Found 29 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50130489
(CHEMBL3633850)Show SMILES CCc1cc(OC)ccc1-c1ccc(C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@](C)(Cc2c(F)cccc2F)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCc2ccccc2)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc3ccc(cc3)-c3ccccc3)NC(=O)CNC2=O)C(=O)N[C@@H](CO)C(O)=O)cc1 |r| Show InChI InChI=1S/C113H144F2N24O32S2/c1-9-66-43-71(171-8)36-37-72(66)69-34-30-65(31-35-69)42-80(130-104(161)81(45-93(151)152)131-105(162)82(53-140)132-108(165)94(61(5)142)137-112(170)113(7,46-73-74(114)24-17-25-75(73)115)138-109(166)95(62(6)143)136-91(148)52-121-99(156)78(38-39-92(149)150)129-107(164)86-27-18-40-139(86)110(167)76(116)44-70-47-117-57-123-70)103(160)128-77(26-16-21-63-19-12-10-13-20-63)101(158)135-84-55-172-173-56-85(106(163)133-83(54-141)111(168)169)134-98(155)59(3)124-89(146)50-119-87(144)48-118-88(145)49-120-96(153)58(2)125-97(154)60(4)126-102(159)79(127-90(147)51-122-100(84)157)41-64-28-32-68(33-29-64)67-22-14-11-15-23-67/h10-15,17,19-20,22-25,28-37,43,47,57-62,76-86,94-95,140-143H,9,16,18,21,26-27,38-42,44-46,48-56,116H2,1-8H3,(H,117,123)(H,118,145)(H,119,144)(H,120,153)(H,121,156)(H,122,157)(H,124,146)(H,125,154)(H,126,159)(H,127,147)(H,128,160)(H,129,164)(H,130,161)(H,131,162)(H,132,165)(H,133,163)(H,134,155)(H,135,158)(H,136,148)(H,137,170)(H,138,166)(H,149,150)(H,151,152)(H,168,169)/t58-,59-,60-,61+,62+,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,94-,95-,113-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as increase in cAMP level incubated for 30 mins |
Eur J Med Chem 103: 175-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.08.046
BindingDB Entry DOI: 10.7270/Q2JH3P05 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50130490
(CHEMBL3633851)Show SMILES [H][C@@]12CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@]1([H])CSSC[C@]([H])(NC(=O)[C@H](CCCc3ccccc3)NC(=O)[C@H](Cc3ccc(cc3)-c3ccc(OC)cc3CC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@]([H])(NC(=O)[C@](C)(Cc3c(F)cccc3F)NC(=O)[C@@]([H])(NC(=O)CNC(=O)[C@H](CCC(O)=O)NC2=O)[C@@H](C)O)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](Cc2ccc(cc2)-c2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N1 |r| Show InChI InChI=1S/C113H142F2N24O31S2/c1-9-66-43-71(170-8)36-37-72(66)69-34-30-65(31-35-69)42-79-103(160)127-76(26-16-21-63-19-12-10-13-20-63)101(158)135-84-55-171-172-56-85(134-98(155)59(3)123-89(146)50-118-87(144)48-117-88(145)49-119-96(153)58(2)124-97(154)60(4)125-102(159)78(126-90(147)51-121-100(84)157)41-64-28-32-68(33-29-64)67-22-14-11-15-23-67)107(164)132-82(53-140)106(163)131-81(44-70-47-116-57-122-70)111(168)139-40-18-27-86(139)108(165)128-77(38-39-92(149)150)99(156)120-52-91(148)136-95(62(6)143)110(167)138-113(7,46-73-74(114)24-17-25-75(73)115)112(169)137-94(61(5)142)109(166)133-83(54-141)105(162)130-80(45-93(151)152)104(161)129-79/h10-15,17,19-20,22-25,28-37,43,47,57-62,76-86,94-95,140-143H,9,16,18,21,26-27,38-42,44-46,48-56H2,1-8H3,(H,116,122)(H,117,145)(H,118,144)(H,119,153)(H,120,156)(H,121,157)(H,123,146)(H,124,154)(H,125,159)(H,126,147)(H,127,160)(H,128,165)(H,129,161)(H,130,162)(H,131,163)(H,132,164)(H,133,166)(H,134,155)(H,135,158)(H,136,148)(H,137,169)(H,138,167)(H,149,150)(H,151,152)/t58-,59-,60-,61+,62+,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,94-,95-,113-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 470 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as increase in cAMP level incubated for 30 mins |
Eur J Med Chem 103: 175-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.08.046
BindingDB Entry DOI: 10.7270/Q2JH3P05 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50130496
(CHEMBL3634088)Show SMILES [H][C@]12CSSC[C@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc3cnc[nH]3)C(=O)NC(C)(Cc3c(F)cccc3F)C(=O)N[C@@]([H])(CSSC[C@H](NC1=O)C(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(OC)cc1CC)C(=O)N[C@@H](CCCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N2 |r| Show InChI InChI=1S/C81H104F2N16O21S4/c1-8-45-30-48(120-7)24-25-49(45)46-22-20-44(21-23-46)29-57-71(110)89-54(19-12-16-43-14-10-9-11-15-43)69(108)90-56(28-42(2)3)70(109)94-60-37-121-123-39-62(88-64(101)35-86-68(107)55(26-27-65(102)103)96-78(118)80(4,5)98-67(106)53(84)31-47-34-85-41-87-47)76(115)99-81(6,33-50-51(82)17-13-18-52(50)83)79(119)97-61(38-122-124-40-63(77(116)117)95-74(60)113)75(114)93-59(36-100)73(112)92-58(32-66(104)105)72(111)91-57/h9-11,13-15,17-18,20-25,30,34,41-42,53-63,100H,8,12,16,19,26-29,31-33,35-40,84H2,1-7H3,(H,85,87)(H,86,107)(H,88,101)(H,89,110)(H,90,108)(H,91,111)(H,92,112)(H,93,114)(H,94,109)(H,95,113)(H,96,118)(H,97,119)(H,98,106)(H,99,115)(H,102,103)(H,104,105)(H,116,117)/t53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,81?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 430 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as increase in cAMP level incubated for 30 mins |
Eur J Med Chem 103: 175-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.08.046
BindingDB Entry DOI: 10.7270/Q2JH3P05 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50130498
(CHEMBL3634090)Show SMILES [H][C@]12CSSC[C@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc3cnc[nH]3)C(=O)NC(C)(Cc3ccccc3)C(=O)N[C@@]([H])(CSSC[C@H](NC1=O)C(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(OC)cc1CC)C(=O)N[C@@H](CCCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N2 |r| Show InChI InChI=1S/C81H106N16O21S4/c1-8-48-32-51(118-7)26-27-52(48)49-24-22-46(23-25-49)31-57-71(108)87-54(21-15-20-45-16-11-9-12-17-45)69(106)88-56(30-44(2)3)70(107)92-60-39-119-121-41-62(86-64(99)37-84-68(105)55(28-29-65(100)101)94-78(116)80(4,5)96-67(104)53(82)33-50-36-83-43-85-50)76(113)97-81(6,35-47-18-13-10-14-19-47)79(117)95-61(40-120-122-42-63(77(114)115)93-74(60)111)75(112)91-59(38-98)73(110)90-58(34-66(102)103)72(109)89-57/h9-14,16-19,22-27,32,36,43-44,53-63,98H,8,15,20-21,28-31,33-35,37-42,82H2,1-7H3,(H,83,85)(H,84,105)(H,86,99)(H,87,108)(H,88,106)(H,89,109)(H,90,110)(H,91,112)(H,92,107)(H,93,111)(H,94,116)(H,95,117)(H,96,104)(H,97,113)(H,100,101)(H,102,103)(H,114,115)/t53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,81?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as increase in cAMP level incubated for 30 mins |
Eur J Med Chem 103: 175-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.08.046
BindingDB Entry DOI: 10.7270/Q2JH3P05 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50130501
(CHEMBL3634093)Show SMILES [H][C@]12CSSC[C@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc3cnc[nH]3)C(=O)N[C@@](C)(Cc3c(F)cccc3F)C(=O)N[C@@]([H])(CSSC[C@H](NC1=O)C(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(OC)cc1CC)C(=O)N[C@@H](CCCc1ccccc1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N2 |r| Show InChI InChI=1S/C90H106F2N16O21S4/c1-6-52-37-57(129-5)31-32-58(52)55-29-25-51(26-30-55)36-65-79(118)98-63(22-13-17-49-15-9-7-10-16-49)78(117)99-66(35-50-23-27-54(28-24-50)53-18-11-8-12-19-53)80(119)103-69-44-130-132-46-71(97-73(110)42-95-77(116)64(33-34-74(111)112)105-87(127)89(2,3)107-76(115)62(93)38-56-41-94-48-96-56)85(124)108-90(4,40-59-60(91)20-14-21-61(59)92)88(128)106-70(45-131-133-47-72(86(125)126)104-83(69)122)84(123)102-68(43-109)82(121)101-67(39-75(113)114)81(120)100-65/h7-12,14-16,18-21,23-32,37,41,48,62-72,109H,6,13,17,22,33-36,38-40,42-47,93H2,1-5H3,(H,94,96)(H,95,116)(H,97,110)(H,98,118)(H,99,117)(H,100,120)(H,101,121)(H,102,123)(H,103,119)(H,104,122)(H,105,127)(H,106,128)(H,107,115)(H,108,124)(H,111,112)(H,113,114)(H,125,126)/t62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,90-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 7.50E+3 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as increase in cAMP level incubated for 30 mins |
Eur J Med Chem 103: 175-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.08.046
BindingDB Entry DOI: 10.7270/Q2JH3P05 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50130502
(CHEMBL3634094)Show SMILES CCc1cc(OC)ccc1-c1ccc(C[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@](C)(Cc2ccccc2F)NC(=O)[C@H](CS)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)C(=O)N[C@@H](CCCc2ccccc2)C(N)=O)cc1 |r| Show InChI InChI=1S/C69H91FN14O16S2/c1-7-41-29-45(100-6)24-25-46(41)42-22-20-40(21-23-42)28-51(61(93)77-49(58(72)90)19-13-16-39-14-9-8-10-15-39)78-63(95)53(35-101)80-62(94)52(34-85)79-65(97)57(38(2)86)82-67(99)69(5,31-43-17-11-12-18-47(43)70)84-64(96)54(36-102)76-55(87)33-74-60(92)50(26-27-56(88)89)81-66(98)68(3,4)83-59(91)48(71)30-44-32-73-37-75-44/h8-12,14-15,17-18,20-25,29,32,37-38,48-54,57,85-86,101-102H,7,13,16,19,26-28,30-31,33-36,71H2,1-6H3,(H2,72,90)(H,73,75)(H,74,92)(H,76,87)(H,77,93)(H,78,95)(H,79,97)(H,80,94)(H,81,98)(H,82,99)(H,83,91)(H,84,96)(H,88,89)/t38-,48+,49+,50+,51+,52+,53+,54+,57+,69+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 850 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as increase in cAMP level incubated for 30 mins |
Eur J Med Chem 103: 175-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.08.046
BindingDB Entry DOI: 10.7270/Q2JH3P05 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50130503
(CHEMBL3634095)Show SMILES CCc1cc(OC)ccc1-c1ccc(C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@](C)(Cc2ccccc2F)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCc2ccccc2)C(=O)N[C@H](CS)C(N)=O)cc1 |r| Show InChI InChI=1S/C74H98FN15O19S2/c1-8-43-30-47(109-7)25-26-48(43)44-23-21-42(22-24-44)29-53(66(102)81-51(65(101)84-55(36-110)62(77)98)20-14-17-41-15-10-9-11-16-41)82-67(103)54(32-59(96)97)83-68(104)56(37-111)85-69(105)60(39(2)91)88-72(108)74(6,33-45-18-12-13-19-49(45)75)90-70(106)61(40(3)92)87-57(93)35-79-64(100)52(27-28-58(94)95)86-71(107)73(4,5)89-63(99)50(76)31-46-34-78-38-80-46/h9-13,15-16,18-19,21-26,30,34,38-40,50-56,60-61,91-92,110-111H,8,14,17,20,27-29,31-33,35-37,76H2,1-7H3,(H2,77,98)(H,78,80)(H,79,100)(H,81,102)(H,82,103)(H,83,104)(H,84,101)(H,85,105)(H,86,107)(H,87,93)(H,88,108)(H,89,99)(H,90,106)(H,94,95)(H,96,97)/t39-,40-,50+,51+,52+,53+,54+,55-,56+,60+,61+,74+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.15E+3 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as increase in cAMP level incubated for 30 mins |
Eur J Med Chem 103: 175-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.08.046
BindingDB Entry DOI: 10.7270/Q2JH3P05 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50130478
(CHEMBL3633839)Show SMILES [H][C@@]12CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@]1([H])CSSC[C@]([H])(NC(=O)[C@H](CCCc3ccccc3)NC(=O)[C@H](Cc3ccc(cc3)-c3ccc(OC)cc3CC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@]([H])(NC(=O)[C@](C)(Cc3c(F)cccc3F)NC(=O)[C@@]([H])(NC(=O)CNC(=O)[C@H](CCC(O)=O)NC2=O)[C@@H](C)O)[C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N1 |r| Show InChI InChI=1S/C100H132F2N24O31S2/c1-9-56-33-59(157-8)27-28-60(56)57-25-23-55(24-26-57)32-66-90(147)114-64(21-13-18-54-16-11-10-12-17-54)89(146)122-71-46-158-159-47-72(121-86(143)51(4)112-78(135)41-105-74(131)38-104-75(132)39-107-84(141)49(2)113-85(142)50(3)111-77(134)42-106-76(133)40-108-88(71)145)94(151)119-69(44-127)93(150)118-68(34-58-37-103-48-110-58)98(155)126-31-15-22-73(126)95(152)115-65(29-30-80(137)138)87(144)109-43-79(136)123-83(53(6)130)97(154)125-100(7,36-61-62(101)19-14-20-63(61)102)99(156)124-82(52(5)129)96(153)120-70(45-128)92(149)117-67(35-81(139)140)91(148)116-66/h10-12,14,16-17,19-20,23-28,33,37,48-53,64-73,82-83,127-130H,9,13,15,18,21-22,29-32,34-36,38-47H2,1-8H3,(H,103,110)(H,104,132)(H,105,131)(H,106,133)(H,107,141)(H,108,145)(H,109,144)(H,111,134)(H,112,135)(H,113,142)(H,114,147)(H,115,152)(H,116,148)(H,117,149)(H,118,150)(H,119,151)(H,120,153)(H,121,143)(H,122,146)(H,123,136)(H,124,156)(H,125,154)(H,137,138)(H,139,140)/t49-,50-,51-,52+,53+,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,82-,83-,100-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 430 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as increase in cAMP level incubated for 30 mins |
Eur J Med Chem 103: 175-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.08.046
BindingDB Entry DOI: 10.7270/Q2JH3P05 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50130486
(CHEMBL3633847)Show SMILES [H][C@@]12CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@]1([H])CSSC[C@]([H])(NC(=O)[C@H](CCCc3ccccc3)NC(=O)[C@H](Cc3ccc(cc3)-c3ccc(OC)cc3CC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@]([H])(NC(=O)[C@](C)(Cc3c(F)cccc3F)NC(=O)[C@@]([H])(NC(=O)CNC(=O)[C@H](CCC(O)=O)NC2=O)[C@@H](C)O)[C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N1 |r| Show InChI InChI=1S/C112H156F2N24O31S2/c1-16-63-40-66(169-15)34-35-67(63)64-32-30-62(31-33-64)39-73-97(154)121-71(28-20-25-61-23-18-17-19-24-61)96(153)128-78-51-170-171-52-79(129-104(161)90(57(8)9)134-105(162)89(56(6)7)131-83(145)48-119-103(160)87(54(2)3)133-107(164)91(58(10)11)135-106(163)88(55(4)5)130-82(144)46-116-81(143)45-117-95(78)152)101(158)126-76(49-139)100(157)125-75(41-65-44-115-53-120-65)110(167)138-38-22-29-80(138)102(159)122-72(36-37-85(147)148)94(151)118-47-84(146)132-93(60(13)142)109(166)137-112(14,43-68-69(113)26-21-27-70(68)114)111(168)136-92(59(12)141)108(165)127-77(50-140)99(156)124-74(42-86(149)150)98(155)123-73/h17-19,21,23-24,26-27,30-35,40,44,53-60,71-80,87-93,139-142H,16,20,22,25,28-29,36-39,41-43,45-52H2,1-15H3,(H,115,120)(H,116,143)(H,117,152)(H,118,151)(H,119,160)(H,121,154)(H,122,159)(H,123,155)(H,124,156)(H,125,157)(H,126,158)(H,127,165)(H,128,153)(H,129,161)(H,130,144)(H,131,145)(H,132,146)(H,133,164)(H,134,162)(H,135,163)(H,136,168)(H,137,166)(H,147,148)(H,149,150)/t59-,60-,71+,72+,73+,74+,75+,76+,77+,78+,79+,80+,87+,88+,89+,90+,91+,92+,93+,112+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as increase in cAMP level incubated for 30 mins |
Eur J Med Chem 103: 175-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.08.046
BindingDB Entry DOI: 10.7270/Q2JH3P05 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50130491
(CHEMBL3633852)Show SMILES CCc1cc(OC)ccc1-c1ccc(C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@](C)(Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCc2ccccc2)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc3ccc(cc3)-c3ccccc3)NC(=O)CNC2=O)C(=O)N[C@@H](CO)C(O)=O)cc1 |r| Show InChI InChI=1S/C113H146N24O32S2/c1-9-69-45-74(169-8)38-39-75(69)72-36-32-67(33-37-72)44-80(128-104(159)81(47-93(149)150)129-105(160)82(55-138)130-108(163)94(63(5)140)135-112(168)113(7,48-68-23-15-11-16-24-68)136-109(164)95(64(6)141)134-91(146)54-119-99(154)78(40-41-92(147)148)127-107(162)86-29-20-42-137(86)110(165)76(114)46-73-49-115-59-121-73)103(158)126-77(28-19-25-65-21-13-10-14-22-65)101(156)133-84-57-170-171-58-85(106(161)131-83(56-139)111(166)167)132-98(153)61(3)122-89(144)52-117-87(142)50-116-88(143)51-118-96(151)60(2)123-97(152)62(4)124-102(157)79(125-90(145)53-120-100(84)155)43-66-30-34-71(35-31-66)70-26-17-12-18-27-70/h10-18,21-24,26-27,30-39,45,49,59-64,76-86,94-95,138-141H,9,19-20,25,28-29,40-44,46-48,50-58,114H2,1-8H3,(H,115,121)(H,116,143)(H,117,142)(H,118,151)(H,119,154)(H,120,155)(H,122,144)(H,123,152)(H,124,157)(H,125,145)(H,126,158)(H,127,162)(H,128,159)(H,129,160)(H,130,163)(H,131,161)(H,132,153)(H,133,156)(H,134,146)(H,135,168)(H,136,164)(H,147,148)(H,149,150)(H,166,167)/t60-,61-,62-,63+,64+,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,94-,95-,113-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 47 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as increase in cAMP level incubated for 30 mins |
Eur J Med Chem 103: 175-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.08.046
BindingDB Entry DOI: 10.7270/Q2JH3P05 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50130411
(CHEMBL3632636)Show SMILES [H][C@@]12CCCN1C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@]1([H])CSSC[C@]3([H])NC(=O)[C@@]([H])(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@]4([H])CCCN4C(=O)[C@H](Cc4cnc[nH]4)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@]([H])(CSSC[C@]([H])(NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)CNC(=O)CNC3=O)C(=O)N1)NC(=O)[C@H](CCCNC(N)=N)NC2=O)[C@@H](C)CC |r| Show InChI InChI=1S/C85H122N28O31S4/c1-5-38(2)67-82(142)110-52-33-145-147-36-55-79(139)107-51(32-114)76(136)106-50(25-66(126)127)84(144)113-20-8-10-56(113)80(140)100-44(9-6-18-90-85(87)88)71(131)108-54(35-148-146-34-53(77(137)109-55)99-63(121)31-93-59(117)27-91-60(118)28-94-68(128)39(3)98-69(129)40(4)97-62(120)30-92-61(119)29-95-70(52)130)78(138)103-47(23-58(86)116)74(134)102-46(21-41-12-14-43(115)15-13-41)73(133)104-48(24-65(124)125)75(135)105-49(22-42-26-89-37-96-42)83(143)112-19-7-11-57(112)81(141)101-45(72(132)111-67)16-17-64(122)123/h12-15,26,37-40,44-57,67,114-115H,5-11,16-25,27-36H2,1-4H3,(H2,86,116)(H,89,96)(H,91,118)(H,92,119)(H,93,117)(H,94,128)(H,95,130)(H,97,120)(H,98,129)(H,99,121)(H,100,140)(H,101,141)(H,102,134)(H,103,138)(H,104,133)(H,105,135)(H,106,136)(H,107,139)(H,108,131)(H,109,137)(H,110,142)(H,111,132)(H,122,123)(H,124,125)(H,126,127)(H4,87,88,90)/t38-,39-,40-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,67-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.140 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as increase in cAMP level incubated for 30 mins |
Eur J Med Chem 103: 175-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.08.046
BindingDB Entry DOI: 10.7270/Q2JH3P05 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50130480
(CHEMBL3633841)Show SMILES CCc1cc(OC)ccc1-c1ccc(C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@](C)(Cc2c(F)cccc2F)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCc2ccccc2)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)CNC(=O)CNC2=O)C(=O)N[C@@H](CO)C(N)=O)cc1 |r| Show InChI InChI=1S/C100H135F2N25O31S2/c1-9-56-33-59(158-8)27-28-60(56)57-25-23-55(24-26-57)32-67(91(149)116-65(21-13-18-54-16-11-10-12-17-54)90(148)123-71-46-159-160-47-72(94(152)120-69(44-128)84(104)142)122-87(145)51(4)114-78(136)41-107-74(132)38-106-75(133)39-109-85(143)49(2)115-86(144)50(3)113-77(135)42-108-76(134)40-110-89(71)147)118-92(150)68(35-81(140)141)119-93(151)70(45-129)121-96(154)82(52(5)130)125-99(157)100(7,36-61-62(101)19-14-20-63(61)102)126-97(155)83(53(6)131)124-79(137)43-111-88(146)66(29-30-80(138)139)117-95(153)73-22-15-31-127(73)98(156)64(103)34-58-37-105-48-112-58/h10-12,14,16-17,19-20,23-28,33,37,48-53,64-73,82-83,128-131H,9,13,15,18,21-22,29-32,34-36,38-47,103H2,1-8H3,(H2,104,142)(H,105,112)(H,106,133)(H,107,132)(H,108,134)(H,109,143)(H,110,147)(H,111,146)(H,113,135)(H,114,136)(H,115,144)(H,116,149)(H,117,153)(H,118,150)(H,119,151)(H,120,152)(H,121,154)(H,122,145)(H,123,148)(H,124,137)(H,125,157)(H,126,155)(H,138,139)(H,140,141)/t49-,50-,51-,52+,53+,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,82-,83-,100-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 13 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as increase in cAMP level incubated for 30 mins |
Eur J Med Chem 103: 175-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.08.046
BindingDB Entry DOI: 10.7270/Q2JH3P05 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50130481
(CHEMBL3633842)Show SMILES CCc1cc(OC)ccc1-c1ccc(C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@](C)(Cc2ccccc2F)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCc2ccccc2)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)CNC(=O)CNC2=O)C(=O)N[C@@H](CO)C(O)=O)cc1 |r| Show InChI InChI=1S/C100H135FN24O32S2/c1-9-57-34-61(157-8)28-29-62(57)58-26-24-56(25-27-58)33-67(90(146)114-65(22-15-19-55-17-11-10-12-18-55)89(145)121-71-47-158-159-48-72(93(149)119-70(46-127)98(154)155)120-86(142)52(4)112-78(134)42-105-74(130)39-104-75(131)40-107-84(140)50(2)113-85(141)51(3)111-77(133)43-106-76(132)41-108-88(71)144)116-91(147)68(36-81(138)139)117-92(148)69(45-126)118-95(151)82(53(5)128)123-99(156)100(7,37-59-20-13-14-21-63(59)101)124-96(152)83(54(6)129)122-79(135)44-109-87(143)66(30-31-80(136)137)115-94(150)73-23-16-32-125(73)97(153)64(102)35-60-38-103-49-110-60/h10-14,17-18,20-21,24-29,34,38,49-54,64-73,82-83,126-129H,9,15-16,19,22-23,30-33,35-37,39-48,102H2,1-8H3,(H,103,110)(H,104,131)(H,105,130)(H,106,132)(H,107,140)(H,108,144)(H,109,143)(H,111,133)(H,112,134)(H,113,141)(H,114,146)(H,115,150)(H,116,147)(H,117,148)(H,118,151)(H,119,149)(H,120,142)(H,121,145)(H,122,135)(H,123,156)(H,124,152)(H,136,137)(H,138,139)(H,154,155)/t50-,51-,52-,53+,54+,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,82-,83-,100-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as increase in cAMP level incubated for 30 mins |
Eur J Med Chem 103: 175-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.08.046
BindingDB Entry DOI: 10.7270/Q2JH3P05 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50130485
(CHEMBL3633846)Show SMILES CCc1cc(OC)ccc1-c1ccc(C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@](C)(Cc2c(F)cccc2F)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCc2ccccc2)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)CNC2=O)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(=O)N[C@@H](CO)C(O)=O)cc1 |r| Show InChI InChI=1S/C112H158F2N24O32S2/c1-16-63-40-66(170-15)34-35-67(63)64-32-30-62(31-33-64)39-74(124-98(155)75(42-86(149)150)125-99(156)76(49-139)126-107(164)92(59(12)141)136-111(169)112(14,43-68-69(113)26-21-27-70(68)114)137-108(165)93(60(13)142)132-84(146)47-119-94(151)73(36-37-85(147)148)123-101(158)80-29-22-38-138(80)109(166)71(115)41-65-44-116-53-121-65)97(154)122-72(28-20-25-61-23-18-17-19-24-61)96(153)128-78-51-171-172-52-79(100(157)127-77(50-140)110(167)168)129-103(160)90(57(8)9)134-104(161)89(56(6)7)131-83(145)48-120-102(159)87(54(2)3)133-106(163)91(58(10)11)135-105(162)88(55(4)5)130-82(144)46-117-81(143)45-118-95(78)152/h17-19,21,23-24,26-27,30-35,40,44,53-60,71-80,87-93,139-142H,16,20,22,25,28-29,36-39,41-43,45-52,115H2,1-15H3,(H,116,121)(H,117,143)(H,118,152)(H,119,151)(H,120,159)(H,122,154)(H,123,158)(H,124,155)(H,125,156)(H,126,164)(H,127,157)(H,128,153)(H,129,160)(H,130,144)(H,131,145)(H,132,146)(H,133,163)(H,134,161)(H,135,162)(H,136,169)(H,137,165)(H,147,148)(H,149,150)(H,167,168)/t59-,60-,71+,72+,73+,74+,75+,76+,77+,78+,79+,80+,87+,88+,89+,90+,91+,92+,93+,112+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 19 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as increase in cAMP level incubated for 30 mins |
Eur J Med Chem 103: 175-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.08.046
BindingDB Entry DOI: 10.7270/Q2JH3P05 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50130488
(CHEMBL3633849)Show SMILES [H][C@@]12CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@]1([H])CSSC[C@]([H])(NC(=O)[C@H](CCCc3ccccc3)NC(=O)[C@H](Cc3ccc(cc3)-c3ccc(OC)cc3CC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@]([H])(NC(=O)[C@](C)(Cc3ccccc3)NC(=O)[C@@]([H])(NC(=O)CNC(=O)[C@H](CCC(O)=O)NC2=O)[C@@H](C)O)[C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1 |r| Show InChI InChI=1S/C117H168N24O31S2/c1-16-71-47-74(172-15)36-37-75(71)72-34-32-69(33-35-72)46-83-107(162)126-76(30-23-29-68-25-19-17-20-26-68)102(157)136-88-58-173-174-59-89(137-106(161)82(45-65(10)11)130-104(159)80(43-63(6)7)125-93(148)54-122-100(155)78(41-61(2)3)128-105(160)81(44-64(8)9)129-103(158)79(42-62(4)5)124-92(147)53-119-91(146)52-120-101(88)156)111(166)134-86(56-142)110(165)133-85(48-73-51-118-60-123-73)115(170)141-40-24-31-90(141)112(167)127-77(38-39-95(150)151)99(154)121-55-94(149)138-98(67(13)145)114(169)140-117(14,50-70-27-21-18-22-28-70)116(171)139-97(66(12)144)113(168)135-87(57-143)109(164)132-84(49-96(152)153)108(163)131-83/h17-22,25-28,32-37,47,51,60-67,76-90,97-98,142-145H,16,23-24,29-31,38-46,48-50,52-59H2,1-15H3,(H,118,123)(H,119,146)(H,120,156)(H,121,154)(H,122,155)(H,124,147)(H,125,148)(H,126,162)(H,127,167)(H,128,160)(H,129,158)(H,130,159)(H,131,163)(H,132,164)(H,133,165)(H,134,166)(H,135,168)(H,136,157)(H,137,161)(H,138,149)(H,139,171)(H,140,169)(H,150,151)(H,152,153)/t66-,67-,76+,77+,78+,79+,80+,81+,82+,83+,84+,85+,86+,87+,88+,89+,90+,97+,98+,117+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as increase in cAMP level incubated for 30 mins |
Eur J Med Chem 103: 175-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.08.046
BindingDB Entry DOI: 10.7270/Q2JH3P05 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50130495
(CHEMBL3633856)Show SMILES [H][C@]12CSSC[C@H](NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CO)C(=O)N[C@@]([H])(CSSC[C@H](NC1=O)C(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N2 |r| Show InChI InChI=1S/C49H79N17O14S4/c1-24(2)15-29-42(74)65-36-23-84-83-21-34(64-39(71)26(51)18-67)47(79)62-32(19-68)45(77)66-35(22-82-81-20-33(38(53)70)63-48(36)80)46(78)58-27(11-6-7-13-50)40(72)57-28(12-8-14-56-49(54)55)41(73)61-31(17-37(52)69)44(76)60-30(43(75)59-29)16-25-9-4-3-5-10-25/h3-5,9-10,24,26-36,67-68H,6-8,11-23,50-51H2,1-2H3,(H2,52,69)(H2,53,70)(H,57,72)(H,58,78)(H,59,75)(H,60,76)(H,61,73)(H,62,79)(H,63,80)(H,64,71)(H,65,74)(H,66,77)(H4,54,55,56)/t26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.470 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as increase in cAMP level incubated for 30 mins |
Eur J Med Chem 103: 175-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.08.046
BindingDB Entry DOI: 10.7270/Q2JH3P05 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50130477
(CHEMBL3633838)Show SMILES CCc1cc(OC)ccc1-c1ccc(C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@](C)(Cc2c(F)cccc2F)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCc2ccccc2)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)CNC(=O)CNC2=O)C(=O)N[C@@H](CO)C(O)=O)cc1 |r| Show InChI InChI=1S/C100H134F2N24O32S2/c1-9-56-33-59(158-8)27-28-60(56)57-25-23-55(24-26-57)32-67(90(147)115-65(21-13-18-54-16-11-10-12-17-54)89(146)122-71-46-159-160-47-72(93(150)120-70(45-128)98(155)156)121-86(143)51(4)113-78(135)41-106-74(131)38-105-75(132)39-108-84(141)49(2)114-85(142)50(3)112-77(134)42-107-76(133)40-109-88(71)145)117-91(148)68(35-81(139)140)118-92(149)69(44-127)119-95(152)82(52(5)129)124-99(157)100(7,36-61-62(101)19-14-20-63(61)102)125-96(153)83(53(6)130)123-79(136)43-110-87(144)66(29-30-80(137)138)116-94(151)73-22-15-31-126(73)97(154)64(103)34-58-37-104-48-111-58/h10-12,14,16-17,19-20,23-28,33,37,48-53,64-73,82-83,127-130H,9,13,15,18,21-22,29-32,34-36,38-47,103H2,1-8H3,(H,104,111)(H,105,132)(H,106,131)(H,107,133)(H,108,141)(H,109,145)(H,110,144)(H,112,134)(H,113,135)(H,114,142)(H,115,147)(H,116,151)(H,117,148)(H,118,149)(H,119,152)(H,120,150)(H,121,143)(H,122,146)(H,123,136)(H,124,157)(H,125,153)(H,137,138)(H,139,140)(H,155,156)/t49-,50-,51-,52+,53+,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,82-,83-,100-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.850 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as increase in cAMP level incubated for 30 mins |
Eur J Med Chem 103: 175-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.08.046
BindingDB Entry DOI: 10.7270/Q2JH3P05 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50130499
(CHEMBL3634091)Show SMILES [H][C@]12CSSC[C@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc3cnc[nH]3)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@]([H])(CSSC[C@H](NC1=O)C(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(OC)cc1CC)C(=O)N[C@@H](CCCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N2 |r| Show InChI InChI=1S/C80H104N16O21S4/c1-7-47-32-50(117-6)25-26-51(47)48-23-21-46(22-24-48)31-57-71(107)86-53(20-14-19-44-15-10-8-11-16-44)69(105)87-55(29-43(2)3)70(106)92-62-40-119-118-38-60(85-64(98)36-83-68(104)54(27-28-65(99)100)95-79(116)80(4,5)96-67(103)52(81)33-49-35-82-42-84-49)75(111)89-56(30-45-17-12-9-13-18-45)72(108)93-61(39-120-121-41-63(78(114)115)94-77(62)113)76(112)91-59(37-97)74(110)90-58(34-66(101)102)73(109)88-57/h8-13,15-18,21-26,32,35,42-43,52-63,97H,7,14,19-20,27-31,33-34,36-41,81H2,1-6H3,(H,82,84)(H,83,104)(H,85,98)(H,86,107)(H,87,105)(H,88,109)(H,89,111)(H,90,110)(H,91,112)(H,92,106)(H,93,108)(H,94,113)(H,95,116)(H,96,103)(H,99,100)(H,101,102)(H,114,115)/t52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as increase in cAMP level incubated for 30 mins |
Eur J Med Chem 103: 175-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.08.046
BindingDB Entry DOI: 10.7270/Q2JH3P05 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50130492
(CHEMBL3633853)Show SMILES [H][C@@]12CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@]1([H])CSSC[C@]([H])(NC(=O)[C@H](CCCc3ccccc3)NC(=O)[C@H](Cc3ccc(cc3)-c3ccc(OC)cc3CC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@]([H])(NC(=O)[C@](C)(Cc3ccccc3)NC(=O)[C@@]([H])(NC(=O)CNC(=O)[C@H](CCC(O)=O)NC2=O)[C@@H](C)O)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](Cc2ccc(cc2)-c2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N1 |r| Show InChI InChI=1S/C113H144N24O31S2/c1-9-69-45-74(168-8)38-39-75(69)72-36-32-67(33-37-72)44-79-103(158)125-76(28-19-25-65-21-13-10-14-22-65)101(156)133-84-57-169-170-58-85(132-98(153)61(3)121-89(144)52-116-87(142)50-115-88(143)51-117-96(151)60(2)122-97(152)62(4)123-102(157)78(124-90(145)53-119-100(84)155)43-66-30-34-71(35-31-66)70-26-17-12-18-27-70)107(162)130-82(55-138)106(161)129-81(46-73-49-114-59-120-73)111(166)137-42-20-29-86(137)108(163)126-77(40-41-92(147)148)99(154)118-54-91(146)134-95(64(6)141)110(165)136-113(7,48-68-23-15-11-16-24-68)112(167)135-94(63(5)140)109(164)131-83(56-139)105(160)128-80(47-93(149)150)104(159)127-79/h10-18,21-24,26-27,30-39,45,49,59-64,76-86,94-95,138-141H,9,19-20,25,28-29,40-44,46-48,50-58H2,1-8H3,(H,114,120)(H,115,143)(H,116,142)(H,117,151)(H,118,154)(H,119,155)(H,121,144)(H,122,152)(H,123,157)(H,124,145)(H,125,158)(H,126,163)(H,127,159)(H,128,160)(H,129,161)(H,130,162)(H,131,164)(H,132,153)(H,133,156)(H,134,146)(H,135,167)(H,136,165)(H,147,148)(H,149,150)/t60-,61-,62-,63+,64+,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,94-,95-,113-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 360 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as increase in cAMP level incubated for 30 mins |
Eur J Med Chem 103: 175-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.08.046
BindingDB Entry DOI: 10.7270/Q2JH3P05 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50130500
(CHEMBL3634092)Show SMILES [H][C@]12CSSC[C@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@H](Cc3cnc[nH]3)NC(C)=O)C(=O)N[C@@](C)(Cc3c(F)cccc3F)C(=O)N[C@@]([H])(CSSC[C@H](NC1=O)C(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(OC)cc1CC)C(=O)N[C@@H](CCCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N2 |r| Show InChI InChI=1S/C83H106F2N16O22S4/c1-9-47-31-50(123-8)25-26-51(47)48-23-21-46(22-24-48)30-58-72(112)91-55(20-13-17-45-15-11-10-12-16-45)70(110)92-57(29-43(2)3)71(111)96-62-38-124-126-40-64(90-66(104)36-87-69(109)56(27-28-67(105)106)98-80(121)82(5,6)100-77(117)59(89-44(4)103)32-49-35-86-42-88-49)78(118)101-83(7,34-52-53(84)18-14-19-54(52)85)81(122)99-63(39-125-127-41-65(79(119)120)97-75(62)115)76(116)95-61(37-102)74(114)94-60(33-68(107)108)73(113)93-58/h10-12,14-16,18-19,21-26,31,35,42-43,55-65,102H,9,13,17,20,27-30,32-34,36-41H2,1-8H3,(H,86,88)(H,87,109)(H,89,103)(H,90,104)(H,91,112)(H,92,110)(H,93,113)(H,94,114)(H,95,116)(H,96,111)(H,97,115)(H,98,121)(H,99,122)(H,100,117)(H,101,118)(H,105,106)(H,107,108)(H,119,120)/t55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,83-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 69 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as increase in cAMP level incubated for 30 mins |
Eur J Med Chem 103: 175-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.08.046
BindingDB Entry DOI: 10.7270/Q2JH3P05 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50130482
(CHEMBL3633843)Show SMILES [H][C@@]12CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@]1([H])CSSC[C@]([H])(NC(=O)[C@H](CCCc3ccccc3)NC(=O)[C@H](Cc3ccc(cc3)-c3ccc(OC)cc3CC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@]([H])(NC(=O)[C@](C)(Cc3ccccc3F)NC(=O)[C@@]([H])(NC(=O)CNC(=O)[C@H](CCC(O)=O)NC2=O)[C@@H](C)O)[C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N1 |r| Show InChI InChI=1S/C100H133FN24O31S2/c1-9-57-34-61(156-8)28-29-62(57)58-26-24-56(25-27-58)33-66-90(146)113-64(22-15-19-55-17-11-10-12-18-55)89(145)121-71-47-157-158-48-72(120-86(142)52(4)111-78(134)42-104-74(130)39-103-75(131)40-106-84(140)50(2)112-85(141)51(3)110-77(133)43-105-76(132)41-107-88(71)144)94(150)118-69(45-126)93(149)117-68(35-60-38-102-49-109-60)98(154)125-32-16-23-73(125)95(151)114-65(30-31-80(136)137)87(143)108-44-79(135)122-83(54(6)129)97(153)124-100(7,37-59-20-13-14-21-63(59)101)99(155)123-82(53(5)128)96(152)119-70(46-127)92(148)116-67(36-81(138)139)91(147)115-66/h10-14,17-18,20-21,24-29,34,38,49-54,64-73,82-83,126-129H,9,15-16,19,22-23,30-33,35-37,39-48H2,1-8H3,(H,102,109)(H,103,131)(H,104,130)(H,105,132)(H,106,140)(H,107,144)(H,108,143)(H,110,133)(H,111,134)(H,112,141)(H,113,146)(H,114,151)(H,115,147)(H,116,148)(H,117,149)(H,118,150)(H,119,152)(H,120,142)(H,121,145)(H,122,135)(H,123,155)(H,124,153)(H,136,137)(H,138,139)/t50-,51-,52-,53+,54+,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,82-,83-,100-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as increase in cAMP level incubated for 30 mins |
Eur J Med Chem 103: 175-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.08.046
BindingDB Entry DOI: 10.7270/Q2JH3P05 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50130479
(CHEMBL3633840)Show SMILES [H][C@]12CSSC[C@]([H])(NC(=O)[C@H](C)NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)CNC(=O)CNC1=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)NC(C)(C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@](C)(Cc1c(F)cccc1F)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(OC)cc1CC)C(=O)N[C@@H](CCCc1ccccc1)C(=O)N2 |r| Show InChI InChI=1S/C99H132F2N24O31S2/c1-11-55-32-58(156-10)27-28-59(55)56-25-23-54(24-26-56)31-65-88(146)113-63(22-15-19-53-17-13-12-14-18-53)87(145)120-70-45-157-158-46-71(119-84(142)50(4)111-76(134)40-104-72(130)37-103-73(131)38-106-82(140)48(2)112-83(141)49(3)110-75(133)41-105-74(132)39-107-86(70)144)92(150)117-68(43-126)90(148)115-66(33-57-36-102-47-109-57)93(151)124-98(7,8)96(154)121-64(29-30-78(136)137)85(143)108-42-77(135)122-81(52(6)129)95(153)125-99(9,35-60-61(100)20-16-21-62(60)101)97(155)123-80(51(5)128)94(152)118-69(44-127)91(149)116-67(34-79(138)139)89(147)114-65/h12-14,16-18,20-21,23-28,32,36,47-52,63-71,80-81,126-129H,11,15,19,22,29-31,33-35,37-46H2,1-10H3,(H,102,109)(H,103,131)(H,104,130)(H,105,132)(H,106,140)(H,107,144)(H,108,143)(H,110,133)(H,111,134)(H,112,141)(H,113,146)(H,114,147)(H,115,148)(H,116,149)(H,117,150)(H,118,152)(H,119,142)(H,120,145)(H,121,154)(H,122,135)(H,123,155)(H,124,151)(H,125,153)(H,136,137)(H,138,139)/t48-,49-,50-,51+,52+,63-,64-,65-,66-,67-,68-,69-,70-,71-,80-,81-,99-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as increase in cAMP level incubated for 30 mins |
Eur J Med Chem 103: 175-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.08.046
BindingDB Entry DOI: 10.7270/Q2JH3P05 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50130483
(CHEMBL3633844)Show SMILES [H][C@@]12CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@]1([H])CSSC[C@]([H])(NC(=O)[C@H](CCCc3ccccc3)NC(=O)[C@H](Cc3ccc(cc3)-c3ccc(OC)cc3CC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@]([H])(NC(=O)[C@](C)(Cc3ccccc3)NC(=O)[C@@]([H])(NC(=O)CNC(=O)[C@H](CCC(O)=O)NC2=O)[C@@H](C)O)[C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N1 |r| Show InChI InChI=1S/C100H134N24O31S2/c1-9-59-35-62(155-8)29-30-63(59)60-27-25-57(26-28-60)34-66-90(145)112-64(23-16-22-56-18-12-10-13-19-56)89(144)120-71-48-156-157-49-72(119-86(141)53(4)110-78(133)43-103-74(129)40-102-75(130)41-105-84(139)51(2)111-85(140)52(3)109-77(132)44-104-76(131)42-106-88(71)143)94(149)117-69(46-125)93(148)116-68(36-61-39-101-50-108-61)98(153)124-33-17-24-73(124)95(150)113-65(31-32-80(135)136)87(142)107-45-79(134)121-83(55(6)128)97(152)123-100(7,38-58-20-14-11-15-21-58)99(154)122-82(54(5)127)96(151)118-70(47-126)92(147)115-67(37-81(137)138)91(146)114-66/h10-15,18-21,25-30,35,39,50-55,64-73,82-83,125-128H,9,16-17,22-24,31-34,36-38,40-49H2,1-8H3,(H,101,108)(H,102,130)(H,103,129)(H,104,131)(H,105,139)(H,106,143)(H,107,142)(H,109,132)(H,110,133)(H,111,140)(H,112,145)(H,113,150)(H,114,146)(H,115,147)(H,116,148)(H,117,149)(H,118,151)(H,119,141)(H,120,144)(H,121,134)(H,122,154)(H,123,152)(H,135,136)(H,137,138)/t51-,52-,53-,54+,55+,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,82-,83-,100-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as increase in cAMP level incubated for 30 mins |
Eur J Med Chem 103: 175-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.08.046
BindingDB Entry DOI: 10.7270/Q2JH3P05 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50130487
(CHEMBL3633848)Show SMILES CCc1cc(OC)ccc1-c1ccc(C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@](C)(Cc2ccccc2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCc2ccccc2)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)CNC2=O)C(=O)N[C@@H](CO)C(O)=O)cc1 |r| Show InChI InChI=1S/C117H170N24O32S2/c1-16-71-47-74(173-15)36-37-75(71)72-34-32-69(33-35-72)46-84(132-108(163)85(49-96(152)153)133-109(164)86(56-142)134-112(167)97(66(12)144)139-116(172)117(14,50-70-27-21-18-22-28-70)140-113(168)98(67(13)145)138-94(149)55-122-99(154)78(38-39-95(150)151)128-111(166)90-31-24-40-141(90)114(169)76(118)48-73-51-119-60-124-73)107(162)127-77(30-23-29-68-25-19-17-20-26-68)102(157)136-88-58-174-175-59-89(110(165)135-87(57-143)115(170)171)137-106(161)83(45-65(10)11)131-104(159)81(43-63(6)7)126-93(148)54-123-100(155)79(41-61(2)3)129-105(160)82(44-64(8)9)130-103(158)80(42-62(4)5)125-92(147)53-120-91(146)52-121-101(88)156/h17-22,25-28,32-37,47,51,60-67,76-90,97-98,142-145H,16,23-24,29-31,38-46,48-50,52-59,118H2,1-15H3,(H,119,124)(H,120,146)(H,121,156)(H,122,154)(H,123,155)(H,125,147)(H,126,148)(H,127,162)(H,128,166)(H,129,160)(H,130,158)(H,131,159)(H,132,163)(H,133,164)(H,134,167)(H,135,165)(H,136,157)(H,137,161)(H,138,149)(H,139,172)(H,140,168)(H,150,151)(H,152,153)(H,170,171)/t66-,67-,76+,77+,78+,79+,80+,81+,82+,83+,84+,85+,86+,87+,88+,89+,90+,97+,98+,117+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 130 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as increase in cAMP level incubated for 30 mins |
Eur J Med Chem 103: 175-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.08.046
BindingDB Entry DOI: 10.7270/Q2JH3P05 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50130494
(CHEMBL3633855)Show SMILES [H][C@@]12CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)CNC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCc1ccccc1)NC(=O)[C@H](Cc1ccc(cc1)-c1ccc(OC)cc1CC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@]([H])(NC(=O)[C@](C)(Cc1c(F)cccc1F)NC(=O)[C@@]([H])(NC(=O)CNC(=O)[C@H](CCC(O)=O)NC2=O)[C@@H](C)O)[C@@H](C)O)C(C)(C)S)C(C)(C)S |r| Show InChI InChI=1S/C104H142F2N24O31S2/c1-13-58-37-61(161-12)31-32-62(58)59-29-27-57(28-30-59)36-68-91(150)118-66(25-17-22-56-20-15-14-16-21-56)90(149)128-84(102(7,8)162)98(157)113-44-76(137)110-46-77(138)115-52(3)87(146)117-51(2)86(145)111-43-75(136)108-42-74(135)109-45-78(139)116-53(4)88(147)127-85(103(9,10)163)99(158)124-72(49-132)94(153)122-70(38-60-41-107-50-114-60)100(159)130-35-19-26-73(130)95(154)119-67(33-34-80(141)142)89(148)112-47-79(140)125-83(55(6)134)97(156)129-104(11,40-63-64(105)23-18-24-65(63)106)101(160)126-82(54(5)133)96(155)123-71(48-131)93(152)121-69(39-81(143)144)92(151)120-68/h14-16,18,20-21,23-24,27-32,37,41,50-55,66-73,82-85,131-134,162-163H,13,17,19,22,25-26,33-36,38-40,42-49H2,1-12H3,(H,107,114)(H,108,136)(H,109,135)(H,110,137)(H,111,145)(H,112,148)(H,113,157)(H,115,138)(H,116,139)(H,117,146)(H,118,150)(H,119,154)(H,120,151)(H,121,152)(H,122,153)(H,123,155)(H,124,158)(H,125,140)(H,126,160)(H,127,147)(H,128,149)(H,129,156)(H,141,142)(H,143,144)/t51?,52?,53?,54-,55-,66?,67?,68?,69?,70?,71?,72?,73+,82+,83+,84?,85?,104+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as increase in cAMP level incubated for 30 mins |
Eur J Med Chem 103: 175-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.08.046
BindingDB Entry DOI: 10.7270/Q2JH3P05 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50130497
(CHEMBL3634089)Show SMILES [H][C@]12CSSC[C@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc3cnc[nH]3)C(=O)NC(C)(Cc3ccccc3F)C(=O)N[C@@]([H])(CSSC[C@H](NC1=O)C(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccc(OC)cc1CC)C(=O)N[C@@H](CCCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N2 |r| Show InChI InChI=1S/C81H105FN16O21S4/c1-8-46-31-50(119-7)25-26-51(46)47-23-21-45(22-24-47)30-57-71(109)88-54(20-14-17-44-15-10-9-11-16-44)69(107)89-56(29-43(2)3)70(108)93-60-38-120-122-40-62(87-64(100)36-85-68(106)55(27-28-65(101)102)95-78(117)80(4,5)97-67(105)53(83)32-49-35-84-42-86-49)76(114)98-81(6,34-48-18-12-13-19-52(48)82)79(118)96-61(39-121-123-41-63(77(115)116)94-74(60)112)75(113)92-59(37-99)73(111)91-58(33-66(103)104)72(110)90-57/h9-13,15-16,18-19,21-26,31,35,42-43,53-63,99H,8,14,17,20,27-30,32-34,36-41,83H2,1-7H3,(H,84,86)(H,85,106)(H,87,100)(H,88,109)(H,89,107)(H,90,110)(H,91,111)(H,92,113)(H,93,108)(H,94,112)(H,95,117)(H,96,118)(H,97,105)(H,98,114)(H,101,102)(H,103,104)(H,115,116)/t53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,81?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as increase in cAMP level incubated for 30 mins |
Eur J Med Chem 103: 175-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.08.046
BindingDB Entry DOI: 10.7270/Q2JH3P05 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50130504
(CHEMBL3634096)Show SMILES CCc1cc(OC)ccc1-c1ccc(C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@](C)(Cc2ccccc2F)NC(=O)[C@H](CS)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)C(=O)N[C@@H](CCCc2ccccc2)C(=O)N[C@H](CS)C(N)=O)cc1 |r| Show InChI InChI=1S/C73H96FN15O19S2/c1-7-42-29-46(108-6)24-25-47(42)43-22-20-41(21-23-43)28-52(65(101)81-50(64(100)85-55(36-109)61(76)97)19-13-16-40-14-9-8-10-15-40)82-66(102)53(31-59(95)96)83-67(103)54(35-90)84-69(105)60(39(2)91)87-71(107)73(5,32-44-17-11-12-18-48(44)74)89-68(104)56(37-110)80-57(92)34-78-63(99)51(26-27-58(93)94)86-70(106)72(3,4)88-62(98)49(75)30-45-33-77-38-79-45/h8-12,14-15,17-18,20-25,29,33,38-39,49-56,60,90-91,109-110H,7,13,16,19,26-28,30-32,34-37,75H2,1-6H3,(H2,76,97)(H,77,79)(H,78,99)(H,80,92)(H,81,101)(H,82,102)(H,83,103)(H,84,105)(H,85,100)(H,86,106)(H,87,107)(H,88,98)(H,89,104)(H,93,94)(H,95,96)/t39-,49+,50+,51+,52+,53+,54+,55-,56+,60+,73+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as increase in cAMP level incubated for 30 mins |
Eur J Med Chem 103: 175-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.08.046
BindingDB Entry DOI: 10.7270/Q2JH3P05 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50130484
(CHEMBL3633845)Show SMILES [H][C@@]12CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@]1([H])CSSC[C@]([H])(NC(=O)[C@H](CCCc3ccccc3)NC(=O)[C@H](Cc3ccc(cc3)-c3ccc(OC)cc3CC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@]([H])(NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@]([H])(NC(=O)CNC(=O)[C@H](CCC(O)=O)NC2=O)[C@@H](C)O)[C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N1 |r| Show InChI InChI=1S/C99H132N24O31S2/c1-8-58-35-61(154-7)28-29-62(58)59-26-24-57(25-27-59)34-65-90(144)111-63(22-15-21-55-17-11-9-12-18-55)89(143)120-71-47-155-156-48-72(119-86(140)52(4)109-78(132)42-102-74(128)39-101-75(129)40-104-84(138)50(2)110-85(139)51(3)108-77(131)43-103-76(130)41-105-88(71)142)95(149)117-69(45-124)94(148)116-68(36-60-38-100-49-107-60)99(153)123-32-16-23-73(123)96(150)112-64(30-31-80(134)135)87(141)106-44-79(133)121-82(53(5)126)97(151)115-66(33-56-19-13-10-14-20-56)92(146)122-83(54(6)127)98(152)118-70(46-125)93(147)114-67(37-81(136)137)91(145)113-65/h9-14,17-20,24-29,35,38,49-54,63-73,82-83,124-127H,8,15-16,21-23,30-34,36-37,39-48H2,1-7H3,(H,100,107)(H,101,129)(H,102,128)(H,103,130)(H,104,138)(H,105,142)(H,106,141)(H,108,131)(H,109,132)(H,110,139)(H,111,144)(H,112,150)(H,113,145)(H,114,147)(H,115,151)(H,116,148)(H,117,149)(H,118,152)(H,119,140)(H,120,143)(H,121,133)(H,122,146)(H,134,135)(H,136,137)/t50-,51-,52-,53+,54+,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,82-,83-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 390 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as increase in cAMP level incubated for 30 mins |
Eur J Med Chem 103: 175-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.08.046
BindingDB Entry DOI: 10.7270/Q2JH3P05 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50130493
(CHEMBL3633854)Show SMILES CCc1cc(OC)ccc1-c1ccc(C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@](C)(Cc2c(F)cccc2F)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)Cc2cnc[nH]2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCc2ccccc2)C(=O)N[C@H](C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CO)C(O)=O)C(C)(C)S)C(C)(C)S)cc1 |r| Show InChI InChI=1S/C104H144F2N24O32S2/c1-13-58-37-61(162-12)31-32-62(58)59-29-27-57(28-30-59)36-69(91(150)119-67(25-17-22-56-20-15-14-16-21-56)90(149)128-84(102(7,8)163)97(156)114-44-76(137)111-46-77(138)116-52(3)87(146)118-51(2)86(145)112-43-75(136)109-42-74(135)110-45-78(139)117-53(4)88(147)127-85(103(9,10)164)98(157)124-72(49-132)100(159)160)121-92(151)70(39-81(143)144)122-93(152)71(48-131)123-95(154)82(54(5)133)126-101(161)104(11,40-63-64(105)23-18-24-65(63)106)129-96(155)83(55(6)134)125-79(140)47-113-89(148)68(33-34-80(141)142)120-94(153)73-26-19-35-130(73)99(158)66(107)38-60-41-108-50-115-60/h14-16,18,20-21,23-24,27-32,37,41,50-55,66-73,82-85,131-134,163-164H,13,17,19,22,25-26,33-36,38-40,42-49,107H2,1-12H3,(H,108,115)(H,109,136)(H,110,135)(H,111,137)(H,112,145)(H,113,148)(H,114,156)(H,116,138)(H,117,139)(H,118,146)(H,119,150)(H,120,153)(H,121,151)(H,122,152)(H,123,154)(H,124,157)(H,125,140)(H,126,161)(H,127,147)(H,128,149)(H,129,155)(H,141,142)(H,143,144)(H,159,160)/t51-,52-,53-,54+,55+,66-,67-,68-,69-,70-,71-,72-,73-,82-,83-,84+,85+,104-/m0/s1 | PDB
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PubMed
| n/a | n/a | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a |
The University of Queensland
Curated by ChEMBL
| Assay Description
Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as increase in cAMP level incubated for 30 mins |
Eur J Med Chem 103: 175-84 (2015)
Article DOI: 10.1016/j.ejmech.2015.08.046
BindingDB Entry DOI: 10.7270/Q2JH3P05 |
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Ligand-Target Pair | |
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