Found 54 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Short transient receptor potential channel 6
(Homo sapiens (Human)) | BDBM50439218
(CHEMBL2418809)Show SMILES CC1CCCN(C1C)C(=O)c1nc(Nc2cc3OCOc3cc2F)sc1Cl Show InChI InChI=1S/C18H19ClFN3O3S/c1-9-4-3-5-23(10(9)2)17(24)15-16(19)27-18(22-15)21-12-7-14-13(6-11(12)20)25-8-26-14/h6-7,9-10H,3-5,8H2,1-2H3,(H,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 6
(Homo sapiens (Human)) | BDBM50439220
(CHEMBL2418807)Show InChI InChI=1S/C18H21N3O3S/c1-11-4-3-7-21(12(11)2)17(22)14-9-25-18(20-14)19-13-5-6-15-16(8-13)24-10-23-15/h5-6,8-9,11-12H,3-4,7,10H2,1-2H3,(H,19,20) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 6
(Homo sapiens (Human)) | BDBM50439217
(CHEMBL2418811)Show SMILES C[C@H]1CCCN([C@H]1C)C(=O)c1nc(Nc2ccc(Cl)cc2F)sc1C |r| Show InChI InChI=1S/C18H21ClFN3OS/c1-10-5-4-8-23(11(10)2)17(24)16-12(3)25-18(22-16)21-15-7-6-13(19)9-14(15)20/h6-7,9-11H,4-5,8H2,1-3H3,(H,21,22)/t10-,11-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 6
(Homo sapiens (Human)) | BDBM50439219
(CHEMBL2418808)Show InChI InChI=1S/C19H22FN3O3S/c1-10-5-4-6-23(11(10)2)18(24)17-12(3)27-19(22-17)21-14-8-16-15(7-13(14)20)25-9-26-16/h7-8,10-11H,4-6,9H2,1-3H3,(H,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 6
(Homo sapiens (Human)) | BDBM50439213
(CHEMBL2418815)Show SMILES CC1N(CCc2ccccc12)C(=O)c1nc(Nc2ccc3OCOc3c2)sc1C Show InChI InChI=1S/C22H21N3O3S/c1-13-17-6-4-3-5-15(17)9-10-25(13)21(26)20-14(2)29-22(24-20)23-16-7-8-18-19(11-16)28-12-27-18/h3-8,11,13H,9-10,12H2,1-2H3,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 3
(Homo sapiens (Human)) | BDBM50439218
(CHEMBL2418809)Show SMILES CC1CCCN(C1C)C(=O)c1nc(Nc2cc3OCOc3cc2F)sc1Cl Show InChI InChI=1S/C18H19ClFN3O3S/c1-9-4-3-5-23(10(9)2)17(24)15-16(19)27-18(22-15)21-12-7-14-13(6-11(12)20)25-8-26-14/h6-7,9-10H,3-5,8H2,1-2H3,(H,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 6
(Homo sapiens (Human)) | BDBM50439216
(CHEMBL2418812)Show SMILES C[C@@H]1CCCN([C@@H]1C)C(=O)c1nc(Nc2ccc(Cl)cc2F)sc1C |r| Show InChI InChI=1S/C18H21ClFN3OS/c1-10-5-4-8-23(11(10)2)17(24)16-12(3)25-18(22-16)21-15-7-6-13(19)9-14(15)20/h6-7,9-11H,4-5,8H2,1-3H3,(H,21,22)/t10-,11-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 6
(Homo sapiens (Human)) | BDBM50439214
(CHEMBL2418814)Show SMILES CC1N(CCc2ccccc12)C(=O)c1csc(Nc2ccc3OCOc3c2)n1 Show InChI InChI=1S/C21H19N3O3S/c1-13-16-5-3-2-4-14(16)8-9-24(13)20(25)17-11-28-21(23-17)22-15-6-7-18-19(10-15)27-12-26-18/h2-7,10-11,13H,8-9,12H2,1H3,(H,22,23) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 6
(Homo sapiens (Human)) | BDBM50439221
(CHEMBL2418806)Show InChI InChI=1S/C18H23N3OS/c1-12-6-8-15(9-7-12)19-18-20-16(11-23-18)17(22)21-10-4-5-13(2)14(21)3/h6-9,11,13-14H,4-5,10H2,1-3H3,(H,19,20) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 3
(Homo sapiens (Human)) | BDBM50439220
(CHEMBL2418807)Show InChI InChI=1S/C18H21N3O3S/c1-11-4-3-7-21(12(11)2)17(22)14-9-25-18(20-14)19-13-5-6-15-16(8-13)24-10-23-15/h5-6,8-9,11-12H,3-4,7,10H2,1-2H3,(H,19,20) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 3
(Homo sapiens (Human)) | BDBM50439217
(CHEMBL2418811)Show SMILES C[C@H]1CCCN([C@H]1C)C(=O)c1nc(Nc2ccc(Cl)cc2F)sc1C |r| Show InChI InChI=1S/C18H21ClFN3OS/c1-10-5-4-8-23(11(10)2)17(24)16-12(3)25-18(22-16)21-15-7-6-13(19)9-14(15)20/h6-7,9-11H,4-5,8H2,1-3H3,(H,21,22)/t10-,11-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 6
(Homo sapiens (Human)) | BDBM50439227
(CHEMBL2418823)Show InChI InChI=1S/C17H19N3O3S/c1-11-4-6-20(7-5-11)16(21)13-9-24-17(19-13)18-12-2-3-14-15(8-12)23-10-22-14/h2-3,8-9,11H,4-7,10H2,1H3,(H,18,19) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 6
(Homo sapiens (Human)) | BDBM50439215
(CHEMBL2418813)Show InChI InChI=1S/C20H17N3O3S/c24-19(23-8-7-13-3-1-2-4-14(13)10-23)16-11-27-20(22-16)21-15-5-6-17-18(9-15)26-12-25-17/h1-6,9,11H,7-8,10,12H2,(H,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 3
(Homo sapiens (Human)) | BDBM50439219
(CHEMBL2418808)Show InChI InChI=1S/C19H22FN3O3S/c1-10-5-4-6-23(11(10)2)18(24)17-12(3)27-19(22-17)21-14-8-16-15(7-13(14)20)25-9-26-16/h7-8,10-11H,4-6,9H2,1-3H3,(H,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 3
(Homo sapiens (Human)) | BDBM50439221
(CHEMBL2418806)Show InChI InChI=1S/C18H23N3OS/c1-12-6-8-15(9-7-12)19-18-20-16(11-23-18)17(22)21-10-4-5-13(2)14(21)3/h6-9,11,13-14H,4-5,10H2,1-3H3,(H,19,20) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 3
(Homo sapiens (Human)) | BDBM50439216
(CHEMBL2418812)Show SMILES C[C@@H]1CCCN([C@@H]1C)C(=O)c1nc(Nc2ccc(Cl)cc2F)sc1C |r| Show InChI InChI=1S/C18H21ClFN3OS/c1-10-5-4-8-23(11(10)2)17(24)16-12(3)25-18(22-16)21-15-7-6-13(19)9-14(15)20/h6-7,9-11H,4-5,8H2,1-3H3,(H,21,22)/t10-,11-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 3
(Homo sapiens (Human)) | BDBM50439213
(CHEMBL2418815)Show SMILES CC1N(CCc2ccccc12)C(=O)c1nc(Nc2ccc3OCOc3c2)sc1C Show InChI InChI=1S/C22H21N3O3S/c1-13-17-6-4-3-5-15(17)9-10-25(13)21(26)20-14(2)29-22(24-20)23-16-7-8-18-19(11-16)28-12-27-18/h3-8,11,13H,9-10,12H2,1-2H3,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 3
(Homo sapiens (Human)) | BDBM50439214
(CHEMBL2418814)Show SMILES CC1N(CCc2ccccc12)C(=O)c1csc(Nc2ccc3OCOc3c2)n1 Show InChI InChI=1S/C21H19N3O3S/c1-13-16-5-3-2-4-14(16)8-9-24(13)20(25)17-11-28-21(23-17)22-15-6-7-18-19(10-15)27-12-26-18/h2-7,10-11,13H,8-9,12H2,1H3,(H,22,23) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 6
(Homo sapiens (Human)) | BDBM50439232
(CHEMBL2418818)Show InChI InChI=1S/C17H21N3OS/c1-12-3-5-14(6-4-12)18-17-19-15(11-22-17)16(21)20-9-7-13(2)8-10-20/h3-6,11,13H,7-10H2,1-2H3,(H,18,19) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 3
(Homo sapiens (Human)) | BDBM50439227
(CHEMBL2418823)Show InChI InChI=1S/C17H19N3O3S/c1-11-4-6-20(7-5-11)16(21)13-9-24-17(19-13)18-12-2-3-14-15(8-12)23-10-22-14/h2-3,8-9,11H,4-7,10H2,1H3,(H,18,19) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 6
(Homo sapiens (Human)) | BDBM43434
(3,4-dihydro-1H-isoquinolin-2-yl-[2-(4-methoxyanili...)Show InChI InChI=1S/C20H19N3O2S/c1-25-17-8-6-16(7-9-17)21-20-22-18(13-26-20)19(24)23-11-10-14-4-2-3-5-15(14)12-23/h2-9,13H,10-12H2,1H3,(H,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 3
(Homo sapiens (Human)) | BDBM50439215
(CHEMBL2418813)Show InChI InChI=1S/C20H17N3O3S/c24-19(23-8-7-13-3-1-2-4-14(13)10-23)16-11-27-20(22-16)21-15-5-6-17-18(9-15)26-12-25-17/h1-6,9,11H,7-8,10,12H2,(H,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 3
(Homo sapiens (Human)) | BDBM50439232
(CHEMBL2418818)Show InChI InChI=1S/C17H21N3OS/c1-12-3-5-14(6-4-12)18-17-19-15(11-22-17)16(21)20-9-7-13(2)8-10-20/h3-6,11,13H,7-10H2,1-2H3,(H,18,19) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 6
(Homo sapiens (Human)) | BDBM50439228
(CHEMBL2418822)Show InChI InChI=1S/C16H17ClFN3OS/c1-10-4-6-21(7-5-10)15(22)14-9-23-16(20-14)19-13-3-2-11(17)8-12(13)18/h2-3,8-10H,4-7H2,1H3,(H,19,20) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 6
(Homo sapiens (Human)) | BDBM50439226
(CHEMBL2418824)Show InChI InChI=1S/C17H21N3OS/c1-12-6-8-14(9-7-12)18-17-19-15(11-22-17)16(21)20-10-4-3-5-13(20)2/h6-9,11,13H,3-5,10H2,1-2H3,(H,18,19) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 6
(Homo sapiens (Human)) | BDBM50439231
(CHEMBL2418819)Show InChI InChI=1S/C16H18ClN3OS/c1-11-6-8-20(9-7-11)15(21)14-10-22-16(19-14)18-13-4-2-12(17)3-5-13/h2-5,10-11H,6-9H2,1H3,(H,18,19) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 3
(Homo sapiens (Human)) | BDBM50439230
(CHEMBL2418820)Show InChI InChI=1S/C17H21N3O2S/c1-12-7-9-20(10-8-12)16(21)15-11-23-17(19-15)18-13-3-5-14(22-2)6-4-13/h3-6,11-12H,7-10H2,1-2H3,(H,18,19) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 3
(Homo sapiens (Human)) | BDBM50439226
(CHEMBL2418824)Show InChI InChI=1S/C17H21N3OS/c1-12-6-8-14(9-7-12)18-17-19-15(11-22-17)16(21)20-10-4-3-5-13(20)2/h6-9,11,13H,3-5,10H2,1-2H3,(H,18,19) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 6
(Homo sapiens (Human)) | BDBM50439230
(CHEMBL2418820)Show InChI InChI=1S/C17H21N3O2S/c1-12-7-9-20(10-8-12)16(21)15-11-23-17(19-15)18-13-3-5-14(22-2)6-4-13/h3-6,11-12H,7-10H2,1-2H3,(H,18,19) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 3
(Homo sapiens (Human)) | BDBM50439231
(CHEMBL2418819)Show InChI InChI=1S/C16H18ClN3OS/c1-11-6-8-20(9-7-11)15(21)14-10-22-16(19-14)18-13-4-2-12(17)3-5-13/h2-5,10-11H,6-9H2,1H3,(H,18,19) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 3
(Homo sapiens (Human)) | BDBM50439216
(CHEMBL2418812)Show SMILES C[C@@H]1CCCN([C@@H]1C)C(=O)c1nc(Nc2ccc(Cl)cc2F)sc1C |r| Show InChI InChI=1S/C18H21ClFN3OS/c1-10-5-4-8-23(11(10)2)17(24)16-12(3)25-18(22-16)21-15-7-6-13(19)9-14(15)20/h6-7,9-11H,4-5,8H2,1-3H3,(H,21,22)/t10-,11-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 6
(Homo sapiens (Human)) | BDBM50439212
(CHEMBL2418816)Show SMILES CC1N(CCc2ncccc12)C(=O)c1nc(Nc2ccc3OCOc3c2)sc1C Show InChI InChI=1S/C21H20N4O3S/c1-12-15-4-3-8-22-16(15)7-9-25(12)20(26)19-13(2)29-21(24-19)23-14-5-6-17-18(10-14)28-11-27-17/h3-6,8,10,12H,7,9,11H2,1-2H3,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50439221
(CHEMBL2418806)Show InChI InChI=1S/C18H23N3OS/c1-12-6-8-15(9-7-12)19-18-20-16(11-23-18)17(22)21-10-4-5-13(2)14(21)3/h6-9,11,13-14H,4-5,10H2,1-3H3,(H,19,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of TRPV1 (unknown origin) by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 3
(Homo sapiens (Human)) | BDBM43434
(3,4-dihydro-1H-isoquinolin-2-yl-[2-(4-methoxyanili...)Show InChI InChI=1S/C20H19N3O2S/c1-25-17-8-6-16(7-9-17)21-20-22-18(13-26-20)19(24)23-11-10-14-4-2-3-5-15(14)12-23/h2-9,13H,10-12H2,1H3,(H,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 6
(Homo sapiens (Human)) | BDBM50439223
(CHEMBL2418804)Show SMILES COc1ccc(Nc2nc(cs2)C(=O)N2CCC(CC2)c2ccccc2)cc1 Show InChI InChI=1S/C22H23N3O2S/c1-27-19-9-7-18(8-10-19)23-22-24-20(15-28-22)21(26)25-13-11-17(12-14-25)16-5-3-2-4-6-16/h2-10,15,17H,11-14H2,1H3,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 3
(Homo sapiens (Human)) | BDBM50439228
(CHEMBL2418822)Show InChI InChI=1S/C16H17ClFN3OS/c1-10-4-6-21(7-5-10)15(22)14-9-23-16(20-14)19-13-3-2-11(17)8-12(13)18/h2-3,8-10H,4-7H2,1H3,(H,19,20) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 6
(Homo sapiens (Human)) | BDBM50439216
(CHEMBL2418812)Show SMILES C[C@@H]1CCCN([C@@H]1C)C(=O)c1nc(Nc2ccc(Cl)cc2F)sc1C |r| Show InChI InChI=1S/C18H21ClFN3OS/c1-10-5-4-8-23(11(10)2)17(24)16-12(3)25-18(22-16)21-15-7-6-13(19)9-14(15)20/h6-7,9-11H,4-5,8H2,1-3H3,(H,21,22)/t10-,11-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 3
(Homo sapiens (Human)) | BDBM50439223
(CHEMBL2418804)Show SMILES COc1ccc(Nc2nc(cs2)C(=O)N2CCC(CC2)c2ccccc2)cc1 Show InChI InChI=1S/C22H23N3O2S/c1-27-19-9-7-18(8-10-19)23-22-24-20(15-28-22)21(26)25-13-11-17(12-14-25)16-5-3-2-4-6-16/h2-10,15,17H,11-14H2,1H3,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 6
(Homo sapiens (Human)) | BDBM50439229
(CHEMBL2418821)Show InChI InChI=1S/C16H18ClN3OS/c1-11-6-8-20(9-7-11)15(21)14-10-22-16(19-14)18-13-5-3-2-4-12(13)17/h2-5,10-11H,6-9H2,1H3,(H,18,19) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 6
(Homo sapiens (Human)) | BDBM50439222
(CHEMBL2418805)Show SMILES Cc1ccc(Nc2nc(cs2)C(=O)N2CCC(CC2)C2CCCCC2)cc1 Show InChI InChI=1S/C22H29N3OS/c1-16-7-9-19(10-8-16)23-22-24-20(15-27-22)21(26)25-13-11-18(12-14-25)17-5-3-2-4-6-17/h7-10,15,17-18H,2-6,11-14H2,1H3,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 6
(Homo sapiens (Human)) | BDBM50439211
(CHEMBL2418817)Show SMILES Cc1sc(Nc2ccc(Cl)cc2F)nc1C(=O)N1CCc2ncccc2C1 Show InChI InChI=1S/C19H16ClFN4OS/c1-11-17(18(26)25-8-6-15-12(10-25)3-2-7-22-15)24-19(27-11)23-16-5-4-13(20)9-14(16)21/h2-5,7,9H,6,8,10H2,1H3,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 3
(Homo sapiens (Human)) | BDBM50439222
(CHEMBL2418805)Show SMILES Cc1ccc(Nc2nc(cs2)C(=O)N2CCC(CC2)C2CCCCC2)cc1 Show InChI InChI=1S/C22H29N3OS/c1-16-7-9-19(10-8-16)23-22-24-20(15-27-22)21(26)25-13-11-18(12-14-25)17-5-3-2-4-6-17/h7-10,15,17-18H,2-6,11-14H2,1H3,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 3
(Homo sapiens (Human)) | BDBM50439229
(CHEMBL2418821)Show InChI InChI=1S/C16H18ClN3OS/c1-11-6-8-20(9-7-11)15(21)14-10-22-16(19-14)18-13-5-3-2-4-12(13)17/h2-5,10-11H,6-9H2,1H3,(H,18,19) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50439221
(CHEMBL2418806)Show InChI InChI=1S/C18H23N3OS/c1-12-6-8-15(9-7-12)19-18-20-16(11-23-18)17(22)21-10-4-5-13(2)14(21)3/h6-9,11,13-14H,4-5,10H2,1-3H3,(H,19,20) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of TRPV4 (unknown origin) by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50439217
(CHEMBL2418811)Show SMILES C[C@H]1CCCN([C@H]1C)C(=O)c1nc(Nc2ccc(Cl)cc2F)sc1C |r| Show InChI InChI=1S/C18H21ClFN3OS/c1-10-5-4-8-23(11(10)2)17(24)16-12(3)25-18(22-16)21-15-7-6-13(19)9-14(15)20/h6-7,9-11H,4-5,8H2,1-3H3,(H,21,22)/t10-,11-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of TRPV1 (unknown origin) by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily A member 1
(Homo sapiens (Human)) | BDBM50439221
(CHEMBL2418806)Show InChI InChI=1S/C18H23N3OS/c1-12-6-8-15(9-7-12)19-18-20-16(11-23-18)17(22)21-10-4-5-13(2)14(21)3/h6-9,11,13-14H,4-5,10H2,1-3H3,(H,19,20) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of TRPA1 (unknown origin) by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 3
(Homo sapiens (Human)) | BDBM50439212
(CHEMBL2418816)Show SMILES CC1N(CCc2ncccc12)C(=O)c1nc(Nc2ccc3OCOc3c2)sc1C Show InChI InChI=1S/C21H20N4O3S/c1-12-15-4-3-8-22-16(15)7-9-25(12)20(26)19-13(2)29-21(24-19)23-14-5-6-17-18(10-14)28-11-27-17/h3-6,8,10,12H,7,9,11H2,1-2H3,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 4
(Homo sapiens (Human)) | BDBM50439217
(CHEMBL2418811)Show SMILES C[C@H]1CCCN([C@H]1C)C(=O)c1nc(Nc2ccc(Cl)cc2F)sc1C |r| Show InChI InChI=1S/C18H21ClFN3OS/c1-10-5-4-8-23(11(10)2)17(24)16-12(3)25-18(22-16)21-15-7-6-13(19)9-14(15)20/h6-7,9-11H,4-5,8H2,1-3H3,(H,21,22)/t10-,11-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.25E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of TRPV4 (unknown origin) by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 3
(Homo sapiens (Human)) | BDBM50439225
(CHEMBL2418825)Show InChI InChI=1S/C22H23N3OS/c1-16-10-12-18(13-11-16)23-22-24-19(15-27-22)21(26)25-14-6-5-9-20(25)17-7-3-2-4-8-17/h2-4,7-8,10-13,15,20H,5-6,9,14H2,1H3,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.26E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 6
(Homo sapiens (Human)) | BDBM50439225
(CHEMBL2418825)Show InChI InChI=1S/C22H23N3OS/c1-16-10-12-18(13-11-16)23-22-24-19(15-27-22)21(26)25-14-6-5-9-20(25)17-7-3-2-4-8-17/h2-4,7-8,10-13,15,20H,5-6,9,14H2,1H3,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.58E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 3
(Homo sapiens (Human)) | BDBM50439211
(CHEMBL2418817)Show SMILES Cc1sc(Nc2ccc(Cl)cc2F)nc1C(=O)N1CCc2ncccc2C1 Show InChI InChI=1S/C19H16ClFN4OS/c1-11-17(18(26)25-8-6-15-12(10-25)3-2-7-22-15)24-19(27-11)23-16-5-4-13(20)9-14(16)21/h2-5,7,9H,6,8,10H2,1H3,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily A member 1
(Homo sapiens (Human)) | BDBM50439217
(CHEMBL2418811)Show SMILES C[C@H]1CCCN([C@H]1C)C(=O)c1nc(Nc2ccc(Cl)cc2F)sc1C |r| Show InChI InChI=1S/C18H21ClFN3OS/c1-10-5-4-8-23(11(10)2)17(24)16-12(3)25-18(22-16)21-15-7-6-13(19)9-14(15)20/h6-7,9-11H,4-5,8H2,1-3H3,(H,21,22)/t10-,11-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of TRPA1 (unknown origin) by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 3
(Homo sapiens (Human)) | BDBM50439224
(CHEMBL2417565)Show SMILES Cc1ccc(Nc2nc(cs2)C(=O)N2CCCC(C2)c2ccccc2)cc1 Show InChI InChI=1S/C22H23N3OS/c1-16-9-11-19(12-10-16)23-22-24-20(15-27-22)21(26)25-13-5-8-18(14-25)17-6-3-2-4-7-17/h2-4,6-7,9-12,15,18H,5,8,13-14H2,1H3,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Short transient receptor potential channel 6
(Homo sapiens (Human)) | BDBM50439224
(CHEMBL2417565)Show SMILES Cc1ccc(Nc2nc(cs2)C(=O)N2CCCC(C2)c2ccccc2)cc1 Show InChI InChI=1S/C22H23N3OS/c1-16-9-11-19(12-10-16)23-22-24-20(15-27-22)21(26)25-13-5-8-18(14-25)17-6-3-2-4-7-17/h2-4,6-7,9-12,15,18H,5,8,13-14H2,1H3,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant TRPC6 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay |
Bioorg Med Chem Lett 23: 4979-84 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.047
BindingDB Entry DOI: 10.7270/Q2319X9H |
More data for this
Ligand-Target Pair | |
Search and Browse
