1ccccn1)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C24H21F4N3O/c25-18-6-1-2-7-19(18)30-22(16-10-12-17(13-11-16)24(26,27)28)23(32)31-15-5-9-21(31)20-8-3-4-14-29-20/h1-4,6-8,10-14,21-22,30H,5,9,15H2	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...				Bioorg Med Chem Lett 23: 2234-7 (2013) Article DOI: 10.1016/j.bmcl.2013.01.062 BindingDB Entry DOI: 10.7270/Q2959JWT
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM50431502 (CHEMBL2348683) Show SMILES Fc1ccccc1C1CCCN1C(=O)C(Nc1ccccc1)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C25H22F4N2O/c26-21-10-5-4-9-20(21)22-11-6-16-31(22)24(32)23(30-19-7-2-1-3-8-19)17-12-14-18(15-13-17)25(27,28)29/h1-5,7-10,12-15,22-23,30H,6,11,16H2	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...				Bioorg Med Chem Lett 23: 2234-7 (2013) Article DOI: 10.1016/j.bmcl.2013.01.062 BindingDB Entry DOI: 10.7270/Q2959JWT
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50179211 (3-bromo-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]p...) Show SMILES COc1cc2Cc3c(Nc4cccc(Br)c4)[nH]nc3-c2cc1OC Show InChI InChI=1S/C18H16BrN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Antiproliferative activity against PDGF-BB stimulated HCASMC				J Med Chem 48: 8163-73 (2005) Article DOI: 10.1021/jm050680m BindingDB Entry DOI: 10.7270/Q2W095HW
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM50431485 (CHEMBL2348661) Show SMILES OC(=O)c1cccc(c1)[C@@H]1CCCN1C(=O)C(Nc1ccccc1F)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C26H22F4N2O3/c27-20-7-1-2-8-21(20)31-23(16-10-12-19(13-11-16)26(28,29)30)24(33)32-14-4-9-22(32)17-5-3-6-18(15-17)25(34)35/h1-3,5-8,10-13,15,22-23,31H,4,9,14H2,(H,34,35)/t22-,23?/m0/s1	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...				Bioorg Med Chem Lett 23: 2234-7 (2013) Article DOI: 10.1016/j.bmcl.2013.01.062 BindingDB Entry DOI: 10.7270/Q2959JWT
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM50431501 (CHEMBL2348682) Show SMILES COc1ccccc1C1CCCN1C(=O)C(Nc1ccccc1)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C26H25F3N2O2/c1-33-23-12-6-5-10-21(23)22-11-7-17-31(22)25(32)24(30-20-8-3-2-4-9-20)18-13-15-19(16-14-18)26(27,28)29/h2-6,8-10,12-16,22,24,30H,7,11,17H2,1H3	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...				Bioorg Med Chem Lett 23: 2234-7 (2013) Article DOI: 10.1016/j.bmcl.2013.01.062 BindingDB Entry DOI: 10.7270/Q2959JWT
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM50431497 (CHEMBL2348676) Show SMILES Fc1ccc(cc1)C1CCCN1C(=O)C(Nc1ccccc1F)c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C25H21F5N2O/c26-19-13-9-16(10-14-19)22-6-3-15-32(22)24(33)23(31-21-5-2-1-4-20(21)27)17-7-11-18(12-8-17)25(28,29)30/h1-2,4-5,7-14,22-23,31H,3,6,15H2	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...				Bioorg Med Chem Lett 23: 2234-7 (2013) Article DOI: 10.1016/j.bmcl.2013.01.062 BindingDB Entry DOI: 10.7270/Q2959JWT
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50179206 (3-trifluoromethyl-N-(6,7-dimethoxy-2,4-dihydroinde...) Show SMILES COc1cc2Cc3c(Nc4cccc(c4)C(F)(F)F)[nH]nc3-c2cc1OC Show InChI InChI=1S/C19H16F3N3O2/c1-26-15-7-10-6-14-17(13(10)9-16(15)27-2)24-25-18(14)23-12-5-3-4-11(8-12)19(20,21)22/h3-5,7-9H,6H2,1-2H3,(H2,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibitory activity against PDGFRbeta kinase				J Med Chem 48: 8163-73 (2005) Article DOI: 10.1021/jm050680m BindingDB Entry DOI: 10.7270/Q2W095HW
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM50431485 (CHEMBL2348661) Show SMILES OC(=O)c1cccc(c1)[C@@H]1CCCN1C(=O)C(Nc1ccccc1F)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C26H22F4N2O3/c27-20-7-1-2-8-21(20)31-23(16-10-12-19(13-11-16)26(28,29)30)24(33)32-14-4-9-22(32)17-5-3-6-18(15-17)25(34)35/h1-3,5-8,10-13,15,22-23,31H,4,9,14H2,(H,34,35)/t22-,23?/m0/s1	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...				Bioorg Med Chem Lett 23: 2234-7 (2013) Article DOI: 10.1016/j.bmcl.2013.01.062 BindingDB Entry DOI: 10.7270/Q2959JWT
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM50431500 (CHEMBL2348681) Show SMILES FC(F)(F)c1ccc(cc1)C(Nc1ccccc1)C(=O)N1CCC[C@H]1c1ccccc1Cl |r| Show InChI InChI=1S/C25H22ClF3N2O/c26-21-10-5-4-9-20(21)22-11-6-16-31(22)24(32)23(30-19-7-2-1-3-8-19)17-12-14-18(15-13-17)25(27,28)29/h1-5,7-10,12-15,22-23,30H,6,11,16H2/t22-,23?/m0/s1	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...				Bioorg Med Chem Lett 23: 2234-7 (2013) Article DOI: 10.1016/j.bmcl.2013.01.062 BindingDB Entry DOI: 10.7270/Q2959JWT
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM50431480 (CHEMBL2348657) Show SMILES OC(=O)c1ccc(cc1)C1CCCN1C(=O)C(Nc1ccccc1F)c1cc2ccccc2s1 Show InChI InChI=1S/C27H23FN2O3S/c28-20-7-2-3-8-21(20)29-25(24-16-19-6-1-4-10-23(19)34-24)26(31)30-15-5-9-22(30)17-11-13-18(14-12-17)27(32)33/h1-4,6-8,10-14,16,22,25,29H,5,9,15H2,(H,32,33)	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...				Bioorg Med Chem Lett 23: 2234-7 (2013) Article DOI: 10.1016/j.bmcl.2013.01.062 BindingDB Entry DOI: 10.7270/Q2959JWT
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM50431488 (CHEMBL2348665) Show SMILES Fc1ccccc1NC(C(=O)N1CCC[C@@H]1c1ccccc1)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C25H22F4N2O/c26-20-9-4-5-10-21(20)30-23(18-12-14-19(15-13-18)25(27,28)29)24(32)31-16-6-11-22(31)17-7-2-1-3-8-17/h1-5,7-10,12-15,22-23,30H,6,11,16H2/t22-,23?/m1/s1	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...				Bioorg Med Chem Lett 23: 2234-7 (2013) Article DOI: 10.1016/j.bmcl.2013.01.062 BindingDB Entry DOI: 10.7270/Q2959JWT
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM50431487 (CHEMBL2348663) Show SMILES Fc1ccccc1NC(C(=O)N1CCC[C@@H]1c1ccccc1F)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C25H21F5N2O/c26-19-7-2-1-6-18(19)22-10-5-15-32(22)24(33)23(31-21-9-4-3-8-20(21)27)16-11-13-17(14-12-16)25(28,29)30/h1-4,6-9,11-14,22-23,31H,5,10,15H2/t22-,23?/m1/s1	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...				Bioorg Med Chem Lett 23: 2234-7 (2013) Article DOI: 10.1016/j.bmcl.2013.01.062 BindingDB Entry DOI: 10.7270/Q2959JWT
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50179207 (3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]...) Show SMILES COc1cc2Cc3c(Nc4cccc(F)c4)[nH]nc3-c2cc1OC Show InChI InChI=1S/C18H16FN3O2/c1-23-15-7-10-6-14-17(13(10)9-16(15)24-2)21-22-18(14)20-12-5-3-4-11(19)8-12/h3-5,7-9H,6H2,1-2H3,(H2,20,21,22)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL					Assay Description Inhibitory activity against PDGFRalpha				J Med Chem 48: 8163-73 (2005) Article DOI: 10.1021/jm050680m BindingDB Entry DOI: 10.7270/Q2W095HW
					More data for this Ligand-Target Pair
Transient receptor potential M8 protein (Canis lupus familiaris (Dog))	BDBM50431472 (CHEMBL2348324) Show SMILES Fc1ccccc1N[C@@H](C(=O)N1CCC[C@H]1c1ccccc1F)c1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C25H21F5N2O/c26-19-7-2-1-6-18(19)22-10-5-15-32(22)24(33)23(31-21-9-4-3-8-20(21)27)16-11-13-17(14-12-16)25(28,29)30/h1-4,6-9,11-14,22-23,31H,5,10,15H2/t22-,23+/m0/s1	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research& Development, L.L.C. Curated by ChEMBL					Assay Description Antagonist activity at dog TRPM8 expressed in HEK293 cells assessed as inhibition of icilin-induced calcium influx incubated for 5 mins prior to icil...				Bioorg Med Chem Lett 23: 2234-7 (2013) Article DOI: 10.1016/j.bmcl.2013.01.062 BindingDB Entry DOI: 10.7270/Q2959JWT
					More data for this Ligand-Target Pair

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