Found 35 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058752
(CHEMBL3335630)Show SMILES COCCOCc1ccc(CN2CCN(Cc3ccc(cc3)C(=O)Nc3ccc(cc3)C#CC34CC5CC(CC(C5)C3)C4)[C@@H](C)C2)cn1 |r,THB:32:33:36:40.38.39,38:37:34:40.39.41,38:39:36.37.42:34,41:39:36:42.33.34,41:33:36:40.38.39| Show InChI InChI=1S/C41H50N4O3/c1-30-26-44(27-33-7-12-39(42-25-33)29-48-18-17-47-2)15-16-45(30)28-32-3-8-37(9-4-32)40(46)43-38-10-5-31(6-11-38)13-14-41-22-34-19-35(23-41)21-36(20-34)24-41/h3-12,25,30,34-36H,15-24,26-29H2,1-2H3,(H,43,46)/t30-,34?,35?,36?,41?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.470 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058757
(CHEMBL3335423)Show SMILES O=C(Nc1ccc(cc1)C#CC12CC3CC(CC(C3)C1)C2)c1ccc(CN2CCN(Cc3cccnc3)CC2)cc1 |THB:10:11:14:18.16.17,16:15:12:18.17.19,16:17:14.15.20:12,19:17:14:20.11.12,19:11:14:18.16.17| Show InChI InChI=1S/C36H40N4O/c41-35(33-7-3-28(4-8-33)25-39-14-16-40(17-15-39)26-29-2-1-13-37-24-29)38-34-9-5-27(6-10-34)11-12-36-21-30-18-31(22-36)20-32(19-30)23-36/h1-10,13,24,30-32H,14-23,25-26H2,(H,38,41) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.970 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058753
(CHEMBL3335427)Show SMILES COCc1ccc(CN2CCN(Cc3ccc(cc3)C(=O)Nc3ccc(cc3)C#CC34CC5CC(CC(C5)C3)C4)[C@@H](C)C2)cn1 |r,THB:29:30:33:37.35.36,35:34:31:37.36.38,35:36:33.34.39:31,38:36:33:39.30.31,38:30:33:37.35.36| Show InChI InChI=1S/C39H46N4O2/c1-28-24-42(25-31-7-12-37(27-45-2)40-23-31)15-16-43(28)26-30-3-8-35(9-4-30)38(44)41-36-10-5-29(6-11-36)13-14-39-20-32-17-33(21-39)19-34(18-32)22-39/h3-12,23,28,32-34H,15-22,24-27H2,1-2H3,(H,41,44)/t28-,32?,33?,34?,39?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058754
(CHEMBL3335426)Show SMILES C[C@H]1CN(Cc2cccnc2)CCN1Cc1ccc(cc1)C(=O)Nc1ccc(cc1)C#CC12CC3CC(CC(C3)C1)C2 |r,THB:31:32:35:39.37.38,37:36:33:39.38.40,37:38:35.36.41:33,40:38:35:41.32.33,40:32:35:39.37.38| Show InChI InChI=1S/C37H42N4O/c1-27-24-40(25-30-3-2-14-38-23-30)15-16-41(27)26-29-4-8-34(9-5-29)36(42)39-35-10-6-28(7-11-35)12-13-37-20-31-17-32(21-37)19-33(18-31)22-37/h2-11,14,23,27,31-33H,15-22,24-26H2,1H3,(H,39,42)/t27-,31?,32?,33?,37?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058760
(CHEMBL3335421)Show SMILES O=C(Nc1ccc(cc1)C#CC1CCCCC1)c1ccc(CN2CCN(Cc3cccnc3)CC2)cc1 Show InChI InChI=1S/C32H36N4O/c37-32(34-31-16-12-27(13-17-31)9-8-26-5-2-1-3-6-26)30-14-10-28(11-15-30)24-35-19-21-36(22-20-35)25-29-7-4-18-33-23-29/h4,7,10-18,23,26H,1-3,5-6,19-22,24-25H2,(H,34,37) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058766
(CHEMBL3335415)Show SMILES C[C@H]1CN(Cc2cccnc2)CCN1Cc1ccc(cc1)C(=O)Nc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C26H27F3N4O/c1-19-16-32(17-21-3-2-12-30-15-21)13-14-33(19)18-20-4-6-22(7-5-20)25(34)31-24-10-8-23(9-11-24)26(27,28)29/h2-12,15,19H,13-14,16-18H2,1H3,(H,31,34)/t19-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058755
(CHEMBL3335425)Show SMILES Nc1ncccc1C(=O)N1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(cc2)C#CC23CC4CC(CC(C4)C2)C3)CC1 |THB:30:31:34:38.36.37,36:35:32:38.37.39,36:37:34.35.40:32,39:37:34:40.31.32,39:31:34:38.36.37| Show InChI InChI=1S/C36H39N5O2/c37-33-32(2-1-13-38-33)35(43)41-16-14-40(15-17-41)24-26-3-7-30(8-4-26)34(42)39-31-9-5-25(6-10-31)11-12-36-21-27-18-28(22-36)20-29(19-27)23-36/h1-10,13,27-29H,14-24H2,(H2,37,38)(H,39,42) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058770
(CHEMBL3335411)Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(CN3CCN(Cc4ccncc4)CC3)cc2)cc1 Show InChI InChI=1S/C25H25F3N4O/c26-25(27,28)22-5-7-23(8-6-22)30-24(33)21-3-1-19(2-4-21)17-31-13-15-32(16-14-31)18-20-9-11-29-12-10-20/h1-12H,13-18H2,(H,30,33) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058762
(CHEMBL3335419)Show SMILES O=C(Nc1ccc(cc1)C#Cc1ccccc1)c1ccc(CN2CCN(Cc3cccnc3)CC2)cc1 Show InChI InChI=1S/C32H30N4O/c37-32(34-31-16-12-27(13-17-31)9-8-26-5-2-1-3-6-26)30-14-10-28(11-15-30)24-35-19-21-36(22-20-35)25-29-7-4-18-33-23-29/h1-7,10-18,23H,19-22,24-25H2,(H,34,37) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058765
(CHEMBL3335416)Show SMILES C[C@@H]1CN(Cc2cccnc2)CCN1Cc1ccc(cc1)C(=O)Nc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C26H27F3N4O/c1-19-16-32(17-21-3-2-12-30-15-21)13-14-33(19)18-20-4-6-22(7-5-20)25(34)31-24-10-8-23(9-11-24)26(27,28)29/h2-12,15,19H,13-14,16-18H2,1H3,(H,31,34)/t19-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058771
(CHEMBL3335410)Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(CN3CCN(Cc4ccccc4)CC3)cc2)cc1 Show InChI InChI=1S/C26H26F3N3O/c27-26(28,29)23-10-12-24(13-11-23)30-25(33)22-8-6-21(7-9-22)19-32-16-14-31(15-17-32)18-20-4-2-1-3-5-20/h1-13H,14-19H2,(H,30,33) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058768
(CHEMBL3335413)Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(CN3CCN(Cc4cccnc4)CC3)cc2)cc1 Show InChI InChI=1S/C25H25F3N4O/c26-25(27,28)22-7-9-23(10-8-22)30-24(33)21-5-3-19(4-6-21)17-31-12-14-32(15-13-31)18-20-2-1-11-29-16-20/h1-11,16H,12-15,17-18H2,(H,30,33) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058756
(CHEMBL3335424)Show SMILES Nc1ncccc1C(=O)N1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(cc2)C#Cc2ccccc2)CC1 Show InChI InChI=1S/C32H29N5O2/c33-30-29(7-4-18-34-30)32(39)37-21-19-36(20-22-37)23-26-10-14-27(15-11-26)31(38)35-28-16-12-25(13-17-28)9-8-24-5-2-1-3-6-24/h1-7,10-18H,19-23H2,(H2,33,34)(H,35,38) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058764
(CHEMBL3335417)Show SMILES C[C@@H]1CN(Cc2ccc(cc2)C(=O)Nc2ccc(cc2)C(F)(F)F)CCN1Cc1cccnc1 |r| Show InChI InChI=1S/C26H27F3N4O/c1-19-16-32(13-14-33(19)18-21-3-2-12-30-15-21)17-20-4-6-22(7-5-20)25(34)31-24-10-8-23(9-11-24)26(27,28)29/h2-12,15,19H,13-14,16-18H2,1H3,(H,31,34)/t19-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058761
(CHEMBL3335420)Show SMILES O=C(Nc1ccc(cc1)C#Cc1cccnc1)c1ccc(CN2CCN(Cc3cccnc3)CC2)cc1 Show InChI InChI=1S/C31H29N5O/c37-31(34-30-13-9-25(10-14-30)5-6-26-3-1-15-32-21-26)29-11-7-27(8-12-29)23-35-17-19-36(20-18-35)24-28-4-2-16-33-22-28/h1-4,7-16,21-22H,17-20,23-24H2,(H,34,37) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058763
(CHEMBL3335418)Show SMILES C[C@H]1CN(Cc2ccc(cc2)C(=O)Nc2ccc(cc2)C(F)(F)F)CCN1Cc1cccnc1 |r| Show InChI InChI=1S/C26H27F3N4O/c1-19-16-32(13-14-33(19)18-21-3-2-12-30-15-21)17-20-4-6-22(7-5-20)25(34)31-24-10-8-23(9-11-24)26(27,28)29/h2-12,15,19H,13-14,16-18H2,1H3,(H,31,34)/t19-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058769
(CHEMBL3335412)Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(CC3CCN(Cc4ccncc4)CC3)cc2)cc1 Show InChI InChI=1S/C26H26F3N3O/c27-26(28,29)23-5-7-24(8-6-23)31-25(33)22-3-1-19(2-4-22)17-20-11-15-32(16-12-20)18-21-9-13-30-14-10-21/h1-10,13-14,20H,11-12,15-18H2,(H,31,33) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058767
(CHEMBL3335414)Show SMILES CN(CCN(C)Cc1cccnc1)Cc1ccc(cc1)C(=O)Nc1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C25H27F3N4O/c1-31(14-15-32(2)18-20-4-3-13-29-16-20)17-19-5-7-21(8-6-19)24(33)30-23-11-9-22(10-12-23)25(26,27)28/h3-13,16H,14-15,17-18H2,1-2H3,(H,30,33) | PDB
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UniChem
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| Article
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| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058758
(CHEMBL3335422)Show SMILES OC1(CCCCC1)C#Cc1ccc(NC(=O)c2ccc(CN3CCN(Cc4cccnc4)CC3)cc2)cc1 Show InChI InChI=1S/C32H36N4O2/c37-31(34-30-12-8-26(9-13-30)14-17-32(38)15-2-1-3-16-32)29-10-6-27(7-11-29)24-35-19-21-36(22-20-35)25-28-5-4-18-33-23-28/h4-13,18,23,38H,1-3,15-16,19-22,24-25H2,(H,34,37) | PDB
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| n/a | n/a | >200 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058778
(CHEMBL3335403)Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(CN3CCOCC3)cn2)cc1 Show InChI InChI=1S/C18H18F3N3O2/c19-18(20,21)14-2-4-15(5-3-14)23-17(25)16-6-1-13(11-22-16)12-24-7-9-26-10-8-24/h1-6,11H,7-10,12H2,(H,23,25) | PDB
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| Article
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| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058783
(CHEMBL3335135)Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(CN3CCOCC3)cc2)cc1 Show InChI InChI=1S/C19H19F3N2O2/c20-19(21,22)16-5-7-17(8-6-16)23-18(25)15-3-1-14(2-4-15)13-24-9-11-26-12-10-24/h1-8H,9-13H2,(H,23,25) | PDB
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| n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058784
(CHEMBL3335134)Show InChI InChI=1S/C18H19IN2O2/c19-16-5-7-17(8-6-16)20-18(22)15-3-1-14(2-4-15)13-21-9-11-23-12-10-21/h1-8H,9-13H2,(H,20,22) | PDB
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| n/a | n/a | 560 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058775
(CHEMBL3335406)Show InChI InChI=1S/C20H20F3NO/c21-20(22,23)19-9-7-17(8-10-19)2-1-16-3-5-18(6-4-16)15-24-11-13-25-14-12-24/h1-10H,11-15H2/b2-1+ | PDB
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| n/a | n/a | 880 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058776
(CHEMBL3335405)Show InChI InChI=1S/C17H17F3N2O2S/c18-17(19,20)12-1-3-13(4-2-12)21-16(23)15-6-5-14(25-15)11-22-7-9-24-10-8-22/h1-6H,7-11H2,(H,21,23) | PDB
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PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058773
(CHEMBL3335408)Show InChI InChI=1S/C19H21IN2O2.ClH/c1-21(18-8-6-17(20)7-9-18)19(23)16-4-2-15(3-5-16)14-22-10-12-24-13-11-22;/h2-9H,10-14H2,1H3;1H | PDB
UniProtKB/SwissProt
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058785
(CHEMBL3335136)Show InChI InChI=1S/C18H19IN2O2/c19-16-2-1-3-17(12-16)20-18(22)15-6-4-14(5-7-15)13-21-8-10-23-11-9-21/h1-7,12H,8-11,13H2,(H,20,22) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058774
(CHEMBL3335407)Show InChI InChI=1S/C18H21IN2O/c19-17-5-7-18(8-6-17)20-13-15-1-3-16(4-2-15)14-21-9-11-22-12-10-21/h1-8,20H,9-14H2 | PDB
UniProtKB/SwissProt
antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058772
(CHEMBL3335409)Show InChI InChI=1S/C18H19IN2O2/c19-16-5-3-15(4-6-16)18(22)20-17-7-1-14(2-8-17)13-21-9-11-23-12-10-21/h1-8H,9-13H2,(H,20,22) | PDB
UniProtKB/SwissProt
antibodypedia
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PC cid
PC sid
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| Article
PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058781
(CHEMBL3335139)Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(CN3CCOCC3)cc2)nc1 Show InChI InChI=1S/C18H18F3N3O2/c19-18(20,21)15-5-6-16(22-11-15)23-17(25)14-3-1-13(2-4-14)12-24-7-9-26-10-8-24/h1-6,11H,7-10,12H2,(H,22,23,25) | PDB
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| CHEMBL
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PC sid
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| Article
PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058777
(CHEMBL3335404)Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(CN3CCOCC3)nc2)cc1 Show InChI InChI=1S/C18H18F3N3O2/c19-18(20,21)14-2-5-15(6-3-14)23-17(25)13-1-4-16(22-11-13)12-24-7-9-26-10-8-24/h1-6,11H,7-10,12H2,(H,23,25) | PDB
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UniChem
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| Article
PubMed
| n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058787
(CHEMBL3335137)Show InChI InChI=1S/C18H20N2O2/c21-18(19-17-4-2-1-3-5-17)16-8-6-15(7-9-16)14-20-10-12-22-13-11-20/h1-9H,10-14H2,(H,19,21) | PDB
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PubMed
| n/a | n/a | 5.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058780
(CHEMBL3335401)Show SMILES FC(F)(F)c1ccc(NC(=O)c2cccc(CN3CCOCC3)c2)cc1 Show InChI InChI=1S/C19H19F3N2O2/c20-19(21,22)16-4-6-17(7-5-16)23-18(25)15-3-1-2-14(12-15)13-24-8-10-26-11-9-24/h1-7,12H,8-11,13H2,(H,23,25) | PDB
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| CHEMBL
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UniChem
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PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058779
(CHEMBL3335402)Show InChI InChI=1S/C19H19F3N2O2/c20-19(21,22)15-5-7-16(8-6-15)23-18(25)17-4-2-1-3-14(17)13-24-9-11-26-12-10-24/h1-8H,9-13H2,(H,23,25) | PDB
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PC sid
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058782
(CHEMBL3335133)Show InChI InChI=1S/C19H22N2O3/c1-23-18-8-6-17(7-9-18)20-19(22)16-4-2-15(3-5-16)14-21-10-12-24-13-11-21/h2-9H,10-14H2,1H3,(H,20,22) | PDB
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| n/a | n/a | 1.39E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058786
(CHEMBL3335138)Show InChI InChI=1S/C18H19IN2O2/c19-16-3-1-2-4-17(16)20-18(22)15-7-5-14(6-8-15)13-21-9-11-23-12-10-21/h1-8H,9-13H2,(H,20,22) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
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PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
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