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PubMed code 26310895

Compile data set for download or QSAR
Found 29 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NAD-dependent protein deacylase sirtuin-6


(Homo sapiens (Human))
BDBM50123364
PNG
(CHEMBL3622696)
Show SMILES O=c1[nH]c2ccc(cc2c(=O)[nH]1)S(=O)(=O)Nc1cccc(CCc2ccncc2)c1
Show InChI InChI=1S/C21H18N4O4S/c26-20-18-13-17(6-7-19(18)23-21(27)24-20)30(28,29)25-16-3-1-2-15(12-16)5-4-14-8-10-22-11-9-14/h1-3,6-13,25H,4-5H2,(H2,23,24,26,27)
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n/an/a 3.70E+4n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human SIRT6 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by fluorescence assay


Eur J Med Chem 102: 530-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.024
BindingDB Entry DOI: 10.7270/Q2K35WGV
More data for this
Ligand-Target Pair
NAD-dependent protein deacylase sirtuin-6


(Homo sapiens (Human))
BDBM50123399
PNG
(CHEMBL3623254)
Show SMILES Cn1c2ccc(cc2c(=O)n(C)c1=O)S(=O)(=O)Nc1ccc(Cc2ccncc2)cc1
Show InChI InChI=1S/C22H20N4O4S/c1-25-20-8-7-18(14-19(20)21(27)26(2)22(25)28)31(29,30)24-17-5-3-15(4-6-17)13-16-9-11-23-12-10-16/h3-12,14,24H,13H2,1-2H3
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n/an/a 3.80E+4n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SIRT6 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by luminescence assay


Eur J Med Chem 102: 530-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.024
BindingDB Entry DOI: 10.7270/Q2K35WGV
More data for this
Ligand-Target Pair
NAD-dependent protein deacylase sirtuin-6


(Homo sapiens (Human))
BDBM50123399
PNG
(CHEMBL3623254)
Show SMILES Cn1c2ccc(cc2c(=O)n(C)c1=O)S(=O)(=O)Nc1ccc(Cc2ccncc2)cc1
Show InChI InChI=1S/C22H20N4O4S/c1-25-20-8-7-18(14-19(20)21(27)26(2)22(25)28)31(29,30)24-17-5-3-15(4-6-17)13-16-9-11-23-12-10-16/h3-12,14,24H,13H2,1-2H3
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n/an/a 4.90E+4n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human SIRT6 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by fluorescence assay


Eur J Med Chem 102: 530-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.024
BindingDB Entry DOI: 10.7270/Q2K35WGV
More data for this
Ligand-Target Pair
NAD-dependent protein deacylase sirtuin-6


(Homo sapiens (Human))
BDBM50123364
PNG
(CHEMBL3622696)
Show SMILES O=c1[nH]c2ccc(cc2c(=O)[nH]1)S(=O)(=O)Nc1cccc(CCc2ccncc2)c1
Show InChI InChI=1S/C21H18N4O4S/c26-20-18-13-17(6-7-19(18)23-21(27)24-20)30(28,29)25-16-3-1-2-15(12-16)5-4-14-8-10-22-11-9-14/h1-3,6-13,25H,4-5H2,(H2,23,24,26,27)
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n/an/a 5.50E+4n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SIRT6 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by luminescence assay


Eur J Med Chem 102: 530-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.024
BindingDB Entry DOI: 10.7270/Q2K35WGV
More data for this
Ligand-Target Pair
NAD-dependent protein deacylase sirtuin-6


(Homo sapiens (Human))
BDBM50123357
PNG
(CHEMBL3622695)
Show SMILES O=c1[nH]c2ccc(cc2c(=O)[nH]1)S(=O)(=O)Nc1ccc(Cn2ccnc2)cc1
Show InChI InChI=1S/C18H15N5O4S/c24-17-15-9-14(5-6-16(15)20-18(25)21-17)28(26,27)22-13-3-1-12(2-4-13)10-23-8-7-19-11-23/h1-9,11,22H,10H2,(H2,20,21,24,25)
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n/an/a 6.00E+4n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human SIRT6 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by fluorescence assay


Eur J Med Chem 102: 530-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.024
BindingDB Entry DOI: 10.7270/Q2K35WGV
More data for this
Ligand-Target Pair
NAD-dependent protein deacylase sirtuin-6


(Homo sapiens (Human))
BDBM50123400
PNG
(CHEMBL3623256)
Show SMILES Cn1c2ccc(cc2sc1=O)S(=O)(=O)Nc1ccc(Oc2cccnc2)cc1
Show InChI InChI=1S/C19H15N3O4S2/c1-22-17-9-8-16(11-18(17)27-19(22)23)28(24,25)21-13-4-6-14(7-5-13)26-15-3-2-10-20-12-15/h2-12,21H,1H3
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n/an/a 7.70E+4n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human SIRT6 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by fluorescence assay


Eur J Med Chem 102: 530-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.024
BindingDB Entry DOI: 10.7270/Q2K35WGV
More data for this
Ligand-Target Pair
NAD-dependent protein deacylase sirtuin-6


(Homo sapiens (Human))
BDBM50123404
PNG
(CHEMBL3623250)
Show SMILES Cn1ccc2cc(NS(=O)(=O)c3ccc4[nH]c(=O)[nH]c(=O)c4c3)ccc12
Show InChI InChI=1S/C17H14N4O4S/c1-21-7-6-10-8-11(2-5-15(10)21)20-26(24,25)12-3-4-14-13(9-12)16(22)19-17(23)18-14/h2-9,20H,1H3,(H2,18,19,22,23)
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n/an/a 8.20E+4n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SIRT6 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by luminescence assay


Eur J Med Chem 102: 530-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.024
BindingDB Entry DOI: 10.7270/Q2K35WGV
More data for this
Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2


(Homo sapiens (Human))
BDBM50123364
PNG
(CHEMBL3622696)
Show SMILES O=c1[nH]c2ccc(cc2c(=O)[nH]1)S(=O)(=O)Nc1cccc(CCc2ccncc2)c1
Show InChI InChI=1S/C21H18N4O4S/c26-20-18-13-17(6-7-19(18)23-21(27)24-20)30(28,29)25-16-3-1-2-15(12-16)5-4-14-8-10-22-11-9-14/h1-3,6-13,25H,4-5H2,(H2,23,24,26,27)
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n/an/a 8.50E+4n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human SIRT2 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by fluorescence assay


Eur J Med Chem 102: 530-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.024
BindingDB Entry DOI: 10.7270/Q2K35WGV
More data for this
Ligand-Target Pair
NAD-dependent protein deacylase sirtuin-6


(Homo sapiens (Human))
BDBM50123400
PNG
(CHEMBL3623256)
Show SMILES Cn1c2ccc(cc2sc1=O)S(=O)(=O)Nc1ccc(Oc2cccnc2)cc1
Show InChI InChI=1S/C19H15N3O4S2/c1-22-17-9-8-16(11-18(17)27-19(22)23)28(24,25)21-13-4-6-14(7-5-13)26-15-3-2-10-20-12-15/h2-12,21H,1H3
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n/an/a 1.02E+5n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SIRT6 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by luminescence assay


Eur J Med Chem 102: 530-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.024
BindingDB Entry DOI: 10.7270/Q2K35WGV
More data for this
Ligand-Target Pair
NAD-dependent protein deacylase sirtuin-6


(Homo sapiens (Human))
BDBM50017341
PNG
(CHEMBL3288034)
Show SMILES O=c1[nH]c2ccc(cc2c(=O)[nH]1)S(=O)(=O)Nc1ccc(Oc2cccnc2)cc1
Show InChI InChI=1S/C19H14N4O5S/c24-18-16-10-15(7-8-17(16)21-19(25)22-18)29(26,27)23-12-3-5-13(6-4-12)28-14-2-1-9-20-11-14/h1-11,23H,(H2,21,22,24,25)
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n/an/a 1.06E+5n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human SIRT6 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by fluorescence assay


Eur J Med Chem 102: 530-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.024
BindingDB Entry DOI: 10.7270/Q2K35WGV
More data for this
Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2


(Homo sapiens (Human))
BDBM50017341
PNG
(CHEMBL3288034)
Show SMILES O=c1[nH]c2ccc(cc2c(=O)[nH]1)S(=O)(=O)Nc1ccc(Oc2cccnc2)cc1
Show InChI InChI=1S/C19H14N4O5S/c24-18-16-10-15(7-8-17(16)21-19(25)22-18)29(26,27)23-12-3-5-13(6-4-12)28-14-2-1-9-20-11-14/h1-11,23H,(H2,21,22,24,25)
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n/an/a 1.14E+5n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human SIRT2 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by fluorescence assay


Eur J Med Chem 102: 530-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.024
BindingDB Entry DOI: 10.7270/Q2K35WGV
More data for this
Ligand-Target Pair
NAD-dependent protein deacylase sirtuin-6


(Homo sapiens (Human))
BDBM50123451
PNG
(CHEMBL3623255)
Show SMILES O=c1[nH]c2ccc(cc2c(=O)[nH]1)S(=O)(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C20H15N3O5S/c24-19-17-12-16(10-11-18(17)21-20(25)22-19)29(26,27)23-13-6-8-15(9-7-13)28-14-4-2-1-3-5-14/h1-12,23H,(H2,21,22,24,25)
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n/an/a 1.27E+5n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SIRT6 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by luminescence assay


Eur J Med Chem 102: 530-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.024
BindingDB Entry DOI: 10.7270/Q2K35WGV
More data for this
Ligand-Target Pair
NAD-dependent protein deacylase sirtuin-6


(Homo sapiens (Human))
BDBM50017341
PNG
(CHEMBL3288034)
Show SMILES O=c1[nH]c2ccc(cc2c(=O)[nH]1)S(=O)(=O)Nc1ccc(Oc2cccnc2)cc1
Show InChI InChI=1S/C19H14N4O5S/c24-18-16-10-15(7-8-17(16)21-19(25)22-18)29(26,27)23-12-3-5-13(6-4-12)28-14-2-1-9-20-11-14/h1-11,23H,(H2,21,22,24,25)
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n/an/a 1.36E+5n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SIRT6 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by luminescence assay


Eur J Med Chem 102: 530-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.024
BindingDB Entry DOI: 10.7270/Q2K35WGV
More data for this
Ligand-Target Pair
NAD-dependent protein deacylase sirtuin-6


(Homo sapiens (Human))
BDBM50123372
PNG
(CHEMBL3623251)
Show SMILES O=c1[nH]c2ccc(cc2c(=O)[nH]1)S(=O)(=O)Nc1ccccc1-c1ccccc1
Show InChI InChI=1S/C20H15N3O4S/c24-19-16-12-14(10-11-17(16)21-20(25)22-19)28(26,27)23-18-9-5-4-8-15(18)13-6-2-1-3-7-13/h1-12,23H,(H2,21,22,24,25)
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n/an/a 1.37E+5n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human SIRT6 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by fluorescence assay


Eur J Med Chem 102: 530-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.024
BindingDB Entry DOI: 10.7270/Q2K35WGV
More data for this
Ligand-Target Pair
NAD-dependent protein deacylase sirtuin-6


(Homo sapiens (Human))
BDBM50123372
PNG
(CHEMBL3623251)
Show SMILES O=c1[nH]c2ccc(cc2c(=O)[nH]1)S(=O)(=O)Nc1ccccc1-c1ccccc1
Show InChI InChI=1S/C20H15N3O4S/c24-19-16-12-14(10-11-17(16)21-20(25)22-19)28(26,27)23-18-9-5-4-8-15(18)13-6-2-1-3-7-13/h1-12,23H,(H2,21,22,24,25)
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n/an/a 1.37E+5n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SIRT6 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by luminescence assay


Eur J Med Chem 102: 530-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.024
BindingDB Entry DOI: 10.7270/Q2K35WGV
More data for this
Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2


(Homo sapiens (Human))
BDBM50123357
PNG
(CHEMBL3622695)
Show SMILES O=c1[nH]c2ccc(cc2c(=O)[nH]1)S(=O)(=O)Nc1ccc(Cn2ccnc2)cc1
Show InChI InChI=1S/C18H15N5O4S/c24-17-15-9-14(5-6-16(15)20-18(25)21-17)28(26,27)22-13-3-1-12(2-4-13)10-23-8-7-19-11-23/h1-9,11,22H,10H2,(H2,20,21,24,25)
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n/an/a 1.59E+5n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human SIRT2 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by fluorescence assay


Eur J Med Chem 102: 530-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.024
BindingDB Entry DOI: 10.7270/Q2K35WGV
More data for this
Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1


(Homo sapiens (Human))
BDBM50123357
PNG
(CHEMBL3622695)
Show SMILES O=c1[nH]c2ccc(cc2c(=O)[nH]1)S(=O)(=O)Nc1ccc(Cn2ccnc2)cc1
Show InChI InChI=1S/C18H15N5O4S/c24-17-15-9-14(5-6-16(15)20-18(25)21-17)28(26,27)22-13-3-1-12(2-4-13)10-23-8-7-19-11-23/h1-9,11,22H,10H2,(H2,20,21,24,25)
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n/an/a 2.38E+5n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human SIRT1 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by fluorescence assay


Eur J Med Chem 102: 530-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.024
BindingDB Entry DOI: 10.7270/Q2K35WGV
More data for this
Ligand-Target Pair
NAD-dependent protein deacylase sirtuin-6


(Homo sapiens (Human))
BDBM50123403
PNG
(CHEMBL3623259)
Show SMILES CC(=O)Nc1ccc(cc1)S(=O)(=O)Nc1ccc(Oc2cccnc2)cc1
Show InChI InChI=1S/C19H17N3O4S/c1-14(23)21-15-6-10-19(11-7-15)27(24,25)22-16-4-8-17(9-5-16)26-18-3-2-12-20-13-18/h2-13,22H,1H3,(H,21,23)
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n/an/a 2.42E+5n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SIRT6 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by luminescence assay


Eur J Med Chem 102: 530-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.024
BindingDB Entry DOI: 10.7270/Q2K35WGV
More data for this
Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-2


(Homo sapiens (Human))
BDBM50123399
PNG
(CHEMBL3623254)
Show SMILES Cn1c2ccc(cc2c(=O)n(C)c1=O)S(=O)(=O)Nc1ccc(Cc2ccncc2)cc1
Show InChI InChI=1S/C22H20N4O4S/c1-25-20-8-7-18(14-19(20)21(27)26(2)22(25)28)31(29,30)24-17-5-3-15(4-6-17)13-16-9-11-23-12-10-16/h3-12,14,24H,13H2,1-2H3
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n/an/a 2.42E+5n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human SIRT2 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by fluorescence assay


Eur J Med Chem 102: 530-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.024
BindingDB Entry DOI: 10.7270/Q2K35WGV
More data for this
Ligand-Target Pair
NAD-dependent protein deacylase sirtuin-6


(Homo sapiens (Human))
BDBM50123401
PNG
(CHEMBL3623257)
Show SMILES O=C1CCc2cc(ccc2N1)S(=O)(=O)Nc1ccc(Oc2cccnc2)cc1
Show InChI InChI=1S/C20H17N3O4S/c24-20-10-3-14-12-18(8-9-19(14)22-20)28(25,26)23-15-4-6-16(7-5-15)27-17-2-1-11-21-13-17/h1-2,4-9,11-13,23H,3,10H2,(H,22,24)
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n/an/a 2.70E+5n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human SIRT6 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by fluorescence assay


Eur J Med Chem 102: 530-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.024
BindingDB Entry DOI: 10.7270/Q2K35WGV
More data for this
Ligand-Target Pair
NAD-dependent protein deacylase sirtuin-6


(Homo sapiens (Human))
BDBM50123401
PNG
(CHEMBL3623257)
Show SMILES O=C1CCc2cc(ccc2N1)S(=O)(=O)Nc1ccc(Oc2cccnc2)cc1
Show InChI InChI=1S/C20H17N3O4S/c24-20-10-3-14-12-18(8-9-19(14)22-20)28(25,26)23-15-4-6-16(7-5-15)27-17-2-1-11-21-13-17/h1-2,4-9,11-13,23H,3,10H2,(H,22,24)
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n/an/a 2.75E+5n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SIRT6 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by luminescence assay


Eur J Med Chem 102: 530-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.024
BindingDB Entry DOI: 10.7270/Q2K35WGV
More data for this
Ligand-Target Pair
NAD-dependent protein deacylase sirtuin-6


(Homo sapiens (Human))
BDBM50123403
PNG
(CHEMBL3623259)
Show SMILES CC(=O)Nc1ccc(cc1)S(=O)(=O)Nc1ccc(Oc2cccnc2)cc1
Show InChI InChI=1S/C19H17N3O4S/c1-14(23)21-15-6-10-19(11-7-15)27(24,25)22-16-4-8-17(9-5-16)26-18-3-2-12-20-13-18/h2-13,22H,1H3,(H,21,23)
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n/an/a 2.97E+5n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human SIRT6 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by fluorescence assay


Eur J Med Chem 102: 530-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.024
BindingDB Entry DOI: 10.7270/Q2K35WGV
More data for this
Ligand-Target Pair
NAD-dependent protein deacylase sirtuin-6


(Homo sapiens (Human))
BDBM50123452
PNG
(CHEMBL3623260)
Show SMILES O=S(=O)(Nc1ccc(Oc2cccnc2)cc1)c1ccccc1
Show InChI InChI=1S/C17H14N2O3S/c20-23(21,17-6-2-1-3-7-17)19-14-8-10-15(11-9-14)22-16-5-4-12-18-13-16/h1-13,19H
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n/an/a 3.00E+5n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SIRT6 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by luminescence assay


Eur J Med Chem 102: 530-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.024
BindingDB Entry DOI: 10.7270/Q2K35WGV
More data for this
Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1


(Homo sapiens (Human))
BDBM50017341
PNG
(CHEMBL3288034)
Show SMILES O=c1[nH]c2ccc(cc2c(=O)[nH]1)S(=O)(=O)Nc1ccc(Oc2cccnc2)cc1
Show InChI InChI=1S/C19H14N4O5S/c24-18-16-10-15(7-8-17(16)21-19(25)22-18)29(26,27)23-12-3-5-13(6-4-12)28-14-2-1-9-20-11-14/h1-11,23H,(H2,21,22,24,25)
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n/an/a 3.14E+5n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human SIRT1 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by fluorescence assay


Eur J Med Chem 102: 530-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.024
BindingDB Entry DOI: 10.7270/Q2K35WGV
More data for this
Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1


(Homo sapiens (Human))
BDBM50123364
PNG
(CHEMBL3622696)
Show SMILES O=c1[nH]c2ccc(cc2c(=O)[nH]1)S(=O)(=O)Nc1cccc(CCc2ccncc2)c1
Show InChI InChI=1S/C21H18N4O4S/c26-20-18-13-17(6-7-19(18)23-21(27)24-20)30(28,29)25-16-3-1-2-15(12-16)5-4-14-8-10-22-11-9-14/h1-3,6-13,25H,4-5H2,(H2,23,24,26,27)
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n/an/a 4.24E+5n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human SIRT1 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by fluorescence assay


Eur J Med Chem 102: 530-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.024
BindingDB Entry DOI: 10.7270/Q2K35WGV
More data for this
Ligand-Target Pair
NAD-dependent protein deacylase sirtuin-6


(Homo sapiens (Human))
BDBM50123402
PNG
(CHEMBL3623258)
Show SMILES O=C1CCCN1c1ccc(cc1)S(=O)(=O)Nc1ccc(Oc2cccnc2)cc1
Show InChI InChI=1S/C21H19N3O4S/c25-21-4-2-14-24(21)17-7-11-20(12-8-17)29(26,27)23-16-5-9-18(10-6-16)28-19-3-1-13-22-15-19/h1,3,5-13,15,23H,2,4,14H2
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n/an/a 4.41E+5n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human SIRT6 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by fluorescence assay


Eur J Med Chem 102: 530-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.024
BindingDB Entry DOI: 10.7270/Q2K35WGV
More data for this
Ligand-Target Pair
NAD-dependent protein deacylase sirtuin-6


(Homo sapiens (Human))
BDBM50123448
PNG
(CHEMBL3623253)
Show SMILES O=c1[nH]c2ccc(cc2c(=O)[nH]1)S(=O)(=O)NC1CCN(Cc2ccccc2)C1
Show InChI InChI=1S/C19H20N4O4S/c24-18-16-10-15(6-7-17(16)20-19(25)21-18)28(26,27)22-14-8-9-23(12-14)11-13-4-2-1-3-5-13/h1-7,10,14,22H,8-9,11-12H2,(H2,20,21,24,25)
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n/an/a 5.17E+5n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SIRT6 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by luminescence assay


Eur J Med Chem 102: 530-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.024
BindingDB Entry DOI: 10.7270/Q2K35WGV
More data for this
Ligand-Target Pair
NAD-dependent protein deacylase sirtuin-6


(Homo sapiens (Human))
BDBM50123405
PNG
(CHEMBL3623252)
Show SMILES O=c1[nH]c2ccc(cc2c(=O)[nH]1)S(=O)(=O)NCc1cccc(Cn2ccnc2)c1
Show InChI InChI=1S/C19H17N5O4S/c25-18-16-9-15(4-5-17(16)22-19(26)23-18)29(27,28)21-10-13-2-1-3-14(8-13)11-24-7-6-20-12-24/h1-9,12,21H,10-11H2,(H2,22,23,25,26)
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n/an/a 2.87E+6n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SIRT6 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by luminescence assay


Eur J Med Chem 102: 530-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.024
BindingDB Entry DOI: 10.7270/Q2K35WGV
More data for this
Ligand-Target Pair
NAD-dependent protein deacetylase sirtuin-1


(Homo sapiens (Human))
BDBM50123399
PNG
(CHEMBL3623254)
Show SMILES Cn1c2ccc(cc2c(=O)n(C)c1=O)S(=O)(=O)Nc1ccc(Cc2ccncc2)cc1
Show InChI InChI=1S/C22H20N4O4S/c1-25-20-8-7-18(14-19(20)21(27)26(2)22(25)28)31(29,30)24-17-5-3-15(4-6-17)13-16-9-11-23-12-10-16/h3-12,14,24H,13H2,1-2H3
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n/an/a 6.52E+6n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of human SIRT1 deacetylase activity using Arg-His-Lys-Lys(AC)-AMC as a substrate by fluorescence assay


Eur J Med Chem 102: 530-9 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.024
BindingDB Entry DOI: 10.7270/Q2K35WGV
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%