| Reaction Details |
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 | Report a problem with these data |
| Target | Transient receptor potential M8 protein |
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| Ligand | BDBM50431486 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_952739 (CHEMBL2350718) |
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| IC50 | 11±n/a nM |
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| Citation |  Zhu, B; Xia, M; Xu, X; Ludovici, DW; Tennakoon, M; Youngman, MA; Matthews, JM; Dax, SL; Colburn, RW; Qin, N; Hutchinson, TL; Lubin, ML; Brandt, MR; Stone, DJ; Flores, CM; Macielag, MJ Arylglycine derivatives as potent transient receptor potential melastatin 8 (TRPM8) antagonists. Bioorg Med Chem Lett23:2234-7 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transient receptor potential M8 protein |
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| Name: | Transient receptor potential M8 protein |
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| Synonyms: | Cold-menthol receptor (TRPM8) | TRPM8 Receptor | Transient receptor potential M8 protein | Transient receptor potential M8 protein (TRPM8) | Transient receptor potential melastatin subfamily, type 8 (TRPM8) |
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| Type: | Enzyme |
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| Mol. Mass.: | 127589.43 |
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| Organism: | Canis lupus familiaris (Dog) |
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| Description: | Q1A7N1 |
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| Residue: | 1104 |
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| Sequence: | MSFEGARLSMRNRRNGTLDSTRTLYSSTSRSTDVSYSESDLVNFIQANFKKRECVFFTKD
SKATENVCKCGYAQSQHIEGTQINSNEKWNYKKHTKEFPTDAFGDIQFETLGKKGKYIRL
SCDTDAETLYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWIL
TGGTHYGLMKYIGEVVRDNTISRNSEENIVAIGIAAWGMVSNRDTLLRNCDAEGYFSAQY
IMDDFKRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTIQDSNYGGKIP
IVCFAQGGGRETLKAINTSIKSKIPCVVVEGSGQIADVIASLVEVEDVLTSSVVKEKLVR
FLPRTVSRLPEEETESWIKWLKEILESSHLLTVIKMEEAGDEIVSNAISYALYKAFSTNE
QDKDNWNGQLKLLLEWNQLDLANEEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLEN
GLNLRKFLTNDVLTELFSNHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRGFRKEDR
SSRDDIDVELHDVSPITRHPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKT
LAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELA
VEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGFVSFRKKPIDKH
KKILWYYVAFFTSPFVVFAWNVVFYIAFLLLFAYVLLMDFHSVPHSPELVLYALVFVLFC
DEVRQWYMNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHPSNKTSLYSGRVIFCLDYIIFT
LRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEHRWRWIF
RSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLV
CIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCNRLNIPFPFVVFAY
FYMVVKKCFGCCCREKHAEPSACCFRNEDNETLAWEGVMKENYLVKINTKANDTSQEMRH
RFRQLDTKINDLKGLLKEIANKIK
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| BDBM50431486 |
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| n/a |
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| Name | BDBM50431486 |
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| Synonyms: | CHEMBL2348662 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H21ClF4N2O |
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| Mol. Mass. | 476.894 |
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| SMILES | Fc1ccccc1NC(C(=O)N1CCC[C@H]1c1ccccc1Cl)c1ccc(cc1)C(F)(F)F |r| |
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| Structure | 
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