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PubMed code 25419444

Compile data set for download or QSAR
Found 28 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Signal transducer and activator of transcription 5B


(Homo sapiens (Human))		BDBM50033887
PNG
(CHEMBL3358611)
Show SMILES CC(C)(C)c1cc(CN(C(=O)CN(Cc2ccc(Cl)cc2)S(=O)(=O)c2c(F)c(F)c(F)c(F)c2F)c2ccc(C(O)=O)c(O)c2)cc(c1)C(C)(C)C
Show InChI InChI=1S/C37H36ClF5N2O6S/c1-36(2,3)22-13-21(14-23(15-22)37(4,5)6)18-45(25-11-12-26(35(48)49)27(46)16-25)28(47)19-44(17-20-7-9-24(38)10-8-20)52(50,51)34-32(42)30(40)29(39)31(41)33(34)43/h7-16,46H,17-19H2,1-6H3,(H,48,49)
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 146n/an/an/an/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Inhibition of STAT5B SH2 domain (unknown origin)-5-FAM-GpYLVLDKW interaction compound treated for 15 mins by fluorescent polarization assay

ACS Med Chem Lett 5: 1202-1206 (2014)


Article DOI: 10.1021/ml500165r
BindingDB Entry DOI: 10.7270/Q25X2BJJ
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 5B


(Homo sapiens (Human))		BDBM50033944
PNG
(CHEMBL3358598)
Show SMILES CN(CC(=O)N(Cc1cc(cc(c1)C(C)(C)C)C(C)(C)C)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C34H44N2O6S/c1-21-13-22(2)31(23(3)14-21)43(41,42)35(10)20-30(38)36(27-11-12-28(32(39)40)29(37)18-27)19-24-15-25(33(4,5)6)17-26(16-24)34(7,8)9/h11-18,37H,19-20H2,1-10H3,(H,39,40)
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 4.77E+3n/an/an/an/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Inhibition of STAT5B SH2 domain (unknown origin)-5-FAM-GpYLVLDKW interaction compound treated for 15 mins by fluorescent polarization assay

ACS Med Chem Lett 5: 1202-1206 (2014)


Article DOI: 10.1021/ml500165r
BindingDB Entry DOI: 10.7270/Q25X2BJJ
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 5B


(Homo sapiens (Human))		BDBM50033946
PNG
(CHEMBL3358596)
Show SMILES CN(CC(=O)N(Cc1ccc2ccccc2c1)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C30H30N2O6S/c1-19-13-20(2)29(21(3)14-19)39(37,38)31(4)18-28(34)32(25-11-12-26(30(35)36)27(33)16-25)17-22-9-10-23-7-5-6-8-24(23)15-22/h5-16,33H,17-18H2,1-4H3,(H,35,36)
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 6.62E+3n/an/an/an/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Inhibition of STAT5B SH2 domain (unknown origin)-5-FAM-GpYLVLDKW interaction compound treated for 15 mins by fluorescent polarization assay

ACS Med Chem Lett 5: 1202-1206 (2014)


Article DOI: 10.1021/ml500165r
BindingDB Entry DOI: 10.7270/Q25X2BJJ
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 5B


(Homo sapiens (Human))		BDBM50033888
PNG
(CHEMBL3358610)
Show SMILES CN(CC(=O)N(Cc1cc(cc(c1)C(C)(C)C)C(C)(C)C)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F
Show InChI InChI=1S/C31H33F5N2O6S/c1-30(2,3)17-10-16(11-18(12-17)31(4,5)6)14-38(19-8-9-20(29(41)42)21(39)13-19)22(40)15-37(7)45(43,44)28-26(35)24(33)23(32)25(34)27(28)36/h8-13,39H,14-15H2,1-7H3,(H,41,42)
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 1.15E+4n/an/an/an/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Inhibition of STAT5B SH2 domain (unknown origin)-5-FAM-GpYLVLDKW interaction compound treated for 15 mins by fluorescent polarization assay

ACS Med Chem Lett 5: 1202-1206 (2014)


Article DOI: 10.1021/ml500165r
BindingDB Entry DOI: 10.7270/Q25X2BJJ
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 5B


(Homo sapiens (Human))		BDBM50033890
PNG
(CHEMBL3358608)
Show SMILES CN(CC(=O)N(Cc1ccc2ccccc2c1)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F
Show InChI InChI=1S/C27H19F5N2O6S/c1-33(41(39,40)26-24(31)22(29)21(28)23(30)25(26)32)13-20(36)34(17-8-9-18(27(37)38)19(35)11-17)12-14-6-7-15-4-2-3-5-16(15)10-14/h2-11,35H,12-13H2,1H3,(H,37,38)
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 1.24E+4n/an/an/an/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Inhibition of STAT5B SH2 domain (unknown origin)-5-FAM-GpYLVLDKW interaction compound treated for 15 mins by fluorescent polarization assay

ACS Med Chem Lett 5: 1202-1206 (2014)


Article DOI: 10.1021/ml500165r
BindingDB Entry DOI: 10.7270/Q25X2BJJ
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 5B


(Homo sapiens (Human))		BDBM50033889
PNG
(CHEMBL3358609)
Show SMILES CN(CC(=O)N(Cc1ccc(cc1)C(C)(C)C)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F
Show InChI InChI=1S/C27H25F5N2O6S/c1-27(2,3)15-7-5-14(6-8-15)12-34(16-9-10-17(26(37)38)18(35)11-16)19(36)13-33(4)41(39,40)25-23(31)21(29)20(28)22(30)24(25)32/h5-11,35H,12-13H2,1-4H3,(H,37,38)
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>6.00E+4n/an/an/an/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Inhibition of STAT5B SH2 domain (unknown origin)-5-FAM-GpYLVLDKW interaction compound treated for 15 mins by fluorescent polarization assay

ACS Med Chem Lett 5: 1202-1206 (2014)


Article DOI: 10.1021/ml500165r
BindingDB Entry DOI: 10.7270/Q25X2BJJ
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 5B


(Homo sapiens (Human))		BDBM50034036
PNG
(CHEMBL3358588)
Show SMILES CN(CC(=O)N(Cc1cccs1)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C24H26N2O6S2/c1-15-10-16(2)23(17(3)11-15)34(31,32)25(4)14-22(28)26(13-19-6-5-9-33-19)18-7-8-20(24(29)30)21(27)12-18/h5-12,27H,13-14H2,1-4H3,(H,29,30)
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>6.00E+4n/an/an/an/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Inhibition of STAT5B SH2 domain (unknown origin)-5-FAM-GpYLVLDKW interaction compound treated for 15 mins by fluorescent polarization assay

ACS Med Chem Lett 5: 1202-1206 (2014)


Article DOI: 10.1021/ml500165r
BindingDB Entry DOI: 10.7270/Q25X2BJJ
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 5B


(Homo sapiens (Human))		BDBM50033939
PNG
(CHEMBL3358601)
Show SMILES CN(CC(=O)N(Cc1nccn1C)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F
Show InChI InChI=1S/C21H17F5N4O6S/c1-28-6-5-27-13(28)8-30(10-3-4-11(21(33)34)12(31)7-10)14(32)9-29(2)37(35,36)20-18(25)16(23)15(22)17(24)19(20)26/h3-7,31H,8-9H2,1-2H3,(H,33,34)
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>6.00E+4n/an/an/an/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Inhibition of STAT5B SH2 domain (unknown origin)-5-FAM-GpYLVLDKW interaction compound treated for 15 mins by fluorescent polarization assay

ACS Med Chem Lett 5: 1202-1206 (2014)


Article DOI: 10.1021/ml500165r
BindingDB Entry DOI: 10.7270/Q25X2BJJ
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 5B


(Homo sapiens (Human))		BDBM50033943
PNG
(CHEMBL3358599)
Show SMILES CN(CC(=O)N(CC1CCCO1)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F
Show InChI InChI=1S/C21H19F5N2O7S/c1-27(36(33,34)20-18(25)16(23)15(22)17(24)19(20)26)9-14(30)28(8-11-3-2-6-35-11)10-4-5-12(21(31)32)13(29)7-10/h4-5,7,11,29H,2-3,6,8-9H2,1H3,(H,31,32)
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>6.00E+4n/an/an/an/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Inhibition of STAT5B SH2 domain (unknown origin)-5-FAM-GpYLVLDKW interaction compound treated for 15 mins by fluorescent polarization assay

ACS Med Chem Lett 5: 1202-1206 (2014)


Article DOI: 10.1021/ml500165r
BindingDB Entry DOI: 10.7270/Q25X2BJJ
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 5B


(Homo sapiens (Human))		BDBM50033945
PNG
(CHEMBL3358597)
Show SMILES CN(CC(=O)N(Cc1ccc(cc1)C(C)(C)C)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C30H36N2O6S/c1-19-14-20(2)28(21(3)15-19)39(37,38)31(7)18-27(34)32(24-12-13-25(29(35)36)26(33)16-24)17-22-8-10-23(11-9-22)30(4,5)6/h8-16,33H,17-18H2,1-7H3,(H,35,36)
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>6.00E+4n/an/an/an/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Inhibition of STAT5B SH2 domain (unknown origin)-5-FAM-GpYLVLDKW interaction compound treated for 15 mins by fluorescent polarization assay

ACS Med Chem Lett 5: 1202-1206 (2014)


Article DOI: 10.1021/ml500165r
BindingDB Entry DOI: 10.7270/Q25X2BJJ
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 5B


(Homo sapiens (Human))		BDBM50033947
PNG
(CHEMBL3358595)
Show SMILES CN(CC(=O)N(Cc1c(F)c(F)c(F)c(F)c1F)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C26H23F5N2O6S/c1-12-7-13(2)25(14(3)8-12)40(38,39)32(4)11-19(35)33(15-5-6-16(26(36)37)18(34)9-15)10-17-20(27)22(29)24(31)23(30)21(17)28/h5-9,34H,10-11H2,1-4H3,(H,36,37)
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>6.00E+4n/an/an/an/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Inhibition of STAT5B SH2 domain (unknown origin)-5-FAM-GpYLVLDKW interaction compound treated for 15 mins by fluorescent polarization assay

ACS Med Chem Lett 5: 1202-1206 (2014)


Article DOI: 10.1021/ml500165r
BindingDB Entry DOI: 10.7270/Q25X2BJJ
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 5B


(Homo sapiens (Human))		BDBM50034005
PNG
(CHEMBL3358592)
Show SMILES CN(CC(=O)N(Cc1ccc(C)cc1)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C27H30N2O6S/c1-17-6-8-21(9-7-17)15-29(22-10-11-23(27(32)33)24(30)14-22)25(31)16-28(5)36(34,35)26-19(3)12-18(2)13-20(26)4/h6-14,30H,15-16H2,1-5H3,(H,32,33)
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>6.00E+4n/an/an/an/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Inhibition of STAT5B SH2 domain (unknown origin)-5-FAM-GpYLVLDKW interaction compound treated for 15 mins by fluorescent polarization assay

ACS Med Chem Lett 5: 1202-1206 (2014)


Article DOI: 10.1021/ml500165r
BindingDB Entry DOI: 10.7270/Q25X2BJJ
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 5B


(Homo sapiens (Human))		BDBM50033893
PNG
(CHEMBL3358605)
Show SMILES CN(CC(=O)N(Cc1ccccc1)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F
Show InChI InChI=1S/C23H17F5N2O6S/c1-29(37(35,36)22-20(27)18(25)17(24)19(26)21(22)28)11-16(32)30(10-12-5-3-2-4-6-12)13-7-8-14(23(33)34)15(31)9-13/h2-9,31H,10-11H2,1H3,(H,33,34)
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>6.00E+4n/an/an/an/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Inhibition of STAT5B SH2 domain (unknown origin)-5-FAM-GpYLVLDKW interaction compound treated for 15 mins by fluorescent polarization assay

ACS Med Chem Lett 5: 1202-1206 (2014)


Article DOI: 10.1021/ml500165r
BindingDB Entry DOI: 10.7270/Q25X2BJJ
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 5B


(Homo sapiens (Human))		BDBM50034080
PNG
(CHEMBL3358587)
Show SMILES CN(CC(=O)N(CC1CCCO1)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C24H30N2O7S/c1-15-10-16(2)23(17(3)11-15)34(31,32)25(4)14-22(28)26(13-19-6-5-9-33-19)18-7-8-20(24(29)30)21(27)12-18/h7-8,10-12,19,27H,5-6,9,13-14H2,1-4H3,(H,29,30)
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>6.00E+4n/an/an/an/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Inhibition of STAT5B SH2 domain (unknown origin)-5-FAM-GpYLVLDKW interaction compound treated for 15 mins by fluorescent polarization assay

ACS Med Chem Lett 5: 1202-1206 (2014)


Article DOI: 10.1021/ml500165r
BindingDB Entry DOI: 10.7270/Q25X2BJJ
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 5B


(Homo sapiens (Human))		BDBM50034008
PNG
(CHEMBL3358589)
Show SMILES CN(CC(=O)N(Cc1nccn1C)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C24H28N4O6S/c1-15-10-16(2)23(17(3)11-15)35(33,34)27(5)14-22(30)28(13-21-25-8-9-26(21)4)18-6-7-19(24(31)32)20(29)12-18/h6-12,29H,13-14H2,1-5H3,(H,31,32)
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>6.00E+4n/an/an/an/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Inhibition of STAT5B SH2 domain (unknown origin)-5-FAM-GpYLVLDKW interaction compound treated for 15 mins by fluorescent polarization assay

ACS Med Chem Lett 5: 1202-1206 (2014)


Article DOI: 10.1021/ml500165r
BindingDB Entry DOI: 10.7270/Q25X2BJJ
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 5B


(Homo sapiens (Human))		BDBM50033993
PNG
(CHEMBL3358593)
Show SMILES CN(CC(=O)N(Cc1ccccc1)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C26H28N2O6S/c1-17-12-18(2)25(19(3)13-17)35(33,34)27(4)16-24(30)28(15-20-8-6-5-7-9-20)21-10-11-22(26(31)32)23(29)14-21/h5-14,29H,15-16H2,1-4H3,(H,31,32)
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>6.00E+4n/an/an/an/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Inhibition of STAT5B SH2 domain (unknown origin)-5-FAM-GpYLVLDKW interaction compound treated for 15 mins by fluorescent polarization assay

ACS Med Chem Lett 5: 1202-1206 (2014)


Article DOI: 10.1021/ml500165r
BindingDB Entry DOI: 10.7270/Q25X2BJJ
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 5B


(Homo sapiens (Human))		BDBM50033940
PNG
(CHEMBL3358600)
Show SMILES CN(CC(=O)N(Cc1cccs1)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F
Show InChI InChI=1S/C21H15F5N2O6S2/c1-27(36(33,34)20-18(25)16(23)15(22)17(24)19(20)26)9-14(30)28(8-11-3-2-6-35-11)10-4-5-12(21(31)32)13(29)7-10/h2-7,29H,8-9H2,1H3,(H,31,32)
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>6.00E+4n/an/an/an/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Inhibition of STAT5B SH2 domain (unknown origin)-5-FAM-GpYLVLDKW interaction compound treated for 15 mins by fluorescent polarization assay

ACS Med Chem Lett 5: 1202-1206 (2014)


Article DOI: 10.1021/ml500165r
BindingDB Entry DOI: 10.7270/Q25X2BJJ
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 5B


(Homo sapiens (Human))		BDBM50033896
PNG
(CHEMBL3358603)
Show SMILES CN(CC(=O)N(CC12CCC(CC1)C2)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F
Show InChI InChI=1S/C24H23F5N2O6S/c1-30(38(36,37)22-20(28)18(26)17(25)19(27)21(22)29)10-16(33)31(11-24-6-4-12(9-24)5-7-24)13-2-3-14(23(34)35)15(32)8-13/h2-3,8,12,32H,4-7,9-11H2,1H3,(H,34,35)
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>6.00E+4n/an/an/an/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Inhibition of STAT5B SH2 domain (unknown origin)-5-FAM-GpYLVLDKW interaction compound treated for 15 mins by fluorescent polarization assay

ACS Med Chem Lett 5: 1202-1206 (2014)


Article DOI: 10.1021/ml500165r
BindingDB Entry DOI: 10.7270/Q25X2BJJ
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 5B


(Homo sapiens (Human))		BDBM50033897
PNG
(CHEMBL3358602)
Show SMILES CN(CC(=O)N(CC1CC1)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F
Show InChI InChI=1S/C20H17F5N2O6S/c1-26(34(32,33)19-17(24)15(22)14(21)16(23)18(19)25)8-13(29)27(7-9-2-3-9)10-4-5-11(20(30)31)12(28)6-10/h4-6,9,28H,2-3,7-8H2,1H3,(H,30,31)
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>6.00E+4n/an/an/an/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Inhibition of STAT5B SH2 domain (unknown origin)-5-FAM-GpYLVLDKW interaction compound treated for 15 mins by fluorescent polarization assay

ACS Med Chem Lett 5: 1202-1206 (2014)


Article DOI: 10.1021/ml500165r
BindingDB Entry DOI: 10.7270/Q25X2BJJ
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 5B


(Homo sapiens (Human))		BDBM50033895
PNG
(CHEMBL3358604)
Show SMILES CN(CC(=O)N(Cc1ccc(C)cc1)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F
Show InChI InChI=1S/C24H19F5N2O6S/c1-12-3-5-13(6-4-12)10-31(14-7-8-15(24(34)35)16(32)9-14)17(33)11-30(2)38(36,37)23-21(28)19(26)18(25)20(27)22(23)29/h3-9,32H,10-11H2,1-2H3,(H,34,35)
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>6.00E+4n/an/an/an/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Inhibition of STAT5B SH2 domain (unknown origin)-5-FAM-GpYLVLDKW interaction compound treated for 15 mins by fluorescent polarization assay

ACS Med Chem Lett 5: 1202-1206 (2014)


Article DOI: 10.1021/ml500165r
BindingDB Entry DOI: 10.7270/Q25X2BJJ
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 5B


(Homo sapiens (Human))		BDBM50033892
PNG
(CHEMBL3358606)
Show SMILES CN(CC(=O)N(Cc1ccc(F)cc1)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F
Show InChI InChI=1S/C23H16F6N2O6S/c1-30(38(36,37)22-20(28)18(26)17(25)19(27)21(22)29)10-16(33)31(9-11-2-4-12(24)5-3-11)13-6-7-14(23(34)35)15(32)8-13/h2-8,32H,9-10H2,1H3,(H,34,35)
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>6.00E+4n/an/an/an/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Inhibition of STAT5B SH2 domain (unknown origin)-5-FAM-GpYLVLDKW interaction compound treated for 15 mins by fluorescent polarization assay

ACS Med Chem Lett 5: 1202-1206 (2014)


Article DOI: 10.1021/ml500165r
BindingDB Entry DOI: 10.7270/Q25X2BJJ
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 5B


(Homo sapiens (Human))		BDBM50033963
PNG
(CHEMBL3358594)
Show SMILES CN(CC(=O)N(Cc1ccc(F)cc1)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C26H27FN2O6S/c1-16-11-17(2)25(18(3)12-16)36(34,35)28(4)15-24(31)29(14-19-5-7-20(27)8-6-19)21-9-10-22(26(32)33)23(30)13-21/h5-13,30H,14-15H2,1-4H3,(H,32,33)
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>6.00E+4n/an/an/an/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Inhibition of STAT5B SH2 domain (unknown origin)-5-FAM-GpYLVLDKW interaction compound treated for 15 mins by fluorescent polarization assay

ACS Med Chem Lett 5: 1202-1206 (2014)


Article DOI: 10.1021/ml500165r
BindingDB Entry DOI: 10.7270/Q25X2BJJ
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 5B


(Homo sapiens (Human))		BDBM50034006
PNG
(CHEMBL3358591)
Show SMILES CN(CC(=O)N(CC12CCC(CC1)C2)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C27H34N2O6S/c1-17-11-18(2)25(19(3)12-17)36(34,35)28(4)15-24(31)29(16-27-9-7-20(14-27)8-10-27)21-5-6-22(26(32)33)23(30)13-21/h5-6,11-13,20,30H,7-10,14-16H2,1-4H3,(H,32,33)
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>6.00E+4n/an/an/an/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Inhibition of STAT5B SH2 domain (unknown origin)-5-FAM-GpYLVLDKW interaction compound treated for 15 mins by fluorescent polarization assay

ACS Med Chem Lett 5: 1202-1206 (2014)


Article DOI: 10.1021/ml500165r
BindingDB Entry DOI: 10.7270/Q25X2BJJ
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 5B


(Homo sapiens (Human))		BDBM50034007
PNG
(CHEMBL3358590)
Show SMILES CN(CC(=O)N(CC1CC1)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C23H28N2O6S/c1-14-9-15(2)22(16(3)10-14)32(30,31)24(4)13-21(27)25(12-17-5-6-17)18-7-8-19(23(28)29)20(26)11-18/h7-11,17,26H,5-6,12-13H2,1-4H3,(H,28,29)
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>6.00E+4n/an/an/an/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Inhibition of STAT5B SH2 domain (unknown origin)-5-FAM-GpYLVLDKW interaction compound treated for 15 mins by fluorescent polarization assay

ACS Med Chem Lett 5: 1202-1206 (2014)


Article DOI: 10.1021/ml500165r
BindingDB Entry DOI: 10.7270/Q25X2BJJ
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 5B


(Homo sapiens (Human))		BDBM50033891
PNG
(CHEMBL3358607)
Show SMILES CN(CC(=O)N(Cc1c(F)c(F)c(F)c(F)c1F)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F
Show InChI InChI=1S/C23H12F10N2O6S/c1-34(42(40,41)22-20(32)18(30)17(29)19(31)21(22)33)6-11(37)35(7-2-3-8(23(38)39)10(36)4-7)5-9-12(24)14(26)16(28)15(27)13(9)25/h2-4,36H,5-6H2,1H3,(H,38,39)
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>6.00E+4n/an/an/an/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Inhibition of STAT5B SH2 domain (unknown origin)-5-FAM-GpYLVLDKW interaction compound treated for 15 mins by fluorescent polarization assay

ACS Med Chem Lett 5: 1202-1206 (2014)


Article DOI: 10.1021/ml500165r
BindingDB Entry DOI: 10.7270/Q25X2BJJ
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))		BDBM50033887
PNG
(CHEMBL3358611)
Show SMILES CC(C)(C)c1cc(CN(C(=O)CN(Cc2ccc(Cl)cc2)S(=O)(=O)c2c(F)c(F)c(F)c(F)c2F)c2ccc(C(O)=O)c(O)c2)cc(c1)C(C)(C)C
Show InChI InChI=1S/C37H36ClF5N2O6S/c1-36(2,3)22-13-21(14-23(15-22)37(4,5)6)18-45(25-11-12-26(35(48)49)27(46)16-25)28(47)19-44(17-20-7-9-24(38)10-8-20)52(50,51)34-32(42)30(40)29(39)31(41)33(34)43/h7-16,46H,17-19H2,1-6H3,(H,48,49)
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 1.44E+5n/an/an/an/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Inhibition of STAT3 (unknown origin)-5-FAM-GpYLVLDKW interaction compound treated for 15 mins by fluorescent polarization assay

ACS Med Chem Lett 5: 1202-1206 (2014)


Article DOI: 10.1021/ml500165r
BindingDB Entry DOI: 10.7270/Q25X2BJJ
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 5B


(Homo sapiens (Human))		BDBM50033887
PNG
(CHEMBL3358611)
Show SMILES CC(C)(C)c1cc(CN(C(=O)CN(Cc2ccc(Cl)cc2)S(=O)(=O)c2c(F)c(F)c(F)c(F)c2F)c2ccc(C(O)=O)c(O)c2)cc(c1)C(C)(C)C
Show InChI InChI=1S/C37H36ClF5N2O6S/c1-36(2,3)22-13-21(14-23(15-22)37(4,5)6)18-45(25-11-12-26(35(48)49)27(46)16-25)28(47)19-44(17-20-7-9-24(38)10-8-20)52(50,51)34-32(42)30(40)29(39)31(41)33(34)43/h7-16,46H,17-19H2,1-6H3,(H,48,49)
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n/an/an/a 42n/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Binding affinity to full-length His-tagged STAT5B (unknown origin) by surface plasmon resonance assay

ACS Med Chem Lett 5: 1202-1206 (2014)


Article DOI: 10.1021/ml500165r
BindingDB Entry DOI: 10.7270/Q25X2BJJ
More data for this
Ligand-Target Pair
Signal transducer and activator of transcription 3


(Homo sapiens (Human))		BDBM50033887
PNG
(CHEMBL3358611)
Show SMILES CC(C)(C)c1cc(CN(C(=O)CN(Cc2ccc(Cl)cc2)S(=O)(=O)c2c(F)c(F)c(F)c(F)c2F)c2ccc(C(O)=O)c(O)c2)cc(c1)C(C)(C)C
Show InChI InChI=1S/C37H36ClF5N2O6S/c1-36(2,3)22-13-21(14-23(15-22)37(4,5)6)18-45(25-11-12-26(35(48)49)27(46)16-25)28(47)19-44(17-20-7-9-24(38)10-8-20)52(50,51)34-32(42)30(40)29(39)31(41)33(34)43/h7-16,46H,17-19H2,1-6H3,(H,48,49)
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n/an/an/a 287n/an/an/an/an/a



University of Toronto Mississauga

Curated by ChEMBL


Assay Description
Binding affinity to full-length His-tagged STAT3 (unknown origin) by surface plasmon resonance assay

ACS Med Chem Lett 5: 1202-1206 (2014)


Article DOI: 10.1021/ml500165r
BindingDB Entry DOI: 10.7270/Q25X2BJJ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%