Found 26 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50442784
(CHEMBL2440443)Show SMILES FC(F)(F)c1cccc2cc3c(nc(=O)[nH]c3=O)n(-c3cccc(Cl)c3)c12 Show InChI InChI=1S/C18H9ClF3N3O2/c19-10-4-2-5-11(8-10)25-14-9(3-1-6-13(14)18(20,21)22)7-12-15(25)23-17(27)24-16(12)26/h1-8H,(H,24,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged HDM2 (unknown origin) assessed as p53 ubiquitination by Western blot analysis |
Bioorg Med Chem 21: 6868-77 (2013)
Article DOI: 10.1016/j.bmc.2013.09.038 BindingDB Entry DOI: 10.7270/Q2KS6T01 |
More data for this Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50442780
(CHEMBL2443391)Show SMILES Cc1cccc(c1)-n1c2nc(=O)[nH]c(=O)c2cc2cccc(c12)C(F)(F)F Show InChI InChI=1S/C19H12F3N3O2/c1-10-4-2-6-12(8-10)25-15-11(5-3-7-14(15)19(20,21)22)9-13-16(25)23-18(27)24-17(13)26/h2-9H,1H3,(H,24,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged HDM2 (unknown origin) assessed as p53 ubiquitination by Western blot analysis |
Bioorg Med Chem 21: 6868-77 (2013)
Article DOI: 10.1016/j.bmc.2013.09.038 BindingDB Entry DOI: 10.7270/Q2KS6T01 |
More data for this Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50442783
(CHEMBL2440442)Show SMILES FC(F)(F)c1cccc2cc3c(nc(=O)[nH]c3=O)n(-c3ccc(Cl)c(Cl)c3)c12 Show InChI InChI=1S/C18H8Cl2F3N3O2/c19-12-5-4-9(7-13(12)20)26-14-8(2-1-3-11(14)18(21,22)23)6-10-15(26)24-17(28)25-16(10)27/h1-7H,(H,25,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.07E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged HDM2 (unknown origin) assessed as p53 ubiquitination by Western blot analysis |
Bioorg Med Chem 21: 6868-77 (2013)
Article DOI: 10.1016/j.bmc.2013.09.038 BindingDB Entry DOI: 10.7270/Q2KS6T01 |
More data for this Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50442785
(CHEMBL2440444)Show SMILES FC(F)(F)c1cccc2cc3c(nc(=O)[nH]c3=O)n(-c3ccc(Cl)cc3)c12 Show InChI InChI=1S/C18H9ClF3N3O2/c19-10-4-6-11(7-5-10)25-14-9(2-1-3-13(14)18(20,21)22)8-12-15(25)23-17(27)24-16(12)26/h1-8H,(H,24,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.19E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged HDM2 (unknown origin) assessed as p53 ubiquitination by Western blot analysis |
Bioorg Med Chem 21: 6868-77 (2013)
Article DOI: 10.1016/j.bmc.2013.09.038 BindingDB Entry DOI: 10.7270/Q2KS6T01 |
More data for this Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50442782
(CHEMBL2443392)Show SMILES Fc1cccc(c1)-n1c2nc(=O)[nH]c(=O)c2cc2cccc(c12)C(F)(F)F Show InChI InChI=1S/C18H9F4N3O2/c19-10-4-2-5-11(8-10)25-14-9(3-1-6-13(14)18(20,21)22)7-12-15(25)23-17(27)24-16(12)26/h1-8H,(H,24,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.23E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged HDM2 (unknown origin) assessed as p53 ubiquitination by Western blot analysis |
Bioorg Med Chem 21: 6868-77 (2013)
Article DOI: 10.1016/j.bmc.2013.09.038 BindingDB Entry DOI: 10.7270/Q2KS6T01 |
More data for this Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50442781
(CHEMBL223723)Show SMILES Fc1ccc(cc1)-n1c2nc(=O)[nH]c(=O)c2cc2cccc(c12)C(F)(F)F Show InChI InChI=1S/C18H9F4N3O2/c19-10-4-6-11(7-5-10)25-14-9(2-1-3-13(14)18(20,21)22)8-12-15(25)23-17(27)24-16(12)26/h1-8H,(H,24,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.31E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged HDM2 (unknown origin) assessed as p53 ubiquitination by Western blot analysis |
Bioorg Med Chem 21: 6868-77 (2013)
Article DOI: 10.1016/j.bmc.2013.09.038 BindingDB Entry DOI: 10.7270/Q2KS6T01 |
More data for this Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50442800
(CHEMBL2443387)Show SMILES Clc1ccc(cc1)-n1c2nc(=O)[nH]c(=O)c2cc2cccc(Cl)c12 Show InChI InChI=1S/C17H9Cl2N3O2/c18-10-4-6-11(7-5-10)22-14-9(2-1-3-13(14)19)8-12-15(22)20-17(24)21-16(12)23/h1-8H,(H,21,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged HDM2 (unknown origin) assessed as p53 ubiquitination by Western blot analysis |
Bioorg Med Chem 21: 6868-77 (2013)
Article DOI: 10.1016/j.bmc.2013.09.038 BindingDB Entry DOI: 10.7270/Q2KS6T01 |
More data for this Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50442791
(CHEMBL2440448)Show SMILES FC(F)(F)c1cccc2cc3c(nc(=O)[nH]c3=O)n(-c3ccccc3)c12 Show InChI InChI=1S/C18H10F3N3O2/c19-18(20,21)13-8-4-5-10-9-12-15(22-17(26)23-16(12)25)24(14(10)13)11-6-2-1-3-7-11/h1-9H,(H,23,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.75E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged HDM2 (unknown origin) assessed as p53 ubiquitination by Western blot analysis |
Bioorg Med Chem 21: 6868-77 (2013)
Article DOI: 10.1016/j.bmc.2013.09.038 BindingDB Entry DOI: 10.7270/Q2KS6T01 |
More data for this Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50442789
(CHEMBL225454)Show SMILES Fc1ccccc1-n1c2nc(=O)[nH]c(=O)c2cc2cccc(c12)C(F)(F)F |(-4.2,-.87,;-2.87,-1.65,;-2.87,-3.19,;-1.54,-3.96,;-.2,-3.18,;-.2,-1.65,;-1.53,-.89,;-1.53,.65,;-2.85,1.42,;-4.19,.65,;-5.51,1.42,;-6.85,.64,;-5.51,2.96,;-4.19,3.73,;-4.19,5.27,;-2.86,2.96,;-1.53,3.73,;-.2,2.96,;1.13,3.74,;2.47,2.96,;2.47,1.42,;1.14,.65,;-.19,1.42,;1.12,-.89,;1.11,-2.43,;-.42,-.88,;2.66,-.89,)| Show InChI InChI=1S/C18H9F4N3O2/c19-12-6-1-2-7-13(12)25-14-9(4-3-5-11(14)18(20,21)22)8-10-15(25)23-17(27)24-16(10)26/h1-8H,(H,24,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.96E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged HDM2 (unknown origin) assessed as p53 ubiquitination by Western blot analysis |
Bioorg Med Chem 21: 6868-77 (2013)
Article DOI: 10.1016/j.bmc.2013.09.038 BindingDB Entry DOI: 10.7270/Q2KS6T01 |
More data for this Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50442779
(CHEMBL2443390)Show SMILES Cc1ccc(cc1)-n1c2nc(=O)[nH]c(=O)c2cc2cccc(c12)C(F)(F)F Show InChI InChI=1S/C19H12F3N3O2/c1-10-5-7-12(8-6-10)25-15-11(3-2-4-14(15)19(20,21)22)9-13-16(25)23-18(27)24-17(13)26/h2-9H,1H3,(H,24,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged HDM2 (unknown origin) assessed as p53 ubiquitination by Western blot analysis |
Bioorg Med Chem 21: 6868-77 (2013)
Article DOI: 10.1016/j.bmc.2013.09.038 BindingDB Entry DOI: 10.7270/Q2KS6T01 |
More data for this Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50442795
(CHEMBL2443382)Show SMILES Clc1ccc(cc1)-n1c2nc(=O)[nH]c(=O)c2cc2cccc(Br)c12 Show InChI InChI=1S/C17H9BrClN3O2/c18-13-3-1-2-9-8-12-15(20-17(24)21-16(12)23)22(14(9)13)11-6-4-10(19)5-7-11/h1-8H,(H,21,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.95E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged HDM2 (unknown origin) assessed as p53 ubiquitination by Western blot analysis |
Bioorg Med Chem 21: 6868-77 (2013)
Article DOI: 10.1016/j.bmc.2013.09.038 BindingDB Entry DOI: 10.7270/Q2KS6T01 |
More data for this Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50442792
(CHEMBL2440449)Show SMILES [O-][N+](=O)c1cccc2cc3c(nc(=O)[nH]c3=O)n(-c3ccc(Cl)cc3)c12 Show InChI InChI=1S/C17H9ClN4O4/c18-10-4-6-11(7-5-10)21-14-9(2-1-3-13(14)22(25)26)8-12-15(21)19-17(24)20-16(12)23/h1-8H,(H,20,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged HDM2 (unknown origin) assessed as p53 ubiquitination by Western blot analysis |
Bioorg Med Chem 21: 6868-77 (2013)
Article DOI: 10.1016/j.bmc.2013.09.038 BindingDB Entry DOI: 10.7270/Q2KS6T01 |
More data for this Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50442793
(CHEMBL239274)Show SMILES [O-][N+](=O)c1ccc2n(-c3ccc(Cl)cc3)c3nc(=O)[nH]c(=O)c3cc2c1 Show InChI InChI=1S/C17H9ClN4O4/c18-10-1-3-11(4-2-10)21-14-6-5-12(22(25)26)7-9(14)8-13-15(21)19-17(24)20-16(13)23/h1-8H,(H,20,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >7.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged HDM2 (unknown origin) assessed as p53 ubiquitination by Western blot analysis |
Bioorg Med Chem 21: 6868-77 (2013)
Article DOI: 10.1016/j.bmc.2013.09.038 BindingDB Entry DOI: 10.7270/Q2KS6T01 |
More data for this Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50442797
(CHEMBL2443384)Show SMILES Cc1ccc2cc3c(nc(=O)[nH]c3=O)n(-c3ccc(Cl)cc3)c2c1 Show InChI InChI=1S/C18H12ClN3O2/c1-10-2-3-11-9-14-16(20-18(24)21-17(14)23)22(15(11)8-10)13-6-4-12(19)5-7-13/h2-9H,1H3,(H,21,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged HDM2 (unknown origin) assessed as p53 ubiquitination by Western blot analysis |
Bioorg Med Chem 21: 6868-77 (2013)
Article DOI: 10.1016/j.bmc.2013.09.038 BindingDB Entry DOI: 10.7270/Q2KS6T01 |
More data for this Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50442790
(CHEMBL2440447)Show SMILES Fc1ccccc1-n1c2cc(ccc2cc2c1nc(=O)[nH]c2=O)C(F)(F)F |(61.91,-22.27,;63.24,-23.04,;63.24,-24.58,;64.58,-25.34,;65.92,-24.56,;65.91,-23.03,;64.58,-22.27,;64.57,-20.73,;65.91,-19.95,;67.24,-20.72,;68.58,-19.95,;68.57,-18.4,;67.23,-17.64,;65.9,-18.41,;64.57,-17.65,;63.24,-18.41,;63.24,-19.96,;61.9,-20.73,;60.57,-19.97,;59.23,-20.74,;60.56,-18.41,;61.9,-17.64,;61.91,-16.1,;69.91,-20.71,;69.92,-22.25,;71.24,-19.94,;71.24,-21.47,)| Show InChI InChI=1S/C18H9F4N3O2/c19-12-3-1-2-4-13(12)25-14-8-10(18(20,21)22)6-5-9(14)7-11-15(25)23-17(27)24-16(11)26/h1-8H,(H,24,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged HDM2 (unknown origin) assessed as p53 ubiquitination by Western blot analysis |
Bioorg Med Chem 21: 6868-77 (2013)
Article DOI: 10.1016/j.bmc.2013.09.038 BindingDB Entry DOI: 10.7270/Q2KS6T01 |
More data for this Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50442798
(CHEMBL2443385)Show SMILES Fc1cccc(c1)-n1c2nc(=O)[nH]c(=O)c2cc2cccc(Cl)c12 Show InChI InChI=1S/C17H9ClFN3O2/c18-13-6-1-3-9-7-12-15(20-17(24)21-16(12)23)22(14(9)13)11-5-2-4-10(19)8-11/h1-8H,(H,21,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged HDM2 (unknown origin) assessed as p53 ubiquitination by Western blot analysis |
Bioorg Med Chem 21: 6868-77 (2013)
Article DOI: 10.1016/j.bmc.2013.09.038 BindingDB Entry DOI: 10.7270/Q2KS6T01 |
More data for this Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50442796
(CHEMBL2443383)Show SMILES Brc1cccc2cc3c(nc(=O)[nH]c3=O)n(-c3ccccc3)c12 Show InChI InChI=1S/C17H10BrN3O2/c18-13-8-4-5-10-9-12-15(19-17(23)20-16(12)22)21(14(10)13)11-6-2-1-3-7-11/h1-9H,(H,20,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged HDM2 (unknown origin) assessed as p53 ubiquitination by Western blot analysis |
Bioorg Med Chem 21: 6868-77 (2013)
Article DOI: 10.1016/j.bmc.2013.09.038 BindingDB Entry DOI: 10.7270/Q2KS6T01 |
More data for this Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50442794
(CHEMBL2440450)Show SMILES [O-][N+](=O)c1cccc2cc3c(nc(=O)[nH]c3=O)n(-c3ccccc3F)c12 |(4.4,-8.56,;5.84,-9.08,;7.03,-8.09,;6.11,-10.6,;4.78,-11.37,;4.78,-12.91,;6.11,-13.68,;7.44,-12.91,;8.78,-13.68,;10.11,-12.91,;10.11,-11.37,;11.44,-10.6,;12.78,-11.37,;14.11,-10.6,;12.78,-12.91,;11.44,-13.68,;11.44,-15.22,;8.78,-10.6,;8.83,-8.6,;7.52,-7.79,;7.56,-6.25,;8.92,-5.52,;10.23,-6.33,;10.18,-7.86,;11.5,-8.67,;7.44,-11.37,)| Show InChI InChI=1S/C17H9FN4O4/c18-11-5-1-2-6-12(11)21-14-9(4-3-7-13(14)22(25)26)8-10-15(21)19-17(24)20-16(10)23/h1-8H,(H,20,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged HDM2 (unknown origin) assessed as p53 ubiquitination by Western blot analysis |
Bioorg Med Chem 21: 6868-77 (2013)
Article DOI: 10.1016/j.bmc.2013.09.038 BindingDB Entry DOI: 10.7270/Q2KS6T01 |
More data for this Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50442788
(CHEMBL2440446)Show SMILES FC(F)(F)c1cccc2n(-c3ccc(Cl)cc3)c3nc(=O)[nH]c(=O)c3cc12 Show InChI InChI=1S/C18H9ClF3N3O2/c19-9-4-6-10(7-5-9)25-14-3-1-2-13(18(20,21)22)11(14)8-12-15(25)23-17(27)24-16(12)26/h1-8H,(H,24,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged HDM2 (unknown origin) assessed as p53 ubiquitination by Western blot analysis |
Bioorg Med Chem 21: 6868-77 (2013)
Article DOI: 10.1016/j.bmc.2013.09.038 BindingDB Entry DOI: 10.7270/Q2KS6T01 |
More data for this Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50442778
(CHEMBL2443389)Show SMILES FC(F)(F)c1cccc2cc3c(nc(=O)[nH]c3=O)n(Cc3ccccc3)c12 Show InChI InChI=1S/C19H12F3N3O2/c20-19(21,22)14-8-4-7-12-9-13-16(23-18(27)24-17(13)26)25(15(12)14)10-11-5-2-1-3-6-11/h1-9H,10H2,(H,24,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged HDM2 (unknown origin) assessed as p53 ubiquitination by Western blot analysis |
Bioorg Med Chem 21: 6868-77 (2013)
Article DOI: 10.1016/j.bmc.2013.09.038 BindingDB Entry DOI: 10.7270/Q2KS6T01 |
More data for this Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50438877
(CHEMBL2420495)Show SMILES Clc1cccc2cc3c(nc(=O)[nH]c3=O)n(-c3ccccc3)c12 Show InChI InChI=1S/C17H10ClN3O2/c18-13-8-4-5-10-9-12-15(19-17(23)20-16(12)22)21(14(10)13)11-6-2-1-3-7-11/h1-9H,(H,20,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged HDM2 (unknown origin) assessed as p53 ubiquitination by Western blot analysis |
Bioorg Med Chem 21: 6868-77 (2013)
Article DOI: 10.1016/j.bmc.2013.09.038 BindingDB Entry DOI: 10.7270/Q2KS6T01 |
More data for this Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50442802
(CHEMBL2443388)Show SMILES Fc1ccccc1-n1c2ccc(Cl)cc2cc2c1nc(=O)[nH]c2=O |(27.54,-55.69,;28.87,-56.46,;28.87,-58,;30.21,-58.77,;31.55,-57.99,;31.54,-56.46,;30.2,-55.69,;30.2,-54.15,;31.53,-53.38,;32.87,-54.14,;34.2,-53.37,;34.2,-51.82,;35.52,-51.04,;32.86,-51.06,;31.53,-51.83,;30.2,-51.07,;28.87,-51.84,;28.87,-53.38,;27.53,-54.15,;26.19,-53.39,;24.86,-54.16,;26.19,-51.83,;27.53,-51.06,;27.54,-49.52,)| Show InChI InChI=1S/C17H9ClFN3O2/c18-10-5-6-13-9(7-10)8-11-15(20-17(24)21-16(11)23)22(13)14-4-2-1-3-12(14)19/h1-8H,(H,21,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged HDM2 (unknown origin) assessed as p53 ubiquitination by Western blot analysis |
Bioorg Med Chem 21: 6868-77 (2013)
Article DOI: 10.1016/j.bmc.2013.09.038 BindingDB Entry DOI: 10.7270/Q2KS6T01 |
More data for this Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50442801
(CHEMBL224408)Show SMILES Clc1ccc(cc1)-n1c2cccc(Cl)c2cc2c1nc(=O)[nH]c2=O Show InChI InChI=1S/C17H9Cl2N3O2/c18-9-4-6-10(7-5-9)22-14-3-1-2-13(19)11(14)8-12-15(22)20-17(24)21-16(12)23/h1-8H,(H,21,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged HDM2 (unknown origin) assessed as p53 ubiquitination by Western blot analysis |
Bioorg Med Chem 21: 6868-77 (2013)
Article DOI: 10.1016/j.bmc.2013.09.038 BindingDB Entry DOI: 10.7270/Q2KS6T01 |
More data for this Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50442799
(CHEMBL2443386)Show SMILES Clc1cccc(c1)-n1c2nc(=O)[nH]c(=O)c2cc2cccc(Cl)c12 Show InChI InChI=1S/C17H9Cl2N3O2/c18-10-4-2-5-11(8-10)22-14-9(3-1-6-13(14)19)7-12-15(22)20-17(24)21-16(12)23/h1-8H,(H,21,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged HDM2 (unknown origin) assessed as p53 ubiquitination by Western blot analysis |
Bioorg Med Chem 21: 6868-77 (2013)
Article DOI: 10.1016/j.bmc.2013.09.038 BindingDB Entry DOI: 10.7270/Q2KS6T01 |
More data for this Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50442786
(CHEMBL2440445)Show SMILES FC(F)(F)c1ccc2cc3c(nc(=O)[nH]c3=O)n(-c3ccc(Cl)cc3)c2c1 Show InChI InChI=1S/C18H9ClF3N3O2/c19-11-3-5-12(6-4-11)25-14-8-10(18(20,21)22)2-1-9(14)7-13-15(25)23-17(27)24-16(13)26/h1-8H,(H,24,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged HDM2 (unknown origin) assessed as p53 ubiquitination by Western blot analysis |
Bioorg Med Chem 21: 6868-77 (2013)
Article DOI: 10.1016/j.bmc.2013.09.038 BindingDB Entry DOI: 10.7270/Q2KS6T01 |
More data for this Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50442787
(CHEMBL390761)Show SMILES FC(F)(F)c1ccc2n(-c3ccc(Cl)cc3)c3nc(=O)[nH]c(=O)c3cc2c1 Show InChI InChI=1S/C18H9ClF3N3O2/c19-11-2-4-12(5-3-11)25-14-6-1-10(18(20,21)22)7-9(14)8-13-15(25)23-17(27)24-16(13)26/h1-8H,(H,24,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nottingham
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged HDM2 (unknown origin) assessed as p53 ubiquitination by Western blot analysis |
Bioorg Med Chem 21: 6868-77 (2013)
Article DOI: 10.1016/j.bmc.2013.09.038 BindingDB Entry DOI: 10.7270/Q2KS6T01 |
More data for this Ligand-Target Pair | |