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PubMed code 2539480

Compile data set for download or QSAR
Found 50 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Beta-1/Beta-2/Beta-3 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM25761
PNG
(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)
Show SMILES CC(C)NCC(O)COc1cccc2ccccc12
Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3
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 2.40n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against beta adrenergic receptor of rat frontal cortex homogenate using (1.0 nM) [3H]- dihydroalprenolol

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50246936
PNG
((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)
Show SMILES CC(C)NC[C@H](O)COc1cccc2ccccc12 |r|
Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3/t14-/m0/s1
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 17n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat striatal membrane homogenate using [3H]5-HT as the radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016913
PNG
(Butyl-ethyl-[2-(naphthalen-1-yloxy)-ethyl]-amine |...)
Show SMILES CCCCN(CC)CCOc1cccc2ccccc12
Show InChI InChI=1S/C18H25NO/c1-3-5-13-19(4-2)14-15-20-18-12-8-10-16-9-6-7-11-17(16)18/h6-12H,3-5,13-15H2,1-2H3
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 39n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016909
PNG
(CHEMBL140417 | Methyl-[2-(naphthalen-1-yloxy)-ethy...)
Show SMILES CCCN(C)CCOc1cccc2ccccc12
Show InChI InChI=1S/C16H21NO/c1-3-11-17(2)12-13-18-16-10-6-8-14-7-4-5-9-15(14)16/h4-10H,3,11-13H2,1-2H3
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 45n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM25761
PNG
(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)
Show SMILES CC(C)NCC(O)COc1cccc2ccccc12
Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3
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 50n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat striatal membrane homogenate using [3H]5-HT as the radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50246936
PNG
((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)
Show SMILES CC(C)NC[C@H](O)COc1cccc2ccccc12 |r|
Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3/t14-/m0/s1
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 55n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016927
PNG
(2-(Naphthalen-1-yloxy)-ethylamine | CHEMBL337539)
Show SMILES NCCOc1cccc2ccccc12
Show InChI InChI=1S/C12H13NO/c13-8-9-14-12-7-3-5-10-4-1-2-6-11(10)12/h1-7H,8-9,13H2
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 60n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016918
PNG
(CHEMBL139103 | Dimethyl-[2-(naphthalen-1-yloxy)-et...)
Show SMILES CN(C)CCOc1cccc2ccccc12
Show InChI InChI=1S/C14H17NO/c1-15(2)10-11-16-14-9-5-7-12-6-3-4-8-13(12)14/h3-9H,10-11H2,1-2H3
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 80n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM25761
PNG
(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)
Show SMILES CC(C)NCC(O)COc1cccc2ccccc12
Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3
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 90n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016911
PNG
(Benzyl-methyl-[2-(naphthalen-1-yloxy)-ethyl]-amine...)
Show SMILES CN(CCOc1cccc2ccccc12)Cc1ccccc1
Show InChI InChI=1S/C20H21NO/c1-21(16-17-8-3-2-4-9-17)14-15-22-20-13-7-11-18-10-5-6-12-19(18)20/h2-13H,14-16H2,1H3
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 95n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016915
PNG
(CHEMBL334465 | Dibutyl-[2-(naphthalen-1-yloxy)-eth...)
Show SMILES CCCCN(CCCC)CCOc1cccc2ccccc12
Show InChI InChI=1S/C20H29NO/c1-3-5-14-21(15-6-4-2)16-17-22-20-13-9-11-18-10-7-8-12-19(18)20/h7-13H,3-6,14-17H2,1-2H3
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 150n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016917
PNG
(CHEMBL169956 | Dibutyl-[3-(naphthalen-1-yloxy)-pro...)
Show SMILES CCCCN(CCCC)CCCOc1cccc2ccccc12
Show InChI InChI=1S/C21H31NO/c1-3-5-15-22(16-6-4-2)17-10-18-23-21-14-9-12-19-11-7-8-13-20(19)21/h7-9,11-14H,3-6,10,15-18H2,1-2H3
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 225n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016920
PNG
(Butyl-ethyl-(3-naphthalen-1-yl-propyl)-amine | CHE...)
Show SMILES CCCCN(CC)CCCc1cccc2ccccc12
Show InChI InChI=1S/C19H27N/c1-3-5-15-20(4-2)16-9-13-18-12-8-11-17-10-6-7-14-19(17)18/h6-8,10-12,14H,3-5,9,13,15-16H2,1-2H3
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 300n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016912
PNG
(CHEMBL138136 | Dimethyl-[3-(naphthalen-1-yloxy)-pr...)
Show SMILES CN(C)CCCOc1cccc2ccccc12
Show InChI InChI=1S/C15H19NO/c1-16(2)11-6-12-17-15-10-5-8-13-7-3-4-9-14(13)15/h3-5,7-10H,6,11-12H2,1-2H3
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 345n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016922
PNG
(CHEMBL136470 | Dimethyl-[4-(naphthalen-1-yloxy)-bu...)
Show SMILES CN(C)CCCCOc1cccc2ccccc12
Show InChI InChI=1S/C16H21NO/c1-17(2)12-5-6-13-18-16-11-7-9-14-8-3-4-10-15(14)16/h3-4,7-11H,5-6,12-13H2,1-2H3
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 400n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016916
PNG
(CHEMBL367935 | [3-(Naphthalen-1-yloxy)-propyl]-dip...)
Show SMILES CCCN(CCC)CCCOc1cccc2ccccc12
Show InChI InChI=1S/C19H27NO/c1-3-13-20(14-4-2)15-8-16-21-19-12-7-10-17-9-5-6-11-18(17)19/h5-7,9-12H,3-4,8,13-16H2,1-2H3
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 450n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016926
PNG
(Butyl-ethyl-[3-(1,2,3,4-tetrahydro-naphthalen-1-yl...)
Show SMILES CCCCN(CC)CCCC1CCCc2ccccc12
Show InChI InChI=1S/C19H31N/c1-3-5-15-20(4-2)16-9-13-18-12-8-11-17-10-6-7-14-19(17)18/h6-7,10,14,18H,3-5,8-9,11-13,15-16H2,1-2H3
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 540n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50016922
PNG
(CHEMBL136470 | Dimethyl-[4-(naphthalen-1-yloxy)-bu...)
Show SMILES CN(C)CCCCOc1cccc2ccccc12
Show InChI InChI=1S/C16H21NO/c1-17(2)12-5-6-13-18-16-11-7-9-14-8-3-4-10-15(14)16/h3-4,7-11H,5-6,12-13H2,1-2H3
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 1.00E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat striatal membrane homogenate using [3H]5-HT as the radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50016912
PNG
(CHEMBL138136 | Dimethyl-[3-(naphthalen-1-yloxy)-pr...)
Show SMILES CN(C)CCCOc1cccc2ccccc12
Show InChI InChI=1S/C15H19NO/c1-16(2)11-6-12-17-15-10-5-8-13-7-3-4-9-14(13)15/h3-5,7-10H,6,11-12H2,1-2H3
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 1.00E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat striatal membrane homogenate using [3H]5-HT as the radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50016913
PNG
(Butyl-ethyl-[2-(naphthalen-1-yloxy)-ethyl]-amine |...)
Show SMILES CCCCN(CC)CCOc1cccc2ccccc12
Show InChI InChI=1S/C18H25NO/c1-3-5-13-19(4-2)14-15-20-18-12-8-10-16-9-6-7-11-17(16)18/h6-12H,3-5,13-15H2,1-2H3
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 1.10E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat striatal membrane homogenate using [3H]5-HT as the radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016914
PNG
(1-Dipropylamino-3-(naphthalen-1-yloxy)-propan-2-ol...)
Show SMILES CCCN(CCC)CC(O)COc1cccc2ccccc12
Show InChI InChI=1S/C19H27NO2/c1-3-12-20(13-4-2)14-17(21)15-22-19-11-7-9-16-8-5-6-10-18(16)19/h5-11,17,21H,3-4,12-15H2,1-2H3
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 1.33E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50016918
PNG
(CHEMBL139103 | Dimethyl-[2-(naphthalen-1-yloxy)-et...)
Show SMILES CN(C)CCOc1cccc2ccccc12
Show InChI InChI=1S/C14H17NO/c1-15(2)10-11-16-14-9-5-7-12-6-3-4-8-13(12)14/h3-9H,10-11H2,1-2H3
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 1.50E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat striatal membrane homogenate using [3H]5-HT as the radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM36108
PNG
((R)-propranolol)
Show SMILES CC(C)[NH2+]C[C@@H](O)COc1cccc2ccccc12
Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3/p+1/t14-/m1/s1
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 1.70E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50016909
PNG
(CHEMBL140417 | Methyl-[2-(naphthalen-1-yloxy)-ethy...)
Show SMILES CCCN(C)CCOc1cccc2ccccc12
Show InChI InChI=1S/C16H21NO/c1-3-11-17(2)12-13-18-16-10-6-8-14-7-4-5-9-15(14)16/h4-10H,3,11-13H2,1-2H3
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 1.80E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat striatal membrane homogenate using [3H]5-HT as the radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
Beta-1/Beta-2/Beta-3 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50016912
PNG
(CHEMBL138136 | Dimethyl-[3-(naphthalen-1-yloxy)-pr...)
Show SMILES CN(C)CCCOc1cccc2ccccc12
Show InChI InChI=1S/C15H19NO/c1-16(2)11-6-12-17-15-10-5-8-13-7-3-4-9-14(13)15/h3-5,7-10H,6,11-12H2,1-2H3
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 2.40E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against beta adrenergic receptor of rat frontal cortex homogenate using (1.0 nM) [3H]- dihydroalprenolol

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016923
PNG
((3-Phenoxy-propyl)-dipropyl-amine | CHEMBL168635)
Show SMILES CCCN(CCC)CCCOc1ccccc1
Show InChI InChI=1S/C15H25NO/c1-3-11-16(12-4-2)13-8-14-17-15-9-6-5-7-10-15/h5-7,9-10H,3-4,8,11-14H2,1-2H3
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 2.75E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016925
PNG
(CHEMBL168224 | [3-(2-Methoxy-phenoxy)-propyl]-dime...)
Show SMILES COc1ccccc1OCCCN(C)C
Show InChI InChI=1S/C12H19NO2/c1-13(2)9-6-10-15-12-8-5-4-7-11(12)14-3/h4-5,7-8H,6,9-10H2,1-3H3
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 3.00E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50016910
PNG
(CHEMBL138509 | Methyl-(3-phenoxy-propyl)-amine)
Show SMILES CNCCCOc1ccccc1
Show InChI InChI=1S/C10H15NO/c1-11-8-5-9-12-10-6-3-2-4-7-10/h2-4,6-7,11H,5,8-9H2,1H3
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 3.10E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat striatal membrane homogenate using [3H]5-HT as the radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016910
PNG
(CHEMBL138509 | Methyl-(3-phenoxy-propyl)-amine)
Show SMILES CNCCCOc1ccccc1
Show InChI InChI=1S/C10H15NO/c1-11-8-5-9-12-10-6-3-2-4-7-10/h2-4,6-7,11H,5,8-9H2,1H3
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 3.30E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016924
PNG
(CHEMBL168577 | Dimethyl-naphthalen-1-ylmethyl-amin...)
Show SMILES CN(C)Cc1cccc2ccccc12
Show InChI InChI=1S/C13H15N/c1-14(2)10-12-8-5-7-11-6-3-4-9-13(11)12/h3-9H,10H2,1-2H3
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 3.42E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016928
PNG
(3-(Butyl-ethyl-amino)-1-naphthalen-1-yl-propan-1-o...)
Show SMILES CCCCN(CC)CCC(=O)c1cccc2ccccc12
Show InChI InChI=1S/C19H25NO/c1-3-5-14-20(4-2)15-13-19(21)18-12-8-10-16-9-6-7-11-17(16)18/h6-12H,3-5,13-15H2,1-2H3
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 3.53E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
Beta-1/Beta-2/Beta-3 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50016918
PNG
(CHEMBL139103 | Dimethyl-[2-(naphthalen-1-yloxy)-et...)
Show SMILES CN(C)CCOc1cccc2ccccc12
Show InChI InChI=1S/C14H17NO/c1-15(2)10-11-16-14-9-5-7-12-6-3-4-8-13(12)14/h3-9H,10-11H2,1-2H3
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 4.50E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against beta adrenergic receptor of rat frontal cortex homogenate using (1.0 nM) [3H]- dihydroalprenolol

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016908
PNG
(CHEMBL136072 | Dimethyl-(3-phenoxy-propyl)-amine)
Show SMILES CN(C)CCCOc1ccccc1
Show InChI InChI=1S/C11H17NO/c1-12(2)9-6-10-13-11-7-4-3-5-8-11/h3-5,7-8H,6,9-10H2,1-2H3
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 4.85E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016919
PNG
(2-(3-Dimethylamino-propoxy)-phenol | CHEMBL170845)
Show SMILES CN(C)CCCOc1ccccc1O
Show InChI InChI=1S/C11H17NO2/c1-12(2)8-5-9-14-11-7-4-3-6-10(11)13/h3-4,6-7,13H,5,8-9H2,1-2H3
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 4.90E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
Beta-1/Beta-2/Beta-3 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50016913
PNG
(Butyl-ethyl-[2-(naphthalen-1-yloxy)-ethyl]-amine |...)
Show SMILES CCCCN(CC)CCOc1cccc2ccccc12
Show InChI InChI=1S/C18H25NO/c1-3-5-13-19(4-2)14-15-20-18-12-8-10-16-9-6-7-11-17(16)18/h6-12H,3-5,13-15H2,1-2H3
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 5.00E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against beta adrenergic receptor of rat frontal cortex homogenate using (1.0 nM) [3H]- dihydroalprenolol

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016907
PNG
(CHEMBL46841 | Dimethyl-(4-phenyl-butyl)-amine)
Show SMILES CN(C)CCCCc1ccccc1
Show InChI InChI=1S/C12H19N/c1-13(2)11-7-6-10-12-8-4-3-5-9-12/h3-5,8-9H,6-7,10-11H2,1-2H3
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 5.00E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
Beta-1/Beta-2/Beta-3 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50016909
PNG
(CHEMBL140417 | Methyl-[2-(naphthalen-1-yloxy)-ethy...)
Show SMILES CCCN(C)CCOc1cccc2ccccc12
Show InChI InChI=1S/C16H21NO/c1-3-11-17(2)12-13-18-16-10-6-8-14-7-4-5-9-15(14)16/h4-10H,3,11-13H2,1-2H3
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 5.30E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against beta adrenergic receptor of rat frontal cortex homogenate using (1.0 nM) [3H]- dihydroalprenolol

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50016917
PNG
(CHEMBL169956 | Dibutyl-[3-(naphthalen-1-yloxy)-pro...)
Show SMILES CCCCN(CCCC)CCCOc1cccc2ccccc12
Show InChI InChI=1S/C21H31NO/c1-3-5-15-22(16-6-4-2)17-10-18-23-21-14-9-12-19-11-7-8-13-20(19)21/h7-9,11-14H,3-6,10,15-18H2,1-2H3
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 5.65E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat striatal membrane homogenate using [3H]5-HT as the radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50016916
PNG
(CHEMBL367935 | [3-(Naphthalen-1-yloxy)-propyl]-dip...)
Show SMILES CCCN(CCC)CCCOc1cccc2ccccc12
Show InChI InChI=1S/C19H27NO/c1-3-13-20(14-4-2)15-8-16-21-19-12-7-10-17-9-5-6-11-18(17)19/h5-7,9-12H,3-4,8,13-16H2,1-2H3
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 6.10E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat striatal membrane homogenate using [3H]5-HT as the radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50016914
PNG
(1-Dipropylamino-3-(naphthalen-1-yloxy)-propan-2-ol...)
Show SMILES CCCN(CCC)CC(O)COc1cccc2ccccc12
Show InChI InChI=1S/C19H27NO2/c1-3-12-20(13-4-2)14-17(21)15-22-19-11-7-9-16-8-5-6-10-18(16)19/h5-11,17,21H,3-4,12-15H2,1-2H3
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 8.00E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat striatal membrane homogenate using [3H]5-HT as the radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
Beta-1/Beta-2/Beta-3 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50016917
PNG
(CHEMBL169956 | Dibutyl-[3-(naphthalen-1-yloxy)-pro...)
Show SMILES CCCCN(CCCC)CCCOc1cccc2ccccc12
Show InChI InChI=1S/C21H31NO/c1-3-5-15-22(16-6-4-2)17-10-18-23-21-14-9-12-19-11-7-8-13-20(19)21/h7-9,11-14H,3-6,10,15-18H2,1-2H3
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 8.30E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against beta adrenergic receptor of rat frontal cortex homogenate using (1.0 nM) [3H]- dihydroalprenolol

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50016915
PNG
(CHEMBL334465 | Dibutyl-[2-(naphthalen-1-yloxy)-eth...)
Show SMILES CCCCN(CCCC)CCOc1cccc2ccccc12
Show InChI InChI=1S/C20H29NO/c1-3-5-14-21(15-6-4-2)16-17-22-20-13-9-11-18-10-7-8-12-19(18)20/h7-13H,3-6,14-17H2,1-2H3
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 9.00E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat striatal membrane homogenate using [3H]5-HT as the radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50016919
PNG
(2-(3-Dimethylamino-propoxy)-phenol | CHEMBL170845)
Show SMILES CN(C)CCCOc1ccccc1O
Show InChI InChI=1S/C11H17NO2/c1-12(2)8-5-9-14-11-7-4-3-6-10(11)13/h3-4,6-7,13H,5,8-9H2,1-2H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat striatal membrane homogenate using [3H]5-HT as the radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50016908
PNG
(CHEMBL136072 | Dimethyl-(3-phenoxy-propyl)-amine)
Show SMILES CN(C)CCCOc1ccccc1
Show InChI InChI=1S/C11H17NO/c1-12(2)9-6-10-13-11-7-4-3-5-8-11/h3-5,7-8H,6,9-10H2,1-2H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat striatal membrane homogenate using [3H]5-HT as the radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50016925
PNG
(CHEMBL168224 | [3-(2-Methoxy-phenoxy)-propyl]-dime...)
Show SMILES COc1ccccc1OCCCN(C)C
Show InChI InChI=1S/C12H19NO2/c1-13(2)9-6-10-15-12-8-5-4-7-11(12)14-3/h4-5,7-8H,6,9-10H2,1-3H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat striatal membrane homogenate using [3H]5-HT as the radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50016921
PNG
(CHEMBL139976 | N,N-Dimethyl-N'-phenyl-propane-1,3-...)
Show SMILES CN(C)CCCNc1ccccc1
Show InChI InChI=1S/C11H18N2/c1-13(2)10-6-9-12-11-7-4-3-5-8-11/h3-5,7-8,12H,6,9-10H2,1-2H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat striatal membrane homogenate using [3H]5-HT as the radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50016907
PNG
(CHEMBL46841 | Dimethyl-(4-phenyl-butyl)-amine)
Show SMILES CN(C)CCCCc1ccccc1
Show InChI InChI=1S/C12H19N/c1-13(2)11-7-6-10-12-8-4-3-5-9-12/h3-5,8-9H,6-7,10-11H2,1-2H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat striatal membrane homogenate using [3H]5-HT as the radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Rattus norvegicus (Rat))		BDBM50016923
PNG
((3-Phenoxy-propyl)-dipropyl-amine | CHEMBL168635)
Show SMILES CCCN(CCC)CCCOc1ccccc1
Show InChI InChI=1S/C15H25NO/c1-3-11-16(12-4-2)13-8-14-17-15-9-6-5-7-10-15/h5-7,9-10H,3-4,8,11-14H2,1-2H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat striatal membrane homogenate using [3H]5-HT as the radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
Beta-1/Beta-2/Beta-3 adrenergic receptor


(Rattus norvegicus (Rat))		BDBM50016915
PNG
(CHEMBL334465 | Dibutyl-[2-(naphthalen-1-yloxy)-eth...)
Show SMILES CCCCN(CCCC)CCOc1cccc2ccccc12
Show InChI InChI=1S/C20H29NO/c1-3-5-14-21(15-6-4-2)16-17-22-20-13-9-11-18-10-7-8-12-19(18)20/h7-13H,3-6,14-17H2,1-2H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against beta adrenergic receptor of rat frontal cortex homogenate using (1.0 nM) [3H]- dihydroalprenolol

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50016921
PNG
(CHEMBL139976 | N,N-Dimethyl-N'-phenyl-propane-1,3-...)
Show SMILES CN(C)CCCNc1ccccc1
Show InChI InChI=1S/C11H18N2/c1-13(2)10-6-9-12-11-7-4-3-5-8-11/h3-5,7-8,12H,6,9-10H2,1-2H3
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>2.50E+4n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand.

J Med Chem 32: 859-63 (1989)


BindingDB Entry DOI: 10.7270/Q2571CMK
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%