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PubMed code 26479029

Compile data set for download or QSAR
Found 79 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Receptor-interacting serine/threonine-protein kinase 3


(Homo sapiens (Human))		BDBM50499143
PNG
(CHEMBL3735817)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1cccc(c1)-c1cccs1
Show InChI InChI=1S/C26H24N6S/c1-30-13-15-31(16-14-30)24-8-7-23-28-25(26(32(23)29-24)19-9-11-27-12-10-19)21-5-2-4-20(18-21)22-6-3-17-33-22/h2-12,17-18H,13-16H2,1H3
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n/an/a 270n/an/an/an/an/an/a



Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged RIPK3 expressed in Spodoptera frugiperda Sf9 cells after 30 mins by scintillation and luminescence countin...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3


(Homo sapiens (Human))		BDBM50499152
PNG
(CHEMBL3735315)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1cccc(c1)-c1ccsc1
Show InChI InChI=1S/C26H24N6S/c1-30-12-14-31(15-13-30)24-6-5-23-28-25(26(32(23)29-24)19-7-10-27-11-8-19)21-4-2-3-20(17-21)22-9-16-33-18-22/h2-11,16-18H,12-15H2,1H3
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n/an/a 300n/an/an/an/an/an/a



Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged RIPK3 expressed in Spodoptera frugiperda Sf9 cells after 30 mins by scintillation and luminescence countin...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3


(Homo sapiens (Human))		BDBM50499134
PNG
(CHEMBL3736408)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C28H26N6/c1-32-16-18-33(19-17-32)26-11-10-25-30-27(28(34(25)31-26)22-12-14-29-15-13-22)24-9-5-8-23(20-24)21-6-3-2-4-7-21/h2-15,20H,16-19H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged RIPK3 expressed in Spodoptera frugiperda Sf9 cells after 30 mins by scintillation and luminescence countin...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3


(Homo sapiens (Human))		BDBM50499147
PNG
(CHEMBL3735482)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1cccc2ccccc12
Show InChI InChI=1S/C26H24N6/c1-30-15-17-31(18-16-30)24-10-9-23-28-25(22-8-4-6-19-5-2-3-7-21(19)22)26(32(23)29-24)20-11-13-27-14-12-20/h2-14H,15-18H2,1H3
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n/an/a 880n/an/an/an/an/an/a



Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged RIPK3 expressed in Spodoptera frugiperda Sf9 cells after 30 mins by scintillation and luminescence countin...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3


(Homo sapiens (Human))		BDBM50499151
PNG
(CHEMBL3736103)
Show SMILES COc1ccc2c(cccc2c1)-c1nc2ccc(nn2c1-c1ccncc1)N1CCN(C)CC1
Show InChI InChI=1S/C27H26N6O/c1-31-14-16-32(17-15-31)25-9-8-24-29-26(27(33(24)30-25)19-10-12-28-13-11-19)23-5-3-4-20-18-21(34-2)6-7-22(20)23/h3-13,18H,14-17H2,1-2H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged RIPK3 expressed in Spodoptera frugiperda Sf9 cells after 30 mins by scintillation and luminescence countin...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3


(Homo sapiens (Human))		BDBM50499139
PNG
(CHEMBL3735563)
Show SMILES CCOc1ccc2c(cccc2c1)-c1nc2ccc(nn2c1-c1ccncc1)N1CCN(C)CC1
Show InChI InChI=1S/C28H28N6O/c1-3-35-22-7-8-23-21(19-22)5-4-6-24(23)27-28(20-11-13-29-14-12-20)34-25(30-27)9-10-26(31-34)33-17-15-32(2)16-18-33/h4-14,19H,3,15-18H2,1-2H3
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n/an/a 1.70E+3n/an/an/an/an/an/a



Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged RIPK3 expressed in Spodoptera frugiperda Sf9 cells after 30 mins by scintillation and luminescence countin...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase


(Sus scrofa)		BDBM50499145
PNG
(CHEMBL3734959)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccccc3)n2n1)-c1cccc2OCOc12
Show InChI InChI=1S/C24H23N5O2/c1-27-12-14-28(15-13-27)21-11-10-20-25-22(18-8-5-9-19-24(18)31-16-30-19)23(29(20)26-21)17-6-3-2-4-7-17/h2-11H,12-16H2,1H3
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n/an/a 2.20E+3n/an/an/an/an/an/a



Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of porcine brain GSK-3 alpha/beta using GS-1 substrate after 30 mins by scintillation and luminescence counting method in the presence of ...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3


(Homo sapiens (Human))		BDBM50499137
PNG
(CHEMBL3735196)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1cccc2OCOc12
Show InChI InChI=1S/C23H22N6O2/c1-27-11-13-28(14-12-27)20-6-5-19-25-21(17-3-2-4-18-23(17)31-15-30-18)22(29(19)26-20)16-7-9-24-10-8-16/h2-10H,11-15H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged RIPK3 expressed in Spodoptera frugiperda Sf9 cells after 30 mins by scintillation and luminescence countin...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase


(Sus scrofa)		BDBM50499135
PNG
(CHEMBL3735309)
Show SMILES C1Oc2cccc(c2O1)-c1nc2cccnn2c1-c1ccncc1
Show InChI InChI=1S/C18H12N4O2/c1-3-13(18-14(4-1)23-11-24-18)16-17(12-6-9-19-10-7-12)22-15(21-16)5-2-8-20-22/h1-10H,11H2
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n/an/a 3.50E+3n/an/an/an/an/an/a



Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of porcine brain GSK-3 alpha/beta using GS-1 substrate after 30 mins by scintillation and luminescence counting method in the presence of ...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50499138
PNG
(CHEMBL3735368)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1cccc(c1)C(=O)N1CCOCC1
Show InChI InChI=1S/C27H29N7O2/c1-31-11-13-32(14-12-31)24-6-5-23-29-25(26(34(23)30-24)20-7-9-28-10-8-20)21-3-2-4-22(19-21)27(35)33-15-17-36-18-16-33/h2-10,19H,11-18H2,1H3
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n/an/a 3.90E+3n/an/an/an/an/an/a



Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant haspin kinase domain expressed in Escherichia coli BL21-KRX using histone H3 (1 to 21) peptide substrate after 30 min...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase


(Sus scrofa)		BDBM50499137
PNG
(CHEMBL3735196)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1cccc2OCOc12
Show InChI InChI=1S/C23H22N6O2/c1-27-11-13-28(14-12-27)20-6-5-19-25-21(17-3-2-4-18-23(17)31-15-30-18)22(29(19)26-20)16-7-9-24-10-8-16/h2-10H,11-15H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of porcine brain GSK-3 alpha/beta using GS-1 substrate after 30 mins by scintillation and luminescence counting method in the presence of ...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3


(Homo sapiens (Human))		BDBM50499135
PNG
(CHEMBL3735309)
Show SMILES C1Oc2cccc(c2O1)-c1nc2cccnn2c1-c1ccncc1
Show InChI InChI=1S/C18H12N4O2/c1-3-13(18-14(4-1)23-11-24-18)16-17(12-6-9-19-10-7-12)22-15(21-16)5-2-8-20-22/h1-10H,11H2
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged RIPK3 expressed in Spodoptera frugiperda Sf9 cells after 30 mins by scintillation and luminescence countin...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3


(Homo sapiens (Human))		BDBM50499150
PNG
(CHEMBL3735590)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1ccc2OCOc2c1
Show InChI InChI=1S/C23H22N6O2/c1-27-10-12-28(13-11-27)21-5-4-20-25-22(17-2-3-18-19(14-17)31-15-30-18)23(29(20)26-21)16-6-8-24-9-7-16/h2-9,14H,10-13,15H2,1H3
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n/an/a 7.60E+3n/an/an/an/an/an/a



Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged RIPK3 expressed in Spodoptera frugiperda Sf9 cells after 30 mins by scintillation and luminescence countin...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase


(Sus scrofa)		BDBM50499152
PNG
(CHEMBL3735315)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1cccc(c1)-c1ccsc1
Show InChI InChI=1S/C26H24N6S/c1-30-12-14-31(15-13-30)24-6-5-23-28-25(26(32(23)29-24)19-7-10-27-11-8-19)21-4-2-3-20(17-21)22-9-16-33-18-22/h2-11,16-18H,12-15H2,1H3
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n/an/a 7.60E+3n/an/an/an/an/an/a



Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of porcine brain GSK-3 alpha/beta using GS-1 substrate after 30 mins by scintillation and luminescence counting method in the presence of ...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase


(Sus scrofa)		BDBM50499133
PNG
(CHEMBL3735836)
Show SMILES COc1cccc(c1)-c1nc2ccc(nn2c1-c1ccncc1)N1CCN(C)CC1
Show InChI InChI=1S/C23H24N6O/c1-27-12-14-28(15-13-27)21-7-6-20-25-22(18-4-3-5-19(16-18)30-2)23(29(20)26-21)17-8-10-24-11-9-17/h3-11,16H,12-15H2,1-2H3
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n/an/a 8.80E+3n/an/an/an/an/an/a



Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of porcine brain GSK-3 alpha/beta using GS-1 substrate after 30 mins by scintillation and luminescence counting method in the presence of ...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3


(Homo sapiens (Human))		BDBM50499141
PNG
(CHEMBL3735260)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2c1)-c1cccc2OCOc12
Show InChI InChI=1S/C24H23N5O2/c1-27-11-13-28(14-12-27)18-5-6-21-26-22(19-3-2-4-20-24(19)31-16-30-20)23(29(21)15-18)17-7-9-25-10-8-17/h2-10,15H,11-14,16H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged RIPK3 expressed in Spodoptera frugiperda Sf9 cells after 30 mins by scintillation and luminescence countin...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50499134
PNG
(CHEMBL3736408)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C28H26N6/c1-32-16-18-33(19-17-32)26-11-10-25-30-27(28(34(25)31-26)22-12-14-29-15-13-22)24-9-5-8-23(20-24)21-6-3-2-4-7-21/h2-15,20H,16-19H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant haspin kinase domain expressed in Escherichia coli BL21-KRX using histone H3 (1 to 21) peptide substrate after 30 min...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase


(Sus scrofa)		BDBM50499149
PNG
(CHEMBL3735582)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1cccc2OCCOc12
Show InChI InChI=1S/C24H24N6O2/c1-28-11-13-29(14-12-28)21-6-5-20-26-22(18-3-2-4-19-24(18)32-16-15-31-19)23(30(20)27-21)17-7-9-25-10-8-17/h2-10H,11-16H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of porcine brain GSK-3 alpha/beta using GS-1 substrate after 30 mins by scintillation and luminescence counting method in the presence of ...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50499142
PNG
(CHEMBL3735077)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3cccnc3)n2n1)-c1cccc2OCOc12
Show InChI InChI=1S/C23H22N6O2/c1-27-10-12-28(13-11-27)20-8-7-19-25-21(17-5-2-6-18-23(17)31-15-30-18)22(29(19)26-20)16-4-3-9-24-14-16/h2-9,14H,10-13,15H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/P25 expressed in Escherichia coli using histone H1 substrate after 30 mins by scintillation and luminescence cou...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50499152
PNG
(CHEMBL3735315)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1cccc(c1)-c1ccsc1
Show InChI InChI=1S/C26H24N6S/c1-30-12-14-31(15-13-30)24-6-5-23-28-25(26(32(23)29-24)19-7-10-27-11-8-19)21-4-2-3-20(17-21)22-9-16-33-18-22/h2-11,16-18H,12-15H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/P25 expressed in Escherichia coli using histone H1 substrate after 30 mins by scintillation and luminescence cou...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase


(Sus scrofa)		BDBM50499136
PNG
(CHEMBL3734840)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1ccc(cc1)C(=O)N1CCOCC1
Show InChI InChI=1S/C27H29N7O2/c1-31-12-14-32(15-13-31)24-7-6-23-29-25(26(34(23)30-24)21-8-10-28-11-9-21)20-2-4-22(5-3-20)27(35)33-16-18-36-19-17-33/h2-11H,12-19H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of porcine brain GSK-3 alpha/beta using GS-1 substrate after 30 mins by scintillation and luminescence counting method in the presence of ...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50499150
PNG
(CHEMBL3735590)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1ccc2OCOc2c1
Show InChI InChI=1S/C23H22N6O2/c1-27-10-12-28(13-11-27)21-5-4-20-25-22(17-2-3-18-19(14-17)31-15-30-18)23(29(20)26-21)16-6-8-24-9-7-16/h2-9,14H,10-13,15H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant haspin kinase domain expressed in Escherichia coli BL21-KRX using histone H3 (1 to 21) peptide substrate after 30 min...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase


(Sus scrofa)		BDBM50499140
PNG
(CHEMBL3736271)
Show SMILES CN1CCN(CC1)c1ccc2nc(-c3ccc(s3)-c3ccccc3)c(-c3ccncc3)n2n1
Show InChI InChI=1S/C26H24N6S/c1-30-15-17-31(18-16-30)24-10-9-23-28-25(26(32(23)29-24)20-11-13-27-14-12-20)22-8-7-21(33-22)19-5-3-2-4-6-19/h2-14H,15-18H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of porcine brain GSK-3 alpha/beta using GS-1 substrate after 30 mins by scintillation and luminescence counting method in the presence of ...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50499140
PNG
(CHEMBL3736271)
Show SMILES CN1CCN(CC1)c1ccc2nc(-c3ccc(s3)-c3ccccc3)c(-c3ccncc3)n2n1
Show InChI InChI=1S/C26H24N6S/c1-30-15-17-31(18-16-30)24-10-9-23-28-25(26(32(23)29-24)20-11-13-27-14-12-20)22-8-7-21(33-22)19-5-3-2-4-6-19/h2-14H,15-18H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/P25 expressed in Escherichia coli using histone H1 substrate after 30 mins by scintillation and luminescence cou...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50499147
PNG
(CHEMBL3735482)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1cccc2ccccc12
Show InChI InChI=1S/C26H24N6/c1-30-15-17-31(18-16-30)24-10-9-23-28-25(22-8-4-6-19-5-2-3-7-21(19)22)26(32(23)29-24)20-11-13-27-14-12-20/h2-14H,15-18H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/P25 expressed in Escherichia coli using histone H1 substrate after 30 mins by scintillation and luminescence cou...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50499145
PNG
(CHEMBL3734959)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccccc3)n2n1)-c1cccc2OCOc12
Show InChI InChI=1S/C24H23N5O2/c1-27-12-14-28(15-13-27)21-11-10-20-25-22(18-8-5-9-19-24(18)31-16-30-19)23(29(20)26-21)17-6-3-2-4-7-17/h2-11H,12-16H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant haspin kinase domain expressed in Escherichia coli BL21-KRX using histone H3 (1 to 21) peptide substrate after 30 min...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50499147
PNG
(CHEMBL3735482)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1cccc2ccccc12
Show InChI InChI=1S/C26H24N6/c1-30-15-17-31(18-16-30)24-10-9-23-28-25(22-8-4-6-19-5-2-3-7-21(19)22)26(32(23)29-24)20-11-13-27-14-12-20/h2-14H,15-18H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant haspin kinase domain expressed in Escherichia coli BL21-KRX using histone H3 (1 to 21) peptide substrate after 30 min...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase


(Sus scrofa)		BDBM50499134
PNG
(CHEMBL3736408)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C28H26N6/c1-32-16-18-33(19-17-32)26-11-10-25-30-27(28(34(25)31-26)22-12-14-29-15-13-22)24-9-5-8-23(20-24)21-6-3-2-4-7-21/h2-15,20H,16-19H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of porcine brain GSK-3 alpha/beta using GS-1 substrate after 30 mins by scintillation and luminescence counting method in the presence of ...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase


(Sus scrofa)		BDBM50499151
PNG
(CHEMBL3736103)
Show SMILES COc1ccc2c(cccc2c1)-c1nc2ccc(nn2c1-c1ccncc1)N1CCN(C)CC1
Show InChI InChI=1S/C27H26N6O/c1-31-14-16-32(17-15-31)25-9-8-24-29-26(27(33(24)30-25)19-10-12-28-13-11-19)23-5-3-4-20-18-21(34-2)6-7-22(20)23/h3-13,18H,14-17H2,1-2H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of porcine brain GSK-3 alpha/beta using GS-1 substrate after 30 mins by scintillation and luminescence counting method in the presence of ...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase


(Sus scrofa)		BDBM50499141
PNG
(CHEMBL3735260)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2c1)-c1cccc2OCOc12
Show InChI InChI=1S/C24H23N5O2/c1-27-11-13-28(14-12-27)18-5-6-21-26-22(19-3-2-4-20-24(19)31-16-30-20)23(29(21)15-18)17-7-9-25-10-8-17/h2-10,15H,11-14,16H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of porcine brain GSK-3 alpha/beta using GS-1 substrate after 30 mins by scintillation and luminescence counting method in the presence of ...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3


(Homo sapiens (Human))		BDBM50499140
PNG
(CHEMBL3736271)
Show SMILES CN1CCN(CC1)c1ccc2nc(-c3ccc(s3)-c3ccccc3)c(-c3ccncc3)n2n1
Show InChI InChI=1S/C26H24N6S/c1-30-15-17-31(18-16-30)24-10-9-23-28-25(26(32(23)29-24)20-11-13-27-14-12-20)22-8-7-21(33-22)19-5-3-2-4-6-19/h2-14H,15-18H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged RIPK3 expressed in Spodoptera frugiperda Sf9 cells after 30 mins by scintillation and luminescence countin...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50499141
PNG
(CHEMBL3735260)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2c1)-c1cccc2OCOc12
Show InChI InChI=1S/C24H23N5O2/c1-27-11-13-28(14-12-27)18-5-6-21-26-22(19-3-2-4-20-24(19)31-16-30-20)23(29(21)15-18)17-7-9-25-10-8-17/h2-10,15H,11-14,16H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/P25 expressed in Escherichia coli using histone H1 substrate after 30 mins by scintillation and luminescence cou...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3


(Homo sapiens (Human))		BDBM50499136
PNG
(CHEMBL3734840)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1ccc(cc1)C(=O)N1CCOCC1
Show InChI InChI=1S/C27H29N7O2/c1-31-12-14-32(15-13-31)24-7-6-23-29-25(26(34(23)30-24)21-8-10-28-11-9-21)20-2-4-22(5-3-20)27(35)33-16-18-36-19-17-33/h2-11H,12-19H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged RIPK3 expressed in Spodoptera frugiperda Sf9 cells after 30 mins by scintillation and luminescence countin...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50499149
PNG
(CHEMBL3735582)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1cccc2OCCOc12
Show InChI InChI=1S/C24H24N6O2/c1-28-11-13-29(14-12-28)21-6-5-20-26-22(18-3-2-4-19-24(18)32-16-15-31-19)23(30(20)27-21)17-7-9-25-10-8-17/h2-10H,11-16H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant haspin kinase domain expressed in Escherichia coli BL21-KRX using histone H3 (1 to 21) peptide substrate after 30 min...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3


(Homo sapiens (Human))		BDBM50499142
PNG
(CHEMBL3735077)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3cccnc3)n2n1)-c1cccc2OCOc12
Show InChI InChI=1S/C23H22N6O2/c1-27-10-12-28(13-11-27)20-8-7-19-25-21(17-5-2-6-18-23(17)31-15-30-18)22(29(19)26-20)16-4-3-9-24-14-16/h2-9,14H,10-13,15H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged RIPK3 expressed in Spodoptera frugiperda Sf9 cells after 30 mins by scintillation and luminescence countin...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50499150
PNG
(CHEMBL3735590)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1ccc2OCOc2c1
Show InChI InChI=1S/C23H22N6O2/c1-27-10-12-28(13-11-27)21-5-4-20-25-22(17-2-3-18-19(14-17)31-15-30-18)23(29(20)26-21)16-6-8-24-9-7-16/h2-9,14H,10-13,15H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/P25 expressed in Escherichia coli using histone H1 substrate after 30 mins by scintillation and luminescence cou...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50499148
PNG
(CHEMBL3734983)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C23H21N7S/c1-28-10-12-29(13-11-28)21-5-4-20-26-22(17-2-3-18-19(14-17)31-15-25-18)23(30(20)27-21)16-6-8-24-9-7-16/h2-9,14-15H,10-13H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant haspin kinase domain expressed in Escherichia coli BL21-KRX using histone H3 (1 to 21) peptide substrate after 30 min...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50499144
PNG
(CHEMBL3735428)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1ccc2OCCOc2c1
Show InChI InChI=1S/C24H24N6O2/c1-28-10-12-29(13-11-28)22-5-4-21-26-23(18-2-3-19-20(16-18)32-15-14-31-19)24(30(21)27-22)17-6-8-25-9-7-17/h2-9,16H,10-15H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant haspin kinase domain expressed in Escherichia coli BL21-KRX using histone H3 (1 to 21) peptide substrate after 30 min...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3


(Homo sapiens (Human))		BDBM50499146
PNG
(CHEMBL3735025)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C28H26N6/c1-32-17-19-33(20-18-32)26-12-11-25-30-27(28(34(25)31-26)24-13-15-29-16-14-24)23-9-7-22(8-10-23)21-5-3-2-4-6-21/h2-16H,17-20H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged RIPK3 expressed in Spodoptera frugiperda Sf9 cells after 30 mins by scintillation and luminescence countin...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50499141
PNG
(CHEMBL3735260)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2c1)-c1cccc2OCOc12
Show InChI InChI=1S/C24H23N5O2/c1-27-11-13-28(14-12-27)18-5-6-21-26-22(19-3-2-4-20-24(19)31-16-30-20)23(29(21)15-18)17-7-9-25-10-8-17/h2-10,15H,11-14,16H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant haspin kinase domain expressed in Escherichia coli BL21-KRX using histone H3 (1 to 21) peptide substrate after 30 min...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50499137
PNG
(CHEMBL3735196)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1cccc2OCOc12
Show InChI InChI=1S/C23H22N6O2/c1-27-11-13-28(14-12-27)20-6-5-19-25-21(17-3-2-4-18-23(17)31-15-30-18)22(29(19)26-20)16-7-9-24-10-8-16/h2-10H,11-15H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/P25 expressed in Escherichia coli using histone H1 substrate after 30 mins by scintillation and luminescence cou...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase


(Sus scrofa)		BDBM50499146
PNG
(CHEMBL3735025)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C28H26N6/c1-32-17-19-33(20-18-32)26-12-11-25-30-27(28(34(25)31-26)24-13-15-29-16-14-24)23-9-7-22(8-10-23)21-5-3-2-4-6-21/h2-16H,17-20H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of porcine brain GSK-3 alpha/beta using GS-1 substrate after 30 mins by scintillation and luminescence counting method in the presence of ...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50499133
PNG
(CHEMBL3735836)
Show SMILES COc1cccc(c1)-c1nc2ccc(nn2c1-c1ccncc1)N1CCN(C)CC1
Show InChI InChI=1S/C23H24N6O/c1-27-12-14-28(15-13-27)21-7-6-20-25-22(18-4-3-5-19(16-18)30-2)23(29(20)26-21)17-8-10-24-11-9-17/h3-11,16H,12-15H2,1-2H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/P25 expressed in Escherichia coli using histone H1 substrate after 30 mins by scintillation and luminescence cou...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50499148
PNG
(CHEMBL3734983)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C23H21N7S/c1-28-10-12-29(13-11-28)21-5-4-20-26-22(17-2-3-18-19(14-17)31-15-25-18)23(30(20)27-21)16-6-8-24-9-7-16/h2-9,14-15H,10-13H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/P25 expressed in Escherichia coli using histone H1 substrate after 30 mins by scintillation and luminescence cou...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50499149
PNG
(CHEMBL3735582)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1cccc2OCCOc12
Show InChI InChI=1S/C24H24N6O2/c1-28-11-13-29(14-12-28)21-6-5-20-26-22(18-3-2-4-19-24(18)32-16-15-31-19)23(30(20)27-21)17-7-9-25-10-8-17/h2-10H,11-16H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/P25 expressed in Escherichia coli using histone H1 substrate after 30 mins by scintillation and luminescence cou...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50499135
PNG
(CHEMBL3735309)
Show SMILES C1Oc2cccc(c2O1)-c1nc2cccnn2c1-c1ccncc1
Show InChI InChI=1S/C18H12N4O2/c1-3-13(18-14(4-1)23-11-24-18)16-17(12-6-9-19-10-7-12)22-15(21-16)5-2-8-20-22/h1-10H,11H2
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant haspin kinase domain expressed in Escherichia coli BL21-KRX using histone H3 (1 to 21) peptide substrate after 30 min...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50499140
PNG
(CHEMBL3736271)
Show SMILES CN1CCN(CC1)c1ccc2nc(-c3ccc(s3)-c3ccccc3)c(-c3ccncc3)n2n1
Show InChI InChI=1S/C26H24N6S/c1-30-15-17-31(18-16-30)24-10-9-23-28-25(26(32(23)29-24)20-11-13-27-14-12-20)22-8-7-21(33-22)19-5-3-2-4-6-19/h2-14H,15-18H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant haspin kinase domain expressed in Escherichia coli BL21-KRX using histone H3 (1 to 21) peptide substrate after 30 min...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50499151
PNG
(CHEMBL3736103)
Show SMILES COc1ccc2c(cccc2c1)-c1nc2ccc(nn2c1-c1ccncc1)N1CCN(C)CC1
Show InChI InChI=1S/C27H26N6O/c1-31-14-16-32(17-15-31)25-9-8-24-29-26(27(33(24)30-25)19-10-12-28-13-11-19)23-5-3-4-20-18-21(34-2)6-7-22(20)23/h3-13,18H,14-17H2,1-2H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant haspin kinase domain expressed in Escherichia coli BL21-KRX using histone H3 (1 to 21) peptide substrate after 30 min...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50499133
PNG
(CHEMBL3735836)
Show SMILES COc1cccc(c1)-c1nc2ccc(nn2c1-c1ccncc1)N1CCN(C)CC1
Show InChI InChI=1S/C23H24N6O/c1-27-12-14-28(15-13-27)21-7-6-20-25-22(18-4-3-5-19(16-18)30-2)23(29(20)26-21)17-8-10-24-11-9-17/h3-11,16H,12-15H2,1-2H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant haspin kinase domain expressed in Escherichia coli BL21-KRX using histone H3 (1 to 21) peptide substrate after 30 min...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase


(Sus scrofa)		BDBM50499148
PNG
(CHEMBL3734983)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C23H21N7S/c1-28-10-12-29(13-11-28)21-5-4-20-26-22(17-2-3-18-19(14-17)31-15-25-18)23(30(20)27-21)16-6-8-24-9-7-16/h2-9,14-15H,10-13H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of porcine brain GSK-3 alpha/beta using GS-1 substrate after 30 mins by scintillation and luminescence counting method in the presence of ...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50499139
PNG
(CHEMBL3735563)
Show SMILES CCOc1ccc2c(cccc2c1)-c1nc2ccc(nn2c1-c1ccncc1)N1CCN(C)CC1
Show InChI InChI=1S/C28H28N6O/c1-3-35-22-7-8-23-21(19-22)5-4-6-24(23)27-28(20-11-13-29-14-12-20)34-25(30-27)9-10-26(31-34)33-17-15-32(2)16-18-33/h4-14,19H,3,15-18H2,1-2H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant haspin kinase domain expressed in Escherichia coli BL21-KRX using histone H3 (1 to 21) peptide substrate after 30 min...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50499144
PNG
(CHEMBL3735428)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1ccc2OCCOc2c1
Show InChI InChI=1S/C24H24N6O2/c1-28-10-12-29(13-11-28)22-5-4-21-26-23(18-2-3-19-20(16-18)32-15-14-31-19)24(30(21)27-22)17-6-8-25-9-7-17/h2-9,16H,10-15H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/P25 expressed in Escherichia coli using histone H1 substrate after 30 mins by scintillation and luminescence cou...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50499152
PNG
(CHEMBL3735315)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1cccc(c1)-c1ccsc1
Show InChI InChI=1S/C26H24N6S/c1-30-12-14-31(15-13-30)24-6-5-23-28-25(26(32(23)29-24)19-7-10-27-11-8-19)21-4-2-3-20(17-21)22-9-16-33-18-22/h2-11,16-18H,12-15H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant haspin kinase domain expressed in Escherichia coli BL21-KRX using histone H3 (1 to 21) peptide substrate after 30 min...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50499137
PNG
(CHEMBL3735196)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1cccc2OCOc12
Show InChI InChI=1S/C23H22N6O2/c1-27-11-13-28(14-12-27)20-6-5-19-25-21(17-3-2-4-18-23(17)31-15-30-18)22(29(19)26-20)16-7-9-24-10-8-16/h2-10H,11-15H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant haspin kinase domain expressed in Escherichia coli BL21-KRX using histone H3 (1 to 21) peptide substrate after 30 min...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50499135
PNG
(CHEMBL3735309)
Show SMILES C1Oc2cccc(c2O1)-c1nc2cccnn2c1-c1ccncc1
Show InChI InChI=1S/C18H12N4O2/c1-3-13(18-14(4-1)23-11-24-18)16-17(12-6-9-19-10-7-12)22-15(21-16)5-2-8-20-22/h1-10H,11H2
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/P25 expressed in Escherichia coli using histone H1 substrate after 30 mins by scintillation and luminescence cou...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3


(Homo sapiens (Human))		BDBM50499138
PNG
(CHEMBL3735368)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1cccc(c1)C(=O)N1CCOCC1
Show InChI InChI=1S/C27H29N7O2/c1-31-11-13-32(14-12-31)24-6-5-23-29-25(26(34(23)30-24)20-7-9-28-10-8-20)21-3-2-4-22(19-21)27(35)33-15-17-36-18-16-33/h2-10,19H,11-18H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged RIPK3 expressed in Spodoptera frugiperda Sf9 cells after 30 mins by scintillation and luminescence countin...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase


(Sus scrofa)		BDBM50499143
PNG
(CHEMBL3735817)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1cccc(c1)-c1cccs1
Show InChI InChI=1S/C26H24N6S/c1-30-13-15-31(16-14-30)24-8-7-23-28-25(26(32(23)29-24)19-9-11-27-12-10-19)21-5-2-4-20(18-21)22-6-3-17-33-22/h2-12,17-18H,13-16H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of porcine brain GSK-3 alpha/beta using GS-1 substrate after 30 mins by scintillation and luminescence counting method in the presence of ...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3


(Homo sapiens (Human))		BDBM50499144
PNG
(CHEMBL3735428)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1ccc2OCCOc2c1
Show InChI InChI=1S/C24H24N6O2/c1-28-10-12-29(13-11-28)22-5-4-21-26-23(18-2-3-19-20(16-18)32-15-14-31-19)24(30(21)27-22)17-6-8-25-9-7-17/h2-9,16H,10-15H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged RIPK3 expressed in Spodoptera frugiperda Sf9 cells after 30 mins by scintillation and luminescence countin...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50499136
PNG
(CHEMBL3734840)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1ccc(cc1)C(=O)N1CCOCC1
Show InChI InChI=1S/C27H29N7O2/c1-31-12-14-32(15-13-31)24-7-6-23-29-25(26(34(23)30-24)21-8-10-28-11-9-21)20-2-4-22(5-3-20)27(35)33-16-18-36-19-17-33/h2-11H,12-19H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/P25 expressed in Escherichia coli using histone H1 substrate after 30 mins by scintillation and luminescence cou...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50499146
PNG
(CHEMBL3735025)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C28H26N6/c1-32-17-19-33(20-18-32)26-12-11-25-30-27(28(34(25)31-26)24-13-15-29-16-14-24)23-9-7-22(8-10-23)21-5-3-2-4-6-21/h2-16H,17-20H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/P25 expressed in Escherichia coli using histone H1 substrate after 30 mins by scintillation and luminescence cou...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50499146
PNG
(CHEMBL3735025)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C28H26N6/c1-32-17-19-33(20-18-32)26-12-11-25-30-27(28(34(25)31-26)24-13-15-29-16-14-24)23-9-7-22(8-10-23)21-5-3-2-4-6-21/h2-16H,17-20H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant haspin kinase domain expressed in Escherichia coli BL21-KRX using histone H3 (1 to 21) peptide substrate after 30 min...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase


(Sus scrofa)		BDBM50499144
PNG
(CHEMBL3735428)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1ccc2OCCOc2c1
Show InChI InChI=1S/C24H24N6O2/c1-28-10-12-29(13-11-28)22-5-4-21-26-23(18-2-3-19-20(16-18)32-15-14-31-19)24(30(21)27-22)17-6-8-25-9-7-17/h2-9,16H,10-15H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of porcine brain GSK-3 alpha/beta using GS-1 substrate after 30 mins by scintillation and luminescence counting method in the presence of ...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase


(Sus scrofa)		BDBM50499150
PNG
(CHEMBL3735590)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1ccc2OCOc2c1
Show InChI InChI=1S/C23H22N6O2/c1-27-10-12-28(13-11-27)21-5-4-20-25-22(17-2-3-18-19(14-17)31-15-30-18)23(29(20)26-21)16-6-8-24-9-7-16/h2-9,14H,10-13,15H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of porcine brain GSK-3 alpha/beta using GS-1 substrate after 30 mins by scintillation and luminescence counting method in the presence of ...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase


(Sus scrofa)		BDBM50499138
PNG
(CHEMBL3735368)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1cccc(c1)C(=O)N1CCOCC1
Show InChI InChI=1S/C27H29N7O2/c1-31-11-13-32(14-12-31)24-6-5-23-29-25(26(34(23)30-24)20-7-9-28-10-8-20)21-3-2-4-22(19-21)27(35)33-15-17-36-18-16-33/h2-10,19H,11-18H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of porcine brain GSK-3 alpha/beta using GS-1 substrate after 30 mins by scintillation and luminescence counting method in the presence of ...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3


(Homo sapiens (Human))		BDBM50499149
PNG
(CHEMBL3735582)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1cccc2OCCOc12
Show InChI InChI=1S/C24H24N6O2/c1-28-11-13-29(14-12-28)21-6-5-20-26-22(18-3-2-4-19-24(18)32-16-15-31-19)23(30(20)27-21)17-7-9-25-10-8-17/h2-10H,11-16H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged RIPK3 expressed in Spodoptera frugiperda Sf9 cells after 30 mins by scintillation and luminescence countin...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50499142
PNG
(CHEMBL3735077)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3cccnc3)n2n1)-c1cccc2OCOc12
Show InChI InChI=1S/C23H22N6O2/c1-27-10-12-28(13-11-27)20-8-7-19-25-21(17-5-2-6-18-23(17)31-15-30-18)22(29(19)26-20)16-4-3-9-24-14-16/h2-9,14H,10-13,15H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant haspin kinase domain expressed in Escherichia coli BL21-KRX using histone H3 (1 to 21) peptide substrate after 30 min...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50499134
PNG
(CHEMBL3736408)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C28H26N6/c1-32-16-18-33(19-17-32)26-11-10-25-30-27(28(34(25)31-26)22-12-14-29-15-13-22)24-9-5-8-23(20-24)21-6-3-2-4-7-21/h2-15,20H,16-19H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/P25 expressed in Escherichia coli using histone H1 substrate after 30 mins by scintillation and luminescence cou...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase


(Sus scrofa)		BDBM50499147
PNG
(CHEMBL3735482)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1cccc2ccccc12
Show InChI InChI=1S/C26H24N6/c1-30-15-17-31(18-16-30)24-10-9-23-28-25(22-8-4-6-19-5-2-3-7-21(19)22)26(32(23)29-24)20-11-13-27-14-12-20/h2-14H,15-18H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of porcine brain GSK-3 alpha/beta using GS-1 substrate after 30 mins by scintillation and luminescence counting method in the presence of ...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3


(Homo sapiens (Human))		BDBM50499145
PNG
(CHEMBL3734959)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccccc3)n2n1)-c1cccc2OCOc12
Show InChI InChI=1S/C24H23N5O2/c1-27-12-14-28(15-13-27)21-11-10-20-25-22(18-8-5-9-19-24(18)31-16-30-19)23(29(20)26-21)17-6-3-2-4-7-17/h2-11H,12-16H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged RIPK3 expressed in Spodoptera frugiperda Sf9 cells after 30 mins by scintillation and luminescence countin...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50499138
PNG
(CHEMBL3735368)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1cccc(c1)C(=O)N1CCOCC1
Show InChI InChI=1S/C27H29N7O2/c1-31-11-13-32(14-12-31)24-6-5-23-29-25(26(34(23)30-24)20-7-9-28-10-8-20)21-3-2-4-22(19-21)27(35)33-15-17-36-18-16-33/h2-10,19H,11-18H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/P25 expressed in Escherichia coli using histone H1 substrate after 30 mins by scintillation and luminescence cou...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50499136
PNG
(CHEMBL3734840)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1ccc(cc1)C(=O)N1CCOCC1
Show InChI InChI=1S/C27H29N7O2/c1-31-12-14-32(15-13-31)24-7-6-23-29-25(26(34(23)30-24)21-8-10-28-11-9-21)20-2-4-22(5-3-20)27(35)33-16-18-36-19-17-33/h2-11H,12-19H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant haspin kinase domain expressed in Escherichia coli BL21-KRX using histone H3 (1 to 21) peptide substrate after 30 min...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50499139
PNG
(CHEMBL3735563)
Show SMILES CCOc1ccc2c(cccc2c1)-c1nc2ccc(nn2c1-c1ccncc1)N1CCN(C)CC1
Show InChI InChI=1S/C28H28N6O/c1-3-35-22-7-8-23-21(19-22)5-4-6-24(23)27-28(20-11-13-29-14-12-20)34-25(30-27)9-10-26(31-34)33-17-15-32(2)16-18-33/h4-14,19H,3,15-18H2,1-2H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/P25 expressed in Escherichia coli using histone H1 substrate after 30 mins by scintillation and luminescence cou...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50499145
PNG
(CHEMBL3734959)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccccc3)n2n1)-c1cccc2OCOc12
Show InChI InChI=1S/C24H23N5O2/c1-27-12-14-28(15-13-27)21-11-10-20-25-22(18-8-5-9-19-24(18)31-16-30-19)23(29(20)26-21)17-6-3-2-4-7-17/h2-11H,12-16H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/P25 expressed in Escherichia coli using histone H1 substrate after 30 mins by scintillation and luminescence cou...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50499143
PNG
(CHEMBL3735817)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1cccc(c1)-c1cccs1
Show InChI InChI=1S/C26H24N6S/c1-30-13-15-31(16-14-30)24-8-7-23-28-25(26(32(23)29-24)19-9-11-27-12-10-19)21-5-2-4-20(18-21)22-6-3-17-33-22/h2-12,17-18H,13-16H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/P25 expressed in Escherichia coli using histone H1 substrate after 30 mins by scintillation and luminescence cou...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase


(Sus scrofa)		BDBM50499142
PNG
(CHEMBL3735077)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3cccnc3)n2n1)-c1cccc2OCOc12
Show InChI InChI=1S/C23H22N6O2/c1-27-10-12-28(13-11-27)20-8-7-19-25-21(17-5-2-6-18-23(17)31-15-30-18)22(29(19)26-20)16-4-3-9-24-14-16/h2-9,14H,10-13,15H2,1H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of porcine brain GSK-3 alpha/beta using GS-1 substrate after 30 mins by scintillation and luminescence counting method in the presence of ...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta/[Tau protein] kinase


(Sus scrofa)		BDBM50499139
PNG
(CHEMBL3735563)
Show SMILES CCOc1ccc2c(cccc2c1)-c1nc2ccc(nn2c1-c1ccncc1)N1CCN(C)CC1
Show InChI InChI=1S/C28H28N6O/c1-3-35-22-7-8-23-21(19-22)5-4-6-24(23)27-28(20-11-13-29-14-12-20)34-25(30-27)9-10-26(31-34)33-17-15-32(2)16-18-33/h4-14,19H,3,15-18H2,1-2H3
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Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of porcine brain GSK-3 alpha/beta using GS-1 substrate after 30 mins by scintillation and luminescence counting method in the presence of ...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3


(Homo sapiens (Human))		BDBM50499148
PNG
(CHEMBL3734983)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C23H21N7S/c1-28-10-12-29(13-11-28)21-5-4-20-26-22(17-2-3-18-19(14-17)31-15-25-18)23(30(20)27-21)16-6-8-24-9-7-16/h2-9,14-15H,10-13H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of full length human GST-tagged RIPK3 expressed in Spodoptera frugiperda Sf9 cells after 30 mins by scintillation and luminescence countin...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1


(Homo sapiens (Human))		BDBM50499151
PNG
(CHEMBL3736103)
Show SMILES COc1ccc2c(cccc2c1)-c1nc2ccc(nn2c1-c1ccncc1)N1CCN(C)CC1
Show InChI InChI=1S/C27H26N6O/c1-31-14-16-32(17-15-31)25-9-8-24-29-26(27(33(24)30-25)19-10-12-28-13-11-19)23-5-3-4-20-18-21(34-2)6-7-22(20)23/h3-13,18H,14-17H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CDK5/P25 expressed in Escherichia coli using histone H1 substrate after 30 mins by scintillation and luminescence cou...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase haspin


(Homo sapiens (Human))		BDBM50499143
PNG
(CHEMBL3735817)
Show SMILES CN1CCN(CC1)c1ccc2nc(c(-c3ccncc3)n2n1)-c1cccc(c1)-c1cccs1
Show InChI InChI=1S/C26H24N6S/c1-30-13-15-31(16-14-30)24-8-7-23-28-25(26(32(23)29-24)19-9-11-27-12-10-19)21-5-2-4-20(18-21)22-6-3-17-33-22/h2-12,17-18H,13-16H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ Fran£ois-Rabelais de Tours

Curated by ChEMBL


Assay Description
Inhibition of human recombinant haspin kinase domain expressed in Escherichia coli BL21-KRX using histone H3 (1 to 21) peptide substrate after 30 min...

Eur J Med Chem 105: 80-105 (2015)


Article DOI: 10.1016/j.ejmech.2015.10.004
BindingDB Entry DOI: 10.7270/Q2736TX4
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%