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PubMed code 23602400

Compile data set for download or QSAR
Found 28 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM14774
PNG
(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)
Show SMILES FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1c(Cl)cncc1Cl
Show InChI InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)
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n/an/a 0.490n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis

Bioorg Med Chem Lett 23: 3325-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50491736
PNG
(CHEMBL2385759)
Show SMILES CC(C)(C)CNC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1
Show InChI InChI=1S/C26H30N4O3S/c1-26(2,3)17-27-22(31)16-18-11-13-20(14-12-18)28-25-23-21(10-7-15-34(23,32)33)29-24(30-25)19-8-5-4-6-9-19/h4-6,8-9,11-14H,7,10,15-17H2,1-3H3,(H,27,31)(H,28,29,30)
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n/an/a 4.70n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis

Bioorg Med Chem Lett 23: 3325-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50491737
PNG
(CHEMBL2385757)
Show SMILES CC(C)CNC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1
Show InChI InChI=1S/C25H28N4O3S/c1-17(2)16-26-22(30)15-18-10-12-20(13-11-18)27-25-23-21(9-6-14-33(23,31)32)28-24(29-25)19-7-4-3-5-8-19/h3-5,7-8,10-13,17H,6,9,14-16H2,1-2H3,(H,26,30)(H,27,28,29)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis

Bioorg Med Chem Lett 23: 3325-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50491759
PNG
(CHEMBL2385755 | US11401286, Example 270)
Show SMILES CCCNC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1
Show InChI InChI=1S/C24H26N4O3S/c1-2-14-25-21(29)16-17-10-12-19(13-11-17)26-24-22-20(9-6-15-32(22,30)31)27-23(28-24)18-7-4-3-5-8-18/h3-5,7-8,10-13H,2,6,9,14-16H2,1H3,(H,25,29)(H,26,27,28)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis

Bioorg Med Chem Lett 23: 3325-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50491753
PNG
(CHEMBL2385758)
Show SMILES CC(C)(C)NC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1
Show InChI InChI=1S/C25H28N4O3S/c1-25(2,3)29-21(30)16-17-11-13-19(14-12-17)26-24-22-20(10-7-15-33(22,31)32)27-23(28-24)18-8-5-4-6-9-18/h4-6,8-9,11-14H,7,10,15-16H2,1-3H3,(H,29,30)(H,26,27,28)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis

Bioorg Med Chem Lett 23: 3325-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50491738
PNG
(CHEMBL2385753 | US11401286, Example 269)
Show SMILES NC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1
Show InChI InChI=1S/C21H20N4O3S/c22-18(26)13-14-8-10-16(11-9-14)23-21-19-17(7-4-12-29(19,27)28)24-20(25-21)15-5-2-1-3-6-15/h1-3,5-6,8-11H,4,7,12-13H2,(H2,22,26)(H,23,24,25)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis

Bioorg Med Chem Lett 23: 3325-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50491754
PNG
(CHEMBL2385756)
Show SMILES CCCCNC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1
Show InChI InChI=1S/C25H28N4O3S/c1-2-3-15-26-22(30)17-18-11-13-20(14-12-18)27-25-23-21(10-7-16-33(23,31)32)28-24(29-25)19-8-5-4-6-9-19/h4-6,8-9,11-14H,2-3,7,10,15-17H2,1H3,(H,26,30)(H,27,28,29)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis

Bioorg Med Chem Lett 23: 3325-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50491740
PNG
(CHEMBL2385749)
Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1
Show InChI InChI=1S/C21H19N3O4S/c25-18(26)13-14-8-10-16(11-9-14)22-21-19-17(7-4-12-29(19,27)28)23-20(24-21)15-5-2-1-3-6-15/h1-3,5-6,8-11H,4,7,12-13H2,(H,25,26)(H,22,23,24)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis

Bioorg Med Chem Lett 23: 3325-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50491751
PNG
(CHEMBL2385754)
Show SMILES CNC(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1
Show InChI InChI=1S/C22H22N4O3S/c1-23-19(27)14-15-9-11-17(12-10-15)24-22-20-18(8-5-13-30(20,28)29)25-21(26-22)16-6-3-2-4-7-16/h2-4,6-7,9-12H,5,8,13-14H2,1H3,(H,23,27)(H,24,25,26)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis

Bioorg Med Chem Lett 23: 3325-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50491739
PNG
(CHEMBL2385750)
Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CS(=O)(=O)CCc23)-c2ccccc2)cc1
Show InChI InChI=1S/C21H19N3O4S/c25-19(26)12-14-6-8-16(9-7-14)22-21-17-10-11-29(27,28)13-18(17)23-20(24-21)15-4-2-1-3-5-15/h1-9H,10-13H2,(H,25,26)(H,22,23,24)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis

Bioorg Med Chem Lett 23: 3325-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50491746
PNG
(CHEMBL2385559)
Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CSCc23)-c2ccccc2)cc1
Show InChI InChI=1S/C20H17N3O2S/c24-18(25)10-13-6-8-15(9-7-13)21-20-16-11-26-12-17(16)22-19(23-20)14-4-2-1-3-5-14/h1-9H,10-12H2,(H,24,25)(H,21,22,23)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis

Bioorg Med Chem Lett 23: 3325-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50491761
PNG
(CHEMBL2385573)
Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCSc23)-c2ccccc2)cc1
Show InChI InChI=1S/C21H19N3O2S/c25-18(26)13-14-8-10-16(11-9-14)22-21-19-17(7-4-12-27-19)23-20(24-21)15-5-2-1-3-6-15/h1-3,5-6,8-11H,4,7,12-13H2,(H,25,26)(H,22,23,24)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis

Bioorg Med Chem Lett 23: 3325-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50491735
PNG
(CHEMBL2385761)
Show SMILES CN(C)C(=O)Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1
Show InChI InChI=1S/C23H24N4O3S/c1-27(2)20(28)15-16-10-12-18(13-11-16)24-23-21-19(9-6-14-31(21,29)30)25-22(26-23)17-7-4-3-5-8-17/h3-5,7-8,10-13H,6,9,14-15H2,1-2H3,(H,24,25,26)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis

Bioorg Med Chem Lett 23: 3325-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50491750
PNG
(CHEMBL2385760)
Show SMILES O=C(Cc1ccc(Nc2nc(nc3CCCS(=O)(=O)c23)-c2ccccc2)cc1)Nc1ccccc1
Show InChI InChI=1S/C27H24N4O3S/c32-24(28-21-10-5-2-6-11-21)18-19-13-15-22(16-14-19)29-27-25-23(12-7-17-35(25,33)34)30-26(31-27)20-8-3-1-4-9-20/h1-6,8-11,13-16H,7,12,17-18H2,(H,28,32)(H,29,30,31)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis

Bioorg Med Chem Lett 23: 3325-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50491744
PNG
(CHEMBL2385563)
Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CS(=O)(=O)Cc23)-c2ccccc2)cc1
Show InChI InChI=1S/C20H17N3O4S/c24-18(25)10-13-6-8-15(9-7-13)21-20-16-11-28(26,27)12-17(16)22-19(23-20)14-4-2-1-3-5-14/h1-9H,10-12H2,(H,24,25)(H,21,22,23)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis

Bioorg Med Chem Lett 23: 3325-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50491747
PNG
(CHEMBL2385558)
Show SMILES OC(=O)CC1CCN(CC1)c1nc(nc2CSCc12)-c1ccccc1
Show InChI InChI=1S/C19H21N3O2S/c23-17(24)10-13-6-8-22(9-7-13)19-15-11-25-12-16(15)20-18(21-19)14-4-2-1-3-5-14/h1-5,13H,6-12H2,(H,23,24)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis

Bioorg Med Chem Lett 23: 3325-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50491745
PNG
(CHEMBL2385560)
Show SMILES OC(=O)CC1CCN(CC1)c1nc(nc2CS(=O)(=O)Cc12)-c1ccccc1
Show InChI InChI=1S/C19H21N3O4S/c23-17(24)10-13-6-8-22(9-7-13)19-15-11-27(25,26)12-16(15)20-18(21-19)14-4-2-1-3-5-14/h1-5,13H,6-12H2,(H,23,24)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis

Bioorg Med Chem Lett 23: 3325-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50491741
PNG
(CHEMBL2385572)
Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3sccc23)-c2ccccc2)cc1
Show InChI InChI=1S/C20H15N3O2S/c24-17(25)12-13-6-8-15(9-7-13)21-19-16-10-11-26-20(16)23-18(22-19)14-4-2-1-3-5-14/h1-11H,12H2,(H,24,25)(H,21,22,23)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis

Bioorg Med Chem Lett 23: 3325-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50491752
PNG
(CHEMBL2385751)
Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCS(=O)(=O)c23)-c2ccccc2)cc1
Show InChI InChI=1S/C20H17N3O4S/c24-17(25)12-13-6-8-15(9-7-13)21-20-18-16(10-11-28(18,26)27)22-19(23-20)14-4-2-1-3-5-14/h1-9H,10-12H2,(H,24,25)(H,21,22,23)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis

Bioorg Med Chem Lett 23: 3325-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50491742
PNG
(CHEMBL2385567)
Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCCc23)-c2ccccc2)cc1
Show InChI InChI=1S/C22H21N3O2/c26-20(27)14-15-10-12-17(13-11-15)23-22-18-8-4-5-9-19(18)24-21(25-22)16-6-2-1-3-7-16/h1-3,6-7,10-13H,4-5,8-9,14H2,(H,26,27)(H,23,24,25)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis

Bioorg Med Chem Lett 23: 3325-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50491748
PNG
(CHEMBL2385570)
Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3ccccc23)-c2ccccc2)cc1
Show InChI InChI=1S/C22H17N3O2/c26-20(27)14-15-10-12-17(13-11-15)23-22-18-8-4-5-9-19(18)24-21(25-22)16-6-2-1-3-7-16/h1-13H,14H2,(H,26,27)(H,23,24,25)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis

Bioorg Med Chem Lett 23: 3325-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50491756
PNG
(CHEMBL2385566)
Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCCc23)-c2ccccc2)cc1
Show InChI InChI=1S/C21H19N3O2/c25-19(26)13-14-9-11-16(12-10-14)22-21-17-7-4-8-18(17)23-20(24-21)15-5-2-1-3-6-15/h1-3,5-6,9-12H,4,7-8,13H2,(H,25,26)(H,22,23,24)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis

Bioorg Med Chem Lett 23: 3325-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50491743
PNG
(CHEMBL2385565)
Show SMILES OC(=O)CCc1ccc(Nc2nc(nc3CS(=O)(=O)Cc23)-c2ccccc2)cc1
Show InChI InChI=1S/C21H19N3O4S/c25-19(26)11-8-14-6-9-16(10-7-14)22-21-17-12-29(27,28)13-18(17)23-20(24-21)15-4-2-1-3-5-15/h1-7,9-10H,8,11-13H2,(H,25,26)(H,22,23,24)
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Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis

Bioorg Med Chem Lett 23: 3325-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50491760
PNG
(CHEMBL2385569)
Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3COCc23)-c2ccccc2)cc1
Show InChI InChI=1S/C20H17N3O3/c24-18(25)10-13-6-8-15(9-7-13)21-20-16-11-26-12-17(16)22-19(23-20)14-4-2-1-3-5-14/h1-9H,10-12H2,(H,24,25)(H,21,22,23)
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n/an/a 2.20E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis

Bioorg Med Chem Lett 23: 3325-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50491758
PNG
(CHEMBL2385564)
Show SMILES OC(=O)Cc1cccc(Nc2nc(nc3CS(=O)(=O)Cc23)-c2ccccc2)c1
Show InChI InChI=1S/C20H17N3O4S/c24-18(25)10-13-5-4-8-15(9-13)21-20-16-11-28(26,27)12-17(16)22-19(23-20)14-6-2-1-3-7-14/h1-9H,10-12H2,(H,24,25)(H,21,22,23)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis

Bioorg Med Chem Lett 23: 3325-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50491757
PNG
(CHEMBL2385562)
Show SMILES OC(=O)CN1CCC(CC1)Nc1nc(nc2CS(=O)(=O)Cc12)-c1ccccc1
Show InChI InChI=1S/C19H22N4O4S/c24-17(25)10-23-8-6-14(7-9-23)20-19-15-11-28(26,27)12-16(15)21-18(22-19)13-4-2-1-3-5-13/h1-5,14H,6-12H2,(H,24,25)(H,20,21,22)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis

Bioorg Med Chem Lett 23: 3325-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50491749
PNG
(CHEMBL2385561)
Show SMILES OC(=O)CN1CCN(CC1)c1nc(nc2CS(=O)(=O)Cc12)-c1ccccc1
Show InChI InChI=1S/C18H20N4O4S/c23-16(24)10-21-6-8-22(9-7-21)18-14-11-27(25,26)12-15(14)19-17(20-18)13-4-2-1-3-5-13/h1-5H,6-12H2,(H,23,24)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis

Bioorg Med Chem Lett 23: 3325-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM50491755
PNG
(CHEMBL2385752)
Show SMILES OC(=O)Cc1ccc(Nc2nc(nc3CCS(=O)(=O)Cc23)-c2ccccc2)cc1
Show InChI InChI=1S/C21H19N3O4S/c25-19(26)12-14-6-8-16(9-7-14)22-21-17-13-29(27,28)11-10-18(17)23-20(24-21)15-4-2-1-3-5-15/h1-9H,10-13H2,(H,25,26)(H,22,23,24)
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n/an/a 7.90E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PDE4B (152 to 564 amino acids) using cAMP as substrate after 30 mins by plate reader analysis

Bioorg Med Chem Lett 23: 3325-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.104
BindingDB Entry DOI: 10.7270/Q2QF8WSQ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%