Affinity Data by PubMed id=25811913

PubMed code 25811913

Found 8 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM152698 ((S)-2-Amino-5-formimidamidopentanoic acid (7)) Show SMILES N[C@@H](CCCNC=N)C(O)=O \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	180	n/a	400	n/a	n/a	n/a	n/a	7.4	n/a
Northwestern University					Assay Description The assay mixture contained L-arginine (10 μM), NADPH (100 μM), oxyhemoglobin (0.125 mg/mL), tetrahydrobiopterin (10 μM), and differen...				Biochemistry 54: 2530-8 (2015) Article DOI: 10.1021/acs.biochem.5b00135 BindingDB Entry DOI: 10.7270/Q23B5XWQ
Northwestern University					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM152697 ((S)-5-Acetimidamido-2-aminopentanoic acid (4, L-NI...) Show SMILES CC(=N)NCCC[C@H](N)C(O)=O \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	Article PubMed	3.65E+3	n/a	8.10E+3	n/a	n/a	n/a	n/a	7.4	n/a
Northwestern University					Assay Description The assay mixture contained L-arginine (10 μM), NADPH (100 μM), oxyhemoglobin (0.125 mg/mL), tetrahydrobiopterin (10 μM), and differen...				Biochemistry 54: 2530-8 (2015) Article DOI: 10.1021/acs.biochem.5b00135 BindingDB Entry DOI: 10.7270/Q23B5XWQ
Northwestern University					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM152699 ((S)-2-Amino-5-propionimidamidopentanoic acid (8) \|...) Show SMILES CCC(=N)NCCC[C@H](N)C(O)=O \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	Article PubMed	7.25E+3	n/a	1.61E+4	n/a	n/a	n/a	n/a	7.4	n/a
Northwestern University					Assay Description The assay mixture contained L-arginine (10 μM), NADPH (100 μM), oxyhemoglobin (0.125 mg/mL), tetrahydrobiopterin (10 μM), and differen...				Biochemistry 54: 2530-8 (2015) Article DOI: 10.1021/acs.biochem.5b00135 BindingDB Entry DOI: 10.7270/Q23B5XWQ
Northwestern University					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM152700 ((S)-2-Amino-5-butyrimidamidopentanoic acid (9) \| h...) Show SMILES CCCC(=N)NCCC[C@H](N)C(O)=O \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	8.61E+3	n/a	1.91E+4	n/a	n/a	n/a	n/a	7.4	n/a
Northwestern University					Assay Description The assay mixture contained L-arginine (10 μM), NADPH (100 μM), oxyhemoglobin (0.125 mg/mL), tetrahydrobiopterin (10 μM), and differen...				Biochemistry 54: 2530-8 (2015) Article DOI: 10.1021/acs.biochem.5b00135 BindingDB Entry DOI: 10.7270/Q23B5XWQ
Northwestern University					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM152702 ((S)-2-Amino-5-(3-methylbutanimidamido)pentanoic ac...) Show SMILES CC(C)CC(=N)NCCC[C@H](N)C(O)=O \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	3.10E+4	n/a	6.87E+4	n/a	n/a	n/a	n/a	7.4	n/a
Northwestern University					Assay Description The assay mixture contained L-arginine (10 μM), NADPH (100 μM), oxyhemoglobin (0.125 mg/mL), tetrahydrobiopterin (10 μM), and differen...				Biochemistry 54: 2530-8 (2015) Article DOI: 10.1021/acs.biochem.5b00135 BindingDB Entry DOI: 10.7270/Q23B5XWQ
Northwestern University					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM152701 ((S)-2-Amino-5-isobutyrimidamidopentanoic acid (10)) Show SMILES CC(C)C(=N)NCCC[C@H](N)C(O)=O \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	6.52E+4	n/a	1.38E+5	n/a	n/a	n/a	n/a	7.4	n/a
Northwestern University					Assay Description The assay mixture contained L-arginine (10 μM), NADPH (100 μM), oxyhemoglobin (0.125 mg/mL), tetrahydrobiopterin (10 μM), and differen...				Biochemistry 54: 2530-8 (2015) Article DOI: 10.1021/acs.biochem.5b00135 BindingDB Entry DOI: 10.7270/Q23B5XWQ
Northwestern University					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM152703 ((S)-2-Amino-5-pivalimidamidopentanoic acid (12)) Show SMILES CC(C)(C)C(=N)NCCC[C@H](N)C(O)=O \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	1.46E+5	n/a	3.23E+5	n/a	n/a	n/a	n/a	7.4	n/a
Northwestern University					Assay Description The assay mixture contained L-arginine (10 μM), NADPH (100 μM), oxyhemoglobin (0.125 mg/mL), tetrahydrobiopterin (10 μM), and differen...				Biochemistry 54: 2530-8 (2015) Article DOI: 10.1021/acs.biochem.5b00135 BindingDB Entry DOI: 10.7270/Q23B5XWQ
Northwestern University					More data for this Ligand-Target Pair
Nitric oxide synthase, inducible (Mus musculus (mouse))	BDBM152704 ((S)-2-Amino-5-benzimidamidopentanoic acid (13)) Show SMILES N[C@@H](CCCNC(=N)c1ccccc1)C(O)=O \|r\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	2.40E+6	n/a	5.33E+6	n/a	n/a	n/a	n/a	7.4	n/a
Northwestern University					Assay Description The assay mixture contained L-arginine (10 μM), NADPH (100 μM), oxyhemoglobin (0.125 mg/mL), tetrahydrobiopterin (10 μM), and differen...				Biochemistry 54: 2530-8 (2015) Article DOI: 10.1021/acs.biochem.5b00135 BindingDB Entry DOI: 10.7270/Q23B5XWQ
Northwestern University					More data for this Ligand-Target Pair

* indicates data uncertainty>20%