Affinity Data by PubMed id=26931395

PubMed code 26931395

Found 13 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histamine H4 receptor (Homo sapiens (Human))	BDBM189355 (4-(4-Methylpiperazin-1-yl)-6-(pyridin-4-yl)-1,3,5-...) Show SMILES CN1CCN(CC1)c1nc(N)nc(n1)-c1ccncc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	3.19E+3	-29.2	n/a	n/a	n/a	n/a	n/a	7.4	4
Jagiellonian University Medical College					Assay Description Prior to the experiments, cell membranes were sedimented by a 10 min centrifugation at 4 °C and 16 0009x g and resuspended in binding buffer (12...				Chem Biol Drug Des 88: 254-63 (2016) Article DOI: 10.1111/cbdd.12752 BindingDB Entry DOI: 10.7270/Q21R6P93
Jagiellonian University Medical College					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM189346 (N-(4-Chlorophenyl)-4-methylpiperazine-1-carboxamid...) Show SMILES CN1CCN(CC1)C(=O)Nc1ccc(Cl)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	3.52E+3	-28.9	n/a	n/a	n/a	n/a	n/a	7.4	4
Jagiellonian University Medical College					Assay Description Prior to the experiments, cell membranes were sedimented by a 10 min centrifugation at 4 °C and 16 0009x g and resuspended in binding buffer (12...				Chem Biol Drug Des 88: 254-63 (2016) Article DOI: 10.1111/cbdd.12752 BindingDB Entry DOI: 10.7270/Q21R6P93
Jagiellonian University Medical College					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM189344 ((3-Chlorophenyl)(4-methylpiperazin-1-yl)methanone ...) Show SMILES CN1CCN(CC1)C(=O)c1cccc(Cl)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	3.88E+3	-28.7	n/a	n/a	n/a	n/a	n/a	7.4	4
Jagiellonian University Medical College					Assay Description Prior to the experiments, cell membranes were sedimented by a 10 min centrifugation at 4 °C and 16 0009x g and resuspended in binding buffer (12...				Chem Biol Drug Des 88: 254-63 (2016) Article DOI: 10.1111/cbdd.12752 BindingDB Entry DOI: 10.7270/Q21R6P93
Jagiellonian University Medical College					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM189352 (4-(4-Methylpiperazin-1-yl)-6-(naphthalen-1-ylmethy...) Show SMILES CN1CCN(CC1)c1nc(N)nc(Cc2cccc3ccccc23)n1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	5.60E+3	-27.9	n/a	n/a	n/a	n/a	n/a	7.4	4
Jagiellonian University Medical College					Assay Description Prior to the experiments, cell membranes were sedimented by a 10 min centrifugation at 4 °C and 16 0009x g and resuspended in binding buffer (12...				Chem Biol Drug Des 88: 254-63 (2016) Article DOI: 10.1111/cbdd.12752 BindingDB Entry DOI: 10.7270/Q21R6P93
Jagiellonian University Medical College					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM189353 (4-Benzyl-6-(4-methylpiperazin-1-yl)-1,3,5-triazin-...) Show SMILES CN1CCN(CC1)c1nc(N)nc(Cc2ccccc2)n1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	7.50E+3	-27.2	n/a	n/a	n/a	n/a	n/a	7.4	4
Jagiellonian University Medical College					Assay Description Prior to the experiments, cell membranes were sedimented by a 10 min centrifugation at 4 °C and 16 0009x g and resuspended in binding buffer (12...				Chem Biol Drug Des 88: 254-63 (2016) Article DOI: 10.1111/cbdd.12752 BindingDB Entry DOI: 10.7270/Q21R6P93
Jagiellonian University Medical College					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM189345 ((4-Chlorophenyl)(4-methylpiperazin-1-yl)methanone ...) Show SMILES CN1CCN(CC1)C(=O)c1ccc(Cl)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	7.55E+3	-27.2	n/a	n/a	n/a	n/a	n/a	7.4	4
Jagiellonian University Medical College					Assay Description Prior to the experiments, cell membranes were sedimented by a 10 min centrifugation at 4 °C and 16 0009x g and resuspended in binding buffer (12...				Chem Biol Drug Des 88: 254-63 (2016) Article DOI: 10.1111/cbdd.12752 BindingDB Entry DOI: 10.7270/Q21R6P93
Jagiellonian University Medical College					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM189351 (4-(4-Methylpiperazin-1-yl)-6-(2-methylpropyl)-1,3,...) Show SMILES CC(C)Cc1nc(N)nc(n1)N1CCN(C)CC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	8.26E+3	-27.0	n/a	n/a	n/a	n/a	n/a	7.4	4
Jagiellonian University Medical College					Assay Description Prior to the experiments, cell membranes were sedimented by a 10 min centrifugation at 4 °C and 16 0009x g and resuspended in binding buffer (12...				Chem Biol Drug Des 88: 254-63 (2016) Article DOI: 10.1111/cbdd.12752 BindingDB Entry DOI: 10.7270/Q21R6P93
Jagiellonian University Medical College					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM189354 (4-((4-Chlorophenoxy)methyl)-6-(4-methylpiperazin-1...) Show SMILES CN1CCN(CC1)c1nc(N)nc(COc2ccc(Cl)cc2)n1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.06E+4	-26.4	n/a	n/a	n/a	n/a	n/a	7.4	4
Jagiellonian University Medical College					Assay Description Prior to the experiments, cell membranes were sedimented by a 10 min centrifugation at 4 °C and 16 0009x g and resuspended in binding buffer (12...				Chem Biol Drug Des 88: 254-63 (2016) Article DOI: 10.1111/cbdd.12752 BindingDB Entry DOI: 10.7270/Q21R6P93
Jagiellonian University Medical College					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM189350 (3-((4-Amino-6-(4-methylpiperazin-1-yl)-1,3,5-triaz...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.46E+4	-25.7	n/a	n/a	n/a	n/a	n/a	7.4	4
Jagiellonian University Medical College					Assay Description Prior to the experiments, cell membranes were sedimented by a 10 min centrifugation at 4 °C and 16 0009x g and resuspended in binding buffer (12...				Chem Biol Drug Des 88: 254-63 (2016) Article DOI: 10.1111/cbdd.12752 BindingDB Entry DOI: 10.7270/Q21R6P93
Jagiellonian University Medical College					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM189348 (3,6-Dichloro-N-(3-(4-methylpiperazin-1-yl)propyl)b...) Show SMILES CN1CCN(CCCNC(=O)c2sc3cc(Cl)ccc3c2Cl)CC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	>1.00E+5	>-21.2	n/a	n/a	n/a	n/a	n/a	7.4	4
Jagiellonian University Medical College					Assay Description Prior to the experiments, cell membranes were sedimented by a 10 min centrifugation at 4 °C and 16 0009x g and resuspended in binding buffer (12...				Chem Biol Drug Des 88: 254-63 (2016) Article DOI: 10.1111/cbdd.12752 BindingDB Entry DOI: 10.7270/Q21R6P93
Jagiellonian University Medical College					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM189343 ((2-Chlorophenyl)(4-methylpiperazin-1-yl)methanone ...) Show SMILES CN1CCN(CC1)C(=O)c1ccccc1Cl Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	>1.00E+5	>-21.2	n/a	n/a	n/a	n/a	n/a	7.4	4
Jagiellonian University Medical College					Assay Description Prior to the experiments, cell membranes were sedimented by a 10 min centrifugation at 4 °C and 16 0009x g and resuspended in binding buffer (12...				Chem Biol Drug Des 88: 254-63 (2016) Article DOI: 10.1111/cbdd.12752 BindingDB Entry DOI: 10.7270/Q21R6P93
Jagiellonian University Medical College					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM189349 (1-(3-Chlorophenyl)-3-(3-(4-methylpiperazin-1-yl)pr...) Show SMILES CN1CCN(CCCNC(=O)Nc2cccc(Cl)c2)CC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>1.00E+5	>-21.2	n/a	n/a	n/a	n/a	n/a	7.4	4
Jagiellonian University Medical College					Assay Description Prior to the experiments, cell membranes were sedimented by a 10 min centrifugation at 4 °C and 16 0009x g and resuspended in binding buffer (12...				Chem Biol Drug Des 88: 254-63 (2016) Article DOI: 10.1111/cbdd.12752 BindingDB Entry DOI: 10.7270/Q21R6P93
Jagiellonian University Medical College					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM189347 (5-Chloro-N-(3-(4-methylpiperazin-1-yl)propyl)-1H-i...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	>1.00E+5	>-21.2	n/a	n/a	n/a	n/a	n/a	7.4	4
Jagiellonian University Medical College					Assay Description Prior to the experiments, cell membranes were sedimented by a 10 min centrifugation at 4 °C and 16 0009x g and resuspended in binding buffer (12...				Chem Biol Drug Des 88: 254-63 (2016) Article DOI: 10.1111/cbdd.12752 BindingDB Entry DOI: 10.7270/Q21R6P93
Jagiellonian University Medical College					More data for this Ligand-Target Pair

* indicates data uncertainty>20%