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PubMed code 25437505

Compile data set for download or QSAR
Found 87 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034956
PNG
(CHEMBL3338150)
Show SMILES CCN(Cc1cc(ccc1-c1cc(CC(O)=O)n2cccnc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C23H22F3N3O3/c1-2-28(22(32)14-4-5-14)13-15-10-16(23(24,25)26)6-7-18(15)19-11-17(12-20(30)31)29-9-3-8-27-21(19)29/h3,6-11,14H,2,4-5,12-13H2,1H3,(H,30,31)
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n/an/a 1.40n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035031
PNG
(CHEMBL3343129)
Show SMILES COCCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C25H26F3N3O4/c1-15-3-7-20-17(12-22(32)33)14-31(23(20)29-15)21-8-6-19(25(26,27)28)11-18(21)13-30(9-10-35-2)24(34)16-4-5-16/h3,6-8,11,14,16H,4-5,9-10,12-13H2,1-2H3,(H,32,33)
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n/an/a 4n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035030
PNG
(CHEMBL3343128)
Show SMILES Cc1ccc2c(CC(O)=O)cn(-c3ccc(cc3CN(CCOc3ccccc3)C(=O)C3CC3)C(F)(F)F)c2n1
Show InChI InChI=1S/C30H28F3N3O4/c1-19-7-11-25-21(16-27(37)38)18-36(28(25)34-19)26-12-10-23(30(31,32)33)15-22(26)17-35(29(39)20-8-9-20)13-14-40-24-5-3-2-4-6-24/h2-7,10-12,15,18,20H,8-9,13-14,16-17H2,1H3,(H,37,38)
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n/an/a 4n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035019
PNG
(CHEMBL3343118)
Show SMILES CCN(Cc1cc(ccc1-c1cc(CC(O)=O)c2ccc(C)nn12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C24H24F3N3O3/c1-3-29(23(33)15-5-6-15)13-17-10-18(24(25,26)27)7-8-19(17)21-11-16(12-22(31)32)20-9-4-14(2)28-30(20)21/h4,7-11,15H,3,5-6,12-13H2,1-2H3,(H,31,32)
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n/an/a 4.20n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034960
PNG
(CHEMBL3342994)
Show SMILES CCN(Cc1cc(ccc1-c1nn(CC(O)=O)c2cccc(F)c12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C23H21F4N3O3/c1-2-29(22(33)13-6-7-13)11-14-10-15(23(25,26)27)8-9-16(14)21-20-17(24)4-3-5-18(20)30(28-21)12-19(31)32/h3-5,8-10,13H,2,6-7,11-12H2,1H3,(H,31,32)
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n/an/a 4.30n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035026
PNG
(CHEMBL3343124)
Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(F)(F)F)C(=O)NCc1ccccc1
Show InChI InChI=1S/C28H27F3N4O3/c1-3-34(27(38)32-15-19-7-5-4-6-8-19)16-21-13-22(28(29,30)31)10-12-24(21)35-17-20(14-25(36)37)23-11-9-18(2)33-26(23)35/h4-13,17H,3,14-16H2,1-2H3,(H,32,38)(H,36,37)
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n/an/a 4.70n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034979
PNG
(CHEMBL3343106)
Show SMILES CCN(Cc1cc(F)ccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(=O)C1CC1
Show InChI InChI=1S/C23H24FN3O3/c1-3-26(23(30)15-5-6-15)12-17-10-18(24)7-9-20(17)27-13-16(11-21(28)29)19-8-4-14(2)25-22(19)27/h4,7-10,13,15H,3,5-6,11-12H2,1-2H3,(H,28,29)
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n/an/a 4.70n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035026
PNG
(CHEMBL3343124)
Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(F)(F)F)C(=O)NCc1ccccc1
Show InChI InChI=1S/C28H27F3N4O3/c1-3-34(27(38)32-15-19-7-5-4-6-8-19)16-21-13-22(28(29,30)31)10-12-24(21)35-17-20(14-25(36)37)23-11-9-18(2)33-26(23)35/h4-13,17H,3,14-16H2,1-2H3,(H,32,38)(H,36,37)
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n/an/a 5n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034980
PNG
(CHEMBL3338153)
Show SMILES CCN(Cc1ccccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(=O)C1CC1
Show InChI InChI=1S/C23H25N3O3/c1-3-25(23(29)16-9-10-16)13-17-6-4-5-7-20(17)26-14-18(12-21(27)28)19-11-8-15(2)24-22(19)26/h4-8,11,14,16H,3,9-10,12-13H2,1-2H3,(H,27,28)
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n/an/a 5n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035023
PNG
(CHEMBL3343121)
Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(F)(F)F)C(=O)COC
Show InChI InChI=1S/C23H24F3N3O4/c1-4-28(20(30)13-33-3)11-16-9-17(23(24,25)26)6-8-19(16)29-12-15(10-21(31)32)18-7-5-14(2)27-22(18)29/h5-9,12H,4,10-11,13H2,1-3H3,(H,31,32)
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n/an/a 5n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034981
PNG
(CHEMBL3343107)
Show SMILES CCN(Cc1cc(Cl)ccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(=O)C1CC1
Show InChI InChI=1S/C23H24ClN3O3/c1-3-26(23(30)15-5-6-15)12-17-10-18(24)7-9-20(17)27-13-16(11-21(28)29)19-8-4-14(2)25-22(19)27/h4,7-10,13,15H,3,5-6,11-12H2,1-2H3,(H,28,29)
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n/an/a 5.20n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034983
PNG
(CHEMBL3343109)
Show SMILES CCN(Cc1cc(OC(F)(F)F)ccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(=O)C1CC1
Show InChI InChI=1S/C24H24F3N3O4/c1-3-29(23(33)15-5-6-15)12-17-10-18(34-24(25,26)27)7-9-20(17)30-13-16(11-21(31)32)19-8-4-14(2)28-22(19)30/h4,7-10,13,15H,3,5-6,11-12H2,1-2H3,(H,31,32)
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n/an/a 5.80n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034982
PNG
(CHEMBL3343108)
Show SMILES CCN(Cc1cc(C)ccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(=O)C1CC1
Show InChI InChI=1S/C24H27N3O3/c1-4-26(24(30)17-7-8-17)13-19-11-15(2)5-10-21(19)27-14-18(12-22(28)29)20-9-6-16(3)25-23(20)27/h5-6,9-11,14,17H,4,7-8,12-13H2,1-3H3,(H,28,29)
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n/an/a 5.90n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035024
PNG
(CHEMBL3343122)
Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(F)(F)F)C(=O)Cc1ccccc1
Show InChI InChI=1S/C28H26F3N3O3/c1-3-33(25(35)13-19-7-5-4-6-8-19)16-21-14-22(28(29,30)31)10-12-24(21)34-17-20(15-26(36)37)23-11-9-18(2)32-27(23)34/h4-12,14,17H,3,13,15-16H2,1-2H3,(H,36,37)
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n/an/a 6n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034959
PNG
(CHEMBL3342993)
Show SMILES CCN(Cc1cc(ccc1-c1nn(CC(O)=O)c2cccc(Cl)c12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C23H21ClF3N3O3/c1-2-29(22(33)13-6-7-13)11-14-10-15(23(25,26)27)8-9-16(14)21-20-17(24)4-3-5-18(20)30(28-21)12-19(31)32/h3-5,8-10,13H,2,6-7,11-12H2,1H3,(H,31,32)
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n/an/a 6.30n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034979
PNG
(CHEMBL3343106)
Show SMILES CCN(Cc1cc(F)ccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(=O)C1CC1
Show InChI InChI=1S/C23H24FN3O3/c1-3-26(23(30)15-5-6-15)12-17-10-18(24)7-9-20(17)27-13-16(11-21(28)29)19-8-4-14(2)25-22(19)27/h4,7-10,13,15H,3,5-6,11-12H2,1-2H3,(H,28,29)
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n/an/a 6.40n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034983
PNG
(CHEMBL3343109)
Show SMILES CCN(Cc1cc(OC(F)(F)F)ccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(=O)C1CC1
Show InChI InChI=1S/C24H24F3N3O4/c1-3-29(23(33)15-5-6-15)12-17-10-18(34-24(25,26)27)7-9-20(17)30-13-16(11-21(31)32)19-8-4-14(2)28-22(19)30/h4,7-10,13,15H,3,5-6,11-12H2,1-2H3,(H,31,32)
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n/an/a 6.70n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035022
PNG
(CHEMBL3343120)
Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(F)(F)F)C(=O)CC1CC1
Show InChI InChI=1S/C25H26F3N3O3/c1-3-30(22(32)10-16-5-6-16)13-18-11-19(25(26,27)28)7-9-21(18)31-14-17(12-23(33)34)20-8-4-15(2)29-24(20)31/h4,7-9,11,14,16H,3,5-6,10,12-13H2,1-2H3,(H,33,34)
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n/an/a 7n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034995
PNG
(CHEMBL3343117)
Show SMILES CCN(Cc1cc(ccc1-c1cc(CC(O)=O)n2ccc(C)nc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C24H24F3N3O3/c1-3-29(23(33)15-4-5-15)13-16-10-17(24(25,26)27)6-7-19(16)20-11-18(12-21(31)32)30-9-8-14(2)28-22(20)30/h6-11,15H,3-5,12-13H2,1-2H3,(H,31,32)
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n/an/a 7n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035019
PNG
(CHEMBL3343118)
Show SMILES CCN(Cc1cc(ccc1-c1cc(CC(O)=O)c2ccc(C)nn12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C24H24F3N3O3/c1-3-29(23(33)15-5-6-15)13-17-10-18(24(25,26)27)7-8-19(17)21-11-16(12-22(31)32)20-9-4-14(2)28-30(20)21/h4,7-11,15H,3,5-6,12-13H2,1-2H3,(H,31,32)
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n/an/a 7.30n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034994
PNG
(CHEMBL3343116)
Show SMILES CCN(Cc1ccccc1-n1cc(CC(O)=O)c2ccc(cc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C24H23F3N2O3/c1-2-28(23(32)15-7-8-15)13-16-5-3-4-6-20(16)29-14-17(11-22(30)31)19-10-9-18(12-21(19)29)24(25,26)27/h3-6,9-10,12,14-15H,2,7-8,11,13H2,1H3,(H,30,31)
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n/an/a 7.70n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034972
PNG
(CHEMBL3343004)
Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C24H24F3N3O3/c1-3-29(23(33)15-5-6-15)12-17-10-18(24(25,26)27)7-9-20(17)30-13-16(11-21(31)32)19-8-4-14(2)28-22(19)30/h4,7-10,13,15H,3,5-6,11-12H2,1-2H3,(H,31,32)
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n/an/a 7.80n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034975
PNG
(CHEMBL3343007)
Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2ccc(nc12)C(F)F)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C24H22F5N3O3/c1-2-31(23(35)13-3-4-13)11-15-9-16(24(27,28)29)5-8-19(15)32-12-14(10-20(33)34)17-6-7-18(21(25)26)30-22(17)32/h5-9,12-13,21H,2-4,10-11H2,1H3,(H,33,34)
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n/an/a 8n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035021
PNG
(CHEMBL3343119)
Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(F)(F)F)C(=O)C1CCC1
Show InChI InChI=1S/C25H26F3N3O3/c1-3-30(24(34)16-5-4-6-16)13-18-11-19(25(26,27)28)8-10-21(18)31-14-17(12-22(32)33)20-9-7-15(2)29-23(20)31/h7-11,14,16H,3-6,12-13H2,1-2H3,(H,32,33)
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n/an/a 8.5n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035023
PNG
(CHEMBL3343121)
Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(F)(F)F)C(=O)COC
Show InChI InChI=1S/C23H24F3N3O4/c1-4-28(20(30)13-33-3)11-16-9-17(23(24,25)26)6-8-19(16)29-12-15(10-21(31)32)18-7-5-14(2)27-22(18)29/h5-9,12H,4,10-11,13H2,1-3H3,(H,31,32)
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n/an/a 9n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034954
PNG
(CHEMBL3338149)
Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2cccnc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C23H22F3N3O3/c1-2-28(22(32)14-5-6-14)12-16-10-17(23(24,25)26)7-8-19(16)29-13-15(11-20(30)31)18-4-3-9-27-21(18)29/h3-4,7-10,13-14H,2,5-6,11-12H2,1H3,(H,30,31)
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n/an/a 9n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034967
PNG
(CHEMBL3342999)
Show SMILES CCN(Cc1cc(ccc1-c1nn(CC(O)=O)c2ccc(C)cc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C24H24F3N3O3/c1-3-29(23(33)15-5-6-15)12-16-11-17(24(25,26)27)7-8-18(16)22-19-10-14(2)4-9-20(19)30(28-22)13-21(31)32/h4,7-11,15H,3,5-6,12-13H2,1-2H3,(H,31,32)
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n/an/a 9n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034980
PNG
(CHEMBL3338153)
Show SMILES CCN(Cc1ccccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(=O)C1CC1
Show InChI InChI=1S/C23H25N3O3/c1-3-25(23(29)16-9-10-16)13-17-6-4-5-7-20(17)26-14-18(12-21(27)28)19-11-8-15(2)24-22(19)26/h4-8,11,14,16H,3,9-10,12-13H2,1-2H3,(H,27,28)
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n/an/a 9.5n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034973
PNG
(CHEMBL3343005)
Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2ccc(CC)nc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C25H26F3N3O3/c1-3-19-8-9-20-16(12-22(32)33)14-31(23(20)29-19)21-10-7-18(25(26,27)28)11-17(21)13-30(4-2)24(34)15-5-6-15/h7-11,14-15H,3-6,12-13H2,1-2H3,(H,32,33)
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n/an/a 10n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034987
PNG
(CHEMBL3343113)
Show SMILES CCN(Cc1cc(ccc1-c1cn(CC(O)=O)c2ccc(C)nc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C24H24F3N3O3/c1-3-29(23(33)15-5-6-15)11-16-10-17(24(25,26)27)7-8-18(16)19-12-30(13-21(31)32)20-9-4-14(2)28-22(19)20/h4,7-10,12,15H,3,5-6,11,13H2,1-2H3,(H,31,32)
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n/an/a 10n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035020
PNG
(CHEMBL3338271)
Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(F)(F)F)C(C)=O
Show InChI InChI=1S/C22H22F3N3O3/c1-4-27(14(3)29)11-16-9-17(22(23,24)25)6-8-19(16)28-12-15(10-20(30)31)18-7-5-13(2)26-21(18)28/h5-9,12H,4,10-11H2,1-3H3,(H,30,31)
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n/an/a 10n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034972
PNG
(CHEMBL3343004)
Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C24H24F3N3O3/c1-3-29(23(33)15-5-6-15)12-17-10-18(24(25,26)27)7-9-20(17)30-13-16(11-21(31)32)19-8-4-14(2)28-22(19)30/h4,7-10,13,15H,3,5-6,11-12H2,1-2H3,(H,31,32)
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n/an/a 10n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034970
PNG
(CHEMBL3343002)
Show SMILES CCN(Cc1cc(ccc1-c1nn(CC(O)=O)c2ccc(F)c(Cl)c12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C23H20ClF4N3O3/c1-2-30(22(34)12-3-4-12)10-13-9-14(23(26,27)28)5-6-15(13)21-19-17(8-7-16(25)20(19)24)31(29-21)11-18(32)33/h5-9,12H,2-4,10-11H2,1H3,(H,32,33)
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n/an/a 10n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035021
PNG
(CHEMBL3343119)
Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(F)(F)F)C(=O)C1CCC1
Show InChI InChI=1S/C25H26F3N3O3/c1-3-30(24(34)16-5-4-6-16)13-18-11-19(25(26,27)28)8-10-21(18)31-14-17(12-22(32)33)20-9-7-15(2)29-23(20)31/h7-11,14,16H,3-6,12-13H2,1-2H3,(H,32,33)
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n/an/a 10n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035029
PNG
(CHEMBL3343127)
Show SMILES Cc1ccc2c(CC(O)=O)cn(-c3ccc(cc3CN(CC3CC3)C(=O)C3CC3)C(F)(F)F)c2n1
Show InChI InChI=1S/C26H26F3N3O3/c1-15-2-8-21-18(11-23(33)34)14-32(24(21)30-15)22-9-7-20(26(27,28)29)10-19(22)13-31(12-16-3-4-16)25(35)17-5-6-17/h2,7-10,14,16-17H,3-6,11-13H2,1H3,(H,33,34)
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n/an/a 11n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034985
PNG
(CHEMBL3343111)
Show SMILES CCN(Cc1cc(F)ccc1-c1cn(CC(O)=O)c2ccccc12)C(=O)C1CC1
Show InChI InChI=1S/C23H23FN2O3/c1-2-25(23(29)15-7-8-15)12-16-11-17(24)9-10-18(16)20-13-26(14-22(27)28)21-6-4-3-5-19(20)21/h3-6,9-11,13,15H,2,7-8,12,14H2,1H3,(H,27,28)
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n/an/a 11n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034994
PNG
(CHEMBL3343116)
Show SMILES CCN(Cc1ccccc1-n1cc(CC(O)=O)c2ccc(cc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C24H23F3N2O3/c1-2-28(23(32)15-7-8-15)13-16-5-3-4-6-20(16)29-14-17(11-22(30)31)19-10-9-18(12-21(19)29)24(25,26)27/h3-6,9-10,12,14-15H,2,7-8,11,13H2,1H3,(H,30,31)
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n/an/a 11n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034985
PNG
(CHEMBL3343111)
Show SMILES CCN(Cc1cc(F)ccc1-c1cn(CC(O)=O)c2ccccc12)C(=O)C1CC1
Show InChI InChI=1S/C23H23FN2O3/c1-2-25(23(29)15-7-8-15)12-16-11-17(24)9-10-18(16)20-13-26(14-22(27)28)21-6-4-3-5-19(20)21/h3-6,9-11,13,15H,2,7-8,12,14H2,1H3,(H,27,28)
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n/an/a 11n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034975
PNG
(CHEMBL3343007)
Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2ccc(nc12)C(F)F)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C24H22F5N3O3/c1-2-31(23(35)13-3-4-13)11-15-9-16(24(27,28)29)5-8-19(15)32-12-14(10-20(33)34)17-6-7-18(21(25)26)30-22(17)32/h5-9,12-13,21H,2-4,10-11H2,1H3,(H,33,34)
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n/an/a 11n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034978
PNG
(CHEMBL3343105)
Show SMILES CCN(Cc1cc(F)ccc1-n1cc(CC(O)=O)c2cccnc12)C(=O)C1CC1
Show InChI InChI=1S/C22H22FN3O3/c1-2-25(22(29)14-5-6-14)12-16-10-17(23)7-8-19(16)26-13-15(11-20(27)28)18-4-3-9-24-21(18)26/h3-4,7-10,13-14H,2,5-6,11-12H2,1H3,(H,27,28)
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Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034956
PNG
(CHEMBL3338150)
Show SMILES CCN(Cc1cc(ccc1-c1cc(CC(O)=O)n2cccnc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C23H22F3N3O3/c1-2-28(22(32)14-4-5-14)13-15-10-16(23(24,25)26)6-7-18(15)19-11-17(12-20(30)31)29-9-3-8-27-21(19)29/h3,6-11,14H,2,4-5,12-13H2,1H3,(H,30,31)
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n/an/a 13n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034982
PNG
(CHEMBL3343108)
Show SMILES CCN(Cc1cc(C)ccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(=O)C1CC1
Show InChI InChI=1S/C24H27N3O3/c1-4-26(24(30)17-7-8-17)13-19-11-15(2)5-10-21(19)27-14-18(12-22(28)29)20-9-6-16(3)25-23(20)27/h5-6,9-11,14,17H,4,7-8,12-13H2,1-3H3,(H,28,29)
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n/an/a 13n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034967
PNG
(CHEMBL3342999)
Show SMILES CCN(Cc1cc(ccc1-c1nn(CC(O)=O)c2ccc(C)cc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C24H24F3N3O3/c1-3-29(23(33)15-5-6-15)12-16-11-17(24(25,26)27)7-8-18(16)22-19-10-14(2)4-9-20(19)30(28-22)13-21(31)32/h4,7-11,15H,3,5-6,12-13H2,1-2H3,(H,31,32)
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n/an/a 13n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035032
PNG
(CHEMBL3343130)
Show SMILES Cc1ccc2c(CC(O)=O)cn(-c3ccc(cc3CN(CCO)C(=O)C3CC3)C(F)(F)F)c2n1
Show InChI InChI=1S/C24H24F3N3O4/c1-14-2-6-19-16(11-21(32)33)13-30(22(19)28-14)20-7-5-18(24(25,26)27)10-17(20)12-29(8-9-31)23(34)15-3-4-15/h2,5-7,10,13,15,31H,3-4,8-9,11-12H2,1H3,(H,32,33)
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n/an/a 14n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034986
PNG
(CHEMBL3343112)
Show SMILES CCN(Cc1cc(F)ccc1-c1cn(CC(O)=O)c2ccc(cc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C24H22F4N2O3/c1-2-29(23(33)14-3-4-14)11-15-9-17(25)6-7-18(15)20-12-30(13-22(31)32)21-8-5-16(10-19(20)21)24(26,27)28/h5-10,12,14H,2-4,11,13H2,1H3,(H,31,32)
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n/an/a 14n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034990
PNG
(CHEMBL3343114)
Show SMILES CCN(Cc1cc(ccc1-c1cn(CC(O)=O)c2ccc(nc12)C(F)(F)F)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C24H21F6N3O3/c1-2-32(22(36)13-3-4-13)10-14-9-15(23(25,26)27)5-6-16(14)17-11-33(12-20(34)35)18-7-8-19(24(28,29)30)31-21(17)18/h5-9,11,13H,2-4,10,12H2,1H3,(H,34,35)
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n/an/a 15n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034969
PNG
(CHEMBL3343001)
Show SMILES CCN(Cc1cc(ccc1-c1nn(CC(O)=O)c2ccc(Cl)c(F)c12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C23H20ClF4N3O3/c1-2-30(22(34)12-3-4-12)10-13-9-14(23(26,27)28)5-6-15(13)21-19-17(8-7-16(24)20(19)25)31(29-21)11-18(32)33/h5-9,12H,2-4,10-11H2,1H3,(H,32,33)
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n/an/a 15n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034968
PNG
(CHEMBL3343000)
Show SMILES CCN(Cc1cc(ccc1-c1nn(CC(O)=O)c2ccc(F)cc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C23H21F4N3O3/c1-2-29(22(33)13-3-4-13)11-14-9-15(23(25,26)27)5-7-17(14)21-18-10-16(24)6-8-19(18)30(28-21)12-20(31)32/h5-10,13H,2-4,11-12H2,1H3,(H,31,32)
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n/an/a 15n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034948
PNG
(CHEMBL3338146)
Show SMILES CCN(Cc1cc(ccc1-c1cn(CC(O)=O)c2cccnc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C23H22F3N3O3/c1-2-28(22(32)14-5-6-14)11-15-10-16(23(24,25)26)7-8-17(15)18-12-29(13-20(30)31)19-4-3-9-27-21(18)19/h3-4,7-10,12,14H,2,5-6,11,13H2,1H3,(H,30,31)
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n/an/a 15n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034966
PNG
(CHEMBL3342998)
Show SMILES CCN(Cc1cc(ccc1-c1nn(CC(O)=O)c2ccc(Cl)cc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C23H21ClF3N3O3/c1-2-29(22(33)13-3-4-13)11-14-9-15(23(25,26)27)5-7-17(14)21-18-10-16(24)6-8-19(18)30(28-21)12-20(31)32/h5-10,13H,2-4,11-12H2,1H3,(H,31,32)
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n/an/a 16n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034986
PNG
(CHEMBL3343112)
Show SMILES CCN(Cc1cc(F)ccc1-c1cn(CC(O)=O)c2ccc(cc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C24H22F4N2O3/c1-2-29(23(33)14-3-4-14)11-15-9-17(25)6-7-18(15)20-12-30(13-22(31)32)21-8-5-16(10-19(20)21)24(26,27)28/h5-10,12,14H,2-4,11,13H2,1H3,(H,31,32)
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n/an/a 17n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034987
PNG
(CHEMBL3343113)
Show SMILES CCN(Cc1cc(ccc1-c1cn(CC(O)=O)c2ccc(C)nc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C24H24F3N3O3/c1-3-29(23(33)15-5-6-15)11-16-10-17(24(25,26)27)7-8-18(16)19-12-30(13-21(31)32)20-9-4-14(2)28-22(19)20/h4,7-10,12,15H,3,5-6,11,13H2,1-2H3,(H,31,32)
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n/an/a 17n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034978
PNG
(CHEMBL3343105)
Show SMILES CCN(Cc1cc(F)ccc1-n1cc(CC(O)=O)c2cccnc12)C(=O)C1CC1
Show InChI InChI=1S/C22H22FN3O3/c1-2-25(22(29)14-5-6-14)12-16-10-17(23)7-8-19(16)26-13-15(11-20(27)28)18-4-3-9-24-21(18)26/h3-4,7-10,13-14H,2,5-6,11-12H2,1H3,(H,27,28)
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n/an/a 17n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034964
PNG
(CHEMBL3342996)
Show SMILES CCN(Cc1cc(ccc1-c1nn(CC(O)=O)c2cccc(C)c12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C24H24F3N3O3/c1-3-29(23(33)15-7-8-15)12-16-11-17(24(25,26)27)9-10-18(16)22-21-14(2)5-4-6-19(21)30(28-22)13-20(31)32/h4-6,9-11,15H,3,7-8,12-13H2,1-2H3,(H,31,32)
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n/an/a 17n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034969
PNG
(CHEMBL3343001)
Show SMILES CCN(Cc1cc(ccc1-c1nn(CC(O)=O)c2ccc(Cl)c(F)c12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C23H20ClF4N3O3/c1-2-30(22(34)12-3-4-12)10-13-9-14(23(26,27)28)5-6-15(13)21-19-17(8-7-16(24)20(19)25)31(29-21)11-18(32)33/h5-9,12H,2-4,10-11H2,1H3,(H,32,33)
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n/an/a 18n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034981
PNG
(CHEMBL3343107)
Show SMILES CCN(Cc1cc(Cl)ccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(=O)C1CC1
Show InChI InChI=1S/C23H24ClN3O3/c1-3-26(23(30)15-5-6-15)12-17-10-18(24)7-9-20(17)27-13-16(11-21(28)29)19-8-4-14(2)25-22(19)27/h4,7-10,13,15H,3,5-6,11-12H2,1-2H3,(H,28,29)
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n/an/a 18n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034945
PNG
(CHEMBL3338144)
Show SMILES CCN(Cc1cc(ccc1-c1nn(CC(O)=O)c2ccccc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C23H22F3N3O3/c1-2-28(22(32)14-7-8-14)12-15-11-16(23(24,25)26)9-10-17(15)21-18-5-3-4-6-19(18)29(27-21)13-20(30)31/h3-6,9-11,14H,2,7-8,12-13H2,1H3,(H,30,31)
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n/an/a 19n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034948
PNG
(CHEMBL3338146)
Show SMILES CCN(Cc1cc(ccc1-c1cn(CC(O)=O)c2cccnc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C23H22F3N3O3/c1-2-28(22(32)14-5-6-14)11-15-10-16(23(24,25)26)7-8-17(15)18-12-29(13-20(30)31)19-4-3-9-27-21(18)19/h3-4,7-10,12,14H,2,5-6,11,13H2,1H3,(H,30,31)
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n/an/a 20n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035029
PNG
(CHEMBL3343127)
Show SMILES Cc1ccc2c(CC(O)=O)cn(-c3ccc(cc3CN(CC3CC3)C(=O)C3CC3)C(F)(F)F)c2n1
Show InChI InChI=1S/C26H26F3N3O3/c1-15-2-8-21-18(11-23(33)34)14-32(24(21)30-15)22-9-7-20(26(27,28)29)10-19(22)13-31(12-16-3-4-16)25(35)17-5-6-17/h2,7-10,14,16-17H,3-6,11-13H2,1H3,(H,33,34)
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n/an/a 22n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034966
PNG
(CHEMBL3342998)
Show SMILES CCN(Cc1cc(ccc1-c1nn(CC(O)=O)c2ccc(Cl)cc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C23H21ClF3N3O3/c1-2-29(22(33)13-3-4-13)11-14-9-15(23(25,26)27)5-7-17(14)21-18-10-16(24)6-8-19(18)30(28-21)12-20(31)32/h5-10,13H,2-4,11-12H2,1H3,(H,31,32)
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n/an/a 23n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034962
PNG
(CHEMBL3342995)
Show SMILES CCN(Cc1cc(ccc1-c1nn(CC(O)=O)c2cccc(OC)c12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C24H24F3N3O4/c1-3-29(23(33)14-7-8-14)12-15-11-16(24(25,26)27)9-10-17(15)22-21-18(5-4-6-19(21)34-2)30(28-22)13-20(31)32/h4-6,9-11,14H,3,7-8,12-13H2,1-2H3,(H,31,32)
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n/an/a 23n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034960
PNG
(CHEMBL3342994)
Show SMILES CCN(Cc1cc(ccc1-c1nn(CC(O)=O)c2cccc(F)c12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C23H21F4N3O3/c1-2-29(22(33)13-6-7-13)11-14-10-15(23(25,26)27)8-9-16(14)21-20-17(24)4-3-5-18(20)30(28-21)12-19(31)32/h3-5,8-10,13H,2,6-7,11-12H2,1H3,(H,31,32)
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n/an/a 23n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034995
PNG
(CHEMBL3343117)
Show SMILES CCN(Cc1cc(ccc1-c1cc(CC(O)=O)n2ccc(C)nc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C24H24F3N3O3/c1-3-29(23(33)15-4-5-15)13-16-10-17(24(25,26)27)6-7-19(16)20-11-18(12-21(31)32)30-9-8-14(2)28-22(20)30/h6-11,15H,3-5,12-13H2,1-2H3,(H,31,32)
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n/an/a 24n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035024
PNG
(CHEMBL3343122)
Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(F)(F)F)C(=O)Cc1ccccc1
Show InChI InChI=1S/C28H26F3N3O3/c1-3-33(25(35)13-19-7-5-4-6-8-19)16-21-14-22(28(29,30)31)10-12-24(21)34-17-20(15-26(36)37)23-11-9-18(2)32-27(23)34/h4-12,14,17H,3,13,15-16H2,1-2H3,(H,36,37)
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n/an/a 25n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034962
PNG
(CHEMBL3342995)
Show SMILES CCN(Cc1cc(ccc1-c1nn(CC(O)=O)c2cccc(OC)c12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C24H24F3N3O4/c1-3-29(23(33)14-7-8-14)12-15-11-16(24(25,26)27)9-10-17(15)22-21-18(5-4-6-19(21)34-2)30(28-22)13-20(31)32/h4-6,9-11,14H,3,7-8,12-13H2,1-2H3,(H,31,32)
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n/an/a 27n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035028
PNG
(CHEMBL3343126)
Show SMILES CC(C)N(Cc1cc(ccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C25H26F3N3O3/c1-14(2)30(24(34)16-5-6-16)13-18-10-19(25(26,27)28)7-9-21(18)31-12-17(11-22(32)33)20-8-4-15(3)29-23(20)31/h4,7-10,12,14,16H,5-6,11,13H2,1-3H3,(H,32,33)
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n/an/a 28n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035022
PNG
(CHEMBL3343120)
Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(F)(F)F)C(=O)CC1CC1
Show InChI InChI=1S/C25H26F3N3O3/c1-3-30(22(32)10-16-5-6-16)13-18-11-19(25(26,27)28)7-9-21(18)31-14-17(12-23(33)34)20-8-4-15(2)29-24(20)31/h4,7-9,11,14,16H,3,5-6,10,12-13H2,1-2H3,(H,33,34)
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n/an/a 29n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034965
PNG
(CHEMBL3342997)
Show SMILES CCN(Cc1cc(ccc1-c1nn(CC(O)=O)c2cccc(C#N)c12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C24H21F3N4O3/c1-2-30(23(34)14-6-7-14)12-16-10-17(24(25,26)27)8-9-18(16)22-21-15(11-28)4-3-5-19(21)31(29-22)13-20(32)33/h3-5,8-10,14H,2,6-7,12-13H2,1H3,(H,32,33)
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n/an/a 33n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034954
PNG
(CHEMBL3338149)
Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2cccnc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C23H22F3N3O3/c1-2-28(22(32)14-5-6-14)12-16-10-17(23(24,25)26)7-8-19(16)29-13-15(11-20(30)31)18-4-3-9-27-21(18)29/h3-4,7-10,13-14H,2,5-6,11-12H2,1H3,(H,30,31)
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n/an/a 34n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034968
PNG
(CHEMBL3343000)
Show SMILES CCN(Cc1cc(ccc1-c1nn(CC(O)=O)c2ccc(F)cc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C23H21F4N3O3/c1-2-29(22(33)13-3-4-13)11-14-9-15(23(25,26)27)5-7-17(14)21-18-10-16(24)6-8-19(18)30(28-21)12-20(31)32/h5-10,13H,2-4,11-12H2,1H3,(H,31,32)
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n/an/a 34n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034953
PNG
(CHEMBL3338148)
Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2ccccc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C24H23F3N2O3/c1-2-28(23(32)15-7-8-15)13-17-11-18(24(25,26)27)9-10-20(17)29-14-16(12-22(30)31)19-5-3-4-6-21(19)29/h3-6,9-11,14-15H,2,7-8,12-13H2,1H3,(H,30,31)
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n/an/a 37n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034984
PNG
(CHEMBL3343110)
Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2ccc(C)nc12)S(C)(=O)=O)C(=O)C1CC1
Show InChI InChI=1S/C24H27N3O5S/c1-4-26(24(30)16-6-7-16)13-18-11-19(33(3,31)32)8-10-21(18)27-14-17(12-22(28)29)20-9-5-15(2)25-23(20)27/h5,8-11,14,16H,4,6-7,12-13H2,1-3H3,(H,28,29)
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n/an/a 40n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034945
PNG
(CHEMBL3338144)
Show SMILES CCN(Cc1cc(ccc1-c1nn(CC(O)=O)c2ccccc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C23H22F3N3O3/c1-2-28(22(32)14-7-8-14)12-15-11-16(23(24,25)26)9-10-17(15)21-18-5-3-4-6-19(18)29(27-21)13-20(30)31/h3-6,9-11,14H,2,7-8,12-13H2,1H3,(H,30,31)
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n/an/a 47n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034974
PNG
(CHEMBL3343006)
Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2ccc(nc12)C1CC1)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C26H26F3N3O3/c1-2-31(25(35)16-5-6-16)13-18-11-19(26(27,28)29)7-10-22(18)32-14-17(12-23(33)34)20-8-9-21(15-3-4-15)30-24(20)32/h7-11,14-16H,2-6,12-13H2,1H3,(H,33,34)
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n/an/a 49n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034976
PNG
(CHEMBL3343008)
Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2ccc(nc12)C(F)(F)F)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C24H21F6N3O3/c1-2-32(22(36)13-3-4-13)11-15-9-16(23(25,26)27)5-7-18(15)33-12-14(10-20(34)35)17-6-8-19(24(28,29)30)31-21(17)33/h5-9,12-13H,2-4,10-11H2,1H3,(H,34,35)
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n/an/a 54n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035030
PNG
(CHEMBL3343128)
Show SMILES Cc1ccc2c(CC(O)=O)cn(-c3ccc(cc3CN(CCOc3ccccc3)C(=O)C3CC3)C(F)(F)F)c2n1
Show InChI InChI=1S/C30H28F3N3O4/c1-19-7-11-25-21(16-27(37)38)18-36(28(25)34-19)26-12-10-23(30(31,32)33)15-22(26)17-35(29(39)20-8-9-20)13-14-40-24-5-3-2-4-6-24/h2-7,10-12,15,18,20H,8-9,13-14,16-17H2,1H3,(H,37,38)
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n/an/a 60n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034970
PNG
(CHEMBL3343002)
Show SMILES CCN(Cc1cc(ccc1-c1nn(CC(O)=O)c2ccc(F)c(Cl)c12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C23H20ClF4N3O3/c1-2-30(22(34)12-3-4-12)10-13-9-14(23(26,27)28)5-6-15(13)21-19-17(8-7-16(25)20(19)24)31(29-21)11-18(32)33/h5-9,12H,2-4,10-11H2,1H3,(H,32,33)
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n/an/a 71n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034990
PNG
(CHEMBL3343114)
Show SMILES CCN(Cc1cc(ccc1-c1cn(CC(O)=O)c2ccc(nc12)C(F)(F)F)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C24H21F6N3O3/c1-2-32(22(36)13-3-4-13)10-14-9-15(23(25,26)27)5-6-16(14)17-11-33(12-20(34)35)18-7-8-19(24(28,29)30)31-21(17)18/h5-9,11,13H,2-4,10,12H2,1H3,(H,34,35)
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n/an/a 82n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034953
PNG
(CHEMBL3338148)
Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2ccccc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C24H23F3N2O3/c1-2-28(23(32)15-7-8-15)13-17-11-18(24(25,26)27)9-10-20(17)29-14-16(12-22(30)31)19-5-3-4-6-21(19)29/h3-6,9-11,14-15H,2,7-8,12-13H2,1H3,(H,30,31)
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n/an/a 84n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035025
PNG
(CHEMBL3343123)
Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(F)(F)F)C(=O)c1ccccn1
Show InChI InChI=1S/C26H23F3N4O3/c1-3-32(25(36)21-6-4-5-11-30-21)14-18-12-19(26(27,28)29)8-10-22(18)33-15-17(13-23(34)35)20-9-7-16(2)31-24(20)33/h4-12,15H,3,13-14H2,1-2H3,(H,34,35)
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n/an/a 97n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034965
PNG
(CHEMBL3342997)
Show SMILES CCN(Cc1cc(ccc1-c1nn(CC(O)=O)c2cccc(C#N)c12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C24H21F3N4O3/c1-2-30(23(34)14-6-7-14)12-16-10-17(24(25,26)27)8-9-18(16)22-21-15(11-28)4-3-5-19(21)31(29-22)13-20(32)33/h3-5,8-10,14H,2,6-7,12-13H2,1H3,(H,32,33)
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n/an/a 103n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034964
PNG
(CHEMBL3342996)
Show SMILES CCN(Cc1cc(ccc1-c1nn(CC(O)=O)c2cccc(C)c12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C24H24F3N3O3/c1-3-29(23(33)15-7-8-15)12-16-11-17(24(25,26)27)9-10-18(16)22-21-14(2)5-4-6-19(21)30(28-22)13-20(31)32/h4-6,9-11,15H,3,7-8,12-13H2,1-2H3,(H,31,32)
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n/an/a 108n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034992
PNG
(CHEMBL3343115)
Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2ccc(C)cc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C25H25F3N2O3/c1-3-29(24(33)16-5-6-16)13-18-11-19(25(26,27)28)7-9-21(18)30-14-17(12-23(31)32)20-8-4-15(2)10-22(20)30/h4,7-11,14,16H,3,5-6,12-13H2,1-2H3,(H,31,32)
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n/an/a 119n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034971
PNG
(CHEMBL3343003)
Show SMILES CCN(Cc1cc(ccc1-c1nn(CC(O)=O)c2cc(F)ccc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C23H21F4N3O3/c1-2-29(22(33)13-3-4-13)11-14-9-15(23(25,26)27)5-7-17(14)21-18-8-6-16(24)10-19(18)30(28-21)12-20(31)32/h5-10,13H,2-4,11-12H2,1H3,(H,31,32)
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n/an/a 127n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034977
PNG
(CHEMBL3343104)
Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2ccc(OC)nc12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C24H24F3N3O4/c1-3-29(23(33)14-4-5-14)12-16-10-17(24(25,26)27)6-8-19(16)30-13-15(11-21(31)32)18-7-9-20(34-2)28-22(18)30/h6-10,13-14H,3-5,11-12H2,1-2H3,(H,31,32)
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n/an/a 135n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50034959
PNG
(CHEMBL3342993)
Show SMILES CCN(Cc1cc(ccc1-c1nn(CC(O)=O)c2cccc(Cl)c12)C(F)(F)F)C(=O)C1CC1
Show InChI InChI=1S/C23H21ClF3N3O3/c1-2-29(22(33)13-6-7-13)11-14-10-15(23(25,26)27)8-9-16(14)21-20-17(24)4-3-5-18(20)30(28-21)12-19(31)32/h3-5,8-10,13H,2,6-7,11-12H2,1H3,(H,31,32)
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n/an/a 160n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins wi...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM50035027
PNG
(CHEMBL3343125)
Show SMILES CCN(Cc1cc(ccc1-n1cc(CC(O)=O)c2ccc(C)nc12)C(F)(F)F)C(=O)CN(C)C
Show InChI InChI=1S/C24H27F3N4O3/c1-5-30(21(32)14-29(3)4)12-17-10-18(24(25,26)27)7-9-20(17)31-13-16(11-22(33)34)19-8-6-15(2)28-23(19)31/h6-10,13H,5,11-12,14H2,1-4H3,(H,33,34)
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n/an/a 163n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measur...

Bioorg Med Chem Lett 24: 5123-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.029
BindingDB Entry DOI: 10.7270/Q2CF9RRW
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%