Affinity Data by PubMed id=26351878

PubMed code 26351878

Found 24 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50330063 (1-(4-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c...) Show SMILES CCCCc1nc2c(N)nc3ccccc3c2n1Cc1ccc(CN)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	55	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay				J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50124348 (CHEMBL3622841) Show SMILES Cl.CCCCCc1c(N)nc2ccccc2c1CCCCN Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	190	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay				J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50124349 (CHEMBL3622840) Show SMILES Cl.CCCCCc1c(N)nc2ccccc2c1Cc1ccc(CN)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	120	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay				J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50124219 (CHEMBL3622861) Show SMILES CCCCCc1cc2ccc(CCCCN)cc2nc1N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay				J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50124342 (CHEMBL3622852) Show SMILES CCCCCc1cc2c(CCCN)cccc2nc1N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	91	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay				J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50124344 (CHEMBL3622847) Show SMILES CCCCCc1cc2c(Cc3ccccc3CN)cccc2nc1N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay				J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50124221 (CHEMBL3622859) Show SMILES CCCCCc1cc2cc(CCCCCN)ccc2nc1N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	519	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay				J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50124225 (CHEMBL3622855) Show SMILES CCCCCc1cc2c(CCCCCCN)cccc2nc1N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	56	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay				J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50124341 (CHEMBL3622853) Show SMILES CCCCCc1cc2c(CCCCN)cccc2nc1N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	27	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay				J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50124347 (CHEMBL3622842) Show SMILES Cl.CCCCCc1c(N)nc2ccccc2c1CCCCCN Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	250	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay				J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50330062 (1-(3-(Aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c...) Show SMILES CCCCc1nc2c(N)nc3ccccc3c2n1Cc1cccc(CN)c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay				J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50124345 (CHEMBL3622846) Show SMILES CCCCCc1cc2c(Cc3ccc(CN)cc3)cccc2nc1N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	38	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay				J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50124215 (CHEMBL3622866) Show SMILES CCCCCc1cc2ccccc2nc1N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay				J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50124343 (CHEMBL3622851) Show SMILES CCCCCc1cc2c(cccc2nc1N)-c1ccc(CN)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	699	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay				J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50124216 (CHEMBL3622865) Show SMILES CCCCCc1cc2c(CCCCCN)cc(CCCCCN)cc2nc1N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	621	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay				J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50124217 (CHEMBL3622863) Show SMILES CCCCCc1cc2ccc(CCCCCCN)cc2nc1N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	85	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay				J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50124220 (CHEMBL3622860) Show SMILES CCCCCc1cc2cc(CCCCCCN)ccc2nc1N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.02E+3	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay				J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50124340 (CHEMBL3622854) Show SMILES CCCCCc1cc2c(CCCCCN)cccc2nc1N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	9	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay				J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50124350 (CHEMBL3622839) Show SMILES Cl.CCCCCc1c(N)nc2ccccc2c1Cc1cccc(CN)c1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	150	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay				J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50124218 (CHEMBL3622862) Show SMILES CCCCCc1cc2ccc(CCCCCN)cc2nc1N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay				J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50124222 (CHEMBL3622858) Show SMILES CCCCCc1cc2cc(CCCCN)ccc2nc1N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	727	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay				J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50124223 (CHEMBL3622857) Show SMILES CCCCCc1cc2c(CCCCNC(N)=N)cccc2nc1N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.86E+3	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay				J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50124224 (CHEMBL3622856) Show SMILES CCCCCc1cc2c(CCCC(N)=O)cccc2nc1N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.18E+3	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay				J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM50124346 (CHEMBL3622844) Show SMILES CCCCCc1cc2c(Cc3cccc(CN)c3)cccc2nc1N Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	49	n/a	n/a	n/a	n/a
University of Kansas Curated by ChEMBL					Assay Description Agonist activity at human TLR8 transfected in HEK293 cells assessed as activation of NF-kB by reporter gene assay				J Med Chem 58: 7833-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b01087 BindingDB Entry DOI: 10.7270/Q2CF9RZK
University of Kansas Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

* indicates data uncertainty>20%