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PubMed code 26271588

Compile data set for download or QSAR
Found 19 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glucagon receptor


(Homo sapiens (Human))		BDBM2437
PNG
(US8507533, 157)
Show SMILES CC1(C)CC(C1)C(Nc1cnc(nc1)-n1cc(cn1)C(F)(F)F)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C25H27F3N6O3/c1-24(2)9-17(10-24)21(15-3-5-16(6-4-15)22(37)29-8-7-20(35)36)33-19-12-30-23(31-13-19)34-14-18(11-32-34)25(26,27)28/h3-6,11-14,17,21,33H,7-10H2,1-2H3,(H,29,37)(H,35,36)
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 5.60n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in Chem-1 cell membranes after 6 to 10 hrs by scintillation proximity assay

Bioorg Med Chem Lett 25: 4057-64 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.092
BindingDB Entry DOI: 10.7270/Q2HM5B7N
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM142039
PNG
(US8927577, 118 | US8927577, 20 | US8927577, 35)
Show SMILES Cc1cc2cc(F)ccc2nc1NC(C1CC(C)(C)C1)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C27H30FN3O3/c1-16-12-19-13-21(28)8-9-22(19)30-25(16)31-24(20-14-27(2,3)15-20)17-4-6-18(7-5-17)26(34)29-11-10-23(32)33/h4-9,12-13,20,24H,10-11,14-15H2,1-3H3,(H,29,34)(H,30,31)(H,32,33)
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 14n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in Chem-1 cell membranes after 6 to 10 hrs by scintillation proximity assay

Bioorg Med Chem Lett 25: 4057-64 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.092
BindingDB Entry DOI: 10.7270/Q2HM5B7N
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50119555
PNG
(CHEMBL3617571)
Show SMILES CC(C)C[C@H](Nc1ccc(cn1)C(=O)NCCC(O)=O)c1cnc(nc1)-c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C25H26F3N5O3/c1-15(2)11-20(33-21-8-5-17(12-30-21)24(36)29-10-9-22(34)35)18-13-31-23(32-14-18)16-3-6-19(7-4-16)25(26,27)28/h3-8,12-15,20H,9-11H2,1-2H3,(H,29,36)(H,30,33)(H,34,35)/t20-/m0/s1
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 15n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in Chem-1 cell membranes after 6 to 10 hrs by scintillation proximity assay

Bioorg Med Chem Lett 25: 4057-64 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.092
BindingDB Entry DOI: 10.7270/Q2HM5B7N
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM123557
PNG
(US8748624, 43)
Show SMILES Cc1cc(ccc1-c1ccc(NCc2ccc(cc2-c2ccc(nc2)C(=O)NCCC(O)=O)C(F)(F)F)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C31H24ClF6N3O3/c1-17-12-20(30(33,34)35)5-7-23(17)24-8-6-22(14-26(24)32)40-15-18-2-4-21(31(36,37)38)13-25(18)19-3-9-27(41-16-19)29(44)39-11-10-28(42)43/h2-9,12-14,16,40H,10-11,15H2,1H3,(H,39,44)(H,42,43)
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 17n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from full length human glucagon receptor expressed in HEK293 cell membranes after 2 hrs by scintillation counting ana...

Bioorg Med Chem Lett 25: 4057-64 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.092
BindingDB Entry DOI: 10.7270/Q2HM5B7N
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50119557
PNG
(CHEMBL3617575)
Show SMILES Cc1cc(Cl)ccc1-c1ccc(NCc2cc(Cl)cc(c2-c2ccc(nc2)C(=O)NCCC(O)=O)C(F)(F)F)cc1
Show InChI InChI=1S/C30H24Cl2F3N3O3/c1-17-12-21(31)5-8-24(17)18-2-6-23(7-3-18)37-16-20-13-22(32)14-25(30(33,34)35)28(20)19-4-9-26(38-15-19)29(41)36-11-10-27(39)40/h2-9,12-15,37H,10-11,16H2,1H3,(H,36,41)(H,39,40)
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 20n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from full length human glucagon receptor expressed in HEK293 cell membranes after 2 hrs by scintillation counting ana...

Bioorg Med Chem Lett 25: 4057-64 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.092
BindingDB Entry DOI: 10.7270/Q2HM5B7N
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50119554
PNG
(CHEMBL3617570)
Show SMILES CC(C)C[C@@H](Nc1cnc(nc1)C(=O)NCCC(O)=O)c1ccc(cc1)-c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C26H27F3N4O3/c1-16(2)13-22(33-21-14-31-24(32-15-21)25(36)30-12-11-23(34)35)19-5-3-17(4-6-19)18-7-9-20(10-8-18)26(27,28)29/h3-10,14-16,22,33H,11-13H2,1-2H3,(H,30,36)(H,34,35)/t22-/m1/s1
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 22n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in Chem-1 cell membranes after 6 to 10 hrs by scintillation proximity assay

Bioorg Med Chem Lett 25: 4057-64 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.092
BindingDB Entry DOI: 10.7270/Q2HM5B7N
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50119553
PNG
(CHEMBL3617566)
Show SMILES CCC[C@H](Nc1ccc(cc1)-n1cc(cn1)-c1ccccc1)c1ccc(cc1)C(=O)NCCC(O)=O |r|
Show InChI InChI=1S/C29H30N4O3/c1-2-6-27(22-9-11-23(12-10-22)29(36)30-18-17-28(34)35)32-25-13-15-26(16-14-25)33-20-24(19-31-33)21-7-4-3-5-8-21/h3-5,7-16,19-20,27,32H,2,6,17-18H2,1H3,(H,30,36)(H,34,35)/t27-/m0/s1
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 26n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in Chem-1 cell membranes after 6 to 10 hrs by scintillation proximity assay

Bioorg Med Chem Lett 25: 4057-64 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.092
BindingDB Entry DOI: 10.7270/Q2HM5B7N
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50119556
PNG
(CHEMBL3617573)
Show SMILES CC(C)c1cc(CNc2ccc(c(Cl)c2)-c2ccc(cc2C)C(F)(F)F)c(-c2ccc(cc2)C(=O)NCCC(O)=O)c(c1)C(F)(F)F
Show InChI InChI=1S/C35H31ClF6N2O3/c1-19(2)23-15-24(18-44-26-9-11-28(30(36)17-26)27-10-8-25(14-20(27)3)34(37,38)39)32(29(16-23)35(40,41)42)21-4-6-22(7-5-21)33(47)43-13-12-31(45)46/h4-11,14-17,19,44H,12-13,18H2,1-3H3,(H,43,47)(H,45,46)
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 30n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from full length human glucagon receptor expressed in HEK293 cell membranes after 2 hrs by scintillation counting ana...

Bioorg Med Chem Lett 25: 4057-64 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.092
BindingDB Entry DOI: 10.7270/Q2HM5B7N
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM160576
PNG
(US9045389, 8)
Show SMILES OC(=O)CCNC(=O)c1ccc(cc1)-c1cc(Cl)ccc1CNc1ccc(cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C29H23Cl3N2O3/c30-22-8-5-21(17-34-24-10-6-18(7-11-24)25-12-9-23(31)16-27(25)32)26(15-22)19-1-3-20(4-2-19)29(37)33-14-13-28(35)36/h1-12,15-16,34H,13-14,17H2,(H,33,37)(H,35,36)
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 33n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from full length human glucagon receptor expressed in HEK293 cell membranes after 2 hrs by scintillation counting ana...

Bioorg Med Chem Lett 25: 4057-64 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.092
BindingDB Entry DOI: 10.7270/Q2HM5B7N
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM142038
PNG
(US8927577, 117 | US8927577, 19 | US8927577, 32)
Show SMILES Cc1cc2ccccc2nc1NC(C1CC(C)(C)C1)c1ccc(cc1)C(=O)NCCC(O)=O
Show InChI InChI=1S/C27H31N3O3/c1-17-14-20-6-4-5-7-22(20)29-25(17)30-24(21-15-27(2,3)16-21)18-8-10-19(11-9-18)26(33)28-13-12-23(31)32/h4-11,14,21,24H,12-13,15-16H2,1-3H3,(H,28,33)(H,29,30)(H,31,32)
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 53n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in Chem-1 cell membranes after 6 to 10 hrs by scintillation proximity assay

Bioorg Med Chem Lett 25: 4057-64 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.092
BindingDB Entry DOI: 10.7270/Q2HM5B7N
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50119552
PNG
(CHEMBL3617565)
Show SMILES CCC[C@@H]([C@@H](c1c[nH]c2c(F)cc(Cl)cc12)c1ccc(OC(F)(F)F)cc1)c1ccc(cc1)C(=O)NCCC(O)=O |r|
Show InChI InChI=1S/C30H27ClF4N2O4/c1-2-3-22(17-4-6-19(7-5-17)29(40)36-13-12-26(38)39)27(18-8-10-21(11-9-18)41-30(33,34)35)24-16-37-28-23(24)14-20(31)15-25(28)32/h4-11,14-16,22,27,37H,2-3,12-13H2,1H3,(H,36,40)(H,38,39)/t22-,27+/m1/s1
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n/an/a 0.240n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in CHO cells after 4 to 12 hrs by liquid scintillation counting analysis

Bioorg Med Chem Lett 25: 4057-64 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.092
BindingDB Entry DOI: 10.7270/Q2HM5B7N
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50119557
PNG
(CHEMBL3617575)
Show SMILES Cc1cc(Cl)ccc1-c1ccc(NCc2cc(Cl)cc(c2-c2ccc(nc2)C(=O)NCCC(O)=O)C(F)(F)F)cc1
Show InChI InChI=1S/C30H24Cl2F3N3O3/c1-17-12-21(31)5-8-24(17)18-2-6-23(7-3-18)37-16-20-13-22(32)14-25(30(33,34)35)28(20)19-4-9-26(38-15-19)29(41)36-11-10-27(39)40/h2-9,12-15,37H,10-11,16H2,1H3,(H,36,41)(H,39,40)
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n/an/a 4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human glucagon receptor expressed in HEK293 cell membranes assessed as inhibition of glucagon-stimulated intracellular cAMP fo...

Bioorg Med Chem Lett 25: 4057-64 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.092
BindingDB Entry DOI: 10.7270/Q2HM5B7N
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50119552
PNG
(CHEMBL3617565)
Show SMILES CCC[C@@H]([C@@H](c1c[nH]c2c(F)cc(Cl)cc12)c1ccc(OC(F)(F)F)cc1)c1ccc(cc1)C(=O)NCCC(O)=O |r|
Show InChI InChI=1S/C30H27ClF4N2O4/c1-2-3-22(17-4-6-19(7-5-17)29(40)36-13-12-26(38)39)27(18-8-10-21(11-9-18)41-30(33,34)35)24-16-37-28-23(24)14-20(31)15-25(28)32/h4-11,14-16,22,27,37H,2-3,12-13H2,1H3,(H,36,40)(H,38,39)/t22-,27+/m1/s1
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n/an/a 19n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human glucagon receptor expressed in CHO cells assessed as inhibition of glucagon-stimulated intracellular cAMP formation prei...

Bioorg Med Chem Lett 25: 4057-64 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.092
BindingDB Entry DOI: 10.7270/Q2HM5B7N
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50119546
PNG
(CHEMBL3617563)
Show SMILES CC(C)(C)CC[C@@H](N1C(=O)C(=NC11CCC(CC1)[Si](C)(C)C)c1cccc(F)c1)c1ccc(cc1)C(=O)NCCC(O)=O |r,wD:6.5,c:10,(-2.56,-5.51,;-3.18,-4.45,;-3.8,-5.51,;-4.41,-4.45,;-2.41,-3.11,;-3.19,-1.78,;-2.42,-.44,;-.88,-.44,;.02,-1.68,;-.35,-2.86,;1.47,-1.19,;1.47,.33,;.02,.8,;1.44,1.44,;1.61,2.97,;.33,3.9,;-1.05,3.27,;-1.21,1.7,;.46,5.44,;1.58,5.96,;-.55,6.15,;.57,6.67,;2.73,-2.08,;2.47,-3.6,;3.65,-4.58,;5.1,-4.04,;5.35,-2.53,;6.51,-2.1,;4.17,-1.55,;-3.19,.89,;-4.73,.9,;-5.5,2.23,;-4.73,3.56,;-3.19,3.56,;-2.42,2.23,;-5.49,4.9,;-6.72,4.91,;-4.72,6.23,;-5.48,7.57,;-4.71,8.9,;-5.47,10.24,;-6.7,10.24,;-4.85,11.31,)|
Show InChI InChI=1S/C34H46FN3O4Si/c1-33(2,3)18-16-28(23-10-12-24(13-11-23)31(41)36-21-17-29(39)40)38-32(42)30(25-8-7-9-26(35)22-25)37-34(38)19-14-27(15-20-34)43(4,5)6/h7-13,22,27-28H,14-21H2,1-6H3,(H,36,41)(H,39,40)/t27?,28-,34?/m1/s1
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n/an/a 22n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human glucagon receptor expressed in CHO cells assessed as inhibition of glucagon-stimulated intracellular cAMP fo...

Bioorg Med Chem Lett 25: 4057-64 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.092
BindingDB Entry DOI: 10.7270/Q2HM5B7N
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM123557
PNG
(US8748624, 43)
Show SMILES Cc1cc(ccc1-c1ccc(NCc2ccc(cc2-c2ccc(nc2)C(=O)NCCC(O)=O)C(F)(F)F)cc1Cl)C(F)(F)F
Show InChI InChI=1S/C31H24ClF6N3O3/c1-17-12-20(30(33,34)35)5-7-23(17)24-8-6-22(14-26(24)32)40-15-18-2-4-21(31(36,37)38)13-25(18)19-3-9-27(41-16-19)29(44)39-11-10-28(42)43/h2-9,12-14,16,40H,10-11,15H2,1H3,(H,39,44)(H,42,43)
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n/an/a 22n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human glucagon receptor expressed in HEK293 cell membranes assessed as inhibition of glucagon-stimulated intracellular cAMP fo...

Bioorg Med Chem Lett 25: 4057-64 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.092
BindingDB Entry DOI: 10.7270/Q2HM5B7N
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50119547
PNG
(CHEMBL3617564)
Show SMILES CC(C)(C)CCOc1cccc(c1)C1=NC2(CCC(CC2)C(C)(C)C)N([C@H](CCC(C)(C)C)c2ccc(cc2)C(=O)NCc2nn[nH]n2)C1=O |r,wD:26.28,t:14,(11.77,-2.99,;10.62,-3.42,;10.41,-4.64,;11.56,-4.21,;9.43,-2.44,;7.98,-2.97,;6.8,-1.99,;5.35,-2.53,;5.1,-4.04,;3.65,-4.58,;2.47,-3.6,;2.73,-2.08,;4.17,-1.55,;1.47,-1.19,;1.47,.33,;.02,.8,;1.44,1.44,;1.61,2.97,;.33,3.9,;-1.05,3.27,;-1.21,1.7,;.46,5.44,;1.58,5.96,;-.55,6.15,;.57,6.67,;-.88,-.44,;-2.42,-.44,;-3.19,-1.78,;-2.41,-3.11,;-3.18,-4.45,;-2.56,-5.51,;-3.8,-5.51,;-4.41,-4.45,;-3.19,.89,;-4.73,.9,;-5.5,2.23,;-4.73,3.56,;-3.19,3.56,;-2.42,2.23,;-5.49,4.9,;-6.72,4.91,;-4.72,6.23,;-5.48,7.57,;-4.71,8.9,;-3.19,9.04,;-2.86,10.54,;-4.19,11.32,;-5.34,10.29,;.02,-1.68,;-.35,-2.86,)|
Show InChI InChI=1S/C40H57N7O3/c1-37(2,3)20-19-32(27-13-15-28(16-14-27)35(48)41-26-33-43-45-46-44-33)47-36(49)34(42-40(47)21-17-30(18-22-40)39(7,8)9)29-11-10-12-31(25-29)50-24-23-38(4,5)6/h10-16,25,30,32H,17-24,26H2,1-9H3,(H,41,48)(H,43,44,45,46)/t30?,32-,40?/m1/s1
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n/an/a 61n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human glucagon receptor expressed in CHO cells assessed as inhibition of glucagon-stimulated intracellular cAMP fo...

Bioorg Med Chem Lett 25: 4057-64 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.092
BindingDB Entry DOI: 10.7270/Q2HM5B7N
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM160576
PNG
(US9045389, 8)
Show SMILES OC(=O)CCNC(=O)c1ccc(cc1)-c1cc(Cl)ccc1CNc1ccc(cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C29H23Cl3N2O3/c30-22-8-5-21(17-34-24-10-6-18(7-11-24)25-12-9-23(31)16-27(25)32)26(15-22)19-1-3-20(4-2-19)29(37)33-14-13-28(35)36/h1-12,15-16,34H,13-14,17H2,(H,33,37)(H,35,36)
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n/an/a 67n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human glucagon receptor expressed in HEK293 cell membranes assessed as inhibition of glucagon-stimulated intracellular cAMP fo...

Bioorg Med Chem Lett 25: 4057-64 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.092
BindingDB Entry DOI: 10.7270/Q2HM5B7N
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50119544
PNG
(CHEMBL3617561)
Show SMILES CC[C@@H](N1C(=O)C(=NC11CCC(CC1)C(C)(C)C)N1CCCCC1)c1ccc(cc1)C(=O)NCCC(O)=O |r,wU:2.1,c:6,(-2.57,1.96,;-3.19,.89,;-2.42,-.44,;-.88,-.44,;.02,-1.68,;-.35,-2.86,;1.47,-1.19,;1.47,.33,;.02,.8,;1.44,1.44,;1.61,2.97,;.33,3.9,;-1.05,3.27,;-1.21,1.7,;.46,5.44,;1.58,5.96,;-.55,6.15,;.57,6.67,;2.73,-2.08,;4.17,-1.55,;5.35,-2.53,;5.1,-4.04,;3.65,-4.58,;2.47,-3.6,;-3.19,-1.78,;-4.73,-1.78,;-5.49,-3.12,;-4.72,-4.45,;-3.18,-4.45,;-2.41,-3.11,;-5.48,-5.79,;-6.71,-5.8,;-4.7,-7.12,;-5.47,-8.46,;-4.69,-9.79,;-5.45,-11.13,;-6.68,-11.14,;-4.83,-12.19,)|
Show InChI InChI=1S/C30H44N4O4/c1-5-24(21-9-11-22(12-10-21)27(37)31-18-15-25(35)36)34-28(38)26(33-19-7-6-8-20-33)32-30(34)16-13-23(14-17-30)29(2,3)4/h9-12,23-24H,5-8,13-20H2,1-4H3,(H,31,37)(H,35,36)/t23?,24-,30?/m1/s1
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n/an/a 209n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human glucagon receptor expressed in CHO cells assessed as inhibition of glucagon-stimulated intracellular cAMP fo...

Bioorg Med Chem Lett 25: 4057-64 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.092
BindingDB Entry DOI: 10.7270/Q2HM5B7N
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50119545
PNG
(CHEMBL3617562)
Show SMILES CC(C)(C)CC[C@@H](N1C(=O)C(=NC11CCC(CC1)C(C)(C)C)C1CCCCC1)c1ccc(cc1)C(=O)NCc1nn[nH]n1 |r,wD:6.5,c:10,(-2.56,-5.51,;-3.18,-4.45,;-3.8,-5.51,;-4.41,-4.45,;-2.41,-3.11,;-3.19,-1.78,;-2.42,-.44,;-.88,-.44,;.02,-1.68,;-.35,-2.86,;1.47,-1.19,;1.47,.33,;.02,.8,;1.44,1.44,;1.61,2.97,;.33,3.9,;-1.05,3.27,;-1.21,1.7,;.46,5.44,;1.58,5.96,;-.55,6.15,;.57,6.67,;2.73,-2.08,;4.17,-1.55,;5.35,-2.53,;5.1,-4.04,;3.65,-4.58,;2.47,-3.6,;-3.19,.89,;-4.73,.9,;-5.5,2.23,;-4.73,3.56,;-3.19,3.56,;-2.42,2.23,;-5.49,4.9,;-6.72,4.91,;-4.72,6.23,;-5.48,7.57,;-4.71,8.9,;-3.19,9.04,;-2.86,10.54,;-4.19,11.32,;-5.34,10.29,)|
Show InChI InChI=1S/C34H51N7O2/c1-32(2,3)19-18-27(23-12-14-25(15-13-23)30(42)35-22-28-37-39-40-38-28)41-31(43)29(24-10-8-7-9-11-24)36-34(41)20-16-26(17-21-34)33(4,5)6/h12-15,24,26-27H,7-11,16-22H2,1-6H3,(H,35,42)(H,37,38,39,40)/t26?,27-,34?/m1/s1
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n/an/a 290n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant human glucagon receptor expressed in CHO cells assessed as inhibition of glucagon-stimulated intracellular cAMP fo...

Bioorg Med Chem Lett 25: 4057-64 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.092
BindingDB Entry DOI: 10.7270/Q2HM5B7N
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%