| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin D2 receptor 2 |
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| Ligand | BDBM50034987 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1431831 (CHEMBL3385688) |
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| IC50 | 17±n/a nM |
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| Citation |  Alonso, JA; Andrés, M; Bravo, M; Calbet, M; Eastwood, PR; Eichhorn, P; Esteve, C; Ferrer, M; Gómez, E; González, J; Mir, M; Moreno, I; Petit, S; Roberts, RS; Sevilla, S; Vidal, B; Vidal, L; Vilaseca, P; Zanuy, M Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists II: lead optimization. Bioorg Med Chem Lett24:5123-6 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin D2 receptor 2 |
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| Name: | Prostaglandin D2 receptor 2 |
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| Synonyms: | CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 43295.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y5Y4 |
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| Residue: | 395 |
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| Sequence: | MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
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| BDBM50034987 |
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| n/a |
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| Name | BDBM50034987 |
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| Synonyms: | CHEMBL3343113 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H24F3N3O3 |
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| Mol. Mass. | 459.4609 |
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| SMILES | CCN(Cc1cc(ccc1-c1cn(CC(O)=O)c2ccc(C)nc12)C(F)(F)F)C(=O)C1CC1 |
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| Structure | 
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